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浅析毛泽东的农业思想

乡镇经济 2006年第3期22卷 52-54页

作者：梅韫芳安徽农业管理干部学院社科系安徽合肥230031

中国是一个农业大国,农民人口占到全国人口的绝大多数。毛泽东作为农民的儿子,历来关心农民的疾苦,他以马克思主义的基本理论为基础、从中国的基本国情出发,提出了许多重视农业、发展农业和维护农民利益的思想。本文试对毛泽东的农业思... 详细信息

中国是一个农业大国,农民人口占到全国人口的绝大多数。毛泽东作为农民的儿子,历来关心农民的疾苦,他以马克思主义的基本理论为基础、从中国的基本国情出发,提出了许多重视农业、发展农业和维护农民利益的思想。本文试对毛泽东的农业思想进行初浅的分析。

关键词：毛泽东农业农民

卡那霉素耳中毒后雏鸡耳蜗神经纤维的透射电镜观察

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复旦学报（医学版） 2001年第1期28卷 24-27页

作者：向明亮穆美云迟放鲁复旦大学附属眼耳鼻喉科医院

目的　探讨卡那霉素对鸟类耳蜗神经纤维有无损伤。方法　将雏鸡连续肌注卡那霉素 10d[2 0 0mg/(kg·d) ],分别于施药 8d、药毕 1、7、10、15、2 1、30、6 0d时行听性脑干反应测听 (ABR)检查 ,完毕后随即处死 ,采用透射电镜观察其耳蜗神... 详细信息

目的　探讨卡那霉素对鸟类耳蜗神经纤维有无损伤。方法　将雏鸡连续肌注卡那霉素 10d[2 0 0mg/(kg·d) ],分别于施药 8d、药毕 1、7、10、15、2 1、30、6 0d时行听性脑干反应测听 (ABR)检查 ,完毕后随即处死 ,采用透射电镜观察其耳蜗神经纤维形态结构变化。结果　ABR检查显示 ,小鸡听功能于停药后即很快开始恢复 ,至药毕 10d时已基本稳定。透射电镜观察 ,施药 8d时 ,基底乳头近端 2 0 %区域的毛细胞已被卡那霉素完全破坏 ,损伤区域的无髓和有髓神经纤维均无明显损伤征象 ,施药 10d毕后所有观察时间点里 ,神经纤维的形态结构同样未见明显异常。结论　卡那霉素对雏鸡耳蜗神经纤维无明显毒性作用。耳蜗神经纤维的未受损可能有助于再生毛细胞极早获得神经再支配及听功能的迅速恢复。

关键词：鸟基底乳头耳蜗神经纤维卡那霉素透射电镜耳中毒

积极心理学视域下高校思政课教学实效提升的路径探索

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安徽水利水电职业技术学院学报 2020年第4期20卷 91-93页

作者：梅韫芳安徽经济管理学院安徽合肥230001

文章基于积极心理学视角,从更新教学理念、改进教学方法、创新教学模式、完善考评机制等方面探索了提升高校思政课教学实效的路径。

关键词：积极心理学高校思政课教学实效路径

Prevalence of Helicobacter pylori infection in Chinese military personnel:A cross-sectional,multicenter-based study

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World Journal of Gastroenterology 2025年第3期31卷 42-49页

作者： Han-Chen Min Chun-Yan Zhang fang-Yu Wang Xiao-Hui Yu Shan-Hong Tang Hong-Wu Zhu Ya-Gang Zhao Ji-Luo Liu Jian Wang Jing-Han Guo Xiao-mei Zhang yun-Sheng Yang Chinese People’s Liberation Army Medical School Chinese People’s Liberation Army General HospitalBeijing 100853China Department of Gastroenterology and Hepatology The First Medical CenterChinese People’s Liberation Army General HospitalBeijing 100853China Sixth Healthcare Department The Second Medical CenterChinese People’s Liberation Army General HospitalBeijing 100853China Department of Gastroenterology The 940th Hospital of Joint Logistic Support Force of Chinese People’s Liberation ArmyLanzhou 730050Gansu ProvinceChina Department of Gastroenterology General Hospital of Western Theater CommandChengdu 610011Sichuan ProvinceChina Department of Gastroenterology General Hospital of Southern Theater CommandGuangzhou 510010Guangdong ProvinceChina Department of Epidemiology Naval Medical UniversityShanghai 200433China School of Medicine Nankai UniversityTianjin 300071China National Clinical Research Center for Geriatric Diseases Chinese People’s Liberation Army General HospitalBeijing 100853China

BACKGROUND Helicobacter pylori(***)infection is a prevalent disease encountered in military internal medicine and recognized as the main cause of dyspepsia,gastritis,and peptic ulcer,which are common diseases in military *** guidelines in China state all patients with evidence of active infection with *** are offered ***,the prevalence of *** infection and its regional distribution in the military population remain unclear,which hinders effective prevention and treatment *** the prevalence of *** infection in the military population will aid in the development of customized strategies to better manage this infectious *** To investigate the prevalence of *** infection in the Chinese military population in different geographic *** This multicenter,retrospective study included 22421 individuals from five tertiary hospitals located in north,east,southwest,and northwest cities of *** infection was identified using the urea breath test,which had been performed between January 2020 and December *** Of the 22421 military service members,7416(33.1%)were urea breath *** highest prevalence of *** was in the 30-39 years age group for military personnel,with an infection rate of 34.9%.The majority of infected subjects were younger than 40-years-old,accounting for 70.4%of the infected *** individuals serviced in Lanzhou and Chengdu showed a higher infection prevalence than those in Beijing,Nanjing,and Guangzhou,with prevalence rates of 44.3%,37.9%,29.0%,31.1%,and 32.3%,*** *** infection remains a common infectious disease among military personnel in China and has a relatively high prevalence rate in northwest China.

关键词： Helicobacter pylori Prevalence Military personnel Urea breath test Multicenter study

Computed tomography enterography-based radiomics for assessing mucosal healing in patients with small bowel Crohn's disease

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World Journal of Gastroenterology 2025年第3期31卷 62-72页

作者： Hao Ding Yuan-Yuan fang Wen-Jie Fan Chen-Yu Zhang Shao-Fei Wang Jing Hu Wei Han Qiao mei Department of Gastroenterology The First Affiliated Hospital of Anhui Medical UniversityHefei 230022Anhui ProvinceChina Department of Radiation Oncology The First Affiliated Hospital of Anhui Medical UniversityHefei 230022Anhui ProvinceChina Department of Gastroenterology Suzhou First People's HospitalSuzhou 234099Anhui ProvinceChina

BACKGROUND Mucosal healing(MH)is the major therapeutic target for Crohn's disease(CD).As the most commonly involved intestinal segment,small bowel(SB)assessment is crucial for CD ***,it poses a significant challenge due to its limited accessibility through conventional endoscopic *** To establish a noninvasive radiomic model based on computed tomography enterography(CTE)for MH assessment in SBCD *** Seventy-three patients diagnosed with SBCD were included and divided into a training cohort(n=55)and a test cohort(n=18).Radiomic features were obtained from CTE images to establish a radiomic *** demographics were analysed to establish a clinical model.A radiomic-clinical nomogram was constructed by combining significant clinical and radiomic *** diagnostic efficacy and clinical benefit were evaluated via receiver operating characteristic(ROC)curve analysis and decision curve analysis(DCA),*** Of the 73 patients enrolled,25 patients achieved *** radiomic-clinical nomogram had an area under the ROC curve of 0.961(95%confidence interval:0.886-1.000)in the training cohort and 0.958(0.877-1.000)in the test cohort and provided superior clinical benefit to either the clinical or radiomic models alone,as demonstrated by *** These results indicate that the CTE-based radiomic-clinical nomogram is a promising imaging biomarker for MH and serves as a potential noninvasive alternative to enteroscopy for MH assessment in SBCD patients.

关键词： Crohn’s disease Computed tomography enterography Mucosal healing Nomogram Radiomics

Trinuclear gold-catalyzed site-selective alkylation of peptides

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Science China Chemistry 2025年第01期 249-256页

作者： Qing-yun fang Chengyihan Gu Yinghan Chen Wencheng Yan Yong Liang Weipeng Li Chengjian Zhu Jie Han Jin Xie State Key Laboratory of Coordination Chemistry Jiangsu Key Laboratory of Advanced Organic Materials Chemistry and Biomedicine Innovation Center (Chem BIC) School of Chemistry and Chemical Engineering Nanjing University Green Catalysis Center College of Chemistry Zhengzhou University State Key Laboratory of Natural Medicines China Pharmaceutical University

Selective modification of peptides has always been a challenging issue. The selective alkylation of peptides can alter the biological activity and physical properties of molecules, and it has gained significant research interest. We herein disclose an intriguing gold-catalyzed alkylation of peptides using bench-stable unactivated alkyl bromides under photoredox catalysis. A wide range of structurally diverse primary, secondary and tertiary alkyl bromides serve as effective coupling partners to precisely connect with the α-C(sp3)–H in glycine residue of peptides. This protocol demonstrates an exceptionally broad scope for alkyl halides and excellent tolerance for a wide range of useful functional groups. A series of relay transformations to construct cyclic peptides, to proceed click reaction and to realize peptide fluorescence labeling further enhance its synthetic practicality. In addition, mechanistic studies and density functional theory(DFT) calculations reveal an inner-sphere and subsequent outersphere single electron transfer(SET) mechanism.

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雏鸡耳卡那霉素中毒后耳蜗再生毛细胞超微结构的动态观察

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复旦学报（医学版） 2002年第2期29卷 94-97页

作者：向明亮穆美云迟放鲁陈洁程岚侯东明上海第二医科大学附属新华医院耳鼻喉科上海200092 复旦大学附属眼耳鼻喉科医院耳鼻喉科研究所上海200031

目的　探讨鸟氨基苷类药物中毒后耳蜗再生毛细胞超微结构的变化与听功能恢复的关系。方法　将雏鸡连续肌注卡那霉素 [2 0 0mg (kg.d) ]10d ,分别于开始给药后第 8天、药毕后第 1、7、10、15、2 1、3 0天时处死 ,采用透射电镜观察其耳蜗... 详细信息

目的　探讨鸟氨基苷类药物中毒后耳蜗再生毛细胞超微结构的变化与听功能恢复的关系。方法　将雏鸡连续肌注卡那霉素 [2 0 0mg (kg.d) ]10d ,分别于开始给药后第 8天、药毕后第 1、7、10、15、2 1、3 0天时处死 ,采用透射电镜观察其耳蜗再生毛细胞超微结构的动态变化。结果　在开始给药后第 8天时 ,可观察到一些再生毛细胞前体。药毕 10天时 ,再生毛细胞的外形及纤毛的阶梯形排列已成熟。至药毕 2 1天时 ,表皮板、囊泡、高尔基体、核糖体、线粒体等亚细胞结构也与正常对照类似。结论　鸟卡那霉素中毒后耳蜗再生毛细胞形态结构的迅速成熟 ,可能是其听功能得以迅速恢复的一个重要基础。

关键词：毛细胞再生鸟耳毒性超微结构雏鸡耳耳蜗再生卡那霉素

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非水相酶促合成癸酸偏甘油酯的研究

生物工程学报 2002年第6期18卷 735-739页

作者：夏咏梅方云章克昌石贵阳王征远江南大学化学与材料工程学院无锡214036 江南大学生物工程学院无锡214036

对无溶剂非水相中癸酸与甘油的酶促酯化反应进行了研究 ,发现Pseudomonasfluoresces脂肪酶 (PFL)、Mu cormiehei脂肪酶 (MML)和Candidaantarictica脂肪酶 (CAL)均有较好的催化活性。CAL酶促转化癸酸的最适反应条件为 :6 0℃ ,加酶量为 ... 详细信息

对无溶剂非水相中癸酸与甘油的酶促酯化反应进行了研究 ,发现Pseudomonasfluoresces脂肪酶 (PFL)、Mu cormiehei脂肪酶 (MML)和Candidaantarictica脂肪酶 (CAL)均有较好的催化活性。CAL酶促转化癸酸的最适反应条件为 :6 0℃ ,加酶量为 2 0～ 10 0u g ,初始加水量为甘油质量的 12 %。CAL的 1,3 位置专一性在最终产物中未表达。CAL酶催化剂的失活主要与机械磨损有关 ,反应 5批次后酶活残留量为 96 .4%。敞开物系、真空脱水或分子筛脱水均为有效脱水方式。敞开物系中反应物量比不影响平衡转化率而会影响单甘酯平衡产率。用碳酸氢钠水溶液萃取可有效脱除产品中的残余癸酸 ,终产品酸价为 0 .6 8mgKOH g。提高甘油比例并使用非脱水原料 ,无外加水结合部分流加癸酸的工艺 ,可以减少减压脱水或敞开反应的时间 ,5h后癸酸最高转化率可达 96 .9%

关键词：非水相酶促合成癸酸偏甘油酯脂肪酶纯化

腹腔镜下袖状胃切除术治疗不同血脂水平肥胖患者的疗效研究

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同济大学学报（医学版） 2020年第2期41卷 178-184页

作者：李贵芳张君宜梅芳芸高晶扬黄玥晔程晓芸曲伸同济大学附属第十人民医院内分泌代谢病科国家标准化代谢性疾病管理中心(十院)上海200072

目的探讨在重度肥胖患者中,不同三酰甘油(TG)水平对减重效果及相关代谢指标的影响。方法回顾性收集2012年12月-2019年4月同济大学附属第十人民医院收治的行LSG手术的105例肥胖患者(BMI≥35kg/m^2)的基线和术后6个月人体测量学指标和临... 详细信息

目的探讨在重度肥胖患者中,不同三酰甘油(TG)水平对减重效果及相关代谢指标的影响。方法回顾性收集2012年12月-2019年4月同济大学附属第十人民医院收治的行LSG手术的105例肥胖患者(BMI≥35kg/m^2)的基线和术后6个月人体测量学指标和临床代谢指标。按基线TG水平分为TG正常组与TG异常组,两组间进行比较,并把腰围(WC)差值和臀围(HC)差值与各检测指标进行相关性分析(差值用Δ表示)。结果基线时,TG正常组空腹血糖(FPG)、餐后2h血糖(2hPG)、总胆固醇(TC)低于TG异常组(P<0.01)。术后6个月,两组多项代谢指标有明显改善,FPG及2hPG、TC无差异。与异常组相比,TG正常组的ΔBMI、ΔWC和ΔHC下降幅度更大。多元线性回归分析显示,TG正常组WC差值(ΔWC)与ΔBMI(r=0.765,P<0.001)、颈围(NC)差值(ΔNC,r=0.394,P=0.021)、肌酐(Cr)差值(ΔCr,r=0.442,P=0.009)存在正相关,与ΔTC(r=-0.449,P=0.008)、高密度脂蛋白(HDL)差值(ΔHDL,r=-0.354,P=0.040)、低密度脂蛋白(LDL)差值(ΔLDL,r=-0.401,P=0.019)存在负相关。结论 LSG能有效改善代谢紊乱情况。TG正常组WC和HC改善更显著,术前TG水平可作为LSG术后预测减重效果的指标之一。

关键词：肥胖袖状胃切除术三酰甘油腰围