Intestinal microcirculation dysfunction in sepsis: pathophysiology, clinical monitoring, and therapeutic interventions

作     者：A-ling Tang Mei-jia Shen Guo-qiang Zhang A-ling Tang;Mei-jia Shen;Guo-qiang Zhang

作者机构：Graduate SchoolBeijing University of Chinese MedicineBeijing 100029China Graduate SchoolPeking Union Medical CollegeBeijing 100730China Department of EmergencyChina-Japan Friendship HospitalBeijing 100029China 

出 版 物：《World Journal of Emergency Medicine》 (世界急诊医学杂志（英文）)

年 卷 期：2022年第13卷第5期

页      面：343-348页

核心收录：

学科分类：100218[医学-急诊医学] 1002[医学-临床医学] 1010[医学-医学技术（可授医学、理学学位）] 10[医学] 

主　　题：Sepsis Microcirculation Intestinal barrier Intestinal ischemia Review 

摘      要：BACKGROUND:Intestinal microcirculation dysfunction is an important factor that causes poor prognosis in sepsis patients and is an important pathophysiological basis for the occurrence and development of *** RESOURCES:PubMed,Web of Science,and China National Knowledge Infrastructure(CNKI)were searched from inception to August 1,*** search was limited to the English language *** reviewers independently identified studies related to intestinal microcirculation dysfunction in *** criteria were duplicate articles according to multiple search ***:Fifty articles were included,and most of them were animal *** studies reported pathogenesis,including endothelial dysfunction,leukocyte recruitment and adhesion,microthrombus formation,microcirculation hypoperfusion,and redistribution of intestinal wall blood *** monitoring methods of intestinal microcirculation were also diverse,including handheld microscopes,intravital microscopy(IVM),laser Doppler blood flow instruments,laser speckle contrast imaging,tissue refl ectance spectrophotometry,biochemical markers of intestinal ischemia,and histopathological *** view of the related pathogenesis of intestinal microcirculation disorder in sepsis,existing studies also have diff erent opinions on its ***:Limited by monitoring,there are few clinical studies on intestinal microcirculation dysfunction in *** research mainly focuses on basic research,but some progress has also been ***,this review may provide a reference for future research on intestinal microcirculation dysfunction in sepsis.