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Intrumer:A Multi Module Distributed Explainable IDS/IPS for Securing Cloud Environment

Computers, Materials & Continua 2025年第1期82卷 579-607页

作者： Nazreen Banu A S.k.B.Sangeetha Department of Computer Science and Engineering SRM Institute of Science and TechnologyVadapalani CampusChennai600026Tamil NaduIndia

The increasing use of cloud-based devices has reached the critical point of cybersecurity and unwanted network *** environments pose significant challenges in maintaining privacy and *** approaches,such as IDS,have been developed to tackle these ***,most conventional Intrusion Detection System(IDS)models struggle with unseen cyberattacks and complex high-dimensional *** fact,this paper introduces the idea of a novel distributed explainable and heterogeneous transformer-based intrusion detection system,named INTRUMER,which offers balanced accuracy,reliability,and security in cloud settings bymultiplemodulesworking together within *** traffic captured from cloud devices is first passed to the TC&TM module in which the Falcon Optimization Algorithm optimizes the feature selection process,and Naie Bayes algorithm performs the classification of *** selected features are classified further and are forwarded to the Heterogeneous Attention Transformer(HAT)*** this module,the contextual interactions of the network traffic are taken into account to classify them as normal or malicious *** classified results are further analyzed by the Explainable Prevention Module(XPM)to ensure trustworthiness by providing interpretable *** the explanations fromthe classifier,emergency alarms are transmitted to nearby IDSmodules,servers,and underlying cloud devices for the enhancement of preventive *** experiments on benchmark IDS datasets CICIDS 2017,Honeypots,and NSL-kDD were conducted to demonstrate the efficiency of the INTRUMER model in detecting network trafficwith high accuracy for different *** outperforms state-of-the-art approaches,obtaining better performance metrics:98.7%accuracy,97.5%precision,96.3%recall,and 97.8%*** results validate the robustness and effectiveness of INTRUMER in securing diverse cloud environments against sophisticated cyber threats.

关键词： Cloud computing intrusion detection system transformers and explainable artificial intelligence(XAI)

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Phenolic compounds as natural feed additives in poultry and swine diets:a review

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Journal of Animal Science and Biotechnology 2021年第3期12卷 841-858页

作者： shad Mahfuz Qinghui Shang Xiangshu Piao State key Laboratory of Animal Nutrition College of Animal Science and TechnologyChina Agricultural UniversityBeijing 100193China

Due to ban on using antibiotics in feed industry,awareness of using natural feed additives have led to a great *** interest of plants phenolic compounds as a potential natural antioxidant source has been considered in research community due to their predictable potential role as feed additives in poultry and swine ***,the mode of action for their functional role and dosage recommendation in animal diets are still remain *** into account,the present review study highlights an outline about the mode of action of phenolic compound and their experimental uses in poultry and swine focusing on the growth performance,antioxidant function,immune function,antimicrobial role and overall health status,justified with the past findings till to ***,the present review study concluded that supplementation of phenolic compounds as natural feed additives may have a role on the antioxidant,immunity,antimicrobial and overall production performance in poultry and swine.

关键词： Antioxidant role Immune response Phenolic compounds Production performance Poultry Swine

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Effects of P301L-TAU on post-translational modifications of microtubules in human iPSC-derived cortical neurons and TAU transgenic mice

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Neural Regeneration Research 2025年第8期20卷 2348-2360页

作者： Mohamed Aghyad Al kabbani Christoph köhler Hans Zempel Institute of Human Genetics Faculty of Medicine and University Hospital CologneUniversity of CologneCologneGermany Center for Molecular Medicine Cologne(CMMC) University of CologneCologneGermany Center Anatomy Department ⅡMedical FacultyUniversity of CologneCologneGermany

TAU is a microtubule-associated protein that promotes microtubule assembly and stability in the *** is missorted and aggregated in an array of diseases known as *** are essential for neuronal function and regulated via a complex set of post-translational modifications,changes of which affect microtubule stability and dynamics,microtubule interaction with other proteins and cellular structures,and mediate recruitment of microtubule-severing *** impairment of microtubule dynamics causes neuronal dysfunction,we hypothesize cognitive impairment in human disease to be impacted by impairment of microtubule *** therefore aimed to study the effects of a disease-causing mutation of TAU(P301L)on the levels and localization of microtubule post-translational modifications indicative of microtubule stability and dynamics,to assess whether P301L-TAU causes stability-changing modifications to *** investigate TAU localization,phosphorylation,and effects on tubulin post-translational modifications,we expressed wild-type or P301L-TAU in human MAPT-kO induced pluripotent stem cell-derived neurons(i Neurons)and studied TAU in neurons in the hippocampus of mice transgenic for human P301L-TAU(p R5 mice).Human neurons expressing the longest TAU isoform(2N4R)with the P301L mutation showed increased TAU phosphorylation at the AT8,but not the p-Ser-262 epitope,and increased polyglutamylation and acetylation of microtubules compared with endogenous TAU-expressing neurons.P301L-TAU showed pronounced somatodendritic presence,but also successful axonal enrichment and a similar axodendritic distribution comparable to exogenously expressed 2N4R-wildtype-TAU.P301L-TAU-expressing hippocampal neurons in transgenic mice showed prominent missorting and tauopathy-typical AT8-phosphorylation of TAU and increased polyglutamylation,but reduced acetylation,of microtubules compared with non-transgenic *** sum,P301L-TAU results in changes in micr

关键词： human induced pluripotent stem cell microtubules P301L pR5 mice TAU tauopathy tubulin code

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Do black-furred animals compensate for high solar absorption with smaller hairs？ A test with a polymorphic squirrel species

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Current Zoology 2011年第6期57卷 731-736页

作者： melanie A. FRATTO Andrew k. DAVIS Odum School of Ecology The University of Georgia Athens GA USA 30602

In polymorphic mammalian species that display multiple color forms, those with dark, or melanic pelage would be prone to overheating, especially if they live in warm climates, because their fur absorbs solar energy at a higher rate. However, experimental studies indicate that certain physical properties of fur of dark individuals appear to prevent, or minimize heat stress, although it is not clear what properties do so. Here, we tested the possibility that black-furred individuals simply have shorter or thinner hair fibers, which would create a lighter （in terms of weight） coat or one that allows greater air flow for evaporative coo- ling. We examined museum specimens of eastern fox squirrels Sciurus niger, a species native to the United States and one that displays brown, grey or all-black pelage color, and used image analysis procedures to quantify hairs from the dorsal surface and tail. From examination of 43 specimens （19 brown, 9 black and 15 grey）, and 1,720 hairs, we found no significant difference in hair lengths across color morphs, but significant differences in hair fiber widths. Black squirrels had thinner body hairs than other forms （7% thinner）, but thicker tail hairs （9% thicker） than the others. Given that the dorsal surface would be directly exposed to solar radiation, we interpret this to be an adaptation to prevent heat stress during the day. The thicker tail hairs may be an adapta- tion for nighttime thermoregulation, since squirrels sleep with their tails wrapped around their bodies. These results add to a growing literature body of the functional significance of mammalian pelage [Current Zoology 57 （6）： 731-736, 2011].

关键词： Polymorphism Melanism Fox squirrels Sciurus niger Heat stress Hair morphology

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Evaluation of sample scale effect on geomechanical tests

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Petroleum Research 2022年第4期7卷 527-535页

作者： Maryam kashfi Saeed shad Davood Zivar Department of Chemical and Petroleum Engineering Sharif University of TechnologyTehranIran PanTerra Geoconsultants B.V LeiderdorpNetherlands

The size of the rock specimen affects the stress concentrates in the vicinity of the top/bottom of the rock specimen during the evaluation of the geomechanical parameters in the laboratory,which causes un-reliable ***,the appropriate size for geomechanical evaluation is not well understood yet because of limitations in the sampling and *** this study,a series of numerical simulations using a finite element package was conducted to investigate the effect of sample aspect ratio,fluid saturation,and porosity,on the mechanical behavior of the rock under elastic and poroelastic *** addition,two concepts,stress/strain homogeneity index(SHI)and representative elementary volume(REV),were developed to find out the appropriate sample *** results show that the presence of stiff platens,which are dissimilar to the specimen material,causes significant stress concentration in the two ends of the *** concentration of stress in the specimen reduces when the aspect ratio *** optimum aspect ratio(length-to-diameter equal to 3)was observed by SHI analysis which after that the changes in stress concentration are *** REV size analysis confirms the obtained optimum aspect ratio by SHI *** saturated specimens show a lower magnitude of stress than applied stress because of the presence of pore pressure,which can carry a portion of the *** higher void ratio results in lower strength of the *** study could be beneficial for the better design of geomechanical tests to have reliable results.

关键词： Geomechanics Stress concentration Stress/strain homogeneity index Representative elementary volume(REV) Poroelastic Scale dependency

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Geomechanical analysis of an oil field:Numerical study of wellbore stability and reservoir subsidence

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Petroleum Research 2023年第3期8卷 350-359页

作者： Saeed shad Parvin kolahkaj Davood Zivar Department of Chemical and Petroleum Engineering Sharif University of TechnologyTehranIran PanTerra Geoconsultants B.V LeiderdorpNetherlands

Geomechanics as the knowledge of rock deformation and stability is an indispensable part of all field development *** geomechanical analyses leads to a safer and more efficient operation otherwise different kinds of instability and distortion might *** this study,the geomechanical behavior of Ilam and Sarvak formations of an oil field in southwest of Iran was *** research objectives can be summarized as wellbore stability evaluation and predicting the value of reservoir subsidence due to pressure drop as a result of reservoir fluid *** fulfill these,a set of petrophysical logs run in the exploration well of this green field were ***,using empirical correlations and statistical methods,required data for evaluating wellbore stability during drilling,specifying safe mud window to discover reservoir breakdown pressure,predicting the possibility of wellbore collapse in field lifetime,and assessing reservoir subsidence were *** results revealed that the average subsidence value as the consequence of production within 21 years is 0.275 ft Which is not *** terms of wellbore stability,it was concluded that all horizontal and vertical wells remain stable during this time *** to conclude,field development is not associated with alarming incidents from geomechanical aspect.

关键词： Dynamic geomechanical properties Subsidence Formation compaction Wellbore stability Stress streonet

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Human endogenous retrovirus type-W and multiple sclerosis–related smoldering neuroinflammation

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Neural Regeneration Research 2025年第3期20卷 813-814页

作者： Joel Gruchot Laura Reiche Andrew Chan Robert Hoepner Patrick küry Department of Neurology Medical Faculty and University Hospital DüsseldorfHeinrich Heine University DüsseldorfDüsseldorfGermany Department of Neurology InselspitalBern University Hospital and University of BernBernSwitzerland

Introduction to human endogenous retrovirus type-W(HERV-W): Genomic inheritance from the past includes retroviral sequences that have been stably incorporated into our genomes and account for up to 8% of human DNA.

关键词： endogenous inflammation Human

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Nucleoside modified mRNA-lipid nanoparticles as a new delivery platform for the repair of the injured spinal cord

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Neural Regeneration Research 2025年第8期20卷 2311-2312页

作者： krisztián Pajer Tamás Bellák Antal Nógrádi Department of Anatomy Histology and EmbryologyAlbert Szent-Györgyi Medical SchoolUniversity of SzegedSzegedHungary

Spinal cord injury and treatment opportunities:The adult mammalian spinal cord has a very limited capacity for spontaneous regeneration due to various intrinsic molecular and cellular *** the spinal cord neurons have the capacity to regenerate their axons,the expression of growth inhibitory factors,lack or suppression of proper guidance cues,and profound inflammatory responses do not permit successful regeneration(khyeam et al.,2021).

关键词： injured capacity modified

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Mechanical behavior of salt rocks: A geomechanical model

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Petroleum 2023年第4期9卷 508-525页

作者： Saeed shad Negar Razaghi Davood Zivar Soheil Mellat Department of Chemical and Petroleum Engineering Sharif University of TechnologyTehranIran PanTerra Geoconsultants BV LeiderdorpNetherlands

The geomechanical behavior of salt rocks is a significant concern during drilling and development operations in some hydrocarbon reservoirs and underground gas storage *** this study,the static and dynamic salt rock geomechanical properties from a field in southwest Iran were evaluated using experiments such as waves'velocities,and thermo-mechanical coupled uniaxial and triaxial compression *** a result and by considering both the petrophysical well logs and laboratory data of the waves’velocities,it is observed that the elastic properties of the core samples are concentrated within a narrow range unless an abnormality causes *** results of uniaxial compression tests showed that rock strength decreases with increasing temperature *** addition,the reduction of rock strength was observed with increasing porosity of the core samples as *** the case of triaxial compression tests,applying confining pressure on the core sample caused an increment in rock strength,while temperature decreased rock *** temperature also increased cohesion and decreases friction *** ratio of changes in stress to strain was used to investigate the dynamic changes in the geomechanical *** maximum 0.25 damage factor was observed for the core samples for different definitions of the damage ***,we propose a novel analytical model to predict the stress-strain behavior of salt rocks at different *** model was validated using experimental results and indicated a satisfactory accuracy.

关键词： Salt rock Underground gas storage Geomechanics Dynamic and static mechanical properties Transition zone Damage factor

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Prediction of rotary drilling penetration rate in iron ore oxides using rock engineering system

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International Journal of Mining Science and Technology 2018年第3期28卷 407-413页

作者： Hossein Inanloo Arabi shad Farhang Sereshki Mohammad Ataei Mohammad karamoozian Department of Mining Petroleum and Geophysics Shahrood University of Technology

Prediction of the drilling penetration rate is one of the important parameters in mining operations. This parameter has a direct impact on the mine planning and cost of mining operations, Generally, effective parameters on the penetration rate is divided into two classes： rock mass properties and specifications of the machine, The chemical components of intact rock have a direct effect in determining rock mechan- ical properties, Theses parameters usually have not been investigated in any research on the rock drill- ability, In this study, physical and mechanical properties of iron ore were studied based on the amount of magnetite percent, According to the results of the tests, the effective parameters on the pen- etration rate of the rotary drilling machines were divided into three classes： specifications of the machi- nes, rock mass properties and chemical component of intact rock, Then, the rock drillahility was studied using rock engineering systems, The results showed that feed, rotation, rock mass index and iron oxide percent have important effect on penetration rate, Then a quadratic equation with 0,896 determination coefficient has been obtained, Also, the results showed that chemical components can he described as new parameters in rotary drill penetration rate,

关键词： Penetration rate Rotary drill Rock engineering system Chemical components

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