Treating ischaemic stroke with intravenous tPA beyond 4.5 hours under the guidance of a MRI DWI/T2WI mismatch was safe and effective
作者机构：Department of NeurologyPudong People’s HospitalShanghaiChina Department of RadiologyThe Affiliated Pudong People’s Hospital of Shanghai University of Medicine&Health SciencesShanghaiChina
出 版 物：《Stroke & Vascular Neurology》 (卒中与血管神经病学（英文）)
年 卷 期：2019年第4卷第1期
页 面：8-13页
核心收录：
基 金：Funded by Key Discipline Group Construction Project of Pudong Health Bureau of Shanghai(Grant No.PWZxq2017-02) by The Featured Clinical Discipline Project of Shanghai Pudong(Grant No.PWYst2018-01)
主 题：T2WI intravenous analysis.
摘 要：Purpose Clinical trials have provided evidence that treating patients with acute ischaemic stroke(AIS)beyond 4.5 hours was *** them using MRI diffusion-weighted imaging/fluid attenuation inversion response(DWI/FLAIR)mismatch to guide intravenous tissue plasminogen activator(tPA)was *** study explored the outcome and safety of using DWI/T2-weighted imaging(T2WI)mismatch to guide intravenous tPA therapy for patients with AIS between 4.5 hours and 12 hours of *** This was a retrospective *** of 1462 AIS patients with the time of onset of4 pints of improvement on NIHSS score within 24 *** tPA,32(5.32%)cases had haemorrhagic transformation.26(4.33%)were asymptomatic ICH and 4(0.67%)*** 90 days,523(87%)achieved a modified Rankin scale of *** Using MRI DWI/T2WI mismatch to identify patients with AIS for intravenous tPA between 4.5 hours and 12 hours was safe and *** outcome was similar to those used DWI/PWI or DWI/FLAIR mismatch as the screening ***,obtaining DWI/T2WI was faster and avoided the need of contrast material.
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