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Chinese preparation Xuesaitong promotes the mobilization of bone marrow mesenchymal stem cells in rats with cerebral infarction

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Neural Regeneration Research 2016年第2期11卷 292-297页

作者： Jin-sheng Zhang Bao-xia Zhang mei-mei du Xiao-ya Wang Wei Li First Affiliated Hospital of Henan University of Traditional Chinese Medicine Zhengzhou Henan Province China Third Affiliated Hospital of Henan University of Traditional Chinese Medicine Zhengzhou Henan Province China

After cerebral ischemia, bone marrow mesenchymal stem cells are mobilized and travel from the bone marrow through peripheral circulation to the focal point of ischemia to initiate tissue regeneration. However, the number of bone marrow mesenchymal stem cells mobilized into peripheral circulation is not enough to exert therapeutic effects, and the method by which blood circulation is promoted to remove blood stasis influences stem cell homing. The main ingredient of Xuesaitong capsules is Panax notoginseng saponins, and Xuesaitong is one of the main drugs used for promoting blood circulation and removing blood stasis. We established rat models of cerebral infarction by occlusion of the middle cerebral artery and then intragastrically administered Xuesaitong capsules（20, 40 and 60 mg/kg per day） for 28 successive days. Enzyme-linked immunosorbent assay showed that in rats with cerebral infarction, middle- and high-dose Xuesaitong significantly increased the level of stem cell factors and the number of CD117-positive cells in plasma and bone marrow and significantly decreased the number of CD54-and CD106-positive cells in plasma and bone marrow. The effect of low-dose Xuesaitong on these factors was not obvious. These findings demonstrate that middle- and high-dose Xuesaitong and hence Panax notoginseng saponins promote and increase the level and mobilization of bone marrow mesenchymal stem cells in peripheral blood.

关键词： nerve regeneration Panax notoginseng saponin Xuesaitong bone marrow mesenchymal stem cell cerebral infarction mobilization peripheral circulation homing nerual regeneration

Engineered interface of three-dimensional coralliform NiS/FeS_(2)heterostructures for robust electrocatalytic water cleavage

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Nano Research 2024年第6期17卷 4693-4701页

作者： Xin Yu Jing mei Yeshuang du Xiaohong Cheng Xing Wang Qi Wu State Key Laboratory of New Textile Materials and Advanced Processing Technologies Wuhan Textile UniversityWuhan 430073China Hubei Key Laboratory of Pollutant Analysis&Reuse Technology College of Chemistry and Chemical EngineeringHubei Normal UniversityHuangshi 435002China Hubei Key Laboratory of Low Dimensional Optoelectronic Materials and Devices Hubei University of Arts and ScienceXiangyang 441053China

Heterojunction structures improve the intrinsic activity of electrocatalysts by enhancing the charge transfer between the catalyst and the *** this paper,the NiS/FeS_(2)heterostructured electrocatalyst is fabricated by a simple sulfidation method using an interface engineering strategy to adjust the surface electron density of the *** expected,NiS/FeS_(2)electrocatalyst exhibits superior activity and durable oxygen evolution reaction(OER)stability,requiring only a low overpotential of 183 mV to achieve a current density of 10 mA·cm^(−2)and can be stable for more than 80 h,superior to NiS,FeS_(2)electrocatalyst individually,and precious RuO_(2).Notably,NiS/FeS_(2)is also a good bifunctional electrocatalyst with good overall water splitting performance,and it only requires a voltage 1.56 V to obtain a current density of 10 mA·cm^(−2)for more than 12 ***,the NiS/FeS_(2)hybridization facilitates the formation of coral-like structures,increasing the electrochemical surface area(ECSA)and enhancing the charge transfer efficiency,thus leading to excellent electrocatalytic *** work proposes a constructive strategy for designing efficient electrocatalysts based on interface engineering,and lays a foundation for designing a new class of electrocatalysts.

关键词： NiS/FeS_(2) interface engineering nanorods bifunctional water splitting

Local search yields a PTAS for fixed-dimensional k-means problem with penalties

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Journal of the Operations Research Society of China 2024年第2期12卷 351-362页

作者： Fan Yuan Da-Chuan Xu Dong-Lei du Dong-mei Zhang Beijing Institute for Scientific and Engineering Computing Beijing University of TechnologyBeijing 100124China Faculty of Management University of New BrunswickFrederictonNB E3B 9Y2Canada School of Computer Science and Technology Shandong Jianzhu UniversityJinan 250101ShandongChina

We study a problem called the k-means problem with penalties(k-MPWP),which is a natural generalization of the typical k-means *** this problem,we have a set D of client points in R^(d),a set F of possible centers in R^(d),and a penalty cost Pj>O for each point j∈*** are also given an integer k which is the size of the center point *** want to find a center point set S■F with size k,choose a penalized subset of clients P■D,and assign every client in D\P to its open *** goal is to minimize the sum of the squared distances between every point in D\P to its assigned centre point and the sum of the penalty costs for all clients in *** using the multi-swap local search technique and under the fixed-dimensional Euclidean space setting,we present a polynomial-time approximation scheme(PTAS)for the k-MPWP.

关键词： Approximation algorithm k-means Local search Penalty

Study on carbon emission calculation method and carbon reduction indexes of urban building stock

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Science China(Technological Sciences) 2024年第9期67卷 2706-2726页

作者： YANG Liu ZHANG Nan LU mei LUO ZhiXing DOU mei State Key Laboratory of Green Building Xi’an University of Architecture and TechnologyXi’an 710055China School of Architecture Xi’an University of Architecture and TechnologyXi’an 710055China School of Language Literature and LawXi’an University of Architecture and TechnologyXi’an 710055China School of Management Xi’an University of Architecture and TechnologyXi’an 710055China China Southwest Architectural Design and Research Institute Corp.Ltd. Chengdu 610041China

Carbon emissions associated with buildings are a major source of urban emissions. To put forward the methods and strategies to curb carbon emissions from urban building stock, it is not only necessary to establish a carbon emission calculation method for fine statistical analysis, but also to evaluate carbon emissions of urban planning schemes with applicable indexes. Currently,researches mainly focus on carbon emissions of individual buildings. When expanded to urban building stock, the calculation faces the lack of basic data, inadequate spatial analysis and unspecific carbon reduction indexes. Therefore, this study proposes a bottom-up calculation method for urban building stock, conducts spatial analysis based on carbon balance of urban grids, reveals the coupling mechanism between urban carbon reduction indexes and grid carbon emissions, and systematically establishes a carbon-reduction-oriented urban planning method that comprises calculation, analysis and evaluation, which is applied to Xi'an,China. This study provides a theoretical reference for cities to formulate carbon reduction targets and implement planning strategies by evaluating and predicting carbon emissions from urban building stock.

关键词： carbon emissions urban building stock calculation method carbon reduction index

Acupotomy alleviates knee osteoarthritis in rabbit by regulating chondrocyte mitophagy via Pink1-Parkin pathway

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Journal of Traditional Chinese Medicine 2024年第3期44卷 468-477页

作者： ZHU Wenting GUO Changqing du mei MA Yunxuan CUI Yongqi CHEN Xilin GUO Changqing the Third Affiliated Hospital of Beijing University of Chinese Medicine Beijing 100029China School of Acupuncture-Moxibustion and Tuina Beijing University of Chinese MedicineBeijing 100029China Department of Medical Technology Shijiazhuang Medical CollegeHebei 050599China

OBJECTIVE:To investigate the effect of acupotomy,on mitophagy and the Pink1-Parkin pathway in chondrocytes from rabbits with knee osteoarthritis(KOA).METHODS:A KOA model was established via the modified Videman *** were randomly divided into a control group(CON),KOA group and KOA+acupotomy group(Acu).Rabbits in the acupotomy group were subjected to acupotomy for 4 weeks after model *** behavior of the rabbits before and after intervention was *** degeneration was evaluated by optical microscopy and fluorescence *** level of mitophagy was evaluated by transmission electron microscopy,immunofluorescence and enzyme-linked immunosorbent assay(ELISA).The expression of phosphatase and tensin homolog(PTEN)-induced kinase 1(Pink1)-Parkin mitophagy pathway components was evaluated by immunofluorescence,Western blotting and real-time polymerase chain ***:In rabbits with KOA,joint pain,mobility disorders and cartilage degeneration were observed,the Mankin score was increased,collagen typeⅡ(Col-Ⅱ)expression was significantly decreased,mitophagy was inhibited,mitochondrial function was impaired,and factors associated with the Pink1-Parkin pathway were *** regulated the expression of Pink1-Parkin pathway-related proteins,the mitophagy-related protein microtubule-associated protein-1 light chain-3,the translocase of the outer membrane,and the inner mitochondrial membrane 23;increased the colocalization of mitochondria and autophagosomes;promoted the removal of damaged mitochondria;restored mitochondrial adenosine-triphosphate(ATP)production;and alleviated cartilage degeneration in rabbits with ***:Acupotomy played a role in alleviating KOA in rabbits by activating mitophagy in chondrocytes via the regulation of proteins that are related to the Pink1-Parkin pathway.

关键词： acupuncture therapy osteoarthritis knee mitophagy PTEN phosphohydrolase cartilage

Complement factor Ⅰ knockdown inhibits colon cancer development by affecting Wnt/β-catenin/c-Myc signaling pathway and glycolysis

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World Journal of Gastrointestinal Oncology 2024年第6期16卷 2646-2662页

作者： Yong-Jun du Yue Jiang Yan-mei Hou Yong-Bo Shi Department of Proctology Hospital of Chengdu University of Traditional Chinese MedicineChengdu 610072Sichuan ProvinceChina School of Clinical Medicine Chengdu University of Traditional Chinese MedicineChengdu 610075Sichuan ProvinceChina Department of Proctology Zigong Hospital of Traditional Chinese MedicineZigong 643000Sichuan ProvinceChina

BACKGROUND Colon cancer(CC)occurrence and progression are considerably influenced by the tumor ***,the exact underlying regulatory mechanisms remain *** To investigate immune infiltration-related differentially expressed genes(DEGs)in CC and specifically explored the role and potential molecular mechanisms of complement factor I(CFI).METHODS Immune infiltration-associated DEGs were screened for CC using *** reverse transcription polymerase chain reaction was used to examine hub DEGs expression in the CC cell *** CFI-knockdown HT29 and HCT116 cell lines were constructed,and the diverse roles of CFI in vitro were assessed using CCK-8,5-ethynyl-2’-deoxyuridine,wound healing,and transwell *** and eosin staining and immunohistochemistry staining were employed to evaluate the influence of CFI on the tumorigenesis of CC xenograft models constructed using BALB/c male nude *** proteins associated with glycolysis and the Wnt pathway were measured using western *** Six key immune infiltration-related DEGs were screened,among which the expression of CFI,complement factor B,lymphoid enhancer binding factor 1,and SRY-related high-mobility-group box 4 was upregulated,whereas that of fatty acid-binding protein 1,and bone morphogenic protein-2 was ***,CFI could be used as a diagnostic biomarker for ***,CFI silencing inhibited CC cell proliferation,migration,invasion,and tumor ***,CFI knockdown downregulated the expression of key glycolysis-related proteins(glucose transporter type 1,hexokinase 2,lactate dehydrogenase A,and pyruvate kinase M2)and the Wnt pathway-related proteins(β-catenin and c-Myc).Further investigation indicated that CFI knockdown inhibited glycolysis in CC by blocking the Wnt/β-catenin/c-Myc *** The findings of the present study demonstrate that CFI plays a crucial role in CC development by influencing g

关键词： Colon cancer Immune infiltration Complement factor I Glycolysis Wnt/β-catenin/c-Myc pathway

Oligomerization of drug transporters:Forms,functions,and mechanisms

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Acta Pharmaceutica Sinica B 2024年第5期14卷 1924-1938页

作者： Chunxu Ni mei Hong College of Life Sciences South China Agricultural UniversityGuangzhou 510642China Guangdong Provincial Key Laboratory of Protein Function and Regulation in Agricultural Organisms South China Agricultural UniversityGuangzhou 510642China

Drug transporters are essential players in the transmembrane transport of a wide variety of clinical *** broad substrate spectra and versatile distribution pattern of these membrane proteins infer their pharmacological and clinical *** our accumulating knowledge on the three-dimensional structure of drug transporters,their oligomerization status has become a topic of intense study due to the possible functional roles carried out by such kind of post-translational modification(PTM).In-depth studies of oligomeric complexes formed among drug transporters as well as their interactions with other regulatory proteins can help us better understand the regulatory mechanisms of these membrane proteins,provide clues for the development of novel drugs,and improve the therapeutic *** this review,we describe different oligomerization forms as well as their structural basis of major drug transporters in the ATP-binding cassette and solute carrier superfamilies,summarize our current knowledge on the influence of oligomerization for protein expression level and transport function of these membrane proteins,and discuss the regulatory mechanisms of ***,we highlight the challenges associated with the current oligomerization studies and propose some thoughts on the pharmaceutical application of this important drug transporter PTM.

关键词： Drug development Drug transporters Oligomerization Protein expression Protein–protein interaction Regulatory mechanism Structural basis Transport function

Carbon nanotube integrated circuit technology:purification,assembly and integration

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International Journal of Extreme Manufacturing 2024年第3期6卷 120-138页

作者： Jianlei Cui Fengqi Wei Xuesong mei State Key Laboratory for Manufacturing Systems Engineering Xi’an Jiaotong UniversityXi’an 710049People’s Republic of China

As the manufacturing process of silicon-based integrated circuits(ICs)approaches its physical limit,the quantum effect of silicon-based field-effect transistors(FETs)has become increasingly *** the burgeoning carbon-based semiconductor technology has become one of the most disruptive technologies in the post-Moore *** one-dimensional nanomaterials,carbon nanotubes(CNTs)are far superior to silicon at the same technology nodes of FETs because of their excellent electrical transport and scaling properties,rendering them the most competitive material in the next-generation ICs ***,certain challenges impede the industrialization of CNTs,particularly in terms of material preparation,which significantly hinders the development of CNT-based *** on CNT-based ICs technology,this review summarizes its main technical status,development trends,existing challenges,and future development directions.

关键词： carbon nanotubes integrated circuits field-effect transistors post-Moore

Effects of the properties of Mg(OH)_(2)precursor on the hydrothermal synthesis of magnesium oxysulfate whiskers

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Particuology 2024年第9期92卷 13-23页

作者： Thanayos Boonrit mei Yang Guangwen Chen Dalian Institute of Chemical Physics Chinese Academy of SciencesDalian116023China University of Chinese Academy of Sciences Beijing100049China

Magnesium oxysulfate(MOS)whiskers are commonly synthesized through a dissolution-precipitation mechanism,wherein Mg(OH)_(2)dissolves to form Mg(OH)64−,followed by reactions with SO_(4)^(2−)and H_(2)O to yield MOS ***,the impact of Mg(OH)_(2)precursor properties on the formation process of MOS whiskers has been insufficiently explored,and sector-like and needle-like morphologies were both observed in previous *** this study,we systematically investigated how the properties of Mg(OH)_(2)precursors influenced the crystalline structure and morphology of MOS *** various experimental conditions,MgSO_(4)·5Mg(OH)_(2)·2H_(2)O(152MOS)whiskers were consistently obtained,regardless of Mg(OH)_(2)morphology and *** size of Mg(OH)_(2)emerged as a critical factor in shaping the morphology of 152MOS ***-sized Mg(OH)_(2)(≤106±37 nm)favored the formation of sector-like whiskers,while larger-sized Mg(OH)_(2)(≥206±98 nm)encouraged the development of needle-like *** distinction was attributed to the slower dissolution rate exhibited by larger-sized Mg(OH)_(2),maintaining a smaller number of 152MOS nuclei and promoting the growth of needle-like whiskers instead of the aggregation of 152MOS nuclei into sector-like *** addition,the effects of the molar ratio of Mg^(2+)to SO_(4)^(2−)and hydrothermal temperature were also *** average length and diameter of the needle-like whiskers prepared with Mg(OH)_(2)of 331±145 nm under optimized conditions were 77±32 and 0.39±0.10μm,*** study presented an effective strategy for controlling the morphology of 152MOS whiskers.

关键词： Magnesium oxysulfate whiskers Morphology control Precursor Microreactor