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Game Theory Model and Equilibrium Analysis of Peasant's Production Decision

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Journal of Northeast Agricultural University(English Edition) 2012年第2期19卷 71-73页

作者： Qi Xue-lian Zhang Ya-zhuo Meng Jun College of Science Northeast Agricultural UniversityHarbin 150030China

Unbalanced agricultural production decision becomes the great block that influences the effective distribution of social resources, national grain security, social stability and economic development. This paper took the game theory as an analyzed tool to describe the interactional processes among the peasants, and set up the game theory model of independent decision and joint decision by peasants. It was shown that the government＇s positive guide and the market environment macroscopically controlled by the government could effectively increased the peasants＇ income

关键词： agricultural production decision game theory Nash equilibrium

Role of juvenile hormone receptor Methoprene-tolerant 1 in silkworm larval brain development and domestication

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Zoological Research 2021年第5期42卷 637-649页

作者： Yong Cui Zu-lian Liu Cen-Cen Li Xiang-Min Wei Yong-Jian Lin Lang You Zi-Dan Zhu Hui-Min Deng Qi-Li Feng Yong-Ping Huang Hui Xiang Guangdong Provincial Key Laboratory of Insect Developmental Biology and Applied Technology Guangzhou Key Laboratory of Insect Development Regulation and Application ResearchInstitute of Insect Science and TechnologySchool of Life SciencesSouth China Normal UniversityGuangzhouGuangdong 510631China Key Laboratory of Insect Developmental and Evolutionary Biology Institute of Plant Physiology and EcologyShanghai Institutes for Biological SciencesChinese Academy of SciencesShanghai 200032China College of Life Sciences Xinyang Normal UniversityXinyangHenan 464000China

The insect brain is the central part of the neurosecretory system,which controls morphology,physiology,and behavior during the insect’s *** are holometabolous insects,and their brains develop during the larval period and metamorphosis into the adult *** the only fully domesticated insect,the Lepidoptera silkworm Bombyx mori experienced changes in larval brain morphology and certain behaviors during the domestication *** regulation in insects is a key factor in multiple ***,how juvenile hormone(JH)signals regulate brain development in Lepidoptera species,especially in the larval stage,remains *** recently identified the JH receptor Methoprene tolerant 1(Met1)as a putative domestication *** artificial selection on Met1 impacts brain and behavioral domestication is another important issue addressing Darwin’s theory on ***,CRISPR/Cas9-mediated knockout of Bombyx Met1 caused developmental retardation in the brain,unlike precocious pupation of the *** the whole transcriptomelevel,theecdysteroid(20-hydroxyecdysone,20 E)signaling and downstream pathways were overactivated in the mutant cuticle but not in the *** related to cell proliferation and specialization processes,such as extracellular matrix(ECM)-receptor interaction and tyrosine metabolism pathways,were suppressed in the *** evolutionary analysis and in vitro assay identified an amino acid replacement located in a novel motif under positive selection in ***,which decreased transcriptional binding *** *** MET1 protein showed a changed structure and dynamic features,as well as a weakened co-expression gene network,compared with *** on comparative transcriptomic analyses,we proposed a pathway downstream of JH signaling(i.e.,tyrosine metabolism pathway)that likely contributed to silkworm larval brain development and domestication and highlighted the importance of the biogenic amine syste

关键词： Met1 Brain Artificial selection Tyrosine metabolism pathway Silkworm

Correlation of Individual Heterozygosity of Microsatellite Marker Loci with Heterosis of Growth Traits in Pig Populations

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Agricultural Sciences in China 2006年第8期5卷 635-642页

作者： ZHANG Jing-hu XIONG Yuan-zhu DENG Chang-yan JIANG Si-wen LEI Ming-gang LI Jia-lian LI Feng-e ZHENG Rong Key Laboratory of Swine Genetics and Breeding Ministry of Agriculture/College of Animal Science and Veterinary Medicine Huazhong Agricultural University Wuhan 430070 P.R.China Department of Biology Science ＆ Technology Zhangzhou Teachers College Zhangzhou 363000 P.R.China

To investigate the correlation of individual heterozygosity and heterosis of three traits in crossbred F1 pig populations, the F1 populations were built by random mating Yorkshire x Meishan （YM, n = 82）, and its reciprocal （MY, n =47） and two straightbred populations （Yorkshire = 34, Meishan = 55） were used as control groups. The heterosis of birth weight （BWT）, average daily gain （ADG）, and feed conversion ratio （FCR） were acquired as well. In the research, the significant marker loci for the heterosis of the three traits were observed by one-way ANOVA （P〈0.01） in a total of 39 marker loci on SSC4, SSC6, SSC7, SSC8, and SSC13, and the numbers of the significant marker loci were 12 （BWT）, 18 （ADG）, and 17 （FCR）, respectively, based on which the general heterozygosity （GH） was divided into significant marker loci heterozygosity （SH） and insignificant marker loci heterozygosity （IH）. Furthermore, the trends of alteration in heterosis with the stepwise increase in heterozygosity by 0.05 were explored. This was done by the regression analysis of the three kinds of heterozygosity against heterosis of the three traits. The results showed that, for BWT, the heterosis increased with the increase in GH （r=0.9337, P=0.0021） and SH （r=0.9165, P=0.0102）; for ADG, the heterosis increased with the increase in IH （r=0.7012, P=0.0353） and GH （r=0.7470, P=0.0537, near significant）; for FCR, the heterosis of feed efficiency increased with the increase in IH （r=0.8721, P=0.0022）. The results indicated that the correlation was not always higher or more significant for SH with heterosis than it was for IH or GH with heterosis, and it might be because of the reciprocal cancellation of the positive effect and negative effect of QTL linked to the significant marker loci.

关键词： pig heterosis microsatellite marker individual heterozygosity

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求解约束优化问题的内外交叉遗传算法

系统工程理论与实践 2012年第1期32卷 189-195页

作者：刘大莲徐尚文北京联合大学基础部北京100101

针对很多约束优化问题的最优解位于可行域的边界上或其附近的特点,提出了一种新的遗传算法.算法将种群中的可行解和不可行解分别存贮在两个容器中,新设计的交叉算子(内外交叉法)尽量让可行域内的可行解与可行域外的不可行解交叉,并顺着... 详细信息

针对很多约束优化问题的最优解位于可行域的边界上或其附近的特点,提出了一种新的遗传算法.算法将种群中的可行解和不可行解分别存贮在两个容器中,新设计的交叉算子(内外交叉法)尽量让可行域内的可行解与可行域外的不可行解交叉,并顺着有利的方向一维搜索到可行域边界,此举既增大了个体接近全局最优解的几率,又增强了算法的收敛速度;粒子群变异法则吸取粒子群(PSO)算法的优点,让粒子沿粒子自身历史最优和全局最优的方向变异,而选择算子则采取了保留固定比例不可行解的方法.仿真结果证明了算法能够在种群规模小,迭代次数少的情况下迅速接近或找到全局最优解.

关键词：约束优化内外交叉法一维搜索粒子群变异法

On the International Dissemination of Zhuang Medicine

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Journalism and Mass Communication 2024年第4期14卷 227-231页

作者： ZHANG Yan TAO Jien lian Yujie CHEN Yingzhu Guangxi University of Chinese Medicine NanningChina First Affiliated Hospital of Guangxi University of Chinese Medicine NanningChina

As an important part of Chinese culture,Zhuang medicine has a long history and unique diagnosis and *** the international dissemination of Chinese culture,the international dissemination of Zhuang medicine has become an increasing *** paper aims to discuss the status quo,challenges of the international dissemination of Zhuang medicine,then puts forwards corresponding solutions and recommendations,so as to make Zhuang medicine known by the world.

关键词： international dissemination Zhuang medicine intercultural communication

Treating ischaemic stroke with intravenous tPA beyond 4.5 hours under the guidance of a MRI DWI/T2WI mismatch was safe and effective

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Stroke & Vascular Neurology 2019年第1期4卷 8-13页

作者： Qing-ke Bai Zhen-guo Zhao lian-jun Lu Jian Shen Jian-ying Zhang Hai-jing Sui Xiu-hai Xie Juan Chen Juan Yang Cui-rong Chen Department of Neurology Pudong People’s HospitalShanghaiChina Department of Radiology The Affiliated Pudong People’s Hospital of Shanghai University of Medicine&Health SciencesShanghaiChina

Purpose Clinical trials have provided evidence that treating patients with acute ischaemic stroke(AIS)beyond 4.5 hours was *** them using MRI diffusion-weighted imaging/fluid attenuation inversion response(DWI/FLAIR)mismatch to guide intravenous tissue plasminogen activator(tPA)was *** study explored the outcome and safety of using DWI/T2-weighted imaging(T2WI)mismatch to guide intravenous tPA therapy for patients with AIS between 4.5 hours and 12 hours of *** This was a retrospective *** of 1462 AIS patients with the time of onset of4 pints of improvement on NIHSS score within 24 *** tPA,32(5.32%)cases had haemorrhagic transformation.26(4.33%)were asymptomatic ICH and 4(0.67%)*** 90 days,523(87%)achieved a modified Rankin scale of *** Using MRI DWI/T2WI mismatch to identify patients with AIS for intravenous tPA between 4.5 hours and 12 hours was safe and *** outcome was similar to those used DWI/PWI or DWI/FLAIR mismatch as the screening ***,obtaining DWI/T2WI was faster and avoided the need of contrast material.

关键词： T2WI intravenous analysis.

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Oncology and Translational Medicine 2022年第6期8卷 301-310页

作者： lian Chen Ling Wu Zhang Lu Qin Huang Liu Huang Department of Oncology Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430022China Union Hospital Tongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430022China

Objective Immune checkpoint inhibitor(ICI)plus angiogenesis inhibitor(AI)combination therapy is a novel treatment model for multiple cancers that normalizes vascular-immune crosstalk to potentiate cancer *** this review,we summarize the characteristics of adverse effects(AEs)and all fatal cases reported in clinical studies involing ICI+AI *** Four databases were systematically searched for eligible studies,and 28 relevant studies were selected for *** Of the patients included,58.1%developed grade≥3 *** most common fatal AEs were cardiovascular events,severe infections,and *** with AI alone,ICI+AI therapy resulted in more cases of grade≥3 proteinuria,liver injury,and fatal AEs(2.49%vs.1.28%,P=0.0041),especially respiratory toxicities and severe infections;however,ICI+AI therapy reduced hematological *** We shared comprehensive and practical safety data to review the adverse events associated with ICI+AI treatment.

关键词： combination therapy immune checkpoint inhibitor angiogenesis inhibitor treatment-related adverse events systematic review meta-analysis

Relationship of Abortion and the Expression of Indoleamine 2,3- dioxygenase (IDO) in Villus and Syncytiotrophoblasts

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Journal of Reproduction and Contraception 2005年第4期16卷 235-242页

作者： Xue-lian LI Sui-qi GUI Hai-yan WANG Department of Gynecology of lntegrated Traditional Chinese and Western Medicine The Hospital of Obstetric ＆ Gynecology Fudan University Shanghai 200011 China

Objective To study the relationship of abortion and the expression of indoleamine 2, 3- dioxygenase （IDO） in villus and syncytiotrophoblast in vitro. Methods RT-PCR was applied to analyze the mRNA transcription of lDO in villus of normal pregnancy and inevitable abortion and JAR cells as well. Immunohistochemistry was applied to analyze the expression of IDO protein in villus. Western blot was applied to determinate the expression of IDO protein on cultured syncytiotrophoblast. Highperformance liquid chromatography was applied to determinate whether there was kynurenine in cell culture medium of syncytiotrophoblast. Results The expression of IDO mRNA and protein in villus of inevitable abortion was lower than that of normal pregnancy; IDO mRNA did not express in JAR cells. IDO protein expressed on cultured syncytiotrophoblast, and there was kynurenine in cell culture medium of syncytiotrophoblast. Conclusion Appropriate expression of IDO in villus is *** maintenance of normal pregnancy and an active IDO protein expresses in syncytiotrophoblast.

关键词： indoleamine 2,3-dioxygenase syncytiotrophoblast villus abortion

Liver histopathological lesions is severe in patients with normal alanine transaminase and low to moderate hepatitis B virus DNA replication

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World Journal of Gastroenterology 2023年第16期29卷 2479-2494页

作者： Su-Wen Jiang Xiang lian Ai-Rong Hu Jia-Lin Lu Zhe-Yun He Xiao-Jun Shi De-Dong Zhu Zong-Yi Wang Guan-Cheng Huang Ningbo Institute of Liver Diseases Ningbo No.2 HospitalNingbo 315020Zhejiang ProvinceChina Department of Infectious Diseases Xiangshan Hospital Affiliated to Wenzhou Medical UniversityNingbo 315020Zhejiang ProvinceChina Department of Infectious Diseases The First Hospital of Ninghai CountyNingbo 315000Zhejiang ProvinceChina Department of Infectious Diseases The Affiliated Yang-Ming Hospital of Ningbo UniversityNingbo 315400Zhejiang ProvinceChina

BACKGROUND Chronic hepatitis B virus(HBV)infection remains a major global public health *** hepatitis B(CHB)patients can be divided into treatment indication and non-treatment indication individuals according to alanine transaminase(ALT),HBV DNA,serum hepatitis B e antigen status,disease status[liver cirrhosis,hepatocellular carcinoma(HCC),or liver failure],liver necroinflammation or fibrosis,patients’age,and family history of HCC or *** example,normal ALT patients in‘immune-tolerant’phase with HBV DNA higher than 10^(7)or 2×10^(7)IU/mL,and those in‘inactive-carrier’phase with HBV DNA lower than 2×10^(3)IU/mL do not require antiviral ***,is it reasonable to set the defined values of HBV DNA as the fundamental basis to estimate the disease state and to determine whether to start treatment?In fact,we should pay more attention to those who do not match the treatment indications(grayzone patients both in the indeterminate phase and in the‘inactive-carrier’phase).AIM To analyze the correlation of HBV DNA level and liver histopathological severity,and to explore the significance of HBV DNA for CHB with normal *** From January 2017 to December 2021,a retrospective cross-sectional set of 1299 patients with chronic HBV infection(HBV DNA>30 IU/mL)who underwent liver biopsy from four hospitals,including 634 with ALT less than 40 U/*** of the patients had received anti-HBV *** degrees of liver necroinflammatory activity and liver fibrosis were evaluated according to the Metavir *** the basis of the HBV DNA level,patients were divided into two groups:Low/moderate replication group,HBV DNA≤10^(7)IU/mL[7.00 Log IU/mL,the European Association for the Study of the Liver(EASL)guidelines]or≤2×10^(7)IU/mL[7.30 Log IU/mL,the Chinese Medical Association(CMA)guidelines];high replication group,HBV DNA>10^(7)IU/mL or>2×10^(7)IU/*** factors(demographic characteristics,laboratory parameters and noninvasive models)for liver h

关键词： Chronic hepatitis B Hepatitis B virus DNA Histology Risk factors