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Alkali Tolerance of Concrete Internal Curing Agent Based on Sodium Carboxymethyl Starch

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Journal of Wuhan University of Technology(Materials Science) 2024年第1期39卷 82-90页

作者：陈梅花刘荣进 CHEN Ping JING Daiyan wan Dandan FU Siyuan College of Materials Science and Engineering Guilin University of TechnologyGuilin 541004China Guangxi Engineering and Technology Center for Utilization of Industrial Waste Residue in Building Materials Guilin 541004China Guangxi Maibu New Material Limited Company Guilin 541004China

Internal curing agents (ICA) based on super absorbent polymer have poor alkali tolerance and reduce the early strength of concrete.An alkali tolerate internal curing agent (CAA-ICA) was designed and prepared by using sodium carboxymethyl starch (CMS) with high hydrophilicity,acrylic acid (AA) containing anionic carboxylic group and acrylamide (AM) containing non-ionic amide group as the main raw materials.The results show that the ratio of CAA-ICA alkali absorption solution is higher than that existing ICA,which solves the low water absorption ratio of the ICA in alkali environment.The water absorption ratio of CAA-ICA in saturated Ca(OH)_(2) solution is 95.8 g·g^(-1),and the alkali tolerance coefficient is 3.4.The application of CAA-ICA in cement-based materials can increase the internal relative humidity and miniaturize the pore structure.The compressive strength of mortar increases up to 12.95%at 28 d,which provids a solution to overcome the reduction of the early strength.

关键词： alkali tolerance sodium carboxymethyl starch internal curing agent compressive strength

Emodin attenuates severe acute pancreatitis-associated acute lung injury by suppressing pancreatic exosome-mediated alveolar macrophage activation

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Acta Pharmaceutica Sinica B 2022年第10期12卷 3986-4003页

作者： Qian Hu Jiaqi Yao Xiajia Wu Juan Li Guixiang Li Wenfu Tang Jingping Liu meihua wan Department of Integrated Traditional Chinese and Western Medicine National Clinical Research Center for GeriatricsWest China HospitalSichuan UniversityChengdu 610041China NHC Key Laboratory of Transplant Engineering and Immunology Frontiers Science Center for Disease-Related Molecular NetworkWest China HospitalSichuan UniversityChengdu 610041China

Severe acute pancreatitis-associated acute lung injury(SAP-ALI) is a serious disease associated with high mortality. Emodin has been applied to alleviate SAP-ALI;however, the mechanism remains unclear. We report that the therapeutic role of emodin in attenuating SAP-ALI is partly dependent on an exosomal mechanism. SAP rats had increased levels of plasma exosomes with altered protein contents compared to the sham rats. These infused plasma exosomes tended to accumulate in the lungs and promoted the hyper-activation of alveolar macrophages and inflammatory damage. Conversely,emodin treatment decreased the plasma/pancreatic exosome levels in the SAP rats. Emodin-primed exosomes showed less pro-inflammatory effects in alveolar macrophages and lung tissues than SAP exosomes. In detail, emodin-primed exosomes suppressed the NF-κB pathway to reduce the activation of alveolar macrophage and ameliorate lung inflammation by regulating PPARγ pathway, while these effects were amplified/abolished by PPARγ agonist/antagonist. Blockage of pancreatic acinar cell exosome biogenesis also exhibited suppression of alveolar macrophage activation and reduction of lung inflammation. This study suggests a vital role of exosomes in participating inflammation-associated organ-injury,and indicates emodin can attenuate SAP-ALI by reducing the pancreatic exosome-mediated alveolar macrophage activation.

关键词： Severe acute pancreatitis Acute lung injury Emodin Exosome Macrophages Lisocitrate dehydrogenase 1 Peroxisome proliferatoractivated receptorγ Nuclear factor kB

Extracellular vesicle activities regulating macrophage- and tissue-mediated injury and repair responses

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Acta Pharmaceutica Sinica B 2021年第6期11卷 1493-1512页

作者： Qian Hu Christopher J.Lyon Jesse K.Fletcher Wenfu Tang meihua wan Tony Y.Hu Department of Integrated Traditional Chinese and Western Medicine West China HospitalSichuan UniversityChengdu 610041China Center of Cellular and Molecular Diagnosis Tulane University School of MedicineNew OrleansLA 70112USA Department of Biochemistry&Molecular Biology Tulane University School of MedicineNew OrleansLA 70112USA

Macrophages are typically identified as classically activated(M1) macrophages and alternatively activated(M2) macrophages,which respectively exhibit pro-and anti-inflammatory phenotypes,and the balance between these two subtypes plays a critical role in the regulation of tissue inflammation,injury,and repair processes.Recent studies indicate that tissue cells and macrophages interact via the release of small extracellular vesicles(EVs) in processes where EVs released by stressed tissue cells can promote the activation and polarization of adjacent macrophages which can in turn release EVs and factors that can promote cell stress and tissue inflammation and injury and vice versa.This review discusses the roles of such EVs in resulating such interactions to influence tissue inflammation and injury in a number of acute and chronic inflammatory disease conditions,and the potential applications,advantage and concerns for using EV-based therapeutic approaches to treat such conditions,including their potential role of drug carriers for the treatment of infectious diseases.

关键词： Extracellular vesicles Macrophage Tissue injury Inflammatory disease Interaction loop Stem cell Sepsis Targeted therapy

Clinical applications of exosome membrane proteins

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Precision Clinical Medicine 2020年第1期3卷 54-66页

作者： Qian Hu Hang Su Juan Li Christopher Lyon Wenfu Tang meihua wan Tony Ye Hu Center of Cellular and Molecular Diagnosis Tulane University School of MedicineNew OrleansLA 70112USA Department of Integrated Traditional Chinese and Western Medicine West China Hospital of Sichuan UniversityChengdu 610041Sichuan ProvinceChina Health Management Center West China Hospital of Sichuan UniversityChengdu 610041Sichuan ProvinceChina Department of Biochemistry&Molecular Biology Tulane University School of MedicineNew OrleansLA 70112USA

Extracellular vesicles(EVs)are small membranous particles that can mediate cell-to-cell communication and which are divided into at least three categories according to their subcellular origin and size:exosomes,microvesicles,and apoptotic bodies.Exosomes are the smallest(30–150 nm)of these EVs,and play an important role in EV-mediated cell-to-cell interactions,by transferring proteins,nucleic acids and,lipids from their parental cells to adjacent or distant cells to alter their phenotypes.Most exosome studies in the past two decades have focused on their nucleic acid composition and their transfer ofmRNAs and microRNAs to neighboring cells.However,exosomes also carry specific membrane proteins that can identify the physiological and pathological states of their parental cells or indicate their preferential target cells or tissues.Exosome membrane protein expression can also be directly employed or modified to allow exosomes to serve as drug delivery systems and therapeutic platforms,including in targeted therapy approaches.This review will briefly summarize information on exosome membrane proteins components and their role in exosome–cell interactions,including proteins associated with specific cell-interactions and diseases,and the potential for using exosome membrane proteins in therapeutic targeting approaches.

关键词： Exosome membrane protein endocytosis membrane fusion diagnostic markers exosome mimetics target therapy

Unruptured pregnancy in a noncommunicating rudimentary horn at37 weeks with a live fetus:a case report

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The Journal of Biomedical Research 2015年第1期29卷 83-86页

作者： Chen Cheng Weiwei Tang Lei Zhang Mei Luo meihua Huang Xiuling Wu Guiping wan Laboratory of Gynecological Oncology Jiangsu Province Hospital on Integration of Chinese and Western Medicine Affiliated to Nanjing University of Traditional Chinese Medicine

We report an extremely rare case of an unmptured non-communicating rudimentary horn full-term pregnancy. A woman who had a uterine malformation was misdiagnosed as uterus didelphys and gave birth to a live, healthy fetus. The correct diagnosis was not made until cesarean section at 37 4/7 weeks. The case suggests that women who are pregnant in a rudimentary horn could obtain a full-term delivery and give birth to a live and healthy baby.

关键词： unruptured non-communicating rudimentary horn full-term delivery

促性腺释放激素激动剂联合补肾活血散瘀汤治疗子宫腺肌病的临床效果

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妇儿健康导刊 2024年第6期3卷 10-13,17页

作者：成臣周文娟黄美华张蕾张丽华孙家莉朱利杨桂云万贵平桂涛南京中医药大学附属江苏省中西医结合医院妇产科江苏南京210028

目的探讨促性腺释放激素激动剂联合补肾活血散瘀汤治疗子宫腺肌病的临床效果。方法选取2018—2022年南京中医药大学附属江苏省中西医结合医院、溧阳市中医医院、泰州市中医院、南通市中医院、苏州市中西医结合医院、镇江市中西医结合医... 详细信息

目的探讨促性腺释放激素激动剂联合补肾活血散瘀汤治疗子宫腺肌病的临床效果。方法选取2018—2022年南京中医药大学附属江苏省中西医结合医院、溧阳市中医医院、泰州市中医院、南通市中医院、苏州市中西医结合医院、镇江市中西医结合医院6所医院的44例肾虚血瘀型子宫腺肌病患者,按照随机信封法分为三组。A组予以促性腺释放激素激动剂(15例),B组予以补肾活血散瘀汤(21例),C组予以促性腺释放激素激动剂联合补肾活血散瘀汤(8例)。排除脱落病例,最终纳入研究病例为A组14例,B组19例,C组7例,比较各组子宫体积、痛经积分、月经量积分及肾虚腰痛积分。结果治疗后,三组子宫体积较治疗前缩小(P 0.05)。治疗后,C组痛经积分低于A组和B组(P <0.05)。治疗后,C组月经量积分低于B组(P <0.05)。治疗后,B组肾虚腰痛积分低于A组(P<0.05)。三组均未出现临床检验指标(血常规、生化、尿常规)异常及相关药物不良反应。结论促性腺释放激素激动剂联合补肾活血散瘀汤治疗子宫腺肌病,可缩小子宫体积,改善痛经、肾虚腰痛症状,减少月经量,且具有安全性,可推广应用。

关键词：子宫腺肌病补肾活血散瘀汤促性腺释放激素激动剂

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儿童结核性脑膜炎170例临床研究

重庆医学 2012年第31期41卷 3273-3275页

作者：毕美华熊菀重庆医科大学附属儿童医院消化感染科 400014

目的探讨儿童结核性脑膜炎(TBM)的临床特点,以提高临床早期诊断和治疗水平。方法回顾性分析2008年1月至2010年12月该院收治的170例TBM患儿的临床特征及实验室检查。结果全组病例中,161例有结核中毒症状,162例有神经系统症状、体征。影... 详细信息

目的探讨儿童结核性脑膜炎(TBM)的临床特点,以提高临床早期诊断和治疗水平。方法回顾性分析2008年1月至2010年12月该院收治的170例TBM患儿的临床特征及实验室检查。结果全组病例中,161例有结核中毒症状,162例有神经系统症状、体征。影像学检查胸部X线片、头颅CT、头颅磁共振异常率分别为78%、90%、89%。脑脊液常规及生化检测分别有143例及146例表现异常,但脑脊液生化检测仅36例有典型表现,159例脑脊液病原学检查有病原学证据者为71例。Ⅰ型TBM治疗有效率为100%,Ⅱ、Ⅲ型TBM有效率分别为96%、83%,Ⅳ型TBM有效率最低(仅为38%),而且恶化或病死率最高。结论儿童TBM临床表现复杂,早期诊断且正规抗结核治疗是提高治愈率、降低病死率的关键。

关键词：结核脑膜儿童临床表现

基于Orem自理理论的针对性护理对Hp感染性消化性溃疡患者治疗效果的影响

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中西医结合护理（中英文） 2022年第12期8卷 184-186页

作者：殷美华万鲁霞顾哲东台市人民医院消化内科江苏盐城224200

目的探究幽门螺杆菌(Hp)感染性消化性溃疡患者采取基于Orem自理理论的针对性护理干预取得的应用效果。方法回顾性分析2020年6月至2022年5月东台市人民医院收治的120例Hp感染性消化性溃疡患者的基线资料,按照护理措施的不同将其划分为对... 详细信息

目的探究幽门螺杆菌(Hp)感染性消化性溃疡患者采取基于Orem自理理论的针对性护理干预取得的应用效果。方法回顾性分析2020年6月至2022年5月东台市人民医院收治的120例Hp感染性消化性溃疡患者的基线资料,按照护理措施的不同将其划分为对照组(61例)和观察组(59例)。对照组采取常规护理,观察组应用基于Orem自理理论的针对性护理,对比2组的胃激素水平、护理依从性和临床症状消退时间。结果出院后2周,2组患者的胃激素水平均较护理前有所改善(P均<0.05),且观察组均优于对照组(P均<0.05)。观察组的护理依从性各项评分均高于对照组(P均<0.05)。观察组的各项临床症状消退时间均早于对照组(P均<0.05)。结论基于Orem自理理论的针对性护理可提高Hp感染性消化性溃疡患者的护理依从性,有效改善其胃激素水平,使其临床症状尽早恢复。

关键词：幽门螺杆菌感染性消化性溃疡基于Orem自理理论针对性护理应用效果

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“逆全球化”:特征、起因与前瞻

学术月刊 2020年第7期52卷 33-47页

作者：万广华朱美华复旦大学经济学院上海200433

从根本上说,全球化的发生、发展和终结是由技术进步、政府政策、全球化的收益和成本决定的。目前我们正面临的"逆全球化",其端倪很早就已经出现,正被国家间和国家内部利益的分配问题推向高潮。同时,以人工智能、物联网和机器人为标志的... 详细信息

从根本上说,全球化的发生、发展和终结是由技术进步、政府政策、全球化的收益和成本决定的。目前我们正面临的"逆全球化",其端倪很早就已经出现,正被国家间和国家内部利益的分配问题推向高潮。同时,以人工智能、物联网和机器人为标志的第四次技术革命将使收入分配问题进一步恶化,并最终导致本轮全球化走向终结。为此,国际组织、各国政府和社会团体需要做好充分的准备,而极力推进"一带一路"建设的中国必须重视全球化所带来的利益分配问题,以抗衡"逆全球化"浪潮,或为下一轮全球化的可持续发展奠定基础。

关键词：全球化终结 “逆全球化” 收入差距第四次技术革命不均等