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Journal of pharmaceutical Analysis 2012年第4期2卷 258-263页

作者： mei yang a,b , xin-jun xu a,b,chun-yan xie a,b , jie-yun huang a,b , zhi-sheng xie a,b , de-po yang a,b a school of pharmaceutical sciences, sun yat-sen university, guangzhou 510006, china b guangdong technology research center for advanced chinese medicine, guangzhou 510006, china school of pharmaceutical sciences Sun Yat-Sen University Guangzhou 510006 China. guangdong technology research center for advanced chinese medicine Guangzhou 510006 China.

An efficient method for the isolation and purification of 12,13-dihydroxyeuparin from Radix Eupatorii Chinensis by high speed counter-current chromatography (HSCCC) was established in this paper. The ether extracts of Radix Eupatorii Chinensis were purified by HSCCC with a solvent system of hexyl hydride-ethyl acetate-methanol-water (1:2:1:2, v/v/v/v). The upper phase was used as the stationary phase and the lower phase as the mobile phase. About 8.4 mg of 12, 13-dihydroxyeuparin was obtained from 200 mg of ether extracts from Radix Eupatorii Chinensis in one-step HSCCC separation, with the purity of 96.71%, as determined by HPLC. After methanol- water recrystallization, the purity of 12,13-dihydroxyeuparin reached 99.83%. Such a simple and effective method was fairly useful to prepare pure compound as reference substances for related study on Radix Eupatorii Chinensis.

关键词： Radix Eupatorii Chinensis High speed counter- current chromatography (HSCCC) 12,13-dihydroxyeuparin

Incidence and prognosis of olfactory and gustatory dysfunctions related to SARS-CoV-2 Omicron strain infection in china:A national multicenter survey of 35,566 individuals

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World Journal of Otorhinolaryngology-Head and Neck Surgery 2024年第2期10卷 113-120页

作者： Meng-Fan Liu Rui-Xia Ma Xian-bao Cao Hua Zhang Shui-Hong Zhou Wei-Hong Jiang yan Jiang Jing-Wu sun Qin-Tai yang xue-Zhong Li Ya-Nan sun Li Shi Min Wang Xi-Cheng Song Fu-Quan Chen Xiao-Shu Zhang Hong-Quan Wei Shao-Qing Yu Dong-Dong Zhu Luo ba zhi-Wei Cao xu-Ping Xiao xin Wei zhi-Hong Lin Feng-Hong Chen chun-Guang Shan Guang-Ke Wang Jing Ye Shen-Hong Qu Chang-Qing Zhao Zhen-Lin Wang Hua-bin Li Feng Liu Xiao-bo Cui sheng-Nan Ye Zheng Liu Yu xu Xiao Cai Wei huang Ru-xin Zhang Yu-Lin Zhao Guo-Dong Yu Guang-Gang Shi mei-Ping Lu yang Shen Yu-Tong Zhao Jia-Hong Pei Shao-bing xie Long-Gang Yu Ye-Hai Liu Shao-Wei Gu Yu-Cheng yang Lei Cheng Jian-Feng liu Graduate school of beijing university of chinese medicine BeijingChina department of Otorhinolaryngology Head and Neck Surgery China-Japan Friendship HospitalBeijingChina department of Otorhinolaryngology Head and Neck Surgery The First People's Hospital of YinchuanYinchuanChina department of Otorhinolaryngology The First People's Hospital of Yunnan ProvinceKunmingChina department of Otorhinolaryngology The First Affiliated Hospital of Xinjiang Medical UniversityUrumqiChina department of Otorhinolaryngology Head and Neck Surgery The First Affiliated Hospital of Zhejiang University School of MedicineHangzhouChina department of Otorhinolaryngology Head and Neck Surgery Xiangya Hospital Central South UniversityChangshaChina department of Otorhinolaryngology Head and Neck Surgery The Affiliated Hospital of Qingdao UniversityQingdaoChina department of Otorhinolaryngology Head and Neck Surgery The First Affiliated Hospital of USTCHefeiChina department of Otorhinolaryngology Head and Neck Surgery The Third Affiliated Hospital of Sun Yat-sen UniversityGuangzhouChina department of Otorhinolaryngology Head and Neck Surgery Qilu Hospital of Shandong UniversityJinanChina department of Otorhinolaryngology Head and Neck Surgery The Second Affiliated Hospital of Harbin Medical UniversityHarbinChina department of Otolaryngology The Second Hospital of Shandong UniversityShandong UniversityJinanChina department of Otorhinolaryngology Head and Neck Surgery Peking University People's HospitalBeijingChina department of Otorhinolaryngology Head and Neck Surgery Yantai Yuhuangding HospitalQingdao UniversityYantaiChina department of Otorhinolaryngology Head and Neck Surgery Xijing HospitalThe Fourth Military Medical UniversityXi'anChina Gansu Provincial center for Disease Control and Prevention LanzhouChina department of Otorhinolaryngology Head and Neck Surgery The First Affiliated Hospital of China Medical UniversityShenyangChina department of Otorhinolaryngology Head and Neck Surgery Tongji Hospit

Objective:This cross-sectional study aimed to determine the epidemiology of olfactory and gustatory dysfunctions related to COVID-19 in china.Methods:This study was conducted by 45 tertiary Grade-A hospitals in china.Online and offline questionnaire data were obtained from patients infected with COVID-19 between december 28,2022,and February 21,2023.The collected information included basic demographics,medical history,smoking and drinking history,vaccination history,changes in olfactory and gustatory functions before and after infection,and other postinfection symptoms,as well as the duration and improvement status of olfactory and gustatory disorders.Results:Complete questionnaires were obtained from 35,566 subjects.The overall incidence of olfactory and taste dysfunction was 67.75%.being female or being a cigarette smoker increased the likelihood of developing olfactory and taste dysfunction.Having received four doses of the vaccine or having good oral health or being a alcohol drinker decreased the risk of such dysfunction.before infection,the average olfactory and taste VAS scores were 8.41 and 8.51,respectively;after infection,they decreased to 3.69 and 4.29 and recovered to 5.83 and 6.55 by the time of the survey.The median duration of dysosmia and dysgeusia was 15 and 12 days,respectively,with 0.5%of patients having symptoms lasting for more than 28 days.The overall self-reported improvement rate was 59.16%.Recovery was higher in males,never smokers,those who received two or three vaccine doses,and those that had never experienced dental health issues,or chronic accompanying symptoms.Conclusions:The incidence of dysosmia and dysgeusia following infection with the SARS-CoV-2 virus is high in china.Incidence and prognosis are influenced by several factors,including sex,SARS-CoV-2 vaccination,history of head-facial trauma,nasal and oral health status,smoking and drinking history,and the persistence of accompanying symptoms.

关键词： epidemiologic studies incidence olfactory disorders prognosis SARS-CoV-2 taste disorders

Volatile components of Rhizoma Alpiniae Officinarum using three different extraction methods combined with gas chromatography-mass spectrometry

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Journal of pharmaceutical Analysis 2013年第3期3卷 215-220页

作者： zhi-sheng xie xin-jun xu chun-yan xie jie-yun huang mei yang de-po yang school of pharmaceutical sciences Sun Yat-Sen University guangdong technology research center for advanced chinese medicine Hainan bright Future pharmaceutical Co.Ltd

Volatile components from Rhizoma Alpiniae Officinarum were respectively extracted by three methods including hydrodistillation, headspace solid-phase microextraction （HS-SPME） and diethyl ether extraction. A total of 40 （hydrodistillation）, 32 （HS-SPME） and 37 （diethyl ether extraction） compounds were respectively identified by gas chromatography-mass spectrometry （GC/MS） and 22 compounds were overlapped, including β-farnesene, 7-muurolene, 2,6-dimethyl-6- （4-methyl-3-pentenyl）bicyclo[3.1.1]hept-2-ene, eucalyptol and cadina-1（10）, 4-diene and so forth, varying in relative contents. HS-SPME is fast, sample saving and solvent-free and it also can achieve similar profiles as those from hydrodistillation and solvent extraction. Therefore, it can be the priority for extracting volatile components from medicinal plants.

关键词： Rhizoma AlpiniaeOfficinarum Volatile components Hydrodistillation Headspace solid-phasemicroextraction Diethyl ether extraction Gas chromatography-mass spectrometry

Simultaneous determination of 12,13-dihydroxyeuparin and glycyrrhizic acid in yanyanfang mixture by high performance liquid chromatography

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Journal of pharmaceutical Analysis 2011年第3期1卷 219-222页

作者： zhi-sheng xie xin-jun xu chun-yan xie jie-yun huang mei yang Rui-Ming Li Xiao Chen school of pharmaceutical sciences Sun Yat-Sen University No. 132 East Waihuan Rd. Guangzhou Higher Education Mega Center Guangzhou 510006 China The First Affiliated Hospital Sun Yat-sen University Guangzhou 510080 China

A reversed phase high performance liquid chromatography （HPLC） method was established for the simultaneous determination of 12, 13-dihydroxyeuparin and glycyrrhizic acid in yanyanfang mixture. A Grace Apollo Cl8 column （250 mm × 4.6 mm, 5 μm） was used as the stationary phase and the mobile phase was composed of acetonitrile and aqueous phosphoric acid （0.2%, v/v）. Gradient elution was carried out at the flow rate of 1.0 mL/min and the column temperature was 30 ℃. An ultraviolet （UV） detector was used with a selected wavelength of 240 nm. Calibration curves were linear within the concentration range of 4.6-45.75 μg/mL for 12, 13-dihydroxyeuparin （r〉0.9999） and 106.9-1068.9μg/mL for glycyrrhizic acid （r〉0.9999）, respectively. Recoveries were 102.18% for 12, 13-dihydroxyeuparin and 101.17% for glycyrrhizic acid. The method developed could be applied to the simultaneous determination of 12, 13- dihydroxyeuparin and glycyrrhizic acid in yanyanfang mixture.

关键词： 12, 13-Dihydroxy-euparin Glycyrrhizic acid yanyanfang mixture High performance liquidchromatography

Preparative separation and purification of deoxyschizandrin from Schisandrae Sphenantherae Fructus by high-speed counter-current chromatography

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Journal of pharmaceutical Analysis 2013年第6期3卷 429-433页

作者： xin-Ying Li mei yang jie-yun huang Xiao-xue Yua Min-Qian Zhao zhi-Kun Liang zhi-sheng xie xin-jun xu school of pharmaceutical sciences Sun Yat-Sen University guangdong technology research center for advanced chinese medicine

A high-speed counter-current chromatography （HSCCC） method was successfully developed for the preparative separation and purification of deoxyschizandrin from Schisandrae Sphenantherae Fructus in one step. The purity of deoxyschizandrin was 98.5%, and the structure was identified by MS, UV and NMR. This method was simple, fast, convenient and appropriate to prepare pure compound as reference substances for related research on Schisandrae Sphenantherae Fmctus.

关键词： Schisandrae Sphe-nantherae Fructus High-speed counter-cur-rent chromatography（HSCCC） deoxyschizandrin

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深圳市新生儿脑卒中多中心现况调查

中国当代儿科杂志 2024年第5期26卷 450-455页

作者：时莉秀冯晋兴韦艳芳路欣茹张雨茜杨林颖何胜男陈佩娟韩静陈诚涂惠英余章斌黄进洁曾淑娟陈晚铃刘颖郭燕平毛姣玉李晓东张谦慎谢治利黄梅英晏昆山应尔雅陈俊王艳荣刘亚萍宋波刘华艳肖晓冬唐红王宇娜蔡茵莎龙琦许汉强王会战孙倩韩芳张瑞彪杨传忠窦蕾时会菊王瑞蒋萍无深圳市儿童医院新生儿科广东深圳518034 深圳市宝安区妇幼保健院新生儿科广东深圳518101 深圳市龙岗区妇幼保健院/汕头大学医学院龙岗妇幼临床学院新生儿科广东深圳518172 深圳市人民医院/暨南大学第二临床医学院/南方科技大学第一附属医院新生儿科广东深圳518020 深圳市龙岗中心医院/广州中医药大学深圳临床医学院新生儿科广东深圳518116 北京大学深圳医院新生儿科广东深圳518036 华中科技大学协和深圳医院新生儿科广东深圳518052 香港大学深圳医院新生儿科广东深圳518053 深圳市龙岗区人民医院新生儿科广东深圳518172 深圳市南山区妇幼保健院新生儿科广东深圳518067 深圳市第三人民医院新生儿科广东深圳518112 深圳市龙华区中心医院新生儿科广东深圳518110 深圳市盐田区人民医院新生儿科广东深圳518081 深圳远东妇产医院新生儿科广东深圳518002 深圳市第二人民医院新生儿科广东深圳518025 陆丰市人民医院新生儿科广东陆丰516500 惠阳三和医院新生儿科广东惠州518200 惠州市第三人民医院新生儿科广东惠州516100 深圳市妇幼保健院新生儿科广东深圳518028 南方科技大学医院新生儿科广东深圳518055 深圳市罗湖区人民医院新生儿科广东深圳518005 深圳新生儿数据协作网

目的总结深圳市新生儿脑卒中发病率、临床特征及预后等情况,提高脑卒中新生儿的早期诊治能力。方法由深圳市儿童医院牵头,收集2020年1月—2022年12月深圳新生儿数据协作网组织21家单位收治的新生儿脑卒中36例,分析深圳市新生儿脑卒中发... 详细信息

目的总结深圳市新生儿脑卒中发病率、临床特征及预后等情况,提高脑卒中新生儿的早期诊治能力。方法由深圳市儿童医院牵头,收集2020年1月—2022年12月深圳新生儿数据协作网组织21家单位收治的新生儿脑卒中36例,分析深圳市新生儿脑卒中发病率、临床特征、治疗、预后等情况。结果深圳市21家医院2020、2021、2022年新生儿脑卒中的发病率分别为1/15137、1/6060、1/7704。缺血性脑卒中占75%(27/36),男性患儿占64%(23/36)。86%(31/36)的患儿在生后3d内起病,53%(19/36)以惊厥起病。颅脑影像学结果显示,22例(61%)大脑左侧发生梗死,13例(36%)基底节梗死;12例完成磁共振血管成像检查,9例(75%)累及大脑中动脉。29例患儿完成脑电图检查,21例(72%)出现尖波,10例(34%)出现电发作。不同医院对症支持治疗不同。12例(33%)完善新生儿行为神经测定评分,平均得分(32±4)分。共随访27例患儿12月龄左右的预后情况,44%(12/27)的患儿预后良好。结论新生儿脑卒中主要为缺血性脑卒中,多以惊厥为首发症状,多累及大脑中动脉,脑电图多出现尖波,神经发育评分较低,以对症支持治疗为主,部分患儿预后不良。

关键词：脑卒中多中心研究新生儿

XELOX doublet regimen versus EOX triplet regimen as first-line treatment for advanced gastric cancer:An open-labeled,multicenter,randomized,prospective phase III trial(EXELOX)

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Cancer Communications 2022年第4期42卷 314-326页

作者： Xiao-Dong Zhu Ming-Zhu huang Yu-sheng Wang Wan-Jing Feng zhi-Yu Chen Yi-Fu He Xiao-Wei Zhang xin Liu Chen-Chen Wang Wen Zhang jie-Er Ying jun Wu Lei yang yan-Ru Qin Jian-Feng Luo Xiao-Ying Zhao Wen-Hua Li Zhe Zhang Li-xin Qiu Qi-Rong Geng Jian-Ling Zou jie-yun Zhang Hong Zheng xue-Feng Song Shu-sheng Wu Cheng-yan Zhang Zhe Gong Qin-Qin Liu Xiao-Feng Wang Qi xu Qi Wang Jian-mei Ji Jian Zhao Wei-Jian Guo department of Gastrointestinal Medical Oncology Fudan University Shanghai Cancer CenterShanghai 200032P.R.China department of Oncology Shanghai Medical CollegeFudan UniversityShanghai 200032P.R.China department of Gastroenterology Shanxi Cancer HospitalTaiyuanShanxi 030013P.R.China department of Medical Oncology The First Affiliated HospitalDivision of Life Science and MedicineUniversity of Science and Technology of ChinaHefeiAnhui 230031P.R.China department of Abdominal Medical Oncology Cancer Hospital of the University of Chinese Academy of Sciences(Zhejiang Cancer Hospital)Institute of Cancer and Basic Medicine(IBMC)Chinese Academy of SciencesHangzhouZhejiang 310005P.R.China department of Medical Oncology The First People’s Hospital of ChangzhouChangzhouJiangsu 213004P.R.China department of Gastroenterology Nantong Tumor HospitalNantongJiangsu 226006P.R.China department of Oncology Zhengzhou University First Affiliated HospitalZhengzhouHenan 450052P.R.China department of biostatistics School of Public HealthFudan UniversityShanghai 200032P.R.China department of medical oncology Cancer Hospital of Fudan UniversityMinhang BranchShanghai 200032P.R.China

background:There is no consensus on whether triplet regimen is better than doublet regimen in the first-line treatment of advanced gastric cancer(AGC).We aimed to compare the efficacy and safety of oxaliplatin plus capecitabine(XELOX)and epirubicin,oxaliplatin,plus capecitabine(EOX)regimens in treating AGC.Methods:This phase III trial enrolled previously untreated patients with AGC whowere randomly assigned to receive the XELOXor EOXregimen.The primary endpoint was non-inferiority in progression-free survival(PFS)for XELOX as compared with EOX on an intention-to-treat basis.Results:between April 10,2015 andAugust 20,2020,448AGCpatientswere randomized to receive XELOX(n=222)or EOX(n=226).The median PFS(mPFS)was 5.0 months(95%confidence interval[CI]=4.5-6.0 months)in the XELOX arm and 5.5 months(95%CI=5.0-6.0 months)in the EOX arm(hazard ratio[HR]=0.989,95%CI=0.812-1.203;P_(non-inferiority)=0.003).There was no significant difference inmedian overall survival(mOS)(12.0 vs.12.0months,P=0.384)or objective response rate(37.4%vs.45.1%,P=0.291)between the two groups.In patients with poorly differentiated adenocarcinoma and liver metastasis,the EOX arm had a significantly longer mOS(P=0.021)and a trend of longer mPFS(P=0.073)than the XELOX arm.The rate of grade 3/4 adverse events(AEs)was 42.2%(90/213)in the XELOX arm and 72.5%(156/215)in the EOX arm(P=0.001).The global health-related quality of life(QoL)score was significantly higher in the XELOX arm than in the EOX arm during chemotherapy.Conclusions:This non-inferiority trial demonstrated that the doublet regimen was as effective as the triplet regimen and had a better safety profile and QoL as a first-line treatment for AGC patients.However,the triplet regimen might have a survival advantage in patients with poorly differentiated adenocarcinoma and liver metastasis.

关键词： advanced gastric cancer chemotherapy XELOX doublet regimen EOX triplet regimen noninferiority quality of life phase III trial

Paired quasi-periodic pulsations of hard X-ray emission in a solar flare

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Science china(Physics,Mechanics & Astronomy) 2023年第5期66卷 195-206页

作者： Hai-sheng Zhao Dong Li Shao-Lin Xiong yan-Qiu Zhang yang Su Wei Chen Yi Zhao Xiao-bo Li Jia-Cong Liu Wen-Xi Peng Rui Qiao xin-Qiao Li Xiang-yang Wen Li-Ming Song Shi-jie Zheng xin-Ying Song Xiao-yun Zhao Yue huang Shuang-Nan Zhang Shuo Xiao Ce Cai Zheng-Hua An Can Chen Gang Chen Wei Chen yan-Qi Du Min Gao Ke Gong Dong-Ya Guo zhi-Wei Guo Jian-Jian He bin Li Chao Li Chao-yang Li Gang Li Jian-Hui Li Lu Li Qing-xin Li yan-Guo Li Jing Liang Xiao-Hua Liang Jin-Yuan Liao Xiao-Jing Liu Ya-Qing Liu Qi Luo Xiang Ma bin Meng Ge Ou Dong-Li Shi Jing-yan Shi Gong-xing sun Xi-Lei sun You-Li Tuo Chen-Wei Wang Hui Wang Jin Wang Jin-Zhou Wang Ping Wang Wen-Shuai Wang Hong Wu sheng-Lun xie yan-bing xu Yu-Peng xu Wang-Chen xue sheng yang Min Yao Jian-Ying Ye Qi-bin Yi Chao-Yue Zhang Da-Li Zhang Fan Zhang Fei Zhang Hong-mei Zhang Kai Zhang Peng Zhang Xiao-Lu Zhang Zhen Zhang Guo-Ying Zhao Shi-Yi Zhao Chao Zheng xing Zhou Yue Zhu Key Laboratory for Particle Astrophysics Institute of High Energy PhysicsChinese Academy of SciencesBeijing 100049China Purple Mountain Observatory Chinese Academy of SciencesNanjing 210023China university of chinese Academy of sciences Beijing 100049China department of Astronomy Beijing Normal UniversityBeijing 100875China school of Computing and Artificial Intelligence Southwest Jiaotong UniversityChengdu 611756China Physics and Space Science College China West Normal UniversityNanchong 637002China Key Laboratory of Stellar and Interstellar Physics and department of Physics Xiangtan UniversityXiangtan 411105China Institute of Astrophysics Central China Normal UniversityWuhan 430079China school of Physics Changchun University of Science and TechnologyChangchun 130022China College of Physics and Engineering Qufu Normal UniversityQufu 273165China College of Physics sciences&technology Hebei UniversityBaoding 071002China

We investigate high time resolution data obtained by the Gravitational wave high-energy Electromagnetic Counterpart All-sky Monitor(GECAM)during the flare event on 2022 April 21 at 01:52 UT.Several subpeaks with durations of 4-6 s have been detected in the hard X-ray precursor phase,and the key feature is that they appear in pairs and seem like double-peak struc-tures.These subpeaks are rarely observed in hard X-ray band and confirmed by the microwave obtained by Nobeyama Radio polarimeters(NoRP)and Radio Solar Telescope Network(RSTN).While an exponential function can describe the continuum component of the time profile from the precursor to part of the impulsive phase.The periods of quasi-periodic pulsations(QPPs)are detected to be about 7.3 and 12.8 s for the precursor and impulsive phase,respectively,with at least 95%confidence level.The paired QPPs are assumed to be double-peak QPPs and then the scenario of current loop coalescence model is found to be in good agreement with our observation.The precursor phase can be interpreted as the oscillating coalescence of two islands,while the impulsive phase can be interpreted as more islands to coalesce one by one to form larger islands.

关键词： solar flare QPPs loop coalescence circular-ribbon flare

A 14-year multi-institutional collaborative study of chinese pelvic floor surgical procedures related to pelvic organ prolapse

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chinese Medical Journal 2021年第2期134卷 200-205页

作者： zhi-Jing sun Xiu-Qi Wang Jing-He Lang Tao xu Yong-Xian Lu Ke-Qin Hua Jin-Song Han Huai-Fang Li Xiao-Wen Tong Ping Wang Jian-Liu Wang xin yang Xiang-Hua huang Pei-Shu Liu yan-Feng Song Hang-mei Jin Jing-yan xie Lu-Wen Wang Qing-Kai Wu Jian Gong yan Wang Li-Qun Wang Zhao-Ai Li Hui-Cheng xu zhi-jun Xia Li-Na Gu Qing Liu Lan Zhu department of Obstetrics and Gynecology Peking Union Medical College HospitalPeking Union Medical CollegeChinese Academy of Medical SciencesBeijing 100730China department of Obstetrics and Gynecology Graduate School of Peking Union Medical CollegeChinese Academy of Medical SciencesBeijing 100730China department of Epidemiology and biostatistics Institute of Basic Medical SciencesChinese Academy of Medical Sciences and School of Basic MedicinePeking Union Medical CollegeBeijing 100730China department of Obstetrics and Gynecology The Fourth Medical CenterChinese PLA General HospitalBeijing 100048China department of Gynecology Obstetrics and Gynecology Hospital of Fudan UniversityShanghai 200433China department of Obstetrics and Gynecology Peking University Third HospitalBeijing 100083China department of Obstetrics and Gynecology Tongji HospitalTongji UniversityShanghai 200065China department of Obstetrics and Gynecology West China Second HospitalSichuan UniversityKey Laboratory of Birth Defects and Related Diseases of Women and ChildrenMinistry of EducationChengduSichuan 061110China department of Obstetrics and Gynecology Peking University People’s HospitalBeijing 100044China department of Obstetrics and Gynecology The Second Hospital of Hebei Medical UniversityShijiazhuangHebei 075100China department of Obstetrics and Gynecology Qilu Hospital of Shandong UniversityJinanShandong 250002China department of Obstetrics and Gynecology 900 Hospital of the Joint Logistics TeamFuzhouFujian 350025China department of Obstetrics and Gynecology Women’s HospitalSchool of MedicineZhejiang UniversityHangzhouZhejiang 310000China department of Obstetrics and Gynecology Nanjing First HospitalNanjing Medical UniversityNanjingJiangsu 210006China department of Obstetrics and Gynecology The Third Affiliated Hospital of Zhengzhou UniversityZhengzhouHenan 450000China department of Obstetrics and Gynecology Shanghai Jiao Tong University Sixth HospitalShanghai 200300China department of Gyn

background:It has been a global trend that increasing complications related to pelvic floor surgeries have been reported over time.The current study aimed to outline the development of chinese pelvic floor surgeries related to pelvic organ prolapse(poP)over the past 14 years and investigate the potential influence of enhanced monitoring conducted by the chinese Association of Urogynecology since 2011.Methods:A total of 44,594 women with poP who underwent pelvic floor surgeries between October 1,2004 and September 30,2018 were included from 22 tertiary academic medical centers.The data were reported voluntarily and obtained from a database.We compared the proportion of each procedure in the 7 years before and 7 years after September 30,2011.The data were analyzed by performing Z test(one-sided).Results:The number of different procedures during October 1,2011-September 30,2018 was more than twice that during October 1,2004-September 30,2011.Regarding pelvic floor surgeries related to poP,the rate of synthetic mesh procedures increased from 38.1%(5298/13,906)during October 1,2004-September 30,2011 to 46.0%(14,107/30,688)during October 1,2011-September 30,2018,whereas the rate of non-mesh procedures decreased from 61.9%(8608/13,906)to 54.0%(16,581/30,688)(Z=15.53,PpoP,the rates of transvaginal placement of surgical mesh(TVM)procedures decreased from 94.1%(4983/5298)to 82.2%(11,603/14,107)(Z=20.79,Pbut the rate of laparoscopic sacrocolpopexy(LSC)procedures increased from 5.9%(315/5298)to 17.8%(2504/14,107).Conclusions:The rate of synthetic mesh procedures increased while that of non-mesh procedures decreased significantly.The rate of TVM procedures decreased while the rate of LSC procedures increased significantly.Trial registration number:NCT03620565,https://register.***.gov.

关键词： Laparoscopic sacrocolpopexy Pelvic organ prolapse Synthetic mesh Transvaginal placement of surgical mesh

chinese expert consensus on the management of hypertension in the very elderly

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Journal of Geriatric Cardiology 2016年第12期13卷 945-953页

作者： Jing LI Yi-xin HU Wen WANG Ning-Yuan FANG xin-Zheng LU Lin PI mei-Lin LIU Wei-Min LI yan-Fang LI Peng QU Qi HUA Qing HE Hai-Ying WU Yuan-Ming ZHANG Xiao-Ping CHEN Lu-Yuan CHEN Li FAN xing-sheng ZHAO zhi-Ming ZHU Yi-Nong JIANG Yi-Fang GUO Hong YUAN Ping-Jin GAO xin-Juan xu jun CAI Liang-Di xie xuan Wu Hospital Capital Medical University Beijing China chinese PLA General Hospital Beijing China chinese Academy of Medical Science Fuwai Hospital Beijing China Renji Hospital Medical College of Shanghai Jiao Tong University ShanghaL China Jiang Su Province People's Hospital Jiangsu China beijing Chui yang Liu Hospital Beijing China Peking university First Hospital Beijing China First Affiliated Hospital of Harbin Medical university Heilongjiang China beijing An Zhen Hospital Capital Medical University Beijing China The Second Affiliated Hospital of Dalian Medical university Liaoning China beijing Hospital Beijing China The First Hospital of xinjiang Medical university Xinjiang Uygur Autonomous Region China West china Hospital Sichuan University Sichuan China The People's Hospital of guangdong Province Guangdong China Inner Mongolia Autonomous Region People's Hospital Inner Mongolia Autonomous Region China Daping Hospital the Third Military Medical university Chongqing China The First Affiliated Hospital of Dalian Medical university Liaoning China Hebei Province People's Hospital Hebei China Xiangya Third Hospital Central South University Hunan China Shanghai Hypertension research Institute Shanghai China The First Hospital of Fujian Medical university Fujian China

population aging has become a major challenge for the healthcare in china. More than 23 million chinese are currently > 80 years,with an annual increase of 5%. The chinese population of 80 years or older is expected t... 详细信息

关键词：一致衰老老人高血压 Octogenarians