Genetically engineered bacteria have aroused attention as micro-nano drug delivery systems in ***,conventional designs of engineered bacteria usually function constantly or autonomously,which might be non-specific or ...
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Genetically engineered bacteria have aroused attention as micro-nano drug delivery systems in ***,conventional designs of engineered bacteria usually function constantly or autonomously,which might be non-specific or ***,designing and optimizing in situ control strategy are important methodological progress for therapeutic researches of intestinal engineered ***,a micro-nano optogenetic system based on probiotic was developed combining microelectronics,nanotechnology,and synthetic biology to achieve in situ controllable drug ***,optogenetic engineered Lactococcus lactis was orally administrated in the intestinal tract.A wearable optical device was designed to control optical signals ***,*** could be customized to secrete peptides according to optical *** an example,optogenetic *** system can be constructed to secrete glucagon-like peptide-1(GLP-1)under the control of the wearable optical device to regulate *** improve the half-life of GLP-1 in vivo,Fc-domain fused GLP-1 was optimally *** this strategy,blood glucose,weight,and other features were well controlled in rats and mice ***,upconversion microcapsules were introduced to increase the excitation wavelength of the optogenetic system for better *** strategy has biomedical potential to expand the toolbox for intestinal engineered bacteria.
The East Kunlun located in the northern margin of the Qinghai-Xizang(Tibet)Plateau,is a composite orogenic belt which has underwent multi-stages tectonic evolution(*** and Chen,1987;Jiang et al.,1992;Yang et al.,1996,...
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The East Kunlun located in the northern margin of the Qinghai-Xizang(Tibet)Plateau,is a composite orogenic belt which has underwent multi-stages tectonic evolution(*** and Chen,1987;Jiang et al.,1992;Yang et al.,1996,2009).The East Kunlun orogenic belt(EKOB)is bounded by Altyn Tagh Fault in the west and Wenquan Fault in the east,bounded by the south margin of Qaidam
The acidity of atmospheric aerosols influences fundamental physicochemical processes that affect climate and human *** recently developed a novel and facilewater-probebased method for directly measuring of the pH for ...
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The acidity of atmospheric aerosols influences fundamental physicochemical processes that affect climate and human *** recently developed a novel and facilewater-probebased method for directly measuring of the pH for micrometer-size droplets,providing a promising technique to better understand aerosol acidity in the *** complex chemical composition of fine particles in the ambient air,however,poses certain challenges to using a water-probe for pH measurement,including interference from interactions between compositions and the influence of similar compositions on water *** explore the universality of our method,it was employed to measure the pH of ammonium,nitrate,carbonate,sulfate,and chloride *** pH of particles covering a broad range(0–14)were accurately determined,thereby demonstrating that our method can be generally applied,even to alkaline ***,a standard spectral library was developed by integrating the standard spectra of common hydrated ions extracted through the *** library can be employed to identify particle composition and overcome the spectral overlap problem resulting from similar *** the spectral library,all ions were identified and their concentrations were determined,in turn allowing successful pH measurement of multicomponent(ammonium-sulfate-nitrate-chloride)*** into the synergistic effect of Cl^(–),NO_(3)^(–),and NH_(4)^(+)depletion obtained with our approach revealed the interplay between pH and volatile *** the ubiquity of component partitioning and pH variation in particles,the water probemay provide a new perspective on the underlying mechanisms of aerosol aging and aerosol–cloud interaction.
Polymer fibers are an important class of materials throughout human history,evolving from natural fibers such as cotton and silk to modern synthetic fibers such as nylon and *** the advancement of materials science,th...
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Polymer fibers are an important class of materials throughout human history,evolving from natural fibers such as cotton and silk to modern synthetic fibers such as nylon and *** the advancement of materials science,the development of new fibers is also *** fibers based on dynamic covalent chemistry have attracted widespread attention due to their unique reversibility and *** covalent chemistry has shown great potential in improving the spinnability of materials,achieving green preparation of fibers,and introducing self-healing,recyclability,and intelligent response properties into *** this review,we divide these fiber materials based on dynamic covalent chemistry into monocomponent fibers,composite fibers,and fiber *** preparation methods,structural characteristics,functional properties,and application performance of these fibers are *** application potential and challenges of fibers based on dynamic covalent chemistry are discussed,and their future development trends are prospected.
Damage to electrical equipment in an earthquake can lead to power outage of power *** fragility analysis is a common method to assess the seismic reliability of electrical *** further guarantee the efficiency of analy...
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Damage to electrical equipment in an earthquake can lead to power outage of power *** fragility analysis is a common method to assess the seismic reliability of electrical *** further guarantee the efficiency of analysis,multi-source uncertainties including the structure itself and seismic excitation need to be considered.A method for seismic fragility analysis that reflects structural and seismic parameter uncertainty was developed in this *** proposed method used a random sampling method based on Latin hypercube sampling(LHS)to account for the structure parameter uncertainty and the group structure characteristics of electrical ***,logistic Lasso regression(LLR)was used to find the seismic fragility surface based on double ground motion intensity measures(IM).The seismic fragility based on the finite element model of an±1000 kV main transformer(UHVMT)was analyzed using the proposed *** results show that the seismic fragility function obtained by this method can be used to construct the relationship between the uncertainty parameters and the failure *** seismic fragility surface did not only provide the probabilities of seismic damage states under different IMs,but also had better stability than the fragility ***,the sensitivity analysis of the structural parameters revealed that the elastic module of the bushing and the height of the high-voltage bushing may have a greater influence.
As a mathematical analysis method,fractal analysis can be used to quantitatively describe irregular shapes with self-similar or self-affine *** analysis has been used to characterize the shapes of metal materials at v...
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As a mathematical analysis method,fractal analysis can be used to quantitatively describe irregular shapes with self-similar or self-affine *** analysis has been used to characterize the shapes of metal materials at various scales and *** methods make it difficult to quantitatively describe the relationship between the regular characteristics and properties of metal material surfaces and ***,fractal analysis can be used to quantitatively describe the shape characteristics of metal materials and to establish the quantitative relationships between the shape characteristics and various properties of metal *** the perspective of two-dimensional planes and three-dimensional curved surfaces,this paper reviews the current research status of the fractal analysis of metal precipitate interfaces,metal grain boundary interfaces,metal-deposited film surfaces,metal fracture surfaces,metal machined surfaces,and metal wear *** relationship between the fractal dimensions and properties of metal material surfaces and interfaces is *** from three perspectives of fractal analysis,namely,research scope,image acquisition methods,and calculation methods,this paper identifies the direction of research on fractal analysis of metal material surfaces and interfaces that need to be *** is believed that revealing the deep influence mechanism between the fractal dimensions and properties of metal material surfaces and interfaces will be the key research direction of the fractal analysis of metal materials in the future.
With the gradual increase in the size and flexibility of composite blades in large wind turbines,problems related toaeroelastic instability and blade vibration are becoming increasingly more *** their impact on thelif...
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With the gradual increase in the size and flexibility of composite blades in large wind turbines,problems related toaeroelastic instability and blade vibration are becoming increasingly more *** their impact on thelifespan of wind turbines,these subjects have become important topics in turbine blade *** this article,firstaspects related to the aeroelastic(structural and aerodynamic)modeling of large wind turbine blades are ***,two main methods for blade vibration control are outlined(passive control and active control),including the case of composite *** improvement schemes are proposed accordingly,with a specialfocus on the industry’s outstanding suppression scheme for stall-induced nonlinear flutter and a new high-frequencymicro-vibration control ***,future research directions are indicated based on existingresearch.
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