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Research on intelligent search-and-secure technology in accelerator hazardous areas based on machine vision

Nuclear Science and Techniques 2024年第4期35卷 96-107页

作者： Ying-Lin Ma Yao Wang Hong-mei shi Hui-Jie Zhang School of Traffic and Transportation Beijing Jiaotong UniversityBeijing 100044China School of Mechanical Electronic and Control EngineeringBeijing Jiaotong UniversityBeijing 100044China Institute of High Energy Physics Chinese Academy of SciencesBeijing 100049China

Prompt radiation emitted during accelerator operation poses a significant health risk,necessitating a thorough search and securing of hazardous areas prior to ***,manual sweep methods are ***,the limitations of manual sweeps have become increasingly evident with the implementation of large-scale *** leveraging advancements in machine vision technology,the automatic identification of stranded personnel in controlled areas through camera imagery presents a viable solution for efficient search and *** the criticality of personal safety for stranded individuals,search and security processes must be sufficiently *** ensure comprehensive coverage,180°camera groups were strategically positioned on both sides of the accelerator tunnel to eliminate blind spots within the monitoring *** YOLOV8 network model was modified to enable the detection of small targets,such as hands and feet,as well as larger targets formed by individuals near the ***,the system incorporates a pedestrian recognition model that detects human body parts,and an information fusion strategy is used to integrate the detected head,hands,and feet with the identified pedestrians as a cohesive *** strategy enhanced the capability of the model to identify pedestrians obstructed by equipment,resulting in a notable improvement in the recall ***,recall rates of 0.915 and 0.82were obtained for Datasets 1 and 2,*** there was a slight decrease in accuracy,it aligned with the intended purpose of the search-and-secure software *** tests conducted within an accelerator tunnel demonstrated the effectiveness of this approach in achieving reliable recognition outcomes.

关键词： Search and secure Machine vision Camera Human body parts recognition Particle accelerator Hazardous area

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Insufficient TRPM5 Mediates Lipotoxicity-induced Pancreaticβ-cell Dysfunction

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Current Medical Science 2024年第2期44卷 346-354页

作者： Kai-yuan WANG shi-mei WU Zheng-jian YAO Yun-xia ZHU Xiao HAN Key Laboratory of Human Functional Genomics of Jiangsu Province Department of Biochemistry and Molecular BiologyNanjing Medical UniversityNanjing 211166China

Objective:While the reduction of transient receptor potential channel subfamily M member 5(TRPM5)has been reported in islet cells from type 2 diabetic(T2D)mouse models,its role in lipotoxicity-induced pancreaticβ-cell dysfunction remains *** study aims to study its ***:Pancreas slices were prepared from mice subjected to a high-fat-diet(HFD)at different time points,and TRPM5 expression in the pancreaticβcells was examined using immunofluorescence ***-stimulated insulin secretion(GSIS)defects caused by lipotoxicity were mimicked by saturated fatty acid palmitate(Palm).Primary mouse islets and mouse insulinoma MIN6 cells were treated with Palm,and the TRPM5 expression was detected using qRT-PCR and Western ***-induced GSIS defects were measured following siRNA-based Trpm5 *** detrimental effects of Palm on primary mouse islets were also assessed after overexpressing Trpm5 via an adenovirus-derived Trpm5(Ad-Trpm5).Results:HFD feeding decreased the mRNA levels and protein expression of TRPM5 in mouse pancreatic *** reduced TRPM5 protein expression in a time-and dose-dependent manner in MIN6 *** also inhibited TRPM5 expression in primary mouse *** of Trpm5 inhibited insulin secretion upon high glucose stimulation but had little effect on insulin *** of Trpm5 reversed Palm-induced GSIS defects and the production of functional maturation molecules unique toβ***:Our findings suggest that lipotoxicity inhibits TRPM5 expression in pancreaticβcells both in vivo and in vitro and,in turn,drivesβ-cell dysfunction.

关键词： type 2 diabetes β-cell dysfunction lipotoxicity TRPM5

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Establishment of NaLuF_(4):15%Tb-based low dose X-PDT agent and its application on efficient antitumor therapy

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International Journal of Minerals,Metallurgy and Materials 2024年第3期31卷 599-610页

作者： Yi Tian Zhiguang Fu Xiaosheng Zhu Chunjing Zhan Jinwei Hu Li Fan Chaojun Song Qian Yang Yu Wang mei shi Department of Radiation Oncology Xijing HospitalThe Fourth Military Medical UniversityXi’an 710032China Department of Oncology Air Force Medical CenterPLAThe Fourth Military Medical UniversityBeijing 100142China Department of Tumor Radiotherapy Air Force Medical CenterPLAThe Fourth Military Medical UniversityBeijing 100142China Department of Gastroenterology Air Force Hospital of Southern Theater CommandGuangzhou 510062China Department of Pharmaceutical Chemistry and Analysis School of PharmacyThe Fourth Military Medical UniversityXi’an 710032China School of Life Sciences Northwestern Polytechnical UniversityXi’an 710072China Institue of Materia Medica School of PharmacyThe Fourth Military Medical UniversityXi’an 710032China

X-ray excited photodynamic therapy(X-PDT)is the bravo answer of photodynamic therapy(PDT)for deep-seated tumors,as it employs X-ray as the irradiation source to overcome the limitation of light penetration ***,high X-ray irradiation dose caused organ lesions and side effects became the major barrier to X-PDT *** address this issue,this work employed a classic-al co-precipitation reaction to synthesize NaLuF_(4):15%Tb^(3+)(NLF)with an average particle size of(23.48±0.91)nm,which was then coupled with the photosensitizer merocyanine 540(MC540)to form the X-PDT system NLF-MC540 with high production of singlet *** system could induce antitumor efficacy to about 24%in relative low dose X-ray irradiation range(0.1-0.3 Gy).In vivo,when NLF-MC540 irradiated by 0.1 Gy X-ray,the tumor inhibition percentage reached 89.5%±5.7%.The therapeutic mechanism of low dose X-PDT was found.A significant increase of neutrophils in serum was found on the third day after *** immunohistochemical staining of tumor sections,the Ly6G^(+),CD8^(+),and CD11c^(+)cells infiltrated in the tumor microenvironment were *** the bilat-eral tumor model,the NLF-MC540 with 0.1 Gy X-ray irradiation could inhibit both the primary tumor and the distant tumor ***-tected by enzyme linked immunosorbent assay(ELISA),two cytokines IFN-γand TNF-αin serum were upregulated 7 and 6 times than negative control,*** by enzyme linked immune spot assay(ELISPOT),the number of immune cells attributable to the IFN-γand TNF-αlevels in the group of low dose X-PDT were 14 and 6 times greater than that in the negative control group,***,it conclude that low dose X-PDT system could successfully upregulate the levels of immune cells,stimulate the secretion of cy-tokines(especially IFN-γand TNF-α),activate antitumor immunity,and finally inhibit colon tumor growth.

关键词： X-ray excited photodynamic therapy singlet oxygen low dose X-Ray irradiation efficient antitumor therapy anti-tumor immunity

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Application of fecal immunochemical test in colorectal cancer screening:A community-based,cross-sectional study in averagerisk individuals in Hainan

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World Journal of Gastrointestinal Oncology 2024年第8期16卷 3445-3456页

作者： Fan Zeng Da-Ya Zhang shi-Ju Chen Run-Xiang Chen Chen Chen shi-mei Huang Da Li Xiao-Dong Zhang Jia-Jia Chen Cui-Yi Mo Lei Gao Jun-Tao Zeng Jian-Xin Xiong Zhai Chen Fei-Hu Bai Graduate School Hainan Medical UniversityHaikou 571199Hainan ProvinceChina Department of Gastroenterology Qionghai People’s HospitalQionghai 571400Hainan ProvinceChina Department of Gastroenterology Sanya Central HospitalSanya 572022Hainan ProvinceChina Department of Gastroenterology Hainan Second People’s HospitalWuzhishang 572299Hainan ProvinceChina Department of Gastroenterology Dongfang People’s HospitalDongfang 572699Hainan ProvinceChina Department of Gastroenterology The Second Affiliated Hospital of Hainan Medical UniversityHaikou 570216Hainan ProvinceChina The Gastroenterology Clinical Medical Center of Hainan Province Haikou 570216Hainan ProvinceChina

BACKGROUND The incidence of colorectal cancer(CRC)in China is steadily rising,with a high proportion of advanced-stage *** highlights the significance of early detection and prevention measures to enhance survival *** immunochemical testing(FIT)is a globally recommended CRC screening method;however,limited research has been conducted on its application in *** To assess the efficacy and adherence of FIT screening among average-risk individuals in Hainan,while also examining the risk factors associated with positive FIT *** This population-based cross-sectional study implemented FIT screening for CRC in 2000 asymptomatic participants aged 40-75 years from five cities and 21 community health centers in Hainan *** study was conducted from August 2022 to April 2023,employing a stratified sampling method to select *** with positive FIT results subsequently underwent *** predictive values for confirmed CRC and advanced adenoma were calculated,and the relationship between relevant variables and positive FIT results was analyzed usingχ2 tests and multivariate logistic *** A total of 1788 participants completed the FIT screening,with a median age of 57 years(interquartile range:40-75).Among them,503(28.1%)were males,and 1285(71.9%)were females,resulting in an 89.4%compliance rate for FIT *** overall positivity rate of FIT was 4.4%[79 out of 1788;95%confidence interval(CI):3%-5%].The specific positivity rates for Haikou,Sanya,Orient City,Qionghai City,and Wuzhishan City were 9.6%(45 of 468;95%CI:8%-11%),1.3%(6 of 445;95%CI:0.1%-3.1%),2.7%(8 of 293;95%CI:1.2%-4.3%),3.3%(9 of 276;95%CI:1.0%-6.3%),and 4.2%(11 of 406;95%CI:1.2%-7.3%),*** associations were found between age,dietary habits,and positive FIT *** of the 79 participants with positive FIT results,55 underwent colonoscopy,demonstrating an 82.2%compliance *** them,10 had a clean

关键词： Fecal immunochemical test Colorectal cancer Adenoma Screening Hainan Province

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综合实践活动与跨学科主题学习统整实施的价值与路径

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教学与管理 2024年第20期 22-24页

作者：施美珠福建省晋江市第六实验小学

综合实践活动是国家课程体系中的一门跨学科必修课程,《义务教育课程方案(2022年版)》优化课程内容结构,又提出设立跨学科主题学习活动。从价值取向分析综合实践活动课程与跨学科主题学习统筹实施的意义,并从二者实施的“痛点”入手,提... 详细信息

综合实践活动是国家课程体系中的一门跨学科必修课程,《义务教育课程方案(2022年版)》优化课程内容结构,又提出设立跨学科主题学习活动。从价值取向分析综合实践活动课程与跨学科主题学习统筹实施的意义,并从二者实施的“痛点”入手,提出构建课时保障机制、构建内容整合机制、构建跨学科共研机制、构建跨学科学习模式等统整实施的路径,以期为推进综合学习提供有益的参考。

关键词：综合实践活动跨学科学习综合素养

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紫铜止水片在水工建筑物中的应用研究

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工程技术研究 2024年第9期9卷 117-119页

作者：石梅安徽省淠史杭灌区管理总局安徽六安237000

紫铜止水片作为一种建筑材料,主要由紫铜(纯铜)或铜合金制成,因材质具有良好的延展性、耐腐蚀性和密封性能,适合用作止水材料。文章以安徽省某灌区渠下涵为例,在明确紫铜止水片在该渠下涵分缝位置防渗漏的关键作用后,对紫铜片展开性能... 详细信息

紫铜止水片作为一种建筑材料,主要由紫铜(纯铜)或铜合金制成,因材质具有良好的延展性、耐腐蚀性和密封性能,适合用作止水材料。文章以安徽省某灌区渠下涵为例,在明确紫铜止水片在该渠下涵分缝位置防渗漏的关键作用后,对紫铜片展开性能试验。立足试验结果,提出紫铜止水片在该水工建筑中的应用设计思路,以供参考。

关键词：紫铜止水片水工建筑物黏接性能

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脉冲-红外吸收法测定稀土铁合金中的氧含量

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稀土 2024年第2期45卷 113-120页

作者：谢敏徐娜李平肖石妹国家钨与稀土产品质量检验检测中心江西赣州341000 江西省钨与稀土研究院江西赣州341000

实验采用脉冲-红外吸收法,建立了稀土铁合金中氧含量的测定方法,分别考察了助熔剂、样品制备方式、加热功率等条件对测定结果的影响。结果表明,选用颗粒制备样品,以镍篮为助熔剂,分析功率为5000 W,在优化条件下,测得该方法检出下限为0.0... 详细信息

实验采用脉冲-红外吸收法,建立了稀土铁合金中氧含量的测定方法,分别考察了助熔剂、样品制备方式、加热功率等条件对测定结果的影响。结果表明,选用颗粒制备样品,以镍篮为助熔剂,分析功率为5000 W,在优化条件下,测得该方法检出下限为0.0014%,应用该方法测试实际样品,相对标准偏差为1.80%~4.46%(n=11),加标回收率为92.3%~115.5%。该方法操作简单快捷,精密度好,结果准确可靠,具有一定的实际应用价值。

关键词：脉冲-红外吸收法稀土铁合金氧含量颗粒制备

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红色纪念建筑作为记忆媒介的复合空间叙事研究——以红旗渠纪念建筑为例

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未来传播 2024年第2期31卷 10-19页

作者：张超苏士梅河南大学新闻与传播学院河南开封475000

纪念建筑作为储存历史记忆的媒介载体及表征符号,在记忆延续与传播过程中具有秉要执本的作用。不同的媒介形式、空间布局、记忆符号对记忆有不同的建构作用,如何合理建构与表征纪念建筑媒介记忆路径尚待深耕探究。文章以文化记忆理论为... 详细信息

纪念建筑作为储存历史记忆的媒介载体及表征符号,在记忆延续与传播过程中具有秉要执本的作用。不同的媒介形式、空间布局、记忆符号对记忆有不同的建构作用,如何合理建构与表征纪念建筑媒介记忆路径尚待深耕探究。文章以文化记忆理论为基础,红旗渠纪念建筑媒介为个案,运用叙事分析和GIS空间认知研究方法,探究红旗渠纪念建筑媒介在人文·自然空间中的红色精神记忆建构逻辑。红旗渠纪念建筑媒介的空间场域由自然和人文双主线构成,通过纪念建筑媒介排列构成的记忆空间对精神记忆进行有序传播。游客通过人文·自然复合沉浸模式、多元文化符号叙事以及场景触感将自我精神嵌入该记忆场域之中,建构自然风光与人文景观媒介相交互的精神记忆场域空间,从而实现红旗渠文化精神在日常生活及旅游中的深化与传承。

关键词：红色纪念建筑红旗渠精神文化记忆建筑媒介 GIS空间认知

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基于双视角建模的多智能体协作强化学习方法

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计算机学报 2024年第7期47卷 1582-1594页

作者：刘全施眉龙黄志刚张立华苏州大学计算机科学与技术学院江苏苏州215006 苏州大学江苏省计算机信息处理技术重点实验室江苏苏州215006

在多智能体协作领域,强化学习算法通过共享智能体的局部信息来实现智能体间的协作.但共享协作机制极易引发过度协作问题,导致智能体忽视自身局部观测信息,丧失策略多样性,最终陷入低效协作的困境.为了解决该问题,本文提出基于双视角建... 详细信息

在多智能体协作领域,强化学习算法通过共享智能体的局部信息来实现智能体间的协作.但共享协作机制极易引发过度协作问题,导致智能体忽视自身局部观测信息,丧失策略多样性,最终陷入低效协作的困境.为了解决该问题,本文提出基于双视角建模的多智能体协作强化学习方法(Bi-ViewModelingCollaborative Multi-Agent Reinforcement Learning,简称BVM-CMARL).该方法从局部和全局两个视角对智能体进行建模,分别用于产生多样性的策略和激励协作.在局部视角最大化局部变分与自身轨迹的互信息,激励智能体的策略多样性;同时在全局视角最大化全局变分与其他智能体动作的互信息,提高智能体协作水平.最后将局部变分训练出的局部Q值与全局变分训练出的全局Q值合并,避免低效协作.将BVM-CMARL算法应用于星际争霸多智能体挑战赛(StarCraft Multi-AgentChallenge,SMAC)中的等级觅食(Level-BasedForaging,LBF)和走廊(Hallway)等环境,与QMIX、QPLEX、RODE、EOI和MAVEN等5种目前优秀的强化学习算法相比,BVM-CMARL算法具有更好的稳定性和性能表现,在SMAC上的平均胜率为82.81%,比次优算法RODE高13.42%.通过设计模型变体,在消融实验中证明了双视角建模对BVM-CMARL的必要性.

关键词：深度强化学习多智能体系统多智能体协作协作建模对比学习

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瞬时弹性成像技术下肝脏硬度值联合血清肝纤维化标志物在肝功能轻度异常慢性乙型肝炎患者中的应用研究

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当代医学 2024年第1期30卷 98-102页

作者：史梅江慧上饶市第二人民医院医技江西上饶334000

目的探讨瞬时弹性成像技术(Fibro Touch)下肝脏硬度值(LSM)联合血清肝纤维化标志物在肝功能轻度异常慢性乙型肝炎(CHB)患者中的应用。方法选取2019年1月至2022年1月上饶市第二人民医院收治的82例肝功能轻度异常CHB患者作为研究对象,以... 详细信息

目的探讨瞬时弹性成像技术(Fibro Touch)下肝脏硬度值(LSM)联合血清肝纤维化标志物在肝功能轻度异常慢性乙型肝炎(CHB)患者中的应用。方法选取2019年1月至2022年1月上饶市第二人民医院收治的82例肝功能轻度异常CHB患者作为研究对象,以肝脏穿刺活检为金标准,对患者进行纤维化分期,分为无肝纤维化组(S0期,n=16)、早期肝纤维化组(S1、S2期,n=33)、进展性肝纤维化组(S3、S4期,n=33)。采用Fibro Touch检测患者LSM,并测定肝功能指标[血清天冬氨酸氨基转移酶(AST)、丙氨酸氨基转移酶(ALT)、总胆红素(TBIL)]及血清肝纤维化标志物[透明质酸(HA)、层黏连蛋白(LN)、Ⅲ型前胶原肽(PⅢP)、Ⅳ型胶原(CⅣ)],绘制ROC曲线分析LSM、血清肝纤维化标志物单项及联合诊断CHB肝纤维化的诊断效能。结果3组AST、ALT、TBIL水平比较差异有统计学意义(P0,P<0.05)。ROC曲线分析结果显示,LSM、血清纤维化指标联合检测诊断CHB患者肝纤维化的预测效能高于各单项检测(P<0.05)。结论Fibro Touch下LSM联合血清肝纤维化标志物可提高肝功能轻度异常CHB肝纤维化的诊断效能,临床应用价值高。

关键词：慢性乙型肝炎瞬时弹性成像技术肝脏硬度值肝纤维化标志物

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