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Lung injury after cardiopulmonary bypass:Alternative treatment prospects

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World Journal of Clinical Cases 2022年第3期10卷 753-761页

作者： Xue-mei zheng Zhuo Yang Guang-Li Yang Yan Huang Jie-Ru Peng Meng-Jun Wu School of Medicine University of Electronic Science and Technology of ChinaChengdu 610000Sichuan ProvinceChina Department of Pharmacy Chengdu Women’s and Children’s Central HospitalSchool of MedicineUniversity of Electronic Science and Technology of ChinaChengdu 610000Sichuan ProvinceChina Department of Medical Administration Chengdu Women’s and Children’s Central HospitalSchool of MedicineUniversity of Electronic Science and Technology of ChinaChengdu 610000Sichuan ProvinceChina National Institute of Drug Clinical Trial Chengdu Women’s and Children’s Central HospitalSchool of MedicineUniversity of Electronic Science and Technology of ChinaChengdu 610000Sichuan ProvinceChina Department of Medical Records Statistics Chengdu Women’s and Children’s Central HospitalSchool of MedicineUniversity of Electronic Science and Technology of ChinaChengdu 610000Sichuan ProvinceChina Department of Anesthesiology The Affiliated HospitalSchool of MedicineChengdu Women's and Children's Central HospitalUniversity of Electronic Science and TechnologyChengdu 610000Sichuan ProvinceChina

Although the lung injury caused by cardiopulmonary bypass(CPB)has been extensively investigated,the incidence and mortality of lung injury after CPB remain a prominent clinical *** poor outcome has been attributed to multifactorial etiology,including the systemic inflammatory response and ischemia reperfusion(I/R)injury during *** injury after CPB is a complex pathophysiological process and has many clinical manifestations of mild to severe *** is associated with *** alleviate this lung injury,interventions that address the pathogenesis are particularly *** review summarizes the pathogenesis,mechanism and treatment options of lung injury after CPB,such as lung protection with intralipid.

关键词： Cardiopulmonary bypass Lung injury Pathogenesis Treatment Intralipid Systemic inflammatory response syndrome

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汉语拼音教学困境及优化策略

教育探究 2024年第2期19卷 37-40页

作者：郑美月福建省福安市城阳亲民小学福建福安355000

汉语拼音是小学语文教学的基础性内容,也是关乎小学生未来学习发展的重要工具。然而,就目前教学现状而言,因受教师群体的教学水平和教育观念以及学生学习的自控能力等因素影响,汉语拼音教学效果并不理想。教师应积极探索有效的拼音教学... 详细信息

汉语拼音是小学语文教学的基础性内容,也是关乎小学生未来学习发展的重要工具。然而,就目前教学现状而言,因受教师群体的教学水平和教育观念以及学生学习的自控能力等因素影响,汉语拼音教学效果并不理想。教师应积极探索有效的拼音教学方法,让学生在情境教学中学习、在童谣中学习、在实践活动中学习、在多媒体互动中学习,从而提升学生汉语拼音学习水平,提高拼音教学的质量。

关键词：汉语拼音教学困境策略

Fine Particulate Matter Exposure Induces Toxicity by Regulating Nuclear Factor-κB/toll-like Receptor 4/myeloid Differentiation Primary Response Signaling Pathways in RAW264.7 Cells

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Biomedical and Environmental Sciences 2023年第5期36卷 458-462页

作者： zheng mei Zhu LU Yao LU Ting Ting QIN Peng LI Yu Qiu SHI Dong Fang The Central Laboratory Changchun Normal UniversityChangchun 130000JilinChina College of Life Science Changchun Normal UniversityChangchun 130000JilinChina Soybean Research Institute Jilin Academy Agricultural of ScienceChangchun 130033JilinChina

Global air pollution has become a major threat to human health. Daily variations in air pollution have been linked to increased risks of cardiopulmonaryrelated morbidity and mortality. In particular, fine particulate matter(PM) with an aerodynamic diameter ≤ 2.5 μm(PM2.5), which mostly originates from coal combustion, vehicle exhaust, and open sources in Chinese cities, is detrimental to health[1].Epidemiological and experimental investigations have demonstrated that long-term exposure to PM2.5, the most dangerous particulate in the Earth’s atmosphere, is a pivotal risk factor for cardiorespiratory diseases.

关键词： pollution mostly Earth

非小细胞肺癌组织PRRX1、VASH-1与微血管密度、临床病理参数和预后的关系研究

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现代生物医学进展 2024年第2期24卷 348-352,390页

作者：郑美玲赵冬陈慧敏朴仁女倪楠宁欣辽宁省金秋医院呼吸内科辽宁沈阳110016 辽宁省金秋医院老年医学科辽宁沈阳110016

目的:探讨非小细胞肺癌(NSCLC)组织配对相关同源框蛋白1(PRRX1)、血管抑制蛋白1(VASH-1)与微血管密度(MVD)、临床病理参数和预后的关系。方法:选择2018年1月至2020年1月辽宁省金秋医院行手术切除的156例NSCLC患者的癌组织及癌旁正常组... 详细信息

目的:探讨非小细胞肺癌(NSCLC)组织配对相关同源框蛋白1(PRRX1)、血管抑制蛋白1(VASH-1)与微血管密度(MVD)、临床病理参数和预后的关系。方法:选择2018年1月至2020年1月辽宁省金秋医院行手术切除的156例NSCLC患者的癌组织及癌旁正常组织标本。应用免疫组织化学染色法检测癌组织及癌旁组织PRRX1、VASH-1的阳性表达率,并进行MVD计数。比较PRRX1阳性表达组/阴性表达组、VASH-1阳性表达组/阴性表达组MVD计数。分析PRRX1、VASH-1与NSCLC患者病理参数的关系。随访3年,应用Kaplan-meier生存曲线分析PRRX1、VASH-1阳性/阴性表达与NSCLC患者预后的关系。结果:与癌旁组织相比,NSCLC患者癌组织PRRX1阳性表达率降低,VASH-1阳性表达率升高(Pmeier法分析显示,PRRX1阳性组3年总体生存率(OS)、3年无病生存率(DFS)高于PRRX1阴性组(P<0.05),VASH-1阴性组3年OS、3年DFS高于VASH-1阳性组(P<0.05)。结论:NSCLC患者的癌组织中PRRX1阳性表达率降低,VASH-1阳性表达率升高,与淋巴结转移、TNM分期及不良预后有关。

关键词：非小细胞肺癌 PRRX1 VASH-1 微血管密度临床病理特征预后

The novel usage of thiourea nitrate in aryl nitration

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Chinese Chemical Letters 2014年第1期25卷 87-89页

作者： Ge Meng mei-Lin zheng A-Qun zheng mei Wang Juan Shi School of Pharmacy Xi’an Jiaotong University School of Science Xi’an Jiaotong University

Thiourea nitrate （TN） was easily prepared from thiourea and nitric acid to explore its use as a new nitration reagent, Nitrations of various aromatic compounds utilizing TN in concentrated sulfuric acid were studied, TN could convert aromatic compounds to the corresponding nitrated derivatives with various abnormal yields under mild conditions. The results suggested that the reaction mechanism might be different from those of traditional nitration reagents.

关键词： Thiourea nitrate Nitration Thiourea Aromatic compounds

抑郁症共病慢性疼痛患者焦虑情绪与疼痛强度、疼痛敏感性的相关性研究

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神经疾病与精神卫生 2024年第3期24卷 170-176页

作者：郑梅高莉玲高桦陈苑苑杨德英谢雯朱翠珍安徽医科大学精神卫生与心理科学学院合肥230022 安徽医科大学附属心理医院合肥市第四人民医院精神科 230022 安徽医科大学附属心理医院合肥市第四人民医院焦虑抑郁科 230022 安徽医科大学附属心理医院合肥市第四人民医院科教科 230022

目的分析抑郁症共病慢性疼痛患者的焦虑情绪对疼痛强度和疼痛敏感性的影响。方法采用横断面调查法,选取2021年9月—2023年6月在安徽省精神卫生中心门诊就诊及住院治疗的108例抑郁症患者为研究对象,根据是否共病慢性疼痛将患者分为共病组... 详细信息

目的分析抑郁症共病慢性疼痛患者的焦虑情绪对疼痛强度和疼痛敏感性的影响。方法采用横断面调查法,选取2021年9月—2023年6月在安徽省精神卫生中心门诊就诊及住院治疗的108例抑郁症患者为研究对象,根据是否共病慢性疼痛将患者分为共病组(52例)和非共病组(56例)。同期在社会公开招募48名健康者纳入对照组。采用贝克焦虑量表(BAI)、贝克抑郁量表(BDI-Ⅱ)调查两组患者焦虑、抑郁症状。采用蒙特利尔认知评估量表(MoCA)、疼痛强度数值评定量表(PI-NRS)和疼痛敏感性问卷(PSQ)调查3组受试者认知功能、疼痛强度及疼痛敏感性。采用多重线性回归分析和受试者工作特征(ROC)曲线分析抑郁症共病慢性疼痛患者的焦虑情绪对疼痛强度和疼痛敏感性的影响。结果两组患者的MoCA总分低于对照组,共病组患者PSQ-total得分、PSQ-minor得分高于对照组,共病组患者BAI总分、躯体性焦虑得分、精神性焦虑得分、BDI-Ⅱ得分、PI-NRS得分高于非共病组,差异均有统计学意义(均P<0.05)。多重线性回归分析显示,抑郁症共病慢性疼痛患者的躯体性焦虑是疼痛强度的影响因素(P<0.01);精神性焦虑是PSQ-minor、PSQ-moderate和PSQ-total的影响因素(P<0.01)。ROC曲线分析显示,BAI总分预测抑郁症共病慢性疼痛患者疼痛程度和敏感性的ROC曲线下面积为0.916,最佳临界值为0.416,敏感度为0.885,特异度为0.875。结论抑郁症共病慢性疼痛患者的焦虑情绪与疼痛强度和疼痛敏感性呈正相关,焦虑情绪的严重程度是抑郁症共病慢性疼痛患者疼痛强度和疼痛敏感性的影响因素。

关键词：抑郁症慢性疼痛焦虑疼痛强度疼痛敏感性

基于组织学差异及自然美学需求的改良五瓣法内眦赘皮矫正术的临床效果观察

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中国医疗美容 2024年第2期14卷 15-19页

作者：曹宁郑美莲汤逸颜游彩莲林广民福建医科大学附属漳州市医院整形美容科福建漳州363000

目的观察应用改良五瓣法进行内眦赘皮矫正的临床效果。方法应用改良五瓣法矫正内眦赘皮患者53例,术前根据患者需求及内眦赘皮类型和程度进行设计,术中根据组织学差异解除内眦区域肌肉及纤维组织张力,随访观察治疗效果。结果53例患者术后... 详细信息

目的观察应用改良五瓣法进行内眦赘皮矫正的临床效果。方法应用改良五瓣法矫正内眦赘皮患者53例,术前根据患者需求及内眦赘皮类型和程度进行设计,术中根据组织学差异解除内眦区域肌肉及纤维组织张力,随访观察治疗效果。结果53例患者术后7天均一期愈合,获随访49例,其中内折型重睑14例,中间型重睑29例,外折型重睑6例,手术效果均符合术前要求,内眦角形态自然,瘢痕均不明显,1例因单侧矫正不足导致双侧不对称,总满意度98%。结论改良五瓣法内眦赘皮矫正术,设计简单灵活,术后瘢痕不显,内眦形态自然美观,手术效果符合当下人们的审美观念和种族认同,是治疗内眦赘皮的有效方法。

关键词：内眦赘皮改良五瓣法内眦赘皮矫正术美学效果评价组织学差异

Correlation of preoperative inflammatory factors and emotional disorders with postoperative delirium in patients with craniocerebral trauma

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World Journal of Psychiatry 2024年第7期14卷 1043-1052页

作者： Peng Cao Zhe-Yong Jia Tao zheng Tao mei Department of Neurosurgery Changde HospitalXiangya School of MedicineCentral South University(The First People’s Hospital of Changde City)Changde 415003Hunan ProvinceChina

BACKGROUND Traumatic brain injury(TBI)imposes a substantial societal and familial burden due to its high disability and fatality rates,rendering it a serious public health *** patients with TBI have poor treatment outcomes and are prone to postoperative delirium(POD),which affects their quality of *** has been linked to increased POD incidence in some studies,while others have found no *** To investigate the correlation of POD risk factors,preoperative inflammatory factors,and mood disorders in patients with *** We retrospectively collected data on the treatment of 80 patients with TBI from November 2021 to September *** were grouped as POD and non-POD,according to their POD status,and the general data of the two groups were *** factor levels were detected preoperatively,and the Hamilton Depression Scale(HAMD)and Hamilton Anxiety Scale(HAMA)were used to investigate the risk factors associated with POD in these *** regression was used to identify the independent risk *** Twenty-one patients(26.25%)developed POD,including 7,10,and 4 cases of the excitatory,inhibitory,and mixed types,*** were 59 cases(73.75%)in the non-POD *** with the non-POD group,the POD group had a significantly higher proportion of patients with low Glasgow Coma Scale(GCS)scores before admission,unilateral mydriasis,preoperative hemorrhagic shock,intraventricular hemorrhage(IVH),and postoperative hyperglycemic hyperosmolar disease(P<0.05).In the POD group,interleukin-6(IL-6),human tumor necrosis factor-α(TNF-α),myeloperoxidase levels,HAMA,and HAMD scores were higher than those in the non-POD group(all P<0.05).Logistic multivariate analysis showed that GCS score at admission,IVH,IL-6,TNF-α,HAMA,and HAMD were independent risk factors for POD in patients with TBI(P<0.05).CONCLUSION Low GCS score at admission,IVH,elevated IL-6 and TNF-α,other inflammatory indicators,anxiety,and depress

关键词： Inflammatory factors Mood disorders Traumatic brain injury Postoperative delirium Relevance Risk factor

Nuclear TAR DNA-binding protein 43 A new target for amyotrophic lateral sclerosis treatment

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Neural Regeneration Research 2013年第35期8卷 3284-3295页

作者： mei zheng Yujie Shi Dongsheng Fan Department of Neurology Peking University Third Hospital School of Pharmaceutical Sciences Peking University

Abnormal TAR DNA-binding protein 43 （TDP-43） inclusion bodies can be detected in the degen- erative neurons of amyotrophic lateral sclerosis. In this study, we induced chronic oxidative stress injury by applying malonate to cultured mouse cortical motor neurons. In the later stages of the malonate insult, TDP-43 expression reduced in the nuclei and transferred to the cytoplasm. This was accompanied by neuronal death, mimicking the pathological changes in TDP-43 that are seen in patients with amyotrophic lateral sclerosis. Interestingly, in the early stages of the response to malonate treatment, nuclear TDP-43 expression increased, and neurons remained relatively intact, without inclusion bodies or fragmentation. Therefore, we hypothesized that the increase of nuclear TDP-43 expression might be a pro-survival factor against oxidative stress injury. This hypothesis was confirmed by an in vitro transgenic experiment, in which overexpression of wild type mouse TDP-43 in cultured cortical motor neurons significantly reduced malonate-induced neuronal death. Our findings suggest that the loss of function of TDP-43 is an important cause of neuronal degen- eration, and upregulation of nuclear TDP-43 expression might be neuroprotective in amyotrophic lateral sclerosis.

关键词： neural regeneration neurodegenerative disease amyotrophic lateral sclerosis TAR DNA-bindingprotein 43 cortex motor neurons oxidative stress sodium malonate neuroprotection grants-supported paper neurodegeneration