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Role of epithelial-to-mesenchymal transition in the pulmonary fi brosis induced by paraquat in rats

World Journal of Emergency Medicine 2021年第3期12卷 214-220页

作者： Jian-hua Yi Zhao-cai zhang mei-bian zhang Xin He Hao-ran Lin Hai-wen Huang Hai-bin Dai Yu-wen Huang Emergency Department the Second Affi liated Hospital of Zhejiang University School of MedicineHangzhou 310009China Scientifi c Research Department the Second Affi liated Hospital of Zhejiang University School of MedicineHangzhou 310009China Zhejiang Provincial Center for Disease Control and Prevention Hangzhou 301051China Shangyu People’s Hospital Shaoxing 312300China Pharmacy Department the Second Affi liated Hospital of Zhejiang University School of MedicineHangzhou 310009China

BACKGROUND:This study aims to explore the characteristics of the epithelial-to-mesenchymal transition(EMT)process and its underlying molecular mechanisms in the period of paraquat(PQ)-induced pulmonary fi brosis(PF).METHODS:Picrosirius red staining and collagen volume fraction were utilized to evaluate the pathological changes of PQ-induced PF in rats.Immunohistochemistry,Western blot,and real-time reverse transcriptase-polymerase chain reaction(RT-PCR)were used to measure the protein and gene expression of EMT markers,EMT-associated transcription factors,and regulators of EMT-related pathways,respectively.RESULTS:The collagen deposition in the alveolar septum and increased PF markers were characteristics of pathological changes in PQ-induced PF,reached a peak on day 14 after PQ poisoning,and then decreased on day 21.The protein and gene expression of the fibrosis marker,EMT markers,transcription factors,and regulators of EMT-related signaling pathways signifi cantly increased at diff erent time points after PQ poisoning compared with corresponding controls(P0.05).CONCLUSIONS:EMT process plays a role in the PQ-induced PF,in which most PF and EMT markers have a peak phenomenon,and its underlying molecular mechanisms might be determined by further studies.

关键词： Pulmonary fibrosis Paraquat Epithelial-to-mesenchymal transition Rats

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Wetting-drying effect on the strength and microstructure of cementphosphogypsum stabilized soils

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Journal of Rock Mechanics and Geotechnical Engineering 2024年第3期16卷 1049-1058页

作者： Lingling Zeng Xia bian Jiaxing Weng Tao zhang College of Civil Engineering Zhejiang University of TechnologyHanzhou310014China Key Laboratory of Ministry of Education for Geomechanics and Embankment Engineering Hohai UniversityNanjing210098China State Key Laboratory for Geomechanics and Deep Underground Engineering China University of Mining and TechnologyXuzhou221116China Jiangsu Water Source Company Ltd.of the Eastern Route of the South-to-North Water Diversion Project Nanjing210000China Power China Zhongnan Engineering Corporation Limited Changsha410027China

Phosphogypsum has often been used as an effective and environmentally friendly binder for partial replacement of cement,improving the engineering properties of slurries with high water content.However,the influence of phosphogypsum on the physicomechnical properties of stabilized soil subjected to wettingedrying cycles is not well understood to date.In this study,the effect of phosphogypsum on the durability of stabilized soil was studied by conducting a series of laboratory experiments,illustrating the changes in mass loss,pH value and unconfined compressive strength(qu)with wettingdrying cycles.The test results showed that the presence of phosphogypsum significantly restrained the mass loss in the early stage(lower than the 4th cycle),which in turn led to a higher qu of stabilized soil than that without phosphogypsum.After the 4th cycle,a sudden increase in mass loss was observed for stabilized soil with phosphogypsum,resulting in a significant drop in qu to a value lower than those without phosphogypsum at the 6th cycle.In addition,the qu of stabilized soils correlated well with the measured soil pH irrespective of phosphogypsum content for all wettingedrying tests.According to the microstructure observation via scanning electron microscope(SEM)and X-ray diffraction(XRD)tests,the mechanisms relating the sudden loss of qu for the stabilized soils with phosphogypsum after the 4th wetting-drying cycle are summarized as follows:(i)the disappearance of ettringite weakening the cementation bonding effect,(ii)the generation of a larger extent of microcrack,and(iii)a lower pH value,in comparison with the stabilized soil without phosphogypsum.

关键词： Wetting-drying Phosphogypsum Microstructure Durability

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Research on Performance Optimization of Spark Distributed Computing Platform

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Computers, Materials & Continua 2024年第5期79卷 2833-2850页

作者： Qinlu He Fan zhang Genqing bian Weiqi zhang Zhen Li School of Information and Control Engineering Xi’an University of Architecture and TechnologyXi’an710054China Shaanxi Institute of Metrology Science Xi’an710043China

Spark,a distributed computing platform,has rapidly developed in the field of big data.Its in-memory computing feature reduces disk read overhead and shortens data processing time,making it have broad application prospects in large-scale computing applications such as machine learning and image processing.However,the performance of the Spark platform still needs to be improved.When a large number of tasks are processed simultaneously,Spark’s cache replacementmechanismcannot identify high-value data partitions,resulting inmemory resources not being fully utilized and affecting the performance of the Spark platform.To address the problem that Spark’s default cache replacement algorithm cannot accurately evaluate high-value data partitions,firstly the weight influence factors of data partitions are modeled and evaluated.Then,based on this weighted model,a cache replacement algorithm based on dynamic weighted data value is proposed,which takes into account hit rate and data difference.Better integration and usage strategies are implemented based on LRU(LeastRecentlyUsed).Theweight update algorithm updates the weight value when the data partition information changes,accurately measuring the importance of the partition in the current job;the cache removal algorithm clears partitions without useful values in the cache to releasememory resources;the weight replacement algorithm combines partition weights and partition information to replace RDD partitions when memory remaining space is insufficient.Finally,by setting up a Spark cluster environment,the algorithm proposed in this paper is experimentally verified.Experiments have shown that this algorithmcan effectively improve cache hit rate,enhance the performance of the platform,and reduce job execution time by 7.61%compared to existing improved algorithms.

关键词： Spark memory optimization memory replacement strategy

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Development status and prospect of underground thermal energy storage technology

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Journal of Groundwater Science and Engineering 2024年第1期12卷 92-108页

作者： Ying-nan zhang Yan-guang Liu Kai bian Guo-qiang Zhou Xin Wang mei-hua Wei School of Earth science and Engineering Hebei University of EngineeringHandan 056038Hebei ProvinceChina Institute of Hydrogeology and Environmental Geology Chinese Academy of Geological SciencesShijiazhuang 050061China Technology Innovation Center of Geothermal&Hot Dry Rock Exploration and Development Ministry of Natural ResourcesShijiazhuang 050061China Shanxi Key Laboratory for Exploration and Exploitation of Geothermal Resources Taiyuan 030024China Shanxi Geological Engineering Exploration Institute Taiyuan 030024China

Underground Thermal Energy Storage(UTES)store unstable and non-continuous energy underground,releasing stable heat energy on demand.This effectively improve energy utilization and optimize energy allocation.As UTES technology advances,accommodating greater depth,higher temperature and multi-energy complementarity,new research challenges emerge.This paper comprehensively provides a systematic summary of the current research status of UTES.It categorized different types of UTES systems,analyzes the applicability of key technologies of UTES,and evaluate their economic and environmental benefits.Moreover,this paper identifies existing issues with UTES,such as injection blockage,wellbore scaling and corrosion,seepage and heat transfer in cracks,etc.It suggests deepening the research on blockage formation mechanism and plugging prevention technology,improving the study of anticorrosive materials and water treatment technology,and enhancing the investigation of reservoir fracture network characterization technology and seepage heat transfer.These recommendations serve as valuable references for promoting the high-quality development of UTES.

关键词： Aquifer thermal energy storage Borehole thermal energy storage Cavern thermal energy storage Thermal energy storage technology Benefit evaluation

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Characterizations of semihoops based on derivations

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Applied Mathematics(A Journal of Chinese Universities) 2024年第2期39卷 291-310页

作者： WANG mei zhang Xiao-hong School of Electrical and Control Engineering Shaanxi University of Science and TechnologyXi'an 710021China School of Arts and Sciences Shaanxi University of Science and TechnologyXi'an 710021China School of Mathematics and Statistics Weinan Normal UniversityWeinan 714099China

In this paper,we discuss the related properties of some particular derivations in semihoops and give some characterizations of them.Then,we prove that every Heyting algebra is isomorphic to the algebra of all multiplicative derivations and show that every Boolean algebra is isomorphic to the algebra of all implicative derivations.Finally,we show that the sets of multiplicative and implicative derivations on bounded regular idempotent semihoops are in oneto-one correspondence.

关键词： (prelinear)semihoop derivation Heyting algebra Galois connection

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Trajectory of COVID-19 response and management strategy in China:scientific rationale driven strategy adjustments

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Frontiers of Medicine 2024年第1期18卷 19-30页

作者： Zeyu zhang Yue Yan Lina Zhao Yizhou bian Ning Zhao You Wu Dahai Zhao Zongjiu zhang Institute for Hospital Management Tsinghua UniversityBeijing100084China School of Medicine Tsinghua UniversityBeijing100084China School of International and Public Affairs Shanghai Jiao Tong UniversityShanghai200030China Yale University-Shanghai Jiao Tong University Joint Center for Health Policy Shanghai Jiao Tong UniversityShanghai200030China

The pneumonia caused by novel coronavirus SARS-CoV-2 infection in early December 2019,which was later named coronavirus disease 2019(COVID-19)by the World Health Organization(WHO),rapidly spread across the world.China has made extraordinary efforts to this unprecedented pandemic,put its response and control at a very high level of infectious disease management(Category B but with measures for Category A),given top priority to the people and their lives,and balanced the pandemic control and socio-economic development.After more than three years’fighting against this disease,China downgraded the management of COVID-19 to Category B infectious disease on January 8,2023 and the WHO declared the end of public health emergency on May 5,2023.However,the ending of pandemic does not mean that the disease is no longer a health threat.Experiences against COVID-19 from China and the whole world should be learned to prepare well for the future public health emergencies.This article gives a systematic review of the trajectory of COVID-19 development in China,summarizes the critical policy arrangements and provides evidence for the adjustment during policy making process,so as to share experiences with international community and contribute to the global health for all humanity.

关键词： COVID-19 public health response and control strategy science-based policy making

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Dynamics of a Reaction-diffusion-ODE System in a Heterogeneous Media

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Acta Mathematicae Applicatae Sinica 2024年第2期40卷 275-301页

作者： Cong-hui zhang Hai-feng zhang mei-rong zhang School of Science Beijing University of Civil Engineering and ArchitectureBeijing 102616China Institute of Applied System Analysis Jiangsu UniversityZhenjiang 212013China Department of Mathematical Sciences Tsinghua UniversityBeijing 100084China

The existence and stability of stationary solutions for a reaction-diffusion-ODE system are investigated in this paper.We first show that there exist both continuous and discontinuous stationary solutions.Then a good understanding of the stability of discontinuous stationary solutions is gained under an appropriate condition.In addition,we demonstrate the influences of the diffusion coefficient on stationary solutions.The results we obtained are based on the super-/sub-solution method and the generalized mountain pass theorem.Finally,some numerical simulations are given to illustrate the theoretical results.

关键词： reaction-diffusion-ODE system discontinuous stationary solutions stability asymptotic behavior monotone solutions

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Limit Theorems for Critical Galton-Watson Processes with Immigration Stopped at Zero

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Acta Mathematica Sinica,English Series 2024年第2期40卷 435-450页

作者： Dou Dou LI mei zhang Xian Yu zhang College of Statistics and Data Science Faculty of ScienceBeijing University of TechnologyBeijing 100124P.R.China Laboratory of Mathematics and Complex Systems(Ministry of Education) School of Mathematical SciencesBeijing Normal UniversityBeijing 100875P.R.China

In this paper,we consider a critical Galton-Watson branching process with immigration stopped at zero W.Some precise estimation on the probability generating function of the n-th population are obtained,and the tail probability of the life period of W is studied.Based on above results,two conditional limit theorems for W are established.

关键词： Branching immigration critical life period limit theorems

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From the perspective of experimental practice: High-throughput computational screening in photocatalysis

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Green Energy & Environment 2024年第1期9卷 1-6页

作者： Yunxuan Zhao Junyu Gao Xuanang bian Han Tang Tierui zhang Key Laboratory of Photochemical Conversion and Optoelectronic Materials Technical Institute of Physics and ChemistryChinese Academy of SciencesBeijing100190China Center of Materials Science and Optoelectronics Engineering University of Chinese Academy of SciencesBeijing100049China Institute for AI Industry Research(AIR) Tsinghua UniversityBeijing100084China

Photocatalysis,a critical strategy for harvesting sunlight to address energy demand and environmental concerns,is underpinned by the discovery of high-performance photocatalysts,thereby how to design photocatalysts is now generating widespread interest in boosting the conversion efﬁ-ciency of solar energy.In the past decade,computational technologies and theoretical simulations have led to a major leap in the development of high-throughput computational screening strategies for novel high-efﬁciency photocatalysts.In this viewpoint,we started with introducing the challenges of photocatalysis from the view of experimental practice,especially the inefﬁciency of the traditional“trial and error”method.Sub-sequently,a cross-sectional comparison between experimental and high-throughput computational screening for photocatalysis is presented and discussed in detail.On the basis of the current experimental progress in photocatalysis,we also exempliﬁed the various challenges associated with high-throughput computational screening strategies.Finally,we offered a preferred high-throughput computational screening procedure for pho-tocatalysts from an experimental practice perspective(model construction and screening,standardized experiments,assessment and revision),with the aim of a better correlation of high-throughput simulations and experimental practices,motivating to search for better descriptors.

关键词： Photocatalysis High-throughput computational screening Photocatalyst Theoretical simulations Experiments

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Robust multi-sensor image matching based on normalized self-similarity region descriptor

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Chinese Journal of Aeronautics 2024年第1期37卷 271-286页

作者： Xuecong LIU Xichao TENG Jing LUO zhang LI Qifeng YU Yijie bian College of Aerospace Science and Engineering National University of Defense TechnologyChangsha 410073China High-Tech Institute Qingzhou 262500China

Multi-modal image matching is crucial in aerospace applications because it can fully exploit the complementary and valuable information contained in the amount and diversity of remote sensing images.However,it remains a challenging task due to significant non-linear radiometric,geometric differences,and noise across different sensors.To improve the performance of heterologous image matching,this paper proposes a normalized self-similarity region descriptor to extract consistent structural information.We first construct the pointwise self-similarity region descriptor based on the Euclidean distance between adjacent image blocks to reflect the structural properties of multi-modal images.Then,a linear normalization approach is used to form Modality Independent Region Descriptor(MIRD),which can effectively distinguish structural features such as points,lines,corners,and flat between multi-modal images.To further improve the matching accuracy,the included angle cosine similarity metric is adopted to exploit the directional vector information of multi-dimensional feature descriptors.The experimental results show that the proposed MIRD has better matching accuracy and robustness for various multi-modal image matching than the state-of-the-art methods.MIRD can effectively extract consistent geometric structure features and suppress the influence of SAR speckle noise using non-local neighboring image blocks operation,effectively applied to various multi-modal image matching.

关键词： Remote sensing Multi-modal image matching Template matching Feature descriptor Similarity metric Synthetic Aperture Radar(SAR)

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