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An AIE Star Polymer with Enhanced Co-Delivery of Drug and Gene for Synergistic Pest Control

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Chinese Journal of Chemistry 2023年第20期41卷 2671-2678页

作者： Bingcheng Zhou Qinhong Jiang Jie Li Shuo Yan Jie Shen Lianying Liu meizhen yin State Key Laboratory of Chemical Resource Engineering Beijing Lab of Biomedical MaterialsBeijing University of Chemical TechnologyBeijing100029 China Department of Plant Biosecurity and MARA Key Laboratory of Surveillance and Management for Plant Quarantine Pests College of Plant ProtectionChina Agricultural UniversityBeijing100193 China

Pesticides,as the most common means of pest managements,have caused a series of problems such as pest resistance and environmental pollution.Aggregation-induced emission(AIE)polymers exhibit great potential in biological applications because their fluorescent intensities significantly enhance in the aggregated state.In this paper,an AIE star polymer including a tetraphenyl ethylene(TPE)core and poly(2-(dimethylamino)ethyl methacrylate)arms is designed and further developed as a multi-functional nanocarrier for agricultural pest control.The nanocarrier shows high water solubility,good size stability and AIE imaging ability.Meanwhile,the twisted AIE core and positively charged polymer arms make the nanocarrier efficiently co-load dinotefuran(DIN)and dsRNA via hydrogen bonds and electrostatic interactions,respectively.The AIE star polymer displays low toxicity and high fluorescence traceability.As a result,the nanocarrier co-loading with DIN and dsRNA exhibits a highly synergistic insecticidal effect with higher pest mortality compared to the separate delivery of DIN and dsRNA.This study develops the AIE star polymer to improve the efficiency of co-delivery of drug and dsRNA and proposes a new strategy toward efficient and synergistic pest control.

关键词： Pest control Nano-delivery system Drug nanocarrier Functional polymers Aggregation-induced emission

Perylenediimide chromophore as an efficient photothermal agent for cancer therapy

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Science Bulletin 2018年第2期63卷 101-107页

作者： Shaobo Zhang Jianhao Li Jie Wei meizhen yin State Key Laboratory of Chemical Resource Engineering Beijing Laboratory of Biomedical Materials Beijing University of Chemical Technology

Photothermal agents with improved bioavailabilities can generate heat from near-infrared light, which has been efficiently used for in vivo photothermal therapy(PTT) for cancer, with minimum tissue invasion. Strategies for developing organic near-infrared-absorbing molecules for photothermal cancer therapy have drawn intensive attention among academic investigators. However, conventional organic nearinfrared-absorbing molecules may not only have complex synthesis procedures, but also easily suffer from photobleaching under light irradiation. These drawbacks might lead to an increase in the synthesis cost, and elicit a risk of side effects in PTT. Thus, it is essential to devise an organic photothermal agent with stable photothermal capacity, which involves a facile synthesis process. In this study, incorporating a secondary amine group(donor) in the bay regions of perylenediimides(PDIs) could lead to a 150-nm bathochromic shift of the absorption maximum. Next, a modification of poly(ethylene glycol)(PEG) at the periphery of the chromophore renders the targeted macromolecule PDI-PEG highly water-soluble,and capable of intense absorption in the near-infrared region. The self-assembled PDI-based nanoparticles(PDI-NPs) have a size of 55 nm in aqueous solutions. PDI-NPs with excellent photostability possess a high photothermal conversion efficiency of up to 43% ± 2%. Finally, PDI-NPs allow for efficient in vitro and in vivo photothermal cancer therapy. Meanwhile, PDI-NPs exhibit quite low cytotoxicity and no biotoxicity on major organs in vivo. Thus, these easily-manufactured PDI-NPs can serve as extremely stable photothermal agents for efficient photothermal cancer therapy.

关键词：癌症治疗代理人色基页面描述语言 vivo 合成过程能力设计大分子

Mechanically controlled FRET to achieve high-contrast fluorescence switching

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Science China Chemistry 2018年第12期61卷 1587-1593页

作者： Shenzhong Mo Lina Tan Bing Fang Zhen Wu Zhiqiang Su Yantu Zhang meizhen yin State Key Laboratory of Chemical Resource Engineering Beijing Laboratory of Biomedical Materials Beijing University of Chemical Technology College of Chemistry & Chemical Engineering Yan'an University

Organic luminescent materials with the ability to reversibly switch the luminescence when subjected to external stimuli have attracted considerable interest in recent years. However, luminescent materials with mechanochromic and photochromic dualresponsive properties are rarely reported. Hererin, we designed and synthesized a molecule P1 with dipeptide as a spacer to link rhodamine B and spiropyran moieties. P1 exhibited efficient photochromic properties both in solution and solid state. Highcontrast independent fluorescence switch was also realized under the stimulus of external force. Moreover, two-step ring opening reaction and subsequent fluorescence resonance energy transfer process between the donor-acceptor pairs within one single molecule achieved successive color switch by mechanical control. Therefore, this behavior of P1 made it a promising candidate for high-contrast and sensitive optical recording and mechanical sensing system.

关键词： spiropyran rhodamine B photochromism mechanochromism fluorescence resonance energy transfer

Organic dye assemblies with aggregation-induced photophysical changes and their bio-applications

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Aggregate

Aggregate 2021年第4期2卷 57-71页

作者： Chendong Ji Liming Lai Pengyu Li Zhen Wu Wenyu Cheng meizhen yin State Key Laboratory of Chemical Resource Engineering Beijing Advanced Innovation Center for Soft Matter Science and EngineeringBeijing Laboratory of Biomedical MaterialsBeijing University of Chemical TechnologyBeijingChina

Phototheranostics provide a safe,effective,and noninvasive way for the diagnosis and treatment of contemporary diseases,and organic dyes play a vital role.For example,chemical modification endowed dyes with powerful reactive oxygen species or heat generation ability,favoring for photodynamic therapy and photoacoustic(PA)imaging guided photothermal therapy(PTT)of serious diseases.Therefore,photophysical properties manipulation of dyes has become the focus in current dye chemistry research.The development of aggregate science has made great effort to solve this problem.In recent years,a large number of studies have focused on molecular aggregation behavior and its effect on photophysical performance.The most famous example is the discovery of aggregation-induced emission(AIE)phenomenon.Based on AIE theory,more theories for revealing the relationship between molecular aggregation behavior and photophysical properties were proposed and elucidated.The photophysical property changes caused by dye aggregation have become a unique discipline,guiding the development of molecular science and material science.With the help of molecular self-assembly,controllable aggregation of dyes can be realized,and stable nano-theranostic reagents can be obtained.Furthermore,constructing dye assemblies with various photophysical properties will greatly reduce the cost of theranostic reagents,thus,expanding biomedical applications of organic dyes.Therefore,this review focuses on the photophysical characteristic changes caused by dye aggregation and their biological applications including,fluorescence/phosphorescence/PA imaging as well as photodynamic and PTT.This review will provide guidance for the design of organic dyes,the development of controllable aggregation methods,and the construction of multifunctional phototheranostic reagents.

关键词： aggregation-induced photophysical changes fluorescence imaging organic dye assemblies phosphorescence photodynamic therapy photothermal therapy

3'-Sialyllactose regulates glucose and lipid metabolic disorders via the gut–liver axis in mice fed a high-fat die

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Food Science and Human Wellness 2024年

作者： Wei Zhang meizhen Zhu Kelsang Dekyi Linxi Zheng Yichen Zhang Youping Lv Dongbei Guo Xiaoxuan Chen Lili Pan Xinyue Wang Hongwei Li State Key Laboratory of Vaccines for Infectious Diseases Xiang An Biomedicine Laboratory School of Public Health Xiamen University State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics National Innovation Platform for Industry-Education Integration in Vaccine Research Xiamen University Department of Nutrition Zhongshan Hospital (Xiamen) Fudan University Xiamen Clinical Research Center for Cancer Therapy

Recent research has indicated that sialic acid， such as free sialic acid (N-acetylneuraminic acid， Neu5Ac) and bound sialic acid (3'-sialyllactose， 3'-SL)， can ameliorate disorders associated with glycolipid metabolism， although the underlying mechanisms have yet to be determined. We examined the effects of 3'-SL on glycolipid metabolism in mice fed a high-fat diet. Male C57BL/6J mice were divided into six groups: two model control groups (normal and high-fat diets) and four intervention groups [Neu5Ac， and low-，moderate-， and high-dose 3'-SL]. After 8 weeks of continuous gavage intervention， mice in the 3'-SL intervention groups had lower body weight and total fat content; reduced fasting blood glucose， triglycerides， low-density lipoproteins and oxidized-low-density lipoproteins; and increased high-density lipoproteins，but no dosage-dependent of 3'-SL intervention was found， 3’-SL＿M intervention as optimal for further exploration. 3'-SL intervention could increase respiratory exchange ratio， energy expenditure， and amount of exercise performed. 3'-SL increased the colonic abundances of Akkermansia， Lactobacillus， and Bacteroides， and reduced those of Erysipelatoclostridium， Faecalibaculum， and Aldercreutzia. Changes were also observed in colonic metabolites， and liver gene transcript and metabolites， which were mainly enriched in bile secretion， taurine and hypotaurine metabolism， and insulin resistance. Additionally， 3'-SL was observed to regulate genes associated with physiological rhythms， including clock， per2， cry1， and bhihe41. Collectively， our findings indicate that 3'-SL can contribute to the prevention and control of disorders associated with glucose and lipid metabolism caused by high-fat diets. Compared with Neu5Ac， 3'-SL intervention can ameliorate intestinal flora disorders， enhance bile acid circulation， increase tissue energy expenditure， and reduce lipid synthesis， thereby promoting lipid-lowering effects mediated via the liver–gut axis， and can also enhance energy metabolism and alleviate diso

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Jointly improving energy efficiency and smoothing power oscillations of integrated offshore wind and photovoltaic power: a deep reinforcement learning approach

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Protection and Control of Modern Power Systems 2023年第2期8卷 156-166页

作者： Xiuxing yin meizhen Lei The State Key Laboratory of Water Resources Engineering and Management Wuhan UniversityWuhan 430072HubeiChina The School of Information Science and Engineering Zhejiang Sci-Tech UniversityHangzhou 310018China

This paper proposes a novel deep reinforcement learning(DRL)control strategy for an integrated offshore wind and photovoltaic(PV)power system for improving power generation efficiency while simultaneously damping oscilla-tions.A variable-speed offshore wind turbine(OWT)with electrical torque control is used in the integrated offshore power system whose dynamic models are detailed.By considering the control system as a partially-observable Markov decision process,an actor-critic architecture model-free DRL algorithm,namely,deep deterministic policy gradient,is adopted and implemented to explore and learn the optimal multi-objective control policy.The potential and effectiveness of the integrated power system are evaluated.The results imply that an OWT can respond quickly to sudden changes of the inflow wind conditions to maximize total power generation.Significant oscillations in the overall power output can also be well suppressed by regulating the generator torque,which further indicates that complementary operation of offshore wind and PV power can be achieved.

关键词： Offshore wind turbine Offshore photovoltaic power Deep reinforcement learning Deep deterministic policy gradient Multi-objective optimal control

稻杆生物炭对土壤中水铁矿的形成、转化和磷酸根、土霉素吸附的影响

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环境科学学报 2024年第3期44卷 377-386页

作者：许晓琴陈再明黄丹汪美贞浙江工商大学环境科学与工程学院杭州310018

以稻杆为原料,通过不同温度(400、700℃)裂解制得生物炭,研究了生物炭添加对弱碱性土壤(潮土,pH=7.8)和酸性土壤(红壤,pH=5.0)的浸出液组成(溶解性硅、磷和溶解性有机碳含量)、土壤浸出液中Fe(Ⅱ)共存时水铁矿的形成(通过Fe(Ⅲ)碱性沉... 详细信息

以稻杆为原料,通过不同温度(400、700℃)裂解制得生物炭,研究了生物炭添加对弱碱性土壤(潮土,pH=7.8)和酸性土壤(红壤,pH=5.0)的浸出液组成(溶解性硅、磷和溶解性有机碳含量)、土壤浸出液中Fe(Ⅱ)共存时水铁矿的形成(通过Fe(Ⅲ)碱性沉淀形成)和转化,以及所形成的水铁矿对代表性化合物(磷酸根和土霉素)吸附行为的影响.结果表明,潮土的弱碱性有利于生物炭中硅组分的溶出,促使土壤浸出液中Fe(Ⅲ)和Fe(Ⅱ)共沉淀过程Fe―O―Si键和水铁矿的形成,缓解水铁矿在Fe(Ⅱ)催化下向针铁矿、纤铁矿和磁铁矿的转化,使水铁矿的比表面积和土霉素吸附分别增大145%~180%和24.1%~91.1%,并通过Fe―O―Si键占据水铁矿表面使磷吸附减少17.6%~26.2%(700℃制备生物炭).红壤的弱酸性限制了生物炭中硅组分的溶出、Fe―O―Si键的形成及其对水铁矿转化和吸附的影响,但未显著改变生物炭溶解性裂解炭组分对水铁矿在Fe(Ⅱ)催化下向针铁矿转化的促进作用.生物炭的硅组分可增强土壤浸出液中水铁矿的稳定,增加土霉素的吸附并减弱磷的吸附,但其功能的发挥受土壤酸碱性的调控.

关键词：稻杆生物炭水铁矿硅 Fe(Ⅱ)催化转化吸附

Corrigendum to“Long-term correction of hemophilia B through CRISPR/Cas9 induced homology-independent targeted integration”[Journal of Genetics and Genomics(2022)49,1114-1126]

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Journal of Genetics and Genomics 2024年第5期51卷 578-578页

作者： Xi Chen Xuran Niu Yang Liu Rui Zheng Lei Yang Jian Lu Shuming yin Yu Wei Jiahao Pan Ahmed Sayed Xueyun Ma meizhen Liu Fengxiang Jing Mingyao Liu Jiazhi Hu Liren Wang Dali Li Shanghai Frontiers Science Center of Genome Editing and Cell Therapy Shanghai Key Laboratory of Regulatory BiologyInstitute of Biomedical Sciences and School of Life SciencesEast China Normal UniversityShanghai 200241China The MOE Key Laboratory of Cell Proliferation and Differentiation Genome Editing Research CenterSchool of Life SciencesPeking-Tsinghua Center for Life SciencesPeking UniversityBeijing 100871China Xinhua Hospital Shanghai Jiao Tong University School of MedicineShanghai 200092China Biochemistry Laboratory Chemistry DepartmentFaculty of ScienceAssiut UniversityAssiut 71516Egypt Shanghai Turtle Technology Co. Shanghai 201900China

The authors regret that the grant number“21CJ1402200”in the Acknowledgments session should be replaced as“21JC1402200”.The corrected contents areprovided as follows.

关键词： CRISPR/Cas9 correction ledgment

党史故事赋能高校思政课的叙事困境与契合路径

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龙岩学院学报 2024年第1期42卷 106-113页

作者：林妹珍龙岩学院福建龙岩364000

党史故事具有鲜明的政治引领性、价值导向性和思想教育性,运用党史故事赋能高校思政课是培养时代新人的必然要求。当前,党史故事融入高校思政课在“叙什么”“谁来叙”“如何叙”等方面存在一定的困境与难点。思政课教师应通过激发叙事... 详细信息

党史故事具有鲜明的政治引领性、价值导向性和思想教育性,运用党史故事赋能高校思政课是培养时代新人的必然要求。当前,党史故事融入高校思政课在“叙什么”“谁来叙”“如何叙”等方面存在一定的困境与难点。思政课教师应通过激发叙事主体、优化叙事内容、创新叙事方式与拓宽叙事场域等方面重构党史故事教学叙事体系,不断增强党史故事赋能高校思政课的力度与效果。

关键词：党史故事高校思政课叙事困境契合路径