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Research on Driver’s Fatigue Detection Based on Information Fusion

Computers, Materials & Continua 2024年第4期79卷 1039-1061页

作者： meiyan Zhang Boqi Zhao Jipu Li Qisong wang Dan Liu Jinwei Sun Jingxiao Liao Harbin Institute of Technology School of Instrument Science and EngineeringHarbin150036China Department of Industrial and Systems Engineering The Hong Kong Polytechnic UniversityHong Kong100872China

Driving fatigue is a physiological phenomenon that often occurs during driving.After the driver enters a fatigued state,the attentionis lax,the response is slow,and the ability todeal with emergencies is significantly reduced,which can easily cause traffic accidents.Therefore,studying driver fatigue detectionmethods is significant in ensuring safe driving.However,the fatigue state of actual drivers is easily interfered with by the external environment(glasses and light),which leads to many problems,such as weak reliability of fatigue driving detection.Moreover,fatigue is a slow process,first manifested in physiological signals and then reflected in human face images.To improve the accuracy and stability of fatigue detection,this paper proposed a driver fatigue detection method based on image information and physiological information,designed a fatigue driving detection device,built a simulation driving experiment platform,and collected facial as well as physiological information of drivers during driving.Finally,the effectiveness of the fatigue detection method was evaluated.Eye movement feature parameters and physiological signal features of drivers’fatigue levels were extracted.The driver fatigue detection model was trained to classify fatigue and non-fatigue states based on the extracted features.Accuracy rates of the image,electroencephalogram(EEG),and blood oxygen signals were 86%,82%,and 71%,separately.Information fusion theory was presented to facilitate the fatigue detection effect;the fatigue features were fused using multiple kernel learning and typical correlation analysis methods to increase the detection accuracy to 94%.It can be seen that the fatigue driving detectionmethod based onmulti-source feature fusion effectively detected driver fatigue state,and the accuracy rate was higher than that of a single information source.In summary,fatigue drivingmonitoring has broad development prospects and can be used in traffic accident prevention and wearable driver fatigue recognition.

关键词： Driving fatigue information fusion EEG blood oxygen

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Dual-targeting AAV9P1-mediated neuronal reprogramming in a mouse model of traumatic brain injury

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Neural Regeneration Research 2024年第3期19卷 629-635页

作者： Jingzhou Liu Xin Xin Jiejie Sun Yueyue Fan Xun Zhou Wei Gong meiyan Yang Zhiping Li Yuli wang Yang Yang Chunsheng Gao State Key Laboratory of Toxicology and Medical Countermeasures Beijing Institute of Pharmacology and ToxicologyBeijingChina Academy of Medical Engineering and Translational Medicine Medical CollegeTianjin UniversityTianjinChina

Traumatic brain injury results in neuronal loss and glial scar formation.Replenishing neurons and eliminating the consequences of glial scar formation are essential for treating traumatic brain injury.Neuronal reprogramming is a promising strategy to convert glial scars to neural tissue.However,previous studies have reported inconsistent results.In this study,an AAV9P1 vector incorporating an astrocyte-targeting P1 peptide and glial fibrillary acidic protein promoter was used to achieve dual-targeting of astrocytes and the glial scar while minimizing off-target effects.The results demonstrate that AAV9P1 provides high selectivity of astrocytes and reactive astrocytes.Moreover,neuronal reprogramming was induced by downregulating the polypyrimidine tract-binding protein 1 gene via systemic administration of AAV9P1 in a mouse model of traumatic brain injury.In summary,this approach provides an improved gene delivery vehicle to study neuronal programming and evidence of its applications for traumatic brain injury.

关键词： AAV9P1 astrocytes astrocyte-to-neuron conversion GFAP promoter glial scar induced neurons neuronal reprogramming P1 peptide PTBP1 traumatic brain injury

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Metabolic fate of tea polyphenols and their crosstalk with gut microbiota

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Food Science and Human Wellness 2022年第3期11卷 455-466页

作者： meiyan wang Jianying Li Ting Hu Hui Zhao Tianjin Key Laboratory of Food and Biotechnology School of Biotechnology and Food ScienceTianjin University of CommerceTianjin 300134China Hubei Key Laboratory for EFGIR Huanggang Normal UniversityHuanggang 438000China

Tea represents an abundant source of naturally occurring polyphenols.Tea polyphenols(TPs)have received growing attentions for its wide consumption in the world,and more importantly its pleiotropic bioeffects for human health.After ingestion,TPs may undergo absorption and phase II reaction in the small intestine,and most undigested proportion would be submitted to the colon to interact with gut microbiota.Interactions between gut microbiota and TPs are bidirectional,including not only bacteria-mediated TPs metabolism,e.g.,removal of gallic acid moiety and ring fission to release phenolic acid catabolites,but also TPs-based modification of bacterial profiles.Crosstalk between TPs and gut microbes may benefit for gut barrier function,for example,improvement of the intestinal permeability to alleviate inflammation.Moreover,by reshaping microbial composition and associated metabolites,TPs may exert a systemic protection on host metabolism,which contributes to improve certain chronic metabolic disorders.Given that,further understanding of the metabolic fate of TPs and interplay with gut microbiota as well as potential health-promoting effects are of great significance to development and application of tea and their polyphenolic components in the future as dietary supplements and/or functional ingredients in medical foods.

关键词： Tea polyphenols Metabolism Gut microbiota Bioeffects

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Regulating electronic environment on alkali metal-doped Cu@NS-SiO_(2) for selective anisole hydrodeoxygenation

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绿色化学工程(英文) 2023年第3期4卷 294-302页

作者： Xiaofei wang Xiaoxue Han Li Kang Shixiang Feng meiyan wang Yue wang Shouying Huang Yujun Zhao Shengping wang Xinbin Ma Key Laboratory for Green Chemical Technology of Ministry of Education Collaborative Innovation Centre of Chemical Science and EngineeringSchool of Chemical Engineering and TechnologyTianjin UniversityTianjin300072China Joint School of National University of Singapore and Tianjin University International Campus of Tianjin UniversityFuzhou350207China Haihe Laboratory of Sustainable Chemical Transformations Tianjin300192China

Lignin utilization is a potential approach for replacing fossil energy and releasing the environment pressure.Herein,we synthesized a series of novel Cu-based catalysts,Cu@NS-SiO_(2)(NS=nano sphere)and alkali metals(Na,K,Rb,and Cs)doped Cu@NS-SiO_(2),and applied them in hydrodeoxygenation reaction of anisole.High Cu dispersion was presented on all catalysts.The modification of alkali metals on Cu@NS-SiO_(2) significantly enhanced the electron density of Cu sites in the following order:Cs>Rb>K>Na,among which Cs decreased the Cu_(2)p_(3)/2 binding energy most(by 0.7 eV).Moreover,the modification did not substantially affect the geometric structure of Cu species.This regulable electronic environment of Cu sites was crucial for selective deoxygenation and inhibiting the hydrogenation of aromatic rings in anisole,and thus promoted the selectivity of benzene.Compared with Cu@NS-SiO_(2)(~59%),the highest benzene selectivity was obtained on Cs/10Cu@NS-SiO_(2) at~83%.

关键词： Anisole Hydrodeoxygenation Arenes Alkali metal Electronic effect

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Copper-based bimetallic electrocatalysts for CO_(2) reduction:From mechanism understandings to product regulations

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Materials Reports(Energy) 2023年第1期3卷 19-34,I0002页

作者： Haibei Yang Hongyuan Chuai Qingrui Meng meiyan wang Sheng Zhang Xinbin Ma Key Laboratory for Green Chemical Technology of Ministry of Education Haihe Laboratory of Sustainable Chemical TransformationsSchool of Chemical Engineering and TechnologyTianjin UniversityTianjin300072China Joint School of National University of Singapore and Tianjin University International Campus of Tianjin UniversityBinhai New CityFuzhou350207China

Electrocatalytic carbon dioxide reduction reaction(CO_(2) RR)is a promising method to solve current environment and energy issues.Copper-based catalysts have been widely studied for converting CO_(2) into value-added hy-drocarbon products.Cu monometallic catalyst has been proved to have some shortcomings,including relatively high energy barriers and diverse reaction pathways,leading to low reaction activities and poor product selec-tivity,respectively.Recently copper-based bimetallic tandem catalysts have attracted extensive attentions due to their special catalyst structure,which can be easily regulated to achieve high CO_(2) RR reactivity and product selectivity.With the development of quantum chemistry calculations and spectroscopic characterization methods,deep understandings of CO_(2) RR from the mechanism perspective provide a broad horizon for the design of effi-cient catalysts.This review offers a good summary of reaction mechanisms and product regulation strategies over copper-based bimetallic catalysts,along with a brief discussion on future directions towards their practical applications.

关键词： Copper Bimetallic electrocatalysts Carbon dioxide reduction Mechanism Product regulations

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Structure variety and its effects on biological activity of tea polysaccharides

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Food Science and Human Wellness 2022年第3期11卷 587-597页

作者： Ting Hu Peng Wu Jianfeng Zhan Weixin wang Junfeng Shen meiyan wang Chi-Tang Ho Shiming Li Hubei Key Laboratory of Economic Forest Germplasm Improvement and Resources Comprehensive Utilization Huanggang Normal UniversityHuanggang 438000China School of Biotechnology and Food Science Tianjin University of CommerceTianjin 300134China Department of Food Science Rutgers UniversityNJ 08901USA

Tea polysaccharides(TPSs),one of the major bioactive ingredients in tea,have been widely studied due to their variety of biological activities,including antioxidant,cancer prevention,hypoglycemia,anti-fatigue,anti-coagulant,anti-obesity and immunomodulatory effect.The biological effectiveness of TPSs has direct relation with their structures such as monosaccharide composition,molecular weight,glycosidic linkages,conformation and others,which can be influenced by tea materials,processing methods,extraction and purification procedures among others.Comparing to the study of tea polyphenols,the exploration of TPSs in structural elucidation and biofunctionality is very preliminary.Yet several factors affecting the structural change of TPSs have been studied and identified.Consequently,the variation of some TPS biological activity brought by the change of TPS structures has been evaluated and preliminary correlation of structure activity relationship of TPSs has been performed.Therefore,this review aims to serve as a summary research report regarding the influencing factors on TPSs structures and consequential effects on the biological activities of TPSs.We hope to provide updated information and systematic references for future study and functional food development of TPSs.

关键词： Tea polysaccharides Structure variety Bioactivities Relationship Influencing factors

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Research Updates of Traditional Rehabilitation Therapy in Treating Cervical Spondylosis

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Journal of Clinical and Nursing Research 2024年第1期8卷 31-35页

作者： Jincheng Hou Rong Hu Siyu wang Yu Yan meiyan Sun Zhongmin Yue School of Nursing Beihua UniversityJilin 132000Jilin ProvinceChina

Cervical spondylosis has many obvious symptoms.Through literature reviews and hospital visits and collecting information under the guidance of our instructors,three methods of traditional rehabilitation therapy are reviewed in this study:massage,cupping,and Gua Sha.Information regarding cervical spondylosis was sorted out,from the causes of the disease and treatment methods to precautionary measures,which are discussed in this paper.

关键词： Traditional rehabilitation Cervical spondylosis

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Modeling neuropsychiatric disorders using human induced pluripotent stem cells

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Protein & Cell 2020年第1期11卷 45-59页

作者： meiyan wang Lei Zhang Fred H.Gage Laboratory of Genetics The Salk Institute for Biological Studies10010 N.Torrey Pines RdLa JollaCA 92037USA Neurobiology Section Division of Biological SciencesUniversity of California San DiegoLa JollaCA 92093USA

Neuropsychiatric disorders are complex disorders characterized by heterogeneous genetic variations,variable symptoms,and widespread changes in anatomical pathology.In the context of neuropsychiatric disorders,limited access to relevant tissue types presents challenges for understanding disease etiology and developing effective treatments.Induced pluripotent stem cells(iPSCs)reprogrammed from patient somatic cells offer an opportunity to recapitulate disease development in relevant cell types,and they provide novel approaches for understanding disease mechanisms and for development of effective treatments.Here we review recent progress and challenges in differentiation paradigms for generating disease-relevant cells and recent studies of neuropsychiatric disorders using human pluripotent stem cell(hPSC)models where cellular phenotypes linked to disease have been reported.The use of iPSC-based disease models holds great promise for understanding disease mechanisms and supporting discovery of effective treatments.

关键词： neuropsychiatric disorders iPSCs brain organoid schizophrenia autism spectrum disorder bipolar disorder

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Emerging Urban Poverty and Effects of the Dibao Program on Alleviating Poverty in China

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China & World Economy 2007年第2期15卷 74-88页

作者： meiyan wang Institute of Population and Labor Economics Chinese Academy of Social Sciences Beijing China

The present paper describes the current urban poverty situation, examines the factors affecting the probability of a household being in poverty and investigates how the urban minimum living standard guarantee （dibao） program helps poor people to get out of poverty. The targeting efficiency of the urban dibao program is discussed. The present study finds that the poverty rate of households with unemployed workers is much higher than that of households without unemployed workers. The urban dibao program is helpful in reducing poverty rates, but it does not reduce poverty rates too much. The government should place emphasis on helping laid-off and unemployed workers to become reemployed. The most urgent problem for the dibao program is improving the efficiency of targeting.

关键词： dibao program unemployment urban poverty

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多位点离子液体聚合物催化CO2环加成反应研究

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化学工业与工程 2024年第2期41卷 2-11页

作者：王昊岳成光王美岩马新宾天津大学化工学院

CO2与环氧化物环加成反应制备环状碳酸酯是一条绿色经济的CO2利用途径。针对现有CO2与环氧化物环加成反应中非均相离子液体催化剂活性低和活性组分易流失等问题，设计制备了系列多位点离子液体超交联聚合物HCPs-[DmPhe]Br,研究了多位点... 详细信息

CO2与环氧化物环加成反应制备环状碳酸酯是一条绿色经济的CO2利用途径。针对现有CO2与环氧化物环加成反应中非均相离子液体催化剂活性低和活性组分易流失等问题，设计制备了系列多位点离子液体超交联聚合物HCPs-[DmPhe]Br,研究了多位点协同作用、超交联聚合物组成和结构等因素对其催化CO2与环氧化物环加成反应性能的影响。其中，同时含有双季铵-卤素离子对、羟基和叔胺结构的HCP-[DmPhe]Br-DCX离子液体超交联聚合物催化剂，在1.3 MPa, 130℃,8 h的条件下，可实现94%的碳酸丁烯酯收率，且催化剂循环稳定性好，重复使用5次，催化活性没有明显降低。另外，超交联聚合物的多孔结构以及大比表面积促进了离子液体的较好分散，使其与离子液体单体具有相当的活性。该工作对CO2与环氧化物环加成反应高效非均相离子液体催化剂的开发与优化具有一定的借鉴意义。

关键词： CO2利用环状碳酸酯离子液体协同作用超交联聚合

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