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Crocetin protects cardiomyocytes against hypoxia/reoxygenation injury by attenuating Drp1-mediated mitochondrial fission via PGC-1α

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Journal of Geriatric Cardiology 2023年第1期20卷 68-82页

作者： You-Ling MOU Rui ZHAO Shi-Ying LYU Zi-Yi ZHANG mei-fei zhu Qian LIU School of Pharmaceutical Sciences Zhejiang Chinese Medical UniversityHangzhouChina Department of Critical Care Medicine the First Affiliated HospitalZhejiang Chinese Medical UniversityHangzhouChina

BACKGROUND Saffron(Crocus sativus L.)has been traditionally used as food,spice,and ***(CRT),as main bioactive component of saffron,has accumulated pieces of beneficial evidence on myocardial ischemia/reperfusion(I/R)***,the mechanisms are poorly *** study aims to investigate the effects of CRT on H9c2 cells under hypoxia/reoxygenation(H/R)and elucidated the possible underlying *** H/R attack was performed on H9c2 *** counting kit-8 was used to detect the cell *** samples and culture supernatants were evaluated via commercial kits to measure the superoxide dismutase(SOD)activity,malondialdehyde(MDA)content,and cellular adenosine triphosphate(ATP)*** fluorescent probes were used to detect cell apoptosis,intracellular and mitochondrial reactive oxygen species(ROS)content,mitochondrial morphology,mitochondrial membrane potential(MMP),and mitochondrial permeability transition pore(mPTP)*** were evaluated via Western *** H/R exposure severely reduced cell viability and increased LDH *** proliferator-activated receptorγcoactivator-1α(PGC-1α)suppression and dynamin-related protein 1(Drp1)activation were coincided with excessive mitochondrial fission,mitochondrial permeability transition pore(mPTP)opening and mitochondrial membrane potential(MMP)collapse in H9c2 cells treated with H/*** fragmentation under H/R injury induced ROS over-production,oxidative stress,and cell ***,CRT treatment significantly prevented mitochondrial fission,mPTP opening,MMP loss,and cell ***,CRT sufficiently activated PGC-1α and inactivated ***,mitochondrial fission inhibition with mdivi-1 similarly suppressed mitochondrial dysfunction,oxidative stress and cell ***,silencing PGC-1α with small interfering RNA(siRNA)abolished the beneficial effects of CRT on H9c2 cells under H/R injury,accompanied with increased Drp1 an

关键词： Drp1 injury traditionally

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Deep-reinforcement-learning-based UAV autonomous navigation and collision avoidance in unknown environments

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Chinese Journal of Aeronautics 2024年第3期37卷 237-257页

作者： fei WANG Xiaoping zhu Zhou ZHOU Yang TANG School of Astronautics Northwestern Polytechnical UniversityXi’an 710072China School of Aeronautics Northwestern Polytechnical UniversityXi’an 710072China

In some military application scenarios,Unmanned Aerial Vehicles(UAVs)need to perform missions with the assistance of on-board cameras when radar is not available and communication is interrupted,which brings challenges for UAV autonomous navigation and collision *** this paper,an improved deep-reinforcement-learning algorithm,Deep Q-Network with a Faster R-CNN model and a Data Deposit Mechanism(FRDDM-DQN),is proposed.A Faster R-CNN model(FR)is introduced and optimized to obtain the ability to extract obstacle information from images,and a new replay memory Data Deposit Mechanism(DDM)is designed to train an agent with a better *** training,a two-part training approach is used to reduce the time spent on training as well as retraining when the scenario *** order to verify the performance of the proposed method,a series of experiments,including training experiments,test experiments,and typical episodes experiments,is conducted in a 3D simulation *** results show that the agent trained by the proposed FRDDM-DQN has the ability to navigate autonomously and avoid collisions,and performs better compared to the FRDQN,FR-DDQN,FR-Dueling DQN,YOLO-based YDDM-DQN,and original FR outputbased FR-ODQN.

关键词： Faster R-CNN model Replay memory Data Deposit Mechanism(DDM) Two-part training approach Image-based Autonomous Navigation and Collision Avoidance(ANCA) Unmanned Aerial Vehicle(UAV)

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Nb_(2)O_(5) nanocrystals decorated graphene composites as anode materials for high-performance dual-ion batteries

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Nano Research 2024年第3期17卷 1535-1541页

作者： Lei Wang fei Huang Guoyin zhu Zhihui Dai Jiangsu Collaborative Innovation Center of Biomedical Functional Materials Jiangsu Key Laboratory of Biofunctional MaterialsSchool of Chemistry and Materials ScienceNanjing Normal UniversityNanjing 210023China Institute of Advanced Materials and Flexible Electronics(IAMFE) School of Chemistry and Materials ScienceNanjing University of Information Science&TechnologyNanjing 210044China School of Chemistry and Molecular Engineering Nanjing Tech UniversityNanjing 211816China

Niobium oxide(Nb_(2)O_(5))is a promising material in photocatalytic,solar cell,electronic like electron field emitters,and especially lithium-ion batteries(LIBs)because of its adjustable morphologies,controllable crystal type,stable structure,and environmental ***,its low electrical conductivity lowers the rate performance and limits the practical applications in ***,we present a one-step solid-state synthesis of orthogonal Nb_(2)O_(5) nanocrystals/graphene composites(Nb_(2)O_(5)/G)as high-performance anode materials in *** from the nanoscale crystalline structure Nb_(2)O_(5) and highly-conductive graphene substrate,the as-prepared Nb_(2)O_(5)/G exhibits excellent electrochemical ***,a reversible structural phase transition between orthogonal Nb_(2)O_(5) and tetragonal Li1-xNbO_(2)(0

关键词： niobium oxide graphene anode dual-ion batteries graphite intercalation

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A DFT study on Pt single atom loaded COF for efficient photocatalytic CO_(2)reduction

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Journal of Materials Science & Technology 2024年第3期170卷 87-94页

作者： fei Xie Chuanbiao Bie Jian Sun Zhenyi Zhang Bicheng zhu Laboratory of Solar Fuel Faculty of Materials Science and ChemistryChina University of GeosciencesWuhan430078China Key Laboratory of New Energy and Rare Earth Resource Utilization of State Ethnic Affairs Commission Key Laboratory of Photosensitive Materials and Devices of Liaoning ProvinceSchool of Physics and Materials EngineeringDalian Minzu UniversityDalian116600China

Photocatalytic CO_(2)reduction provides a promising strategy for the alleviation of greenhouse effect and energy shortage *** single atom modification is an effective method to improve the CO_(2)reduction performance of covalent organic framework(COF)photocatalysts,while the intrinsic mechanism is not revealed in ***,a Pt-COF photocatalytic system was constructed by embedding Pt single atom in TFPT-TMT-COF(TFPT:1,3,5-tris(4-formylphenyl)-triazine,TMT:2,4,6-trimethyl-1,3,5-triazine).Based on density functional theory(DFT)calculation,the geometric structure and electronic property of Pt-COF were investigated,and the CO_(2)adsorption and reduction reaction process on Pt-COF were *** results show that the Pt atom can be steadily anchored in COF via the formation of Pt-N and Pt-C ***,there is strong electronic interaction between Pt and *** incorporation of Pt atom benefits the CO_(2)reduction activity of COF from multiple aspects:(ⅰ)reducing the band gap and improving light absorption;(ⅱ)enhancing CO_(2)adsorption and activating the CO_(2)molecule;(ⅲ)decreasing the energy barrier in the hydrogenation step of CO_(2)→COOH,thus facilitating CO_(2)conversion to CO;(ⅳ)inhibiting the hydrogenation of CO,thereby increasing the selectivity of *** work brings a novel insight into the excellent CO_(2)reduction performance of Pt modified COF,and provides useful references for the design of single atom photocatalysts.

关键词： Photocatalysis Carbon dioxide reduction Covalent organic framework Pt single atom Theoretical calculation

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3D robust anisotropic diffusion filtering algorithm for sparse view neutron computed tomography 3D image reconstruction

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Nuclear Science and Techniques 2024年第3期35卷 13-29页

作者： Yang Liu Teng-fei zhu Zhi Luo Xiao-Ping Ouyang School of Nuclear Science and Engineering North China Electric Power UniversityBeijing 102206China State Key Laboratory of Nuclear Resources and Environment East China University of TechnologyNanchang 330013China State Key Laboratory of Intense Pulsed Radiation Simulation and Effect Xi’an 710024China

The most critical part of a neutron computed tomography(NCT) system is the image processing algorithm,which directly affects the quality and speed of the reconstructed *** types of noise in the system can degrade the quality of the reconstructed ***,to improve the quality of the reconstructed images of NCT systems,efficient image processing algorithms must be *** anisotropic diffusion filtering(ADF) algorithm can not only effectively suppress the noise in the projection data,but also preserve the image edge structure information by reducing the diffusion at the image ***,we propose the application of the ADF algorithm for NCT image *** compare the performance of different algorithms in NCT systems,we reconstructed images using the ordered subset simultaneous algebraic reconstruction technique(OS-SART) algorithm with different regular terms as image processing *** the iterative reconstruction,we selected two image processing algorithms,the Total Variation and split Bregman solved total variation algorithms,for comparison with the performance of the ADF ***,the filtered back-projection algorithm was used for comparison with an iterative *** reconstructing the projection data of the numerical and clock models,we compared and analyzed the effects of each algorithm applied in the NCT *** on the reconstruction results,OS-SART-ADF outperformed the other algorithms in terms of denoising,preserving the edge structure,and suppressing *** example,when the 3D Shepp–Logan was reconstructed at 25 views,the root mean square error of OS-SART-ADF was the smallest among the four iterative algorithms,at only *** universal quality index,mean structural similarity,and correlation coefficient of the reconstructed image were the largest among all algorithms,with values of 0.9877,0.9878,and 0.9887,respectively.

关键词： NCT OS-SART Sparse-view Anisotropic diffusion filtering

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Structural and magnetic properties of micropolycrystalline cobalt thin films fabricated by direct current magnetron sputtering

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International Journal of Minerals,Metallurgy and Materials 2024年第2期31卷 384-394页

作者： Kerui Song Zhou Li mei Fang zhu Xiao Qian Lei School of Materials Science and Engineering Central South UniversityChangsha 410083China State Key Laboratory of Powder Metallurgy Central South UniversityChangsha 410083China Hunan Key Laboratory of Super-Microstructure and Ultrafast Process School of Physics and electronicsCentral South UniversityChangsha 410083China Key Laboratory of Non-Ferrous Metal Materials Science and Engineering Ministry of EducationChangsha 410083China

Pure cobalt(Co)thin films were fabricated by direct current magnetron sputtering,and the effects of sputtering power and pres-sure on the microstructure and electromagnetic properties of the films were *** the sputtering power increases from 15 to 60 W,the Co thin films transition from an amorphous to a polycrystalline state,accompanied by an increase in the intercrystal pore ***,the resistivity decreases from 276 to 99μΩ·cm,coercivity increases from 162 to 293 Oe,and in-plane magnetic aniso-tropy *** the sputtering pressure decreases from 1.6 to 0.2 Pa,grain size significantly increases,resistivity significantly de-creases,and the coercivity significantly increases(from 67 to 280 Oe),which can be attributed to the increase in defect ***-pondingly,a quantitative model for the coercivity of Co thin films was *** polycrystalline films sputtered under pressures of 0.2 and 0.4 Pa exhibit significant in-plane magnetic anisotropy,which is primarily attributable to increased microstress.

关键词： cobalt thin film magnetron sputtering microstructure electromagnetic properties

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CMAES-WFD:Adversarial Website Fingerprinting Defense Based on Covariance Matrix Adaptation Evolution Strategy

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Computers, Materials & Continua 2024年第5期79卷 2253-2276页

作者： Di Wang Yuefei zhu Jinlong fei Maohua Guo School of Cyberspace Security Information Engineering UniversityZhengzhou450000China

Website fingerprinting,also known asWF,is a traffic analysis attack that enables local eavesdroppers to infer a user’s browsing destination,even when using the Tor anonymity *** advanced attacks based on deep neural network(DNN)can performfeature engineering and attain accuracy rates of over 98%,research has demonstrated thatDNNis vulnerable to adversarial *** a result,many researchers have explored using adversarial samples as a defense mechanism against DNN-based WF attacks and have achieved considerable ***,these methods suffer from high bandwidth overhead or require access to the target model,which is *** paper proposes CMAES-WFD,a black-box WF defense based on adversarial *** process of generating adversarial examples is transformed into a constrained optimization problem solved by utilizing the Covariance Matrix Adaptation Evolution Strategy(CMAES)optimization *** are injected into the local parts of the original traffic to control bandwidth *** to the experiment results,CMAES-WFD was able to significantly decrease the accuracy of Deep Fingerprinting(DF)and VarCnn to below 8.3%and the bandwidth overhead to a maximum of only 14.6%and 20.5%,***,for Automated Website Fingerprinting(AWF)with simple structure,CMAES-WFD reduced the classification accuracy to only 6.7%and the bandwidth overhead to less than 7.4%.Moreover,it was demonstrated that CMAES-WFD was robust against adversarial training to a certain extent.

关键词： Traffic analysis deep neural network adversarial sample Tor website fingerprinting

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Recent progress of in-situ characterization of LiNi_(1−x−y)Co_(x)Mn_(y)O_(2) cathodes for lithium metal batteries: A mini review

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Nano Research 2024年第3期17卷 1384-1401页

作者： Huanzhu Lv Xiaoqi zhu Jun mei Yuanhua Xia Bin Wang Institute of Fundamental and Frontier Science University of Electronic Science and Technology of ChinaChengdu 611731China Chengdu Development Center of Science and Technology China Academy of Engineering PhysicsChengdu 610200China Key Laboratory of Neutron Physics and Institute of Nuclear Physics and Chemistry China Academy of Engineering Physics(CAEP)Mianyang 621999China

In the context of the gradual popularity of electric vehicles(EVs),the development of lithium battery systems with high energy density and power density is regarded as the foremost way to improve the range of ***_(1-x-y)Co_(x)Mn_(y)O_(2)(NCM)cathodes have been the focus of researchers due to their high energy density,excellent power performance,and low-temperature ***,the elaboration of the decay mechanism of NCM cathode based on lithium metal batteries(LMBs)is still being restricted to the primary *** the past decades,the development and application of advanced in-situ characterization tools have facilitated researchers'understanding of the internal operation mechanism of batteries during charging and *** this minireview,the latest progress of in-situ observation of the NCM cathode by X-ray diffraction(XRD),fourier transform infrared(FT-IR)spectroscopy,Raman spectroscopy,atomic force microscopy(AFM),transmission electron microscope(TEM),optical microscope,and other characterization tools is *** mechanisms of structural degradation,cathode-electrolyte interfaces(CEIs)composition,and dynamic changes of NCM,electrolyte breakdown,and gas production are ***,based on the existing research progress,the opportunities and challenges for future in-situ characterization technology in the study of the mechanism of LMBs are discussed in ***,the purpose of this minireview is to summarize recent work that focuses on the outstanding application of in-situ characterization techniques in the mechanistic study of LMBs,and pointing the way to the future development of high energy density and power density LMBs systems.

关键词： lithium metal batteries(LMBs) In-situ characterization LiNi_(1-x-y)Co_(x)Mn_(y)O_(2)(NCM)

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Geographically and Temporally Weighted Regression in Assessing Dengue Fever Spread Factors in Yunnan Border Regions

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Biomedical and Environmental Sciences 2024年第5期37卷 511-520页

作者： zhu Xiao Xiang WANG Song Wang LI Yan fei ZHANG Ye Wu SU Xue mei ZHAO Xiao Tao National Key Laboratory of Intelligent Tracking and Forecasting for Infectious Diseases Chinese Center for Disease Control and PreventionBeijing 102211China Yunnan Institute of Parasitic Diseases Pu’er 665000YunnanChina

Objective This study employs the Geographically and Temporally Weighted Regression(GTWR)model to assess the impact of meteorological elements and imported cases on dengue fever outbreaks,emphasizing the spatial-temporal variability of these factors in border *** We conducted a descriptive analysis of dengue fever’s temporal-spatial distribution in Yunnan border *** annual data from 2013 to 2019,with each county in the Yunnan border serving as a spatial unit,we constructed a GTWR model to investigate the determinants of dengue fever and their spatio-temporal heterogeneity in this *** The GTWR model,proving more effective than Ordinary Least Squares(OLS)analysis,identified significant spatial and temporal heterogeneity in factors influencing dengue fever’s spread along the Yunnan ***,the GTWR model revealed a substantial variation in the relationship between indigenous dengue fever incidence,meteorological variables,and imported cases across different *** In the Yunnan border areas,local dengue incidence is affected by temperature,humidity,precipitation,wind speed,and imported cases,with these factors’influence exhibiting notable spatial and temporal variation.

关键词： Dengue fever Meteorological factor Geographically and temporally weighted regression

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Could the EU carbon border adjustment mechanism promote climate mitigation?An economy-wide analysis

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Advances in Climate Change Research 2024年第3期15卷 557-571页

作者： Kun ZHANG Yun-fei YAO Xiang-Yan QIAN Yu-fei ZHANG Qiao-mei LIANG Yi-Ming WEI College of Economics and Management Beijing University of TechnologyBeijing 100124China Center for Energy and Environmental Policy Research Beijing Institute of TechnologyBeijing 100081China School of Management and Economics Beijing Institute of TechnologyBeijing 100081China Beijing Key Laboratory of Energy Economics and Environmental Management Beijing 100081China Sinopec Research Institute of Petroleum Engineering SinopecBeijing 100101China College of Economics and Management Nanjing Agricultural UniversityNanjing 210095China

Due to concerns about carbon leakage and sectoral competitiveness,the European Union(EU)proposed implementing the carbon border adjustment mechanism(CBAM).The effectiveness and potential negative consequences of CBAM have aroused extensive *** the perspective of the economy-wide analysis,this study uses a global computable general equilibrium model to explore the rationality of CBAM from the aspects of socioeconomic impact and the effects of promoting climate ***,the potential alternative mechanism of CBAM is *** results show that CBAM can reduce the EU's gross domestic product(GDP)loss;however,the GDP loss in all other regions ***,CBAM raises household welfare losses in most regions,including the ***,although CBAM can reduce the marginal abatement cost in eight regions,it comes at the cost of greater economic ***,the economic and household welfare cost of raising emissions reduction targets in regions like the USA and Japan is substantially higher than the impact of passively accepting the CBAM;therefore,CBAM's ability to drive ambitious emission reduction initiatives may be ***,for the potential alternative mechanism,from the perspective of reducing economic cost and household welfare losses,the EU could implement domestic tax cuts in the short-term and promote global unified carbon pricing in the long-term.

关键词： Border adjustment mechanism Computable general equilibrium model Carbon price Climate policy Global carbon pricing

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