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Intestinal microcirculation dysfunction in sepsis: pathophysiology, clinical monitoring, and therapeutic interventions

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World Journal of Emergency Medicine 2022年第5期13卷 343-348页

作者： A-ling Tang mei-jia Shen Guo-qiang Zhang Graduate School Beijing University of Chinese MedicineBeijing 100029China Graduate School Peking Union Medical CollegeBeijing 100730China Department of Emergency China-Japan Friendship HospitalBeijing 100029China

BACKGROUND:Intestinal microcirculation dysfunction is an important factor that causes poor prognosis in sepsis patients and is an important pathophysiological basis for the occurrence and development of *** RESOURCES:PubMed,Web of Science,and China National Knowledge Infrastructure(CNKI)were searched from inception to August 1,*** search was limited to the English language *** reviewers independently identified studies related to intestinal microcirculation dysfunction in *** criteria were duplicate articles according to multiple search ***:Fifty articles were included,and most of them were animal *** studies reported pathogenesis,including endothelial dysfunction,leukocyte recruitment and adhesion,microthrombus formation,microcirculation hypoperfusion,and redistribution of intestinal wall blood *** monitoring methods of intestinal microcirculation were also diverse,including handheld microscopes,intravital microscopy(IVM),laser Doppler blood flow instruments,laser speckle contrast imaging,tissue refl ectance spectrophotometry,biochemical markers of intestinal ischemia,and histopathological *** view of the related pathogenesis of intestinal microcirculation disorder in sepsis,existing studies also have diff erent opinions on its ***:Limited by monitoring,there are few clinical studies on intestinal microcirculation dysfunction in *** research mainly focuses on basic research,but some progress has also been ***,this review may provide a reference for future research on intestinal microcirculation dysfunction in sepsis.

关键词： Sepsis Microcirculation Intestinal barrier Intestinal ischemia Review

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Inference and prioritization of tissue-specific regulons in Arabidopsis and Oryza

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aBIOTECH 2024年第3期5卷 309-324页

作者： Honggang Dai Yaxin Fan Yichao mei ling-ling Chen Junxiang Gao Hubei Key Laboratory of Agricultural Bioinformatics College of InformaticsHuazhong Agricultural UniversityWuhan430070China State Key Laboratory for Conservation and Utilization of Subtropical Agro-bioresources College of Life Science and TechnologyGuangxi UniversityNanning530004China

A regulon refers to a group of genes regulated by a transcription factor binding to regulatory motifs to achieve specific biological *** infer tissue-specific gene regulons in Arabidopsis,we developed a novel pipeline named *** utilizes a gene expression matrix that includes 3400 Arabidopsis transcriptomes to make initial predictions about the regulatory relationships between transcription factors(TFs)and target genes(TGs)using co-expression *** further improves these anticipated interactions by integrating TF binding site enrichment analysis to eliminate false positives that are only supported by expression *** further trained a graph convolutional network with 133 transcription factors,supported by ChIP-seq,as positive samples,to learn the regulatory logic between TFs and TGs to improve the accuracy of the regulatory *** evaluate the functionality of InferReg,we utilized it to discover tissue-specific regulons in 5 Arabidopsis tissues:flower,leaf,root,seed,and *** ranked the activities of regulons for each tissue based on reliability using Borda ranking and compared them with existing *** results demonstrated that InferReg not only identified known tissue-specific regulons but also discovered new *** applying InferReg to rice expression data,we were able to identify rice tissue-specific regulons,showing that our approach can be applied more *** used InferReg to successfully identify important regulons in various tissues of Arabidopsis and Oryza,which has improved our understanding of tissue-specific regulations and the roles of regulons in tissue differentiation and development.

关键词： Transcriptional regulation Graph convolutional network Tissue-specific Regulon Transcription factor

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Ensemble Based Diagnosis of the Track Errors of Super Typhoon Mangkhut(2018)

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Journal of Meteorological Research 2020年第2期34卷 353-367页

作者： ling huang Qilin WAN Chunxia LIU Huijun huang Institute of Tropical and Marine Meteorology of China Meteorological Administration Guangzhou 510000

Super Typhoon Mangkhut(2018)was the most high-impact typhoon in 2018 because of its long lifespan and significant *** operational track forecasts in the short-to-medium range(deterministic and probabilistic forecast)showed a great uncertainty and the forecast landing points varied with different lead *** study applied ensembles of high-resolution ECMWF forecasts to investigate the major factors and mechanisms of the bias production of the Mangkhut forecast *** ensembles with the largest track bias were analyzed to examine the possible bias associated *** results suggested that environmental steering flows were the main cause for the erroneous southward track error with a variance contribution of 72%.The tropical cyclone(TC)size difference and the interaction of the TC with the subtropical high(SH)were other two key factors that contributed to the track ***,larger TCs may have led to a stronger erosion of the southern part of the SH,and thus induced significant changes in the large-scale environment and eventually resulted in an additional northward movement of TC.

关键词： Super Typhoon Mangkhut ECMWF ensemble tropical cyclone track

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The dynamical holographic QCD method for hadron physics and QCD matter

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Communications in Theoretical Physics 2022年第9期74卷 218-234页

作者： Yidian Chen Danning Li mei huang School of Nuclear Science and Technology University of Chinese Academy of SciencesBeijing 100049China Department of Physics and Siyuan Laboratory Jinan UniversityGuangzhou 510632China

In this paper we present a short overview on the dynamical holographic QCD(DhQCD)method for hadron physics and QCD *** five-dimensional DhQCD model is constructed in the graviton-dilaton-scalar framework with the dilaton background fieldΦand the scalar field X dual to the gluon condensate and the chiral condensate operator thus can represent the gluodynamics(linear confinement)and chiral dynamics(chiral symmetry breaking),*** dilaton background field and the scalar field are a function of the 5th dimension,which plays the role of the energy scale,in this way,the DhQCD model can resemble the renormalization group from ultraviolet(UV)to infrared(IR).By solving the Einstein equation,the metric structure at IR is automatically deformed by the nonperturbative gluon condensation and chiral condensation in the *** review the results on the hadron spectra including the glueball spectra,the light/heavy meson spectra,as well as on QCD phase transitions,and thermodynamical as well as transport properties in the framework of the DhQCD model.

关键词： holographic QCD gauge/gravity duality QCD matter hadron physics

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Spermatocytic tumor:A rare case report

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World Journal of Clinical Cases 2021年第35期9卷 11115-11121页

作者： mei-ling Hao Chun-Hui Li Department of Pathology Chengde Medical College Affiliated HospitalChengde 067000Hebei ProvinceChina

BACKGROUND Spermatocytic tumor is a rare,malignant neoplasm of the *** the prognosis for this tumor type is favorable,accurate diagnosis and differentiation from other malignant testicular neoplasms(classic seminoma and lymphoma)are *** add to the existing literature on the diagnosis of spermatocytic tumor,herein we report the detailed clinical and histopathologic findings for a case that we *** SUMMARY A 60-year-old Chinese man presented with a solid mass in the right *** mass was surgically removed and spermatocytic tumor was *** microscopy,the tumor cells displayed an unusual arrangement in lobules,presenting a pseudo-glandular *** summarize and compare the diagnostic features of this tumor and those of the differential diagnoses,we report our case findings and those mentioned in the literature for various testicular *** imaging methods can detect masses early in development,their diagnostic capabilities are ***,histopathology,and immunohistochemistry are necessary for confirmatory *** It is important to identify and review the key diagnostic features of spermatocytic tumor.

关键词： Spermatocytic tumor Germ cell tumor Immunohistochemistry Pseudoglandular Case report

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Improvement of location methods based on RFID

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The Journal of China Universities of Posts and Telecommunications 2013年第6期20卷 36-41页

作者： WU ling huang Li-ya Institute of Electronic Science and Engineering Nanjing University of Posts and Telecommunications

The most common location algorithms based on received signal strength （RSS） are location identification based on dynamic active radio frequency identification （LANDMARC） and virtual reference elimination （VIRE）. However, both the original algorithms suffer from some drawbacks. In this paper, several aspects of the two original algorithms have been modified to reduce the positioning errors. Firstly, Lagrange interpolation has been used instead of linear interpolation. Secondly, adaptive threshold has been introduced in the new algorithm. Thirdly, insert virtual reference tags to improve the location accuracy of the boundary of the sensing area. Finally, combine LANDMARC with VIRE to absorb both advantages. Compared with the original algorithms, on average, simulated results show that the modified algorithms can improve the location performance efficiently and achieve the goal of accurate positioning in indoor environment.

关键词： LANDMARC VIRE received signal strength indicator (RSSI) Lagrange adaptive threshold

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Evaluation of the efficacy of laser peripheral iridoplasty in reversing the darkroom provocative test result in Chinese patients with primary angle closure status post laser iridotomy

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International Journal of Ophthalmology(English edition) 2015年第3期8卷 580-584页

作者： Ping huang ling-ling Wu Department of Ophthalmology Peking University Third Hospital Key Laboratory of Vision Loss and RestorationMinistry of Education

AIM: To investigate the efficacy and safety of krypton laser peripheral iridoplasty(LPIP) for Chinese patients with primary angle closure(PAC) or primary angle-closure glaucoma(PACG) status post laser iridotomy in reversing the positive results of the dark room provocative test(DRPT).METHODS: This study was prospective, noncomparative,interventional case series. Thirty-three patients(thirty-eight eyes) with PAC or PACG status post patent laser iridotomy and maintained normal intraocular pressure(IOP) but with positive DRPT results were enrolled. All the subjects were treated with krypton LPIP. DRPT was repeated after krypton LPIP. Results of DRPT were recorded. The visual acuity, IOP and gonioscopy were analyzed before and after krypton LPIP. A minimum time limit for follow-up was ***: Thirty-three patients(thirty-eight eyes)were followed for 17.7 ±8.37mo(range 7-41mo) after LPIP. Positive results of DRPT decreased from 38 eyes to9 eyes(23.7%) after LPIP. Peripheral anterior synechiae of angle in 34 of 38 eyes(89.5%) remained unchanged at dynamic gonioscopy throughout the follow-up period after ***: LPIP decreased positive rates of the DRPT significantly. The mechanism may be that LPIP minimized contact between the peripheral iris and trabecular meshwork, which is a key factor for developing peripheral anterior synechiae.

关键词： iridoplasty angle-closure glaucoma laser

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A Comparative Study on the Microstructure and Properties of ITO Targets and Thin Films Prepared from Two Different Powders

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Acta Metallurgica Sinica(English Letters) 2021年第5期34卷 675-693页

作者： Fangsheng mei Tiechui Yuan Ruidi Li Jingwei huang Powder Metallurgy Research Institute Central South UniversityChangsha410083China Science and Technology on High Strength Structural Materials Laboratory Central South UniversityChangsha410083China

With the rapid development of indium tin oxide(ITO)in the electronic display industry,choosing which raw powders to prepare high-quality ITO targets has always been a controversial *** the work,in order to clearly understand the effect of the raw powders on the microstructure and properties of ITO targets and thin films,tin-doped indium oxide(dITO)and In_(2)O_3-SnO_(2)mixed(mITO)powders were chosen to prepare ITO targets for depositing the films and a comparative study on their microstructure and properties was *** is found that,(1)dITO targets possess a higher solid solubility of tin in indium oxide and more uniform elemental distribution,while there are a higher density,a finer grain size and a higher mass ratio of In_(2)O_3 to SnO_(2)for the mITO targets;(2)dITO films with more coarser columnar grains and a rougher surface prefer to grow along the[100]direction in an Ar atmosphere;(3)the conductive property of ITO films only depends on the doping amount of tin and is independent of the raw powders and the preparation process of the target source;(4)dITO films possess the superior optical property and narrower optical band gap;(5)the etching property of mITO films is superior to that of dITO films due to the lower solid solubility of tin in indium oxide.

关键词： Tin-doped indium oxide In_(2)O_3-SnO_(2) mixed powder Solid solubility of tin in indium oxide Photoelectric property Etching property

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Study of Resistin gene expression in peripheral blood mononuclear cell and its gene polymorphism in a small range population

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2007年第2期8卷 132-135页

作者： YANG Yun-mei XU Zhe-rong WU ling-jiao huang Wei-dong Department of Very Important People the First Affiliated Hospital School of Medicine Zhejiang University Hangzhou 310003 China Institute of Infectious Disease the First Affiliated Hospital School of Medicine Zhejiang University Hangzhou 310003 China Department of Emergency the First Affiliated Hospital School of Medicine Zhejiang University Hangzhou 310003 China

Objective: To observe the expression of Resistin mRNA in peripheral blood mononuclear cells and its gene poly-morphism in coding region in a small range population in Zhejiang Province of China. Methods: Eighty-three cases of type 2 diabetes mellitus and 53 healthy people were included. The expression of Resistin mRNA in peripheral blood mononuclear cells was detected by RT-PCR and semi-quantitative PCR assay. The sequencing work was done in Resistin cDNA and gene poly-morphism was analyzed. Results: At the same condition, in 83 diabetes patients, Resistin mRNA was detected in 23 cases (11 males and 12 females). There was no Resistin mRNA expression in 53 healthy people. The ratio of PCR products between Resistin and glyceraldehyde-3-phosphate dehydrogenase (GAPDH) was from 0.564 to 1.238, averaging 0.804±0.436. The sequence of Resistin cDNA is almost identical with each other and with that in GenBank with no single nucleotide polymorphism being found. Conclusion: Resistin mRNA is expressed in human peripheral blood mononuclear cells in some type 2 diabetes mellitus, but its expression is at a low level. Among the experiment population we did not find polymorphism phenomenon in Resistin coding region. The different individual’s Resistin coding region is highly coincident.

关键词： Resistin mRNA Peripheral blood mononuclear cells Coding region Gene polymorphism

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Embryo-Engineered Nonhuman Primate Models:Progress and Gap to Translational Medicine

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Research 2021年第1期2021卷 1627-1639页

作者： mei huang Jiao Yang Peng Li Yongchang Chen Yunnan Key Laboratory of Primate Biomedical Research Institute of Primate Translational MedicineKunming University of Science and TechnologyKunming 650500China State Key Laboratory of Primate Biomedical Research Kunming 650500China

Animal models of human diseases are vital in better understanding the mechanism of pathogenesis and essential for evaluating and validating potential therapeutic *** close relatives of humans,nonhuman primates(NHPs)play an increasingly indispensable role in advancing translational medicine *** this review,we summarized the progress of NHP models generated by embryo engineering,analyzed their unique advantages in mimicking clinical patients,and discussed the remaining gap between basic research of NHP models to translational medicine.

关键词： diseases Medicine translational

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