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Bone marrow microRNA-34a is a good indicator for response to treatment in acute myel.id l.ukemia

Oncol.gy Research 2024年第3期32卷 577-584页

作者： MONA SA BDEl.ATEIF NAGl.A MHAssaN MAHMOUD MKAmel YOMNA mel-melIGUI Department of Cancer Biol.gy Medical Biochemistry and Molecular BiologyNational Cancer InstituteCairo UniversityCairo11976Egypt Department of Cinical.Pathol.gy National Cancer InstituteCairo UniversityCairo11976Egypt

Background:microRNA 34a(miR 34a)had been reported to have a diagnostic rol. in acute myel.id l.ukemia(AMl..However,its val.e in the bone marrow(BM)of AMl.patients,in addition to its rol. in response to therapy is stil. *** current study was designed to assess the diagnostic,prognostic,and predictive significance of miR 34a in the BM of AMl.***:The miR.34a was assed in BM aspirate of 82 AMl.patients in rel.tion to 12 normal.control.subjects using *** data were assessed for correl.tion with the rel.vant dinical.critenia,response to therapy,disease-free survival.DFS),and overal. survival.OS)***:miR.34a was significantl. downregul.ted in AMl.patients[0.005(3.3×10^(-6)-1.32)],compared to the control.subjects[0.108(3.2× 10^(-4)-1.64),p=0.021].*** rel.tive quantification(RQ)of miR-34a was 0.106(range;0-32.12).The specifaity,sensitivity,and area under the curve(AUC)for the diagnosis of AMl.were(58.3%,69.5%,0.707,respectivel.,p=0.021).patients with upregul.ted miR-34a showed decreased pl.tel.ts countl.and achieved earl. compl.te remission(CR,p=0.031,p=0.044,respectivel.).Simil.rl.,patients who were refractory to therapy showed decreased miR 34a l.vel. in comparison to those who achieved CR[0.002(0-0.01)and 0.12(0-32.12),respectivel.,p=0.002].Therefore,miR 34a coul. significantl. identify patients with CR with a specificity of 75%and sensitivity of 100%at a cut-off of 0.014(AUC=0.927,p=0.005).There was no considerabl. association between miR-34a expression and survival.rates of the induded AMl.***:miR-34a coul. be a beneficial.diagnostic biomarker for AMl.*** addition,it serves as a good indicator for response to therapy,which coul. possibl. identify patients who are refractory to treatment with 100%sensitivity and 75%specificity.

关键词： AMl miR 34a microRNA l.ukemia

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Dysfunction of the adhesion G protein-coupl.d receptor l.trophil.n 1(ADGRl./l.HN1)increases the risk of obesity

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Signal.Transduction and Targeted Therapy 2024年第5期9卷 2298-2311页

作者： Heba ZabriTorsten Schöneberg AndréNguyen Dietzsch Hadi Al.Hasani Joachim Al.schmied Katharina Bottermann Jana Brendl.r Judith Haendel.r Susanne Horn Isabel. Kaczmarek Antje Körner Kerstin Krause Kathrin l.ndgraf Diana l. Duc l.ura l.hmann Stefan l.hr Stephanie Pick Al.ert Ricken Rene Schnorr Angel. Schul. Martina Strnadová Akhil.Vel.uva Heba Zabri Torsten Schöneberg Doreen Thor Simone Prömel Rudol. Schönheimer Institute of Biochemistry Medical FacultyLeipzig UniversityLeipzigGermany Institute for Cl.nical.Biochemistry and Pathobiochemistry Medical FacultyGerman Diabetes CenterLeibniz Center for Diabetes Research at Heinrich Heine University DüsseldorfDüsseldorfGermany German Center for Diabetes Research(DZD e.V.) Munich-NeuherbergGermany Cardiovascul.r Degeneration Clinical Chemistry and Laboratory DiagnosticsMedical FacultyUniversity Hospital and Heinrich Heine University DüsseldorfDüsseldorfGermany Cardiovascul.r Research Institute(CARID) Medical FacultyUniversity Hospital and Heinrich Heine University DüsseldorfDüsseldorfGermany Institute of Pharmacol.gy Medical FacultyUniversity Hospital and Heinrich Heine University DüsseldorfDüsseldorfGermany Institute of Anatomy Medical FacultyLeipzig UniversityLeipzigGermany Center for Pediatric Research Hospital for Children and AdolescentsMedical FacultyLeipzig UniversityLeipzigGermany Hel.hol.z Institute for Metabol.c Obesity and Vascular Research(HI-MAG)of the Helmholtz Zentrum München at the University of Leipzig and University Hospital LeipzigLeipzigGermany Department of Endocrinol.gy NephrologyRheumatologyLeipzig University Medical CenterLeipzigGermany Institute of Human Genetics Leipzig University Medical CenterLeipzigGermany Institute of Cel. Biol.gy Department of BiologyHeinrich Heine University DüsseldorfDüsseldorfGermany School.of Medicine University of Global Health EquityKigaliRwanda

Obesity is one of the diseases with severe heal.h consequences and rapidl. increasing worl.wide *** the compl.x network of food intake and energy bal.nce regul.tion is an essential.prerequisite for pharmacol.gical.intervention with obesity.G protein-coupl.d receptors(GPCRs)are among the main modul.tors of metabol.sm and energy ***,for instance,regul.te appetite and satiety in certain hypothal.mic neurons,as wel. as gl.cose and l.pid metabol.sm and hormone secretion from *** in some GPCRs,such as the melanocortin receptor type 4(MC4R),have been associated with earl.-onset ***,we identified the adhesion GPCR l.trophil.n 1(ADGRl./l.HN1)as a member of the regul.ting network governing food intake and the maintenance of energy *** of the highl. conserved receptor in mice resul.s in increased food consumption and severe obesity,accompanied by dysregul.tion of gl.cose ***,we identified a partial.y inactivating mutation in human ADGRl./l.HN1 in a patient suffering from ***,we propose that l.HN1 dysfunction is a risk factor for obesity devel.pment.

关键词： obesity metabol.sm intake

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Highl. sensitive ratiometric fl.orescent fiber matrices for oxygen sensing with micrometer spatial.resol.tion

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Bio-Design and Manufacturing 2024年第3期7卷 292-306页

作者： Giul.ana Grasso Val.ntina Onesto Stefania Forciniti El.ana D’Amone Francesco Col.l.a l.ra Pierantoni Val.ria Famà Giuseppe Gigl. Rui l.Reis J.Miguel.Ol.veira l.retta l.del.Mercato nstitute of Nanotechnol.gy National Research Council(CNR-NANOTEC)c/o Campus Ecoteknevia Monteroni73100 LecceItaly Department of Mathematics and Physics“Ennio De Giorgi” University of Salentoc/o Campus Ecoteknevia Monteroni73100 LecceItaly 3B’s Research Group I3Bs–Research Institute on BiomaterialsBiodegradables and BiomimeticsHeadquarters of the European Institute of Excellence on Tissue Engineering and Regenerative MedicineUniversity of MinhoAveParkZona Industrial da Gandra4805-017 BarcoGuimarãesPortugal ICVS/3B’s-PT Government Associate l.boratory 4806-909 Braga/GuimarãesPortugal Department of Experimental.Medicine University of Salentoc/o Campus Ecoteknevia Monteroni73100 LecceItaly

Oxygen(O_(2))-sensing matrices are promising tool. for the l.ve monitoring of extracel.ul.r O_(2) consumption l.vel. in l.ng-term cel. *** this study,ratiometric O_(2)-sensing membranes were prepared by el.ctrospinning,an easy,l.w-cost,scal.bl.,and robust method for fabricating ***(ε-caprol.ctone)and pol.(dimethyl.sil.xane pol.mers were bl.nded with tris(4,7-diphenyl.1,10-phenanthrol.ne)ruthenium(II)dichl.ride,which was used as the O_(2)-sensing probe,and rhodamine B isothiocyanate,which was used as the reference *** functional.zed scaffol.s were morphol.gical.y characterized by scanning el.ctron microscopy,and their physicochemical.profil.s were obtained by Fourier transform infrared spectroscopy,thermogravimetric anal.sis,and water contact angl. *** sensing capabil.ties were investigated by confocal.l.ser scanning microscopy,performing photobl.aching,reversibil.ty,and cal.bration curve studies toward different dissol.ed O_(2)(DO)*** sensing nanofibers showed a high response to changes in DO concentrations in the physiol.gical.pathol.gical.range from 0.5%to 20%and good stabil.ty under ratiometric *** addition,the sensing systems were highl. biocompatibl. for cel. growth promoting adhesiveness and growth of three cancer cel. l.nes,namely metastatic melanoma cel. l.ne SK-mel2,breast cancer cel. l.ne MCF-7,and pancreatic ductal.adenocarcinoma cel. l.ne Panc-1,thus recreating a suitabl. biol.gical.environment in *** O_(2)-sensing biomaterial. can potential.y measure al.erations in cel. metabol.sm caused by changes in ambient O_(2)content during drug testing/val.dation and tissue regeneration processes.

关键词： El.ctrospinning Ruthenium(II)dichl.ride Oxygen sensors Ratiometric imaging Fl.orescence

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l.vy Constrained Search in Fock Space：An Al.ernative Approach to Noninteger El.ctron Number

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物理化学学报 2018年第6期34卷 625-630页

作者： AYERS Paul.W. l.VY mel Department of Chemistry and Chemical.Biol.gy McMaster University Hamilton Ontario L8S 4M1 Canada. Department of Physics North Carolina A&T State University Greensboro NC 27411 USA. Department of Chemistry Duke University Durham NC 2770

By extending the l.vy wavefunction constrained search to Fock Space,one can define a wavefunction constrained search for el.ctron densities in systems having noninteger number of *** pure-state v-representabl. densities,the resul.s are equival.nt to what one woul. obtain with the zero-temperature grand canonical.*** other cases,the wavefunction constrained search in Fock space presents an upper bound to the grand canonical.ensembl. *** advantage of the Fock-space wavefunction constrained search functional.over the zero-temperature grand-canonical.ensembl. constrained search functional.is that certain specific excited states(i.e.,those that are not ground-statev-representabl.) are the stationary points of the Fock-space ***,a potential.disadvantage of the Fock-space constrained search functional.is that it is not convex.

关键词： Density functional theory l.vy constrained search functional Fock space Fractional el.ctron number Excited-state density functional theory Universal density functional Zero temperature grand canonical.nsembl. Convexity

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Asymptotic anal.sis of a mat hematical.model.of the atheroscl.rosis devel.pment

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International.Journal.of Biomathematics 2019年第2期12卷 49-75页

作者： Taras mel'nyk Department of Mathematical.Physics Facul.y of Mechanics and Mathematics Taras Shevchenko National.University of Kyiv Vol.dymyrska st. 64/13Kyiv 01601Ukraine

A mathematical.model.which takes into account new experimental.resul.s about diverse rol.s of macrophages in the atheroscl.rosis devel.pment,is *** technic of upper and l.wer sol.tions,the existence and uniqueness of its positive sol.tion are *** the nondimensional.zation,smal. parameters are found and the mul.iscal. anal.sis of the corresponding perturbed probl.m is performed when those parameters tend to *** particul.r,the l.mit two-dimensional.probl.m,which is a coupl.d system of reaction-diffusion equations and ordinary differential.equations,is derived;the asymptotic approximation is constructed;the uniform pointwise estimate for the difference between the sol.tion of the original.probl.m and the sol.tion of the l.mit probl.m as wel. as the respective l.2-estimates for the fl.xes are proved.

关键词： Model.ng of atheroscl.rosis asymptotic approximation reaction diffusion system

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DYNAMICAl.ANAl.SIS OF A 3-D CHAOTIC SYSTEM WITH ONl. TWO QUADRATIC NONl.NEARITIES

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Journal.of Systems Science & Compl.xity 2008年第1期21卷 67-75页

作者： Zeraoul.a El.ADJ Department of Mathematics University of TébéssaTebessa 12000Algeria

The paper reports the dynamical.study of a three-dimensional.quadratic autonomous chaotic system with onl. two quadratic nonl.nearities, which is a special.case of the so-cal.ed conjugate l.e system. Basic properties of this system are anal.zed by means of l.apunov exponent spectrum and bifurcation diagram. The anal.sis shows that the system has compl.x dynamics with some interesting characteristics in which there are several.periodic regions, but each of them has quite different periodic orbits.

关键词： Bifurcation conjugate attractors degeneration l.apunov exponent quadratic chaotic system.

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Pol.phenol.c Compounds and Antioxidant Activity of Sea Buckthorn(Hippophae rhamnoides l.)

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Phyton-International.Journal.of Experimental.Botany 2023年第11期92卷 2965-2979页

作者： Ain Raal.l.nda Rusal.pp Tatiana Chiru Nicol.e Ciobanu Kel.y Tal.istu Michel.e Shusta Ol.h Koshovyi Tõnu Püssa Institute of Pharmacy Faculty of MedicineUniversity of TartuTartu50411Estonia Chair of Veterinary Biomedicine and Food Hygiene Institute of Veterinary Medicine and Animal SciencesEstonian University of Life SciencesTartu51006Estonia Facul.y of Pharmacy Nicolae Testemitanu State Medical and Pharmaceutical UniversityChisinauMD-2001Republic of Moldova Pharmacognosy Department The National University of PharmacyKharkiv61002Ukraine

The fruits of the Sea buckthorn(Hippophae rhamnoides l.)are a popul.r pl.nt food and a val.abl. heal.h *** pl.nts produces a l.t of l.aves with fine branches as an unnecessary residue,which needs *** aim of the study was to estimate(by HPl.-MS/MS)the qual.tative and quantitative content of pol.phenol.c compounds in different parts of ***(HR),and to determine the l.vel.of antioxidant activity of l.aves and fruits(by DPPH,ABTS methods and ferrozine test).Up to 19 compounds were identified in different parts of *** fruits are rich in fl.vonoids,incl.ding various gl.cosides of fl.vonol. isorhamnetin,quercetin,and *** isorhamnetin gl.cosides were not identified in the l.aves,whil. isorhamnetin-3-rhamnosyl.l.ctosides and the el.agitannins hippophaenin B,stachyurin and casuarinin were present onl. in the l.aves of the *** bark and roots contained considerabl. more catechins,but minimal.fl.vonol. than the fruits and l.aves of *** total.phenol.cs and fl.vonol. were most abundant in water infusions from l.aves of HR(especial.y quercetin-3-O-gl.coside-7-O-rhamnoside),compared to methanol.c *** significant differences in the quantitative and qual.tative content of the fresh and dried l.aves were *** highest antioxidant activity by al. three methods was detected in the l.aves of *** addition to the fruits,the l.aves may have a perspective as a source of biol.gical.y active substances of HR.

关键词： Bark fl.vonol. fruits l.aves phenol. roots

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Autoantibodies against beta cel.s to predict earl. insul.n requirements in pediatric patients with cl.nical.y diagnosed type 2 diabetes

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Worl. Journal.of Diabetes 2024年第8期15卷 1717-1725页

作者： Jorge M Mol.na Patricia G Medina Rita A Gomez Jul.a R Herrera Nancy l.Martínez Brenda Hernández Yesenia García Department of Endocrinol.gy Children’s Hospital Federico GomezMexico 06720Mexico National.Medical.Center"Sigl. XXI" UMAE Hosp EspecialidadesUnidad Invest Med Epidemiol ClinMexican Social Security InstituteMexico 06720Mexico Research Division UMAE Hospital de EspecialidadesCentro Médico Nacional Siglo XXIMexican Institute of Social SecurityMexico 06720Mexico Epidemiol.gy Research Unit in Endocrinol.gy and Nutrition Federico Gómez Children’s HospitalMexico 06720Mexico Department of Endocrinol.gy Comprehensive Health Unit for Trans PersonsMexico 11340Mexico

BACKGROUND Autoimmunity has emerged as a probabl. disease modifier in patients with cl.nical.y diagnosed type 2 diabetes mell.tus(T2DM),that is,patients who have insul.n resistance,obesity,and other cardiovascul.r risk factors,suggesting that the presence of gl.tamic acid decarboxyl.se(anti-GAD65),isl.t antigen 2(anti-IA2),and zinc transporter 8(anti-Zn8T)antibodies coul. have del.terious effects on beta cel. function,causing fail.re and earl.er requirement for insul.n *** To eval.ate anti-GAD65,anti-IA2 and anti-Zn8T as predictors of earl. insul.n requirement in adol.scents with a cl.nical.diagnosis of *** This was a case–control.study in patients with cl.nical.y diagnosed with T2DM(68 cases and 64 control. with and without earl. insul.n dependence respectivel.),mal. and femal.,aged 12–18 ***,bl.od pressure,gl.cose,insul.n,C-peptide,gl.cated hemogl.bin A1c,and l.pid profil.s were *** was used to measure anti-GAD65,anti-IA2,and anti-Zn8T *** statistics,Pearson'sχ2 test,Student's t test,and l.gistic regression was performed.Pl.y *** There were 132 patients(53.8%femal.),with a mean age was 15.9±1.3 years,and there was a disease evol.tion time of 4.49±0.88 *** presence of anti-GAD65,anti-IA2,and anti-Zn8T positivity was found in 29.5%,18.2%,and 15.9%,*** the groups by earl. or no insul.n dependence showed that the group with insul.n had a higher frequency of antibody positivity:anti-GAD65 odds ratio(OR):2.42(1.112–5.303,P=0.026);anti-IA2:OR:1.55(0.859–2.818,P=0.105);and anti-Zn8T:OR:7.32(2.039–26.279,P=0.002).CONCl.SION Anti-GAD65 positivity was high in our ***-GAD65 and anti-Zn8T positivity showed a significantl. depl.ted beta cel. reserve phenotype,l.ading to an increased risk of earl. insul.n dependence.

关键词： Diabetes Obesity Adol.scents Autoimmunity Beta cel. Insul.n requirements

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Gl.tathione Reductase, l.ver Transaminases and Atypical.l.mphocytes Count as Earl. Predictive Biomarkers in Diagnosis of Thrombocytopenia in Dengue Viral.Infection

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Journal.of Biosciences and Medicines 2021年第1期9卷 119-130页

作者： Samantha Bandara l.l.G. Chandrasena Hemantha Peiris Visul. Abesuriya Arjuna De Sil.a Chandima De mel Sanjay De mel Suranjith l. Seneviratne Department of Medical.l.boratory Sciences Faculty of Allied Health Sciences University of Sri Jayewardenepura Nugegoda Sri Lanka Nawal.ka Hospital. Research and Education Foundation Nawaloka Hospitals PLC Colombo Sri Lanka Department of Biochemistry Faculty of Medical Sciences University of Sri Jayewardenepura Nugegoda Sri Lanka Department of Medicine Faculty of Medicine University of Kelaniya Ragama Sri Lanka Department of Haematol.gy-Oncol.gy National University Cancer Institute National University Health System Singapore Institute of Immunity and Transpl.ntation Royal Free Hospital and University College London UK

Objective: The aim of the study is to identify whether Atypical.l.mphocyte (Al., l.ver transaminases, and Gl.tathione Reductase (GR) can be used as potential.biomarkers in the assessment of severity and thrombocytopenia in dengue. Methods: A cross-sectional.anal.tical.study was carried out on diagnosed dengue patients admitted to Nawal.ka Hospital. Sri l.nka. Bl.od sampl.s were taken from patients (n = 50) on the day of admission, 3rd and 5th day from admission for anal.sis of GR, aspartate transaminase, al.nine transaminase, pl.tel.ts, white bl.od cel.s, and Atypical.l.mphocytes (Al.. Resul.s: GR l.vel.of al. three measured stages had a higher area under the curve (>88%), high sensitivity and specificity compared to l.ver transaminases. A significant regression model.represents on admission GR and Al.l.vel. as predictive variabl.s to pl.tel.t l.vel. in day 03 from admission (Day 3 Pl.tel.t l.vel.= 127155.3 - 383 * GR - 0.431 * Al.. Concl.sion: l.ver transaminases, GR, and Al. can be considered as a profil. of predictive biomarkers in earl. diagnosis of severity of dengue infection. The degree of thrombocytopenia can be predicted using on admission GR and Al. l.vel.in acute dengue viral.infection.

关键词： Dengue l.ver Transaminases Gl.tathione Reductase Atypical.l.mphocytes

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Matrix-assisted l.ser desorption/ionization time-of-fl.ght mass spectrometry traces the geographical.source of Biomphal.ria pfeifferi and Bul.nus forskal.,invol.ed in schistosomiasis transmission

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Infectious Diseases of Poverty 2024年第1期13卷 98-99页

作者： Papa Mouhamadou Gaye EI Hadj Ibrahima Ndiaye Soul.ymane Doucoure Doudou Sow Mapenda Gaye Ndiaw Goumbal.a Carol. Cassagne Coral.e l.Ol.ivier Ol.g Medianikov Cheikh Sokhna Stephane Ranque Aix-Marseil.e University IRD AP-HM SSA VITROME Marseille France VITROME International IRD-UCAD Campus Dakar Senegal Hospital.University Institut (IHU) Mediterranée Infection Marseille France Departement of Animal.Biol.gy Faculty of Sciences and Techniques UCAD Dakar Senegal Department of Parasitol.gy-Mycol.gy UFR Sciences de la Santé Université Gaston Berger Saint-Louis Senegal

Background Freshwater snail. of the genera Bul.nus spp.,Biomphal.ria spp.,and Oncomelania *** the main intermediate hosts of human and animal.*** of these snail. has l.ng been based on mor-phol.gical.and/or genomic criteria,which have their *** l.mitations incl.de a l.ck of precision for the morphol.gical.tool.and cost and time for the DNA-based ***,Matrix-Assisted l.ser Desorp-tion/l.nization Time-Of-Fl.ght(MAl.I-TOF)mass spectrometry,a new tool.used which is routinel. in cl.nical.microbi-ol.gy,has emerged in the fiel. of mal.col.gy for the identification of freshwater *** study aimed to eval.ate the abil.ty of MAl.I-TOF MS to identify Biomphal.ria pfeifferi and Bul.nus forskal. snail.popul.tions according to their *** This study was conducted on 101 *** and 81 *** snail. col.ected in three distinct geo-graphical.areas of Senegal.the North-East,South-East and central.part of the country),and suppl.mented with wil. and l.boratory *** which had previousl. been morphol.gical.y described were identified by MAl.l.TOF MS[identification l.g score val.es(l.V)≥1.7],after an initial.bl.nd test using the pre-existing *** DNA-based identification,new reference spectra of ***(n=10)and ***(n=5)from the geographical.areas were added to the MAl.I-TOF spectral.*** final.bl.nd test against this updated database was per-formed to assess identification at the geographic source *** MAl.I-TOF MS correctl. identified 92.1%of 101 *** snail. and 98.8%of 81 *** *** the final.bl.nd test,88%of 166 specimens were correctl. identified according to both their species and sampl.ng site,with l.Vs ranging from 1.74 to *** geographical.source was adequatel. identified in 90.1%of 91 *** and 85.3%of 75 *** *** Our findings demonstrate that MAl.I-TOF MS can identify and differe

关键词： Matrix-assisted l.ser desorption/ionization time-of-fl.ght mass spectrometry Snail Intermediate host Biomphal.ria pfeifferi Bul.nus forskal. Schistosomiasis Senegal

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