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Therapeutic effect of Captopril on rheumatoid arthritis in rats

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Asian Pacific Journal of Tropical Medicine 2014年第12期7卷 996-999页

作者： hong-mei liu Kai-Jie Wang Tangshan Clinic Medicine College of Hebei Medical University

Objective:To investigate the therapeutic effect of the intervention treatment with different doses of Captopril on TNF-α contents in serum of rheumatoid arthritis(RA) rats,and to provide the theoretical proofs for clinical application of Captopril in treatments ol rheumatoid ***:Fifty Wistar rats were randomly divided into 5 groups,*** A,Group *** *** D,Group E with 10 rats in each *** of Freund’s complete adjuvant was employed to establish adjuvant-induced arthritis model in *** A was model group;after model establishment,rats were treated with 20 mL normal saline as placebo(ip.).Rats in Group B were treated with 8 mg/kg cyclophosphamide(ip.).Rats in Group C.D and E were intraperitoneally injected with 30 mg/kg.100 mg/kg and 300 mg/kg Captopril *** in each group were subjected to continuous treatment for 3 weeks,and then *** of rats were excised and blood was ***- α content in serum were detected using ELISA:each group rats were compared for the hind legs *** ankle tissues of rats were collected to prepare section,and microscopic observation of pathological changes was ***:TNF- α content in serum of Group A rats was significantly higher than that of rats in other 4 groups(P0.05).From Day 8,ankle arthrocele of rats in Groups B.C.D and E was obviously relieved compared with that of Group A rats:the anti-inflammatory effects were gradually enhanced with the extension of medication *** of Groups C.D and E showed significant activities against tardive aithrocele:

关键词： Captopril Rheumatoid arthritis TNF- alpha Anti-inflammatory effect

Effect of captopril on serum TNF-α level in acute lung injury rats induced by HCL

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Asian Pacific Journal of Tropical Medicine 2014年第11期7卷 905-908页

作者： hong-mei liu Yu-Na Guo Tangshang Clinical College of Hebei Medical University Pain Clinics Xuanwu Hospital Capital Medical University

Objective:To observe the effect of captopril on the tumor necrosis factor-α(TNF- α) level and arterial blood gases in acute lung injury(All) induced by HCL in rats,and to analyze its protective ***:Fifty Wistar rats were selected and randomly divided into three groups,with 20 rats in Group Ⅰ and Ⅱ,respectively and 10 animals in Group Ⅲ.ALI model was constructed by intratracheal injection of diluted hydrochloric acid(pH=1.***.1.2 mL/kg).Group Ⅰrats received not any treatment after construction of AM *** Ⅱ rats were treated with captopril(5 mg/kg,i.p.) 5 min after induction of *** Ⅲ served as normal control without any *** minutes after construction of ALI model,all the rats were *** was withdrawn for detection of TNF- α level and arterial blood gases *** lung tissue slices of the three groups were prepared for observation of pathologic histology ***:TNF- α level in serum of Group Ⅰ and Ⅱ rats was significantly higher than that in Group Ⅲ(P<0.05),while TNF- α level in serum of Group Ⅱ was significantly lower in Group Ⅰ(P<0.05).PaCO_2 level was significantly higher(P<0.05),while PaO_2 was significantly lower(P<0.05) in Group Ⅰ and Ⅱ rats than those in Group Ⅲ.PaCO_2 was significantly lower(P<0.05) and PaO_2 was significantly higher(P<0.05) in Group Ⅱ than those in Group Ⅰ.Histological observation showed diffuse congestion and severe edema of luug tissue,obvious thickening and structure damage of alveolar walls and a large amount of neutrophil infiltration in Group Ⅰ *** Ⅱ rats showed mild edema of lung tissue;only a small portion of alveolar walls showed thickening and only a few of neutrophil infiltration could be *** degree of injury was remarkably slighter than that of Group Ⅰ *** Ⅲ rats showed clear lung tissue structure and normal morphology:alveolar walls were uniform and the margin was smooth and few neutrophil could be ***:Captopril can significantly r

关键词： Captopril Acute lung injury TNF-α Lung function

Envafolimab combined with chemotherapy in the treatment of combined small cell lung cancer: A case report

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World Journal of Clinical Cases 2023年第5期11卷 1115-1121页

作者： mei-hong liu Yan-Xia Li Zhuo liu Department of Pulmonary and Critical Care Medicine First Affiliated Hospital of Dalian Medical UniversityDalian 116011Liaoning ProvinceChina

BACKGROUND Combined small cell lung cancer(C-SCLC) is a special subtype of small cell lung cancer that is relatively rare, aggressive, and prone to early metastasis and has a poor prognosis. Currently, there are limited studies on C-SCLC, and there is no uniform standard treatment, especially for extensive C-SCLC, which still faces great challenges. In recent years, the development and progress of immunotherapy have provided more possibilities for the treatment of C-SCLC. We used immunotherapy combined with first-line chemotherapy to treat extensive-stage C-SCLC to explore its antitumor activity and *** SUMMARY We report a case of C-SCLC that presented early with adrenal, rib, and mediastinal lymph node metastases. The patient received carboplatin and etoposide with concurrent initiation of envafolimab. After 6 cycles of chemotherapy, the lung lesion was significantly reduced, and the comprehensive efficacy evaluation showed a partial response. No serious drug-related adverse events occurred during the treatment, and the drug regimen was well *** Envafolimab combined with carboplatin and etoposide in the treatment of extensive-stage C-SCLC has preliminary antitumor activity and good safety and tolerability.

关键词： Combined small cell lung cancer Envafolimab Carboplatin Etoposide Prognosis Case report

Critical respiratory failure due to pregnancy complicated by COVID-19 and bacterial coinfection:A case report

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World Journal of Clinical Cases 2023年第23期11卷 5559-5566页

作者： Shuang Zhou mei-hong liu Xiao-Peng Deng Department of Pulmonary and Critical Care Medicine First Affiliated Hospital of Dalian Medical UniversityDalian 116011Liaoning ProvinceChina Department of Gynaecology and Obstetrics Dalian Women and Children’s Medical GroupDalian 116011Liaoning ProvinceChina

BACKGROUND In the past 3 years,the global pandemic of coronavirus disease 2019(COVID-19)has posed a great threat to human life and *** the causes of death in COVID-19 patients,combined or secondary bacterial infection is an important *** a special group,pregnant women experience varying degrees of change in their immune status,cardiopulmonary function,and anatomical structure during pregnancy,which puts them at higher risk of contracting ***-19 infection during pregnancy is associated with increased adverse events such as hospitalisation,admission to the intensive care unit,and mechanical ***,pregnancy combined with coinfection of COVID-19 and bacteria often leads to critical respiratory failure,posing severe challenges in the diagnosis and treatment *** SUMMARY We report a case of COVID-19 complicated with Staphylococcus aureus(***)coinfection in a pre-gnant woman at 34 wk of *** rapid progression of pulmonary lesions caused severe respiratory failure,and she received noninvasive ventilator-assisted respiratory ***,we delivered a foetus via emergency caesarean section after accelerating the maturity of the foetal pulmonary system,and the respiratory condition of the puerperant woman significantly improved after the delivery of the *** fluid was taken under tracheoscopy to quickly search for pathogens by the metagenomic nextgeneration sequencing(mNGS),and both COVID-19 and *** were *** targeted anti-infective treatment,the maternal condition gradually improved,and the patient was discharged from the *** The coinfection of pregnancy with COVID-19 and bacteria often leads to critical respiratory failure,which is a great challenge in the process of diagnosis and *** is crucial to choose the right time to deliver the foetus and to quickly find pathogens by mNGS.

关键词： Pregnancy Coronavirus disease 2019 Combined with staphylococcus aureus Metagenomic next-generation sequencing Critical respiratory failure Case report

Vedolizumab-associated diffuse interstitial lung disease in patients with ulcerative colitis:A case report

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World Journal of Clinical Cases 2022年第5期10卷 1716-1722页

作者： Jie Zhang mei-hong liu Xue Gao Chang Dong Yan-Xia Li Department of Pulmonary and Critical Care Medicine First Affiliated Hospital of Dalian Medical UniversityDalian 116011Liaoning ProvinceChina Department of Pathology First Affiliated Hospital of Dalian Medical UniversityDalian 116011Liaoning ProvinceChina

BACKGROUND Vedolizumab,a newer class of integrin antagonist biological agents,has been applied to treat patients with moderate-to-severe Crohn’s disease(CD)and ulcerative colitis(UC),especially for patients who are refractory to traditional therapies and tumor necrosis factor ***,some rare but lifethreatening adverse effects warrant *** describe the first fatal case of vedolizumab-associated severe diffuse interstitial lung disease in *** SUMMARY We present a case of new-onset diffuse parenchymal lung disease developing under treatment with vedolizumab in a patient with *** two doses of vedolizumab,he developed persistent fever and progressively worsening *** workups,including bronchoalveolar lavage,transbronchial lung biopsy and metagenomic next-generation sequencing,identified no infectious causes,and other potential causes(such as tumors and cardiogenic pulmonary edema)were also *** a result,a diagnosis of vedolizumabrelated interstitial lung disease was ***,although corticosteroids and empiric antibiotics were administered,the patient eventually died of respiratory *** Vedolizumab-related interstitial lung disease in patients with UC is rare but potentially *** and pulmonologists should be aware of vedolizumab-related adverse drug reactions.

关键词： Vedolizumab Adverse effects Ulcerative colitis Inflammatory bowel disease Interstitial lung disease Case report

Study on gene expression patterns and functional pathways of peripheral blood monocytes reveals potential molecular mechanism of surgical treatment for periodontitis

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World Journal of Clinical Cases 2019年第12期7卷 1383-1392页

作者： Jin-Ji Ma hong-mei liu Xiang-Hua Xu Li-Xin Guo Qing Lin Jinan Stomatological Hospital Gaoxin Branch Jinan 250001 Shandong Province China Department of Endodontics Jinan Stomatological Hospital Jinan 250001 Shandong Province China Department of Stomatology Shandong Provincial Hospital Jinan 250001 Shandong Province China

BACKGROUND Periodontitis is a chronic inflammation of periodontal supporting tissue caused by local factors. Periodontal surgery can change the gene expression of peripheral blood mononuclear cells. However, little is known about the potential mechanism of surgical treatment for periodontitis. AIM To explore the potential molecular mechanism of surgical treatment for periodontitis. METHODS First, based on the expression profiles of genes related to surgical treatment for periodontitis, a set of expression disorder modules related to surgical treatment for periodontitis were obtained by enrichment analysis. Subsequently, based on crosstalk analysis, we proved that there was a significant crosstalk relationship between module 3 and module 5. Finally, based on predictive analysis of multidimensional regulators, we identified a series of regulatory factors, such as endogenous genes, non-coding RNAs (ncRNAs), and transcription factors, which have potential regulatory effects on periodontitis. RESULTS A total of 337 genes related to surgical treatment for periodontitis were obtained, and 3896 genes related to periodontitis were amplified. Eight expression modules of periodontitis were obtained, involving the aggregation of 2672 gene modules. These modules are mainly involved in G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger, and adenylate cyclasemodulating G-protein coupled receptor signaling pathway. In addition, eight endogenous genes (including EGF, RPS27A, and GNB3) were screened by network connectivity analysis. Finally, based on this set of potential dysfunction modules, 94 transcription factors (including NFKB1, SP1, and STAT3) and 1198 ncRNAs (including MALAT1, CRNDE, and ANCR) were revealed. These core regulators are thought to be involved in the potential molecular mechanism of periodontitis after surgical treatment. CONCLUSION Based on the results of this study, we can show biologists and pharmacists a new idea to re

关键词： Peripheral blood mononuclear cells Gene expression Dysregulation module Potential molecular mechanism Gene expression pattern

Dispersion modeling and health risk assessment of dioxin emissions from a municipal solid waste incinerator in Hangzhou,China

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2012年第1期13卷 69-78页

作者： Xiao-jun MA Xu-guang JIANG Yu-qi JIN hong-mei liu Xiao-dong LI Tong CHEN Jian-hua YAN State Key Laboratory of Clean Energy Utilization Institute for Thermal Power E~Tgineering Zhejiang University Hangzhou 310027 China

The emission of dioxins from municipal solid waste incinerators(MSWIs) has become a widespread *** effect of meteorological parameters(wind speed,atmospheric stability and mixing height) on the hourly ground level concentration(GLC) of dioxins was estimated using air dispersion ***,the health risks of dioxin exposure were evaluated for children and adults using the Nouwen *** total environmental exposure via air inhalation and food ingestion was calculated,based on linear fit *** results indicate that potentially severe pollution from dioxins occurs at a wind speed of 1.5 m/s with atmospheric stability class *** addition,local residents in the study area are exposed to severe weather conditions most of the time,and the risk exposures for children are far higher than those for *** total exposure for children far exceeds the tolerable daily intake of dioxin recommended by the World Health Organization(WHO) of 1-4 pg TEQ/(kg·d) under severe weather *** from modeling calculations of health risk assessment were consistent with dioxin levels obtained during actual monitoring of emissions.

关键词： Dioxins Meteorology Air dispersion model Health risk assessment Dioxin exposure

S100B protein in serum is elevated after global cerebral ischemic injury

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World Journal of Emergency Medicine 2013年第3期4卷 165-168页

作者： Bao-di Sun hong-mei liu Shi-nan Nie Department of Emergency Medicine Jinling HospitalNanjing UniversitySchool of Medicine

BACKGROUND:S100B protein in patients with cardiac arrest,hemorrhagic shock and other causes of global cerebral ischemic injury will be dramatically *** brain injury may elevate the level of serum S100 B protein and the severity of brain ***:This article is a critical and descriptive review on S100 B protein in serum after ischemic brain *** searched Pubmed database with key words or terms such as "S100B protein", "cardiac arrest", "hemorrhagic shock" and "ischemia reperfusion injury" appeared in the last five ***:S100B protein in patients with cardiac arrest,hemorrhagic shock and other causes of ischemic brain injury will be dramatically *** brain injury elevated the level of serum S100 B protein,and the severity of brain ***:The level of S100 B protein in serum is elevated after ischemic brain injury,but its mechanism is unclear.

关键词： S100B Ischemic brain injury Cardiac arrest Hemorrhagic shock

Immunogenicity of the recombinant adenovirus type 5 vector with type 35 fiber containing HIV-1 gag gene

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Journal of Microbiology and Immunology 2006年第4期4卷 306-312页

作者： XIN LEI liu SHUNAG QING YU XIA FENG XIAO LI WANG hong mei liu XIAO mei ZHANG hong XIA LI LING ZHOU YI ZENG College of Life Science and Bio-engineering Beijing University of Technology Beijing P. R. China State Key Laboratory for Infectious Disease Prevention and Control National Institute for Viral Disease Control and Prevention Chinese Center for Disease Control and Prevention Beijing P. R. China

The immune efficiency of a recombinant adenovirus type 5 with type 35 fiber containing HIV-1 gag gene （rAd5/F35-mod. gag） was investigated in BALB/c mice, in which the rAd5/F35-mod, gag was firstly identified with PCR, then transfected to 293 cells and the in vitro expression level of Gag protein was determined by Western blotting and indirect immuno-fluorescent assay. Mice were immunized with intramuscular injections of rAd5/F35-mod, gag, rAd5-mod, gag or DNA and were boosted after 3 weeks. To test the effect of pre-existing anti-viral immunity on immunization, mice were also injected with Ad5- GFP vector and then immunized 4 and 7 weeks later with Ad5/F35-mod. gag vector. The P24-specific IgG antibody in sera of immunized mice was determined by ELISA and the specific cytotoxic T lymphocyte （CTL） response was assayed by intracellular cytokine staining. It was demonstrated that the rAd5/F35- rood. gag vector could express efficiently the HIV Gag protein in 293 cells in vitro and induce strong HIV- specific immune responses in vivo. The strongest CTL and serum IgG response occurred when mice were immunized twice with injection of rAd5/F35 alone, but the anti-Ad5 antibody after primary infection with adenovirus could inhibit the specific immune responses induced by rAd5/F35 vector. It is concluded that single immunization with recombinant adenovirus rAd5/F35-mod, gag can induce specific CTL and serum IgG antibody responses in mice, but the immunogenicity of rAd5/F35 is comparably weaker than that of rAd5.

关键词： H1V-1 AIDS vaccines Adenoviridae