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Material characterization and inter/intra-particle validation for DEM simulation of urea coating process

Particuology 2024年第5期88卷 32-48页

作者： Salma A.Nouh KuZilati KuShaari lau Kok Keong Shafirah Samsuri Chemical Engineering Department Universiti Teknologi PETRONAS32610 Seri IskandarPerak Darul RidzuanMalaysia

Particle coating is a common operation in the controlled-release fertilizer (CRF) industry,where a coating layer is appliedto the urea cores.A discrete element method (DEM) computer simulation was applied to model the coating process for the urea granules using measured model *** accuracy of DEM input parameters for the coating material properties and the physical and mechanical characterizations of urea granules are crucial to the study of particle coating ***,to enhance the simulation accuracy,information on the material properties (urea granules) is *** this study,the elasticity parameters,shear modulus ,coefficient of restitution (CoR),and coefficient of rolling and static friction (CoRF) and (CoSF) of urea granules are estimated experimentally in addition to the physical *** sensitivity of the angle of repose of the urea bed was investigated at different coefficients of *** to the obtained experimental value of the angle of repose,values of 0.2 and 0.3 for CoRF and CoSF,respectively,were adjusted to obtain consistent urea granules’ motion for simulation and the ***,the spray droplet sizes and velocity distributions were estimated using the video-imaging process *** on this experimental characterization,elasticity parameters and spray properties were integrated into DEM simulation software as input data to perform numerical analysis of the coating process to compare simulation and experimental results,which show uniformity at three different pan speeds with a maximum deviation of 0.033 at 5 ***,consistency between DEM and experiment results was achieved in terms of average coating thickness (μm) of the selected samples and average intra-particle thickness variation ( CoV intra ).These results revealed that the coating film thickness is proportional to the rotation speed for the experiment and *** enhance the inter-particle coating uniformity,the effects of the

关键词： Contact model Discrete element method Urea fertilizer Coating process

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A ruptured recurrent small bowel gastrointestinal stromal tumour causing hemoperitoneum

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Frontiers of Medicine 2015年第1期9卷 108-111页

作者： Eric C.H. Lai Kam Man Chung Stephanie H.Y. lau Wan Yee lau Faculty of Medicine The Chinese University of Hong Kong Shatin Hong Kong SAR China Dr. K.M. Chung's Clinic Rm 807 Hang Seng Tsimshatsui Building 18 Carnarvon Road Tsimshatsui Hong Kong SAR China Department of Surgery Pamela Youde Nethersole Eastern Hospital Hong Kong SAR China Department of Surgery Queen Elizabeth Hospital Hong Kong SAR China

Hemoperitoneum is a rare and potentially life-threatening complication of GIST. We reported a 54- year-old man who developed disseminated intra-abdominal recurrence from a previously resected gastrointestinal stromal tumour （GIST） of the small bowel, and the patient presented with hemoperitoneum. Emergent debulking surgery was performed. A high dose imatinib was prescribed. Despite the presence of residual disease, the patient was well clinically 8 months after the operation. Even though, there is no evidence to support the routine use of debulking surgery in the management of GIST. In our patient, disease progression after second line targeted therapy and the absence of alternative treatment options for spontaneous rupture and hemoperitoneum prompted us to treat the patient aggressively. Resection of the ruptured GIST was carried out for control of bleeding and to prevent recurrent bleeding in this patient with good surgical risks. During the treatment decision-making, the patient＇s general condition, the risk of surgery and the extent of dissemination were taken into consideration. In this patient who presented with spontaneous rupture of a small intestinal GIST, the novel use of targeted therapy and aggressive surgical treatment produced reasonably good survival outcome.

关键词： gastrointestinal stromal tumour hemoperitoneum small bowel GIST small bowel neoplasm imatinib

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Comments on“Hepatic radioembolization with yttrium-90 glass microspheres for treatment of primary liver cancer”by Cao et al,Chin Med J 1999;112:430-432

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Chinese Medical Journal 2001年第4期114卷 97-98页

作者： SHo WY lau WT Leung Chinese Univ Hong Kong Prince Wales Hosp Dept Surg Shatin Hong Kong Peoples R China Chinese Univ Hong Kong Prince Wales Hosp Dept Clin Oncol Shatin Hong Kong Peoples R China

Editors,　　We would like to congratulate Cao and his colleagues on the extremely good mean survival rate of 19.5 months achieved in 17 patients with non-resectable liver cancer (16 primary and 1 metastatic).1　Because the results of their study sounds so promising, centres having access to glass yttrium-90 (90Y) microspheres may want to try their methods. It is therefore necessary to clarify some of the points mentioned in their report.

关键词： yttrium Comments on

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Evolving treatment landscape for early and advanced pancreatic cancer

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World Journal of Gastrointestinal Oncology 2017年第7期9卷 281-292页

作者： Sally C lau Winson Y Cheung Division of Medical Oncology University of British Columbia British Columbia Cancer Agency Department of Oncology University of Calgary Tom Baker Cancer Center

Pancreatic ductal adenocarcinoma is an infrequent cancer with a high disease related mortality rate, even in the context of early stage disease. Until recently, the rate of death from pancreatic cancer has remained largely similar whereby gemcitabine monotherapy was the mainstay of systemic treatment for most stages of disease. With the discovery of active multiagent chemotherapy regimens, namely FOLFIRINOX and gemcitabine plus nab-paclitaxel, the treatment landscape of pancreatic cancer is slowly evolving. FOLFIRINOX and gemcitabine plus nab-paclitaxel are now considered standard first line treatment options in metastatic pancreatic cancer. Studies are ongoing to investigate the utility of these same regimens in the adjuvant setting. The potential of these treatments to downstage disease is also being actively examined in the locally advanced context since neoadjuvant approaches may improve resection rates and surgical outcomes. As more emerging data become available, the management of pancreatic cancer is anticipated to change significantly in the coming years.

关键词： Cancer Neoplasm Pancreas Adjuvant treatment Systemic treatment Gemcitabine FOLFIRINOX Nab-paclitaxel

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Duplex micro RNAs assay based on target-triggered universal reporter hybridization

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Journal of Pharmaceutical Analysis 2018年第4期8卷 265-270页

作者： Yinan Wang Yue Sun Choiwan lau Jianzhong Lu School of Pharmacy Fudan University

In this paper, we designed and evaluated a duplex detection strategy for micro RNAs（mi RNAs） using universal probe-based target-triggered double hybridization and fluorescent microsphere-based assay system（x MAP array）. In the absence of target mi RNA, reporter DNA cannot hybridize stably with the immobilized capture DNA due to its low melting temperature. Only after adding target mi RNA, can reporter probe hybridize with capture probe to form a stable three-component complex. This targettriggered stable hybridization makes this method possible for highly selective and sensitive detection of multiple mi RNAs. We exemplified a quantitative detection of duplex mi RNAs with a limit of detection of40 p M. The x MAP array platform holds the potential of extending this approach to simultaneous detection of up to 100 mi RNA targets. Considering the simplicity, rapidity and multiplexing, this work promised a potential detection of multiple mi RNA biomarkers for early disease diagnosis and prognosis.

关键词： xMAP array Multiple microRNAs Target-triggered Universal reporter

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Deterministic approaches for noncoherent communicationswith chaotic carriers

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Journal of Systems Engineering and Electronics 2005年第2期16卷 253-257页

作者： LiuXiongying QiuShuisheng Francis.C.M.lau CollegeofElectronicandInformationEngineering SouthChinaUniversityofTechnologyGuangzhou510640P.R.China DepartmentofElectronicandInformationEngineering HongkongPolytechnicUniversityHongkongP.R.China

Two problems are proposed. The first one is the noise decontamination of chaotic carriers using a deterministic approach to reconstruct pseudo trajectories, the second is the design of communications schemes with chaotic carriers. After presenting our deterministic noise decontamination algorithm, conventional chaos shift keying (CSK) communication system is applied. The difference of Euclidean distance between noisy trajectory and decontaminated trajectory in phase space could be utilized to non-coherently detect the sent symbol simply and effectively. It is shown that this detection method can achieve the bit error rate performance comparable to other non-coherent systems.

关键词： gradient descent reconstruction chaotic communications noncoherent detection.

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Wan-Yee Joseph lau:the promoter of modernization and internationalization of Chinese surgery

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Oncology and Translational Medicine 2024年第1期10卷 1-3页

作者： Wan-Yee Joseph lau Faculty of Medicine The Chinese University of Hong KongHong KongChina

To my knowledge,there have been 3 books[1–3]and 2 book chapters written about me.[4–5]For those who are interested in the details of my life,please refer to these books/book *** title of this article is an English translation of the title of the book I refer to as reference 1,which I find appropriate to describe the role that I play in China.

关键词： please details translation

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Cosmic microwave background constraints on the tensor-to-scalar ratio

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Research in Astronomy and Astrophysics 2014年第6期14卷 635-647页

作者： King lau Jia-Yu Tang Ming-Chung Chu Department of Physics and Institute of Theoretical Physics The Chinese University of Hong Kong

One of the main goals of modern cosmic microwave background （CMB） missions is to measure the tensor-to-scalar ratio r accurately to constrain inflation models. Due to ignorance about the reionization history Xe （z）, this analysis is usu- ally done by assuming an instantaneous reionization Xe （z） which, however, can bias the best-fit value of r. Moreover, due to the strong mixing of B-mode and E-mode polarizations in cut-sky measurements, multiplying the sky coverage fraction fsky by the full-sky likelihood would not give satisfactory results. In this work, we forecast constraints on r for the Planck mission taking into account the general reionization scenario and cut-sky effects. Our results show that by applying an N-point interpo- lation analysis to the reionization history, the bias induced by the assumption of in- stantaneous reionization is removed and the value of r is constrained within 5% error level, if the true value of r is greater than about 0.1.

关键词： cosmology: cosmic microwave background -- cosmology: cosmologicalparameters -- cosmology: early universe -- gravitational waves

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Primary Immunodeficiencies:“New” Disease in an Old Country

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Cellular & Molecular Immunology 2009年第6期6卷 397-406页

作者： Pamela P.W.Lee Yu-Lung lau Department of Paediatrics and Adolescent Medicine The University of Hong KongHKSARChina Department of Paediatrics and Adolescent Medicine Room 1171/F New Clinical BuildingQueen Mary HospitalPokfulamHong KongChina

Primary immunodeficiency disorders(PIDs)are rare inborn errors of the immune *** with PIDs are unique models that exemplify the functional and phenotypic consequences of various immune defects underlying infections,autoimmunity,lymphoproliferation,allergy and *** 150 PID syndromes were characterized in the past 60 years,with an ever growing list of new entities being *** of their rarity,multi-center collaboration for pooled data analysis and molecular studies is important to gain meaningful insights into the phenotypic and genetic diversities of *** this article,we summarize our research findings on PIDs in Chinese population in the past 20 *** collaboration among various immunology centers,cross-referrals and systematic data analysis constitute the foundation for research on *** directions include establishment of a national PID registry,raising awareness of PIDs and securing sufficient resources for patient care and scientific research.

关键词： primary immunodeficiency disorders immunodeficiencies development research China

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Modeling of cable vibration effects of cable-stayed bridges

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Earthquake Engineering and Engineering Vibration 2002年第1期1卷 74-85页

作者： S.H.Cheng David T.lau Department of Civil and Environmental Engineering Carleton UniversityOttawaOntarioCanadaPost-doctoral fellow Department of Civil and Environmental Engineering Carleton UniversityOttawaOntarioCanada Professor

The analysis of dynamic responses of cable-stayed bridges subjected to wind and earthquake loads generally considers only the motions of the bridge deck and *** influence of the stay cable vibration on the responses of the bridge is either ignored or considered by approximate *** transverse vibration of the stay cables,which can be significant in some cases,are usually neglected in previous *** the present study,a new three-node cable element has been developed to model the transverse motions of the *** interactions between the cable behavior and the other parts of the bridge superstructure are considered by the concept of dynamic *** nonlinear effect of the cable caused by its self-weight is included in the *** examples are presented to demonstrate the accuracy and efficiency of the proposed model. The impact of cable vibration behavior on the dynamic characteristics of cable-stayed bridges is discussed.

关键词： cable-stayed bridges cable vibration dynamics finite elements long-span structures

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