检索结果-南通市图书馆

Chinese Journal of Cancer 2012年第5期31卷 233-240页

作者： cui Hai Yong-Min Jin Wen-Biao Jin Zhe-Zhu Han mei-nv cui Xue-Zhe Piao Xiong-Hu Shen Song-Nan Zhang Hong-Hua Sun Department of Oncology Affiliated Hospital of Yanbian UniversityYanjiJilin 133000P.R.China

Although gene therapy was regarded as a promising approach for glioma treatment,its therapeutic efficacy was often disappointing because of the lack of efficient drug delivery *** stem cells(MSCs) have been reported to have a tropism for brain tumors and thus could be used as delivery vehicles for glioma ***,in this study,we attempted to treat glioma by using MSCs as a vehicle for delivering replication-competent *** firstly compared the infectivity of type 3,type 5,and type 35 fiber-modified adenoviruses in *** also determined suitable adenovirus titer in vitro and then used this titer to analyze the ability of MSCs to deliver replication-competent adenovirus into glioma in *** results indicated that type 35 fiber-modified adenovirus showed higher infectivity than did naked type 3 or type 5 fiber-modified *** carrying replication-competent adenovirus significantly inhibited tumor growth in vivo compared with other control *** conclusion,MSCs are an effective vehicle that can successfully transport replication-competent adenovirus into glioma,making it a potential therapeutic strategy for treating malignant glioma.

关键词：脑胶质瘤病毒复制间质干细胞腺病毒治疗能力骨髓间充质干细胞车辆

Skew-gradient representations of constrained mechanical systems

在线全文

学校读者我要写书评

暂无评论

Applied Mathematics and Mechanics(English Edition) 2015年第7期36卷 873-882页

作者： Fengxiang mei Jinchao cui School of Aerospace Engineering Beijing Institute of Technology School of Science Jiangnan University

The characteristics of stationary and non-stationary skew-gradient systems are studied. The skew-gradient representations of holonomic systems, Birkhoffian systems, generalized Birkhoffian systems, and generalized Hamiltonian systems are given. The characteristics of skew-gradient systems are used to study integration and stability of the solution of constrained mechanical systems. Examples are given to illustrate applications of the result.

关键词： constrained mechanical system skew-gradient system integration stability

解淀粉芽孢杆菌wxy-b3产脂肽类物质对苹果斑点落叶病菌的抑菌活性研究

在线全文

学校读者我要写书评

暂无评论

陕西科技大学学报 2025年第1期43卷 46-51页

作者：崔皓玥田露胡乐梅龚国利陕西科技大学食品科学与工程学院陕西西安710021

苹果斑点落叶病菌是苹果生产过程中常见的病害,严重危害苹果农作物的产量.脂肽作为一种主要来源于微生物次生代谢产物的抗菌剂,具有广谱抑菌、低耐药性、安全低毒等优势.本研究发现,解淀粉芽孢杆菌wxy-b3产生的脂肽类物质能够抑制苹果... 详细信息

苹果斑点落叶病菌是苹果生产过程中常见的病害,严重危害苹果农作物的产量.脂肽作为一种主要来源于微生物次生代谢产物的抗菌剂,具有广谱抑菌、低耐药性、安全低毒等优势.本研究发现,解淀粉芽孢杆菌wxy-b3产生的脂肽类物质能够抑制苹果斑点落叶病菌的生长,对苹果斑点落叶病菌的最小抑菌浓度为16 mg/mL,此浓度可造成该病原菌细胞膜电位超极化、线粒体膜电位去极化、大分子蛋白质和核酸泄露,以及胞内活性氧和丙二醛含量分别累积增加0.33倍和5.44倍,并通过扫描电镜进一步观察到MIC处理组的细胞形态起皱、细胞膜破损.上述结果表明,脂肽可能通过破坏细胞膜系统,导致细胞形态发生变化,细胞膜破裂,改变细胞膜通透性来达到抑菌效果.该研究将为脂肽作为抑制苹果斑点落叶病菌的抗菌剂奠定理论基础.

关键词：解淀粉芽孢杆菌脂肽类物质苹果斑点落叶病菌抑菌活性

Carbon nanotube integrated circuit technology:purification,assembly and integration

在线全文

学校读者我要写书评

暂无评论

International Journal of Extreme Manufacturing 2024年第3期6卷 120-138页

作者： Jianlei cui Fengqi Wei Xuesong mei State Key Laboratory for Manufacturing Systems Engineering Xi’an Jiaotong UniversityXi’an 710049People’s Republic of China

As the manufacturing process of silicon-based integrated circuits(ICs)approaches its physical limit,the quantum effect of silicon-based field-effect transistors(FETs)has become increasingly *** the burgeoning carbon-based semiconductor technology has become one of the most disruptive technologies in the post-Moore *** one-dimensional nanomaterials,carbon nanotubes(CNTs)are far superior to silicon at the same technology nodes of FETs because of their excellent electrical transport and scaling properties,rendering them the most competitive material in the next-generation ICs ***,certain challenges impede the industrialization of CNTs,particularly in terms of material preparation,which significantly hinders the development of CNT-based *** on CNT-based ICs technology,this review summarizes its main technical status,development trends,existing challenges,and future development directions.

关键词： carbon nanotubes integrated circuits field-effect transistors post-Moore

Process in laser drilling of deep microholes without taper on metal materials

在线全文

学校读者我要写书评

暂无评论

Science China(Technological Sciences) 2024年第1期67卷 37-59页

作者： FAN RunZe mei XueSong cui JianLei State Key Laboratory for Manufacturing Systems Engineering Xi’an Jiaotong UniversityXi’an 710054China

Deep microhole machining is currently a prominent research area within the aerospace field,encompassing blade film cooling and fuel injection control ***,taper defects in metal materials may lead to performance degradation or even structural damage over a component’s *** and helical drilling,facilitated by ultrashort pulse lasers,have proven more suitable for achieving high-precision,deep holes in metal ***,excessive repetition rates can also result in severe thermal *** methods are commonly employed for controlling taper,including parameter optimization,assistance,and secondary *** laser beam drilling is widely utilized and has been integrated into relevant machining systems for commercial *** deep microholes include film cooling holes and injection *** drilling is a potential machining method for new materials in the aerospace *** laser drilling processing has been studied,numerous related scientific challenges and technical difficulties must be addressed before practical implementation.

关键词： aerospace laser drilling deep microhole taper control

同方期刊数据库

Theory, experiment and applications of metamaterials

在线全文

学校读者我要写书评

暂无评论

Science China(Physics,Mechanics & Astronomy) 2015年第12期58卷 142-152页

作者： TANG WenXuan mei ZhongLei cui TieJun State Key Laboratory of Millimeter Waves Southeast University School of Information Science and Engineering Lanzhou University

In this review article, a brief introduction on the theory, experiments and applications of metamaterials is presented. The main focuses are concentrated on the composing meta-atoms, the method of transformation optics, the experimental demonstration of negative refraction, and the realizations of invisibility cloaks and electromagnetic black hole. At the end of this review, some typical applications of metamaterials, including high-performance antennas made of zero-refractive-index materials, inhomogeneous metamaterial lenses, and planar metasurfaces, are introduced in details.

关键词： metamaterials transformation optics invisibility cloaks lens antennas metasurfaces

Well-posedness and Stability for an Elliptic-parabolic Free Boundary Problem Modeling the Growth of Multi-layer Tumors

在线全文

学校读者我要写书评

暂无评论

Acta Mathematicae Applicatae Sinica 2009年第4期25卷 547-560页

作者： Xiu-mei Hou Shang-bin cui Department of Mathematics Sun Yat-sen University Guangzhou 510275 China

In this paper we study a free boundary problem modeling the growth of multi-layer tumors. This free boundary problem contains one parabolic equation and one elliptic equation, defined on an unbounded domain in R2 of the form 0 〈 y 〈p（x,t）, where p（x,t） is an unknown function. Unlike previous works on this tumor model where unknown functions are assumed to be periodic and only elliptic equations are evolved in the model, in this paper we consider the case where unknown functions are not periodic functions and both elliptic and parabolic equations appear in the model. It turns out that this problem is more difficult to analyze rigorously. We first prove that this problem is locally well-posed in little H61der spaces. Next we investigate asymptotic behavior of the solution. By using the principle of linearized stability, we prove that if the surface tension coefficient y is larger than a threshold value y〉0, then the unique flat equilibrium is asymptotically stable provided that the constant c representing the ratio between the nutrient diffusion time and the tumor-cell doubling time is sufficiently small.

关键词： Free boundary problem multi-layer tumors well-posedness asymptotic behavior

基于人工势场法的复杂环境下多无人车避障与编队控制

在线全文

学校读者我要写书评

暂无评论

工程科学学报 2025年第2期47卷 364-373页

作者：梅艺林崔立堃胡雪岩胡广琦王浩陕西理工大学机械工程学院汉中723001

针对动态、密集障碍物等复杂环境下多车避障与编队控制存在的容易与障碍物碰撞、编队不稳定等问题,提出一种基于势场法的多车避障与编队控制方法.修改引力势场函数使引力大小在距离较大或较小时收敛于某一值,解决前期引力过大引起的无... 详细信息

针对动态、密集障碍物等复杂环境下多车避障与编队控制存在的容易与障碍物碰撞、编队不稳定等问题,提出一种基于势场法的多车避障与编队控制方法.修改引力势场函数使引力大小在距离较大或较小时收敛于某一值,解决前期引力过大引起的无人车与障碍物碰撞以及目标点不可达问题;采用更平滑的斥力计算公式对斥力势场函数进行优化,解决无人车距离障碍物过近时斥力过大引起的无人车在障碍物附近徘徊的问题;定义编队稳定力使编队前进过程中保持稳定队形的同时解决传统人工势场法存在的局部极小值问题;引入动态障碍物速度斥力势场与障碍物数量稀疏区域引力势场使编队在复杂环境下具有更高的避障与路径规划成功率.通过仿真实验与传统人工势场法以及改进后的算法进行对比,实验结果表明:本文方法在复杂环境下能够维持编队稳定性,具有较高的抗干扰能力;相较于传统算法与文献算法在动态障碍物环境下避障成功率分别提高了35%与10%,在密集动态障碍物环境下分别提高了55%与10%;能够在密集动态障碍物环境下躲避障碍物规划出合理的路径.

关键词：人工势场编队控制避障动态障碍物密集障碍物

同方期刊数据库

Numerical investigation of the failure mechanism of cubic concrete specimens in SHPB tests

在线全文

学校读者我要写书评

暂无评论

Defence Technology（防务技术） 2022年第1期18卷 1-11页

作者： mei Li Hong Hao Jian cui Yi-fei Hao Labomtory of Coast Civil Structure Safety of Ministry of Education Tianjin UniversityTiarjin300072China chool of Civil Engineering.Tianin University Tianjin300072China entre for Infrastructural Monitoring and Protection School of Civil and Mechanical Engineering Curtin UniversityPerth Western Australia6845Australia

Cylindrical specimens are commonly used in Split Hopkinson pressure bar(SHPB)tests to study the uniaxial dynamic properties of concrete-like *** recent years,true tri-axial SHPB equipment has also been developed or is under development to investigate the material dynamic properties under tri-axial impact *** such tests,cubic specimens are *** is well understood that static material strength obtained from cylinder and cube specimens are *** factors are obtained and adopted in some guidelines to convert the material streng th obtained from the two types of *** uniaxial impact tests have also demonstrated that the failure mode and the strain rate effect of cubic specimens are very different from that of cylindrical ***,the mechanical background of these findings is *** an extension of the previous laboratory study,this study performs numerical SHPB tests of cubic and cylindrical concrete specimens subjected to uniaxial impact load with the validated numerical *** stress states of cubic specimens in relation to its failure mode under different strain rates is analyzed and compared with cylindrical *** detailed analyses of the numerical simulation results show that the lateral inertial confinement of the cylindrical specimen is higher than that of the cubic specimen under the same strain *** cubic specimen,the corners aremore severely damaged because of the lower lateral confinement and the occurrence of the tensile radial stress which is not observed in cylindrical *** results explain why the dynamic material strengths obtained from the two types of specimens are different and are strain rate *** on the simulation results,an empirical formula of conversion factor as a function of strain rate is proposed,which supplements the traditional conversion factor for quasi-static material *** can be used for transforming the dynamic compressive strength from

关键词： Concrete Lateral inertial confinement Shape effet Dynamic failure mechanism Strain rate

Synthesis and Resolution of 10,11-Dihydro-10-hydroxycyproheptadine

在线全文

学校读者我要写书评

暂无评论

Chinese Chemical Letters 2006年第4期17卷 444-446页

作者： Jian mei cui Da Li YIN Institute of Materia Medica Peking Union Medical College ＆ Chinese Academy of Medical Sciences Beijing 100050

10, 11-Dihydro-10-hydroxycyproheptadine was synthesized in a new and facile synthetic route and resolved by L-（-）-2-（1, 3）-dioxo-1, 3-dihydroisoindol-2-yl）-propionic acid and D-（＋）-tartaric acid, respectively.... 详细信息

关键词： H1 receptor antagonist, chiral center, racemate resolution, specific rotation.