An AIE Star Polymer with Enhanced Co-Delivery of Drug and Gene for Synergistic Pest Control
作者机构：State Key Laboratory of Chemical Resource EngineeringBeijing Lab of Biomedical MaterialsBeijing University of Chemical TechnologyBeijing100029 China Department of Plant Biosecurity and MARA Key Laboratory of Surveillance and Management for Plant Quarantine PestsCollege of Plant ProtectionChina Agricultural UniversityBeijing100193 China
出 版 物：《Chinese Journal of Chemistry》 (中国化学（英文版）)
年 卷 期：2023年第41卷第20期
页 面：2671-2678页
核心收录：
学科分类：081704[工学-应用化学] 07[理学] 08[工学] 0817[工学-化学工程与技术] 070303[理学-有机化学] 0703[理学-化学]
基 金：This work was financially supported by the National Natural Science Foundation of China(Grant No.52130309) China Postdoctoral Science Foundation(No.2021M700349)
主 题：Pest control Nano-delivery system Drug nanocarrier Functional polymers Aggregation-induced emission
摘 要：Pesticides,as the most common means of pest managements,have caused a series of problems such as pest resistance and environmental ***-induced emission(AIE)polymers exhibit great potential in biological applications because their fluorescent intensities significantly enhance in the aggregated *** this paper,an AIE star polymer including a tetraphenyl ethylene(TPE)core and poly(2-(dimethylamino)ethyl methacrylate)arms is designed and further developed as a multi-functional nanocarrier for agricultural pest *** nanocarrier shows high water solubility,good size stability and AIE imaging ***,the twisted AIE core and positively charged polymer arms make the nanocarrier efficiently co-load dinotefuran(DIN)and dsRNA via hydrogen bonds and electrostatic interactions,*** AIE star polymer displays low toxicity and high fluorescence *** a result,the nanocarrier co-loading with DIN and dsRNA exhibits a highly synergistic insecticidal effect with higher pest mortality compared to the separate delivery of DIN and *** study develops the AIE star polymer to improve the efficiency of co-delivery of drug and dsRNA and proposes a new strategy toward efficient and synergistic pest control.
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