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Analysis of the anti-T2DM components in dichloromethane fraction of Schisandra sphenanthera and its mechanism

Traditional Medicine Research 2025年第1期10卷 27-43页

作者： Shi-Bo Feng Hai-Hui Jiang Hui-Li Kang Yi Jiang Hua-Wei Zhang xiao-mei Song Yu-Ze Li Wen-Li Huang Dong-Dong Zhang Chong Deng School of Pharmacy Shaanxi University of Chinese MedicineXianyang 712046China School of Pharmacy and Shaanxi Qinling Application Development and Engineering Center of Chinese Herbal Medicine Shaanxi University of Chinese MedicineXianyang 712046China Key Laboratory for Research and Development of“Qin Medicine”of Shaanxi Administration of Traditional Chinese Medicine Xianyang 712046China Shaanxi Key Laboratory of Research and Application of“Taibai Qi Yao” Xianyang 712046China

Background:The type 2 diabetes mellitus(T2DM)pharmacodynamic study of various parts of Schisandra sphenanthera was conducted in the previous stage,and it was found that dichloromethane extracted part(SDP)had a significant hypoglycemic ***,the components of SDP were analyzed,and the specific mechanism of its anti-T2DM was ***:We used a high-fat,high-sugar diet in combination with streptozotocin to induce a T2DM rat model,and the model rats were divided into two groups according to body weight and blood ***,oral glucose tolerance test,fasting blood glucose,low density lipoprotein cholesterol,superoxide dismutase,insulin,glycated hemoglobin,total cholesterol,nonesterified free fatty acids,alanine aminotransferase,high-density lipoprotein cholesterol,aspartate aminotransferase,malondialdehyde,and glutathione peroxidase were measured,organ indices were calculated,and pathological sections of pancreas and liver were *** 16S rRNA V3–V4 region of intestinal flora was sequenced to explore the effect of SDP on biochemical indicators and intestinal *** on the above indicators,the anti-T2DM mechanism of SDP in Schisandra sphenanthera was ***:After six weeks of administration,the biochemical indices of diabetic rats were diminished compared to the control *** SDP could significantly increase the gut microbialα-diversity index,resulting in significant changes in the flora of T2DM rats,with increased richness and diversity,reduced harmful flora,and significantly back-regulated the levels of acetic acid,propionic acid,and butyric ***:SDP can improve the symptoms associated with elevated blood glucose,dyslipidemia,elevated fasting insulin levels,and damaged glucose tolerance in *** against T2DM may be through the control of intestinal flora to normalize and exert anti-diabetic effect;its main active components may be lignans and terpenoids.

关键词： Schisandra sphenanthera T2DM intestinal flora HPLC

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The Products of Three Theta Functions and the General Cubic Theta Functions

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Acta Mathematica Sinica,English Series 2010年第6期26卷 1115-1124页

作者： xiao mei YANG Department of Mathematics East China Normal University Shanghai 200241 P. R. China

In this paper we establish two theta function identities with four parameters by the theory of theta functions. Using these identities we introduce common generalizations of Hirschhorn-Garvan-Borwein cubic theta functions, and also re-derive the quintuple product identity, one of Ramanujan＇s identities, Winquist＇s identity and many other interesting identities.

关键词： Jacobi theta function quintuple product identity Winquist's identity Ramanujan identity

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Plant enhanced degradation of phenanthrene in the contaminated soil

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Journal of Environmental Sciences 2006年第3期18卷 510-513页

作者： LIAO Min XIE xiao-mei School of Environmental and Resources Sciences Zhejiang University Hangzhou 310029 China

The degradative characteristics ofphenanthrene, microbial biomass carbon, plate counts ofheterotrophic bacteria and most probable number （MPN） of phenanthrene degraders in non-rhizosphere or rhizosphere soils with uninoculating or inoculating phenanthrene degraders were measured. At the initial concentration of 20 mg phenanthrene/kg soil, the half-lives of phenanthrene in uninoculated non-rhizosphere soil, uninoculated rhizosphere soil, inoculated non-rhizosphere soil, and inoculated rhizosphere soil were measured to be 81.5, 47.8, 15.1 and 6.4 d, respectively, and corresponding kinetic data fitted first-order kinetics. The highest degradation rate of phenanthrene was observed in inoculated rhizosphere soil. The degradative characteristics of phenanthrene were closely related to the effects of vegetation on soil microbial process. Vegetation could enhance the magnitude of rhizosphere microbial communities, microbial biomass content, and heterotrophic bacterial community, but barely influence those community components responsible for phenanthrene degradation. Results suggested that combination of vegetation and inoculation with degrading microorganisms of target organic contaminants was a better pathway to enhance degradation of the organic contaminants in soil.

关键词： phenanthrene bioremediation degradation

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Regulation of influenza virus infection by microRNAs

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Journal of Integrative Agriculture 2019年第7期18卷 1421-1427页

作者： ZOU Zhong GONG Wen-xiao HUANG Kun SUN xiao-mei JIN mei-lin State Key Laboratory of Agricultural Microbiology Huazhong Agricultural UniversityWuhan 430070P R.China College of Veterinary Medicine Huazhong Agricultural UniversityWuhan 430070P.R. China Key Laboratory of Development of Veterinary Diagnostic Products Ministry of Agriculture and Rural AffairsWuhan 430070P.R. China

MicroRNAs(miRNAs) are small noncoding RNAs of 18–25 nucleotides(nt) in length that represent key regulators of many normal cellular functions through the inhibition of mRNA translation and mRNA *** date,over 2 500 mature miRNAs have been identified in plants,animals and several types of *** A virus(IAV),which is a negativesense,single-stranded RNA virus,does not encode viral ***,IAV infection can alter the expression of host miRNAs,either in cell culture or in *** turn,host miRNAs regulate IAV life cycle through directly binding to IAV genome or indirectly targeting host factors associated with viral *** this review,we briefly summarized the role and significance of miRNA in relation to IAV *** the role of cellular miRNAs during viral infection may be beneficial to the identification of novel therapeutic strategies to block IAV replication.

关键词： microRNAs influenza A virus pathogenesis therapeutic strategies

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Microstructure and mechanical properties of Ti-Cu amorphous coating synthesized on pure Cu substrate by mechanical alloying method

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Rare Metals 2020年第10期39卷 1222-1228页

作者： Cheng Chen xiao-mei Feng Yi-fu Shen School of Mechanical and Power Engineering Nanjing Tech UniversityNanjing 211800China College of Materials Science and Technology Nanjing University of Aeronautics and AstronauticsNanjing 210016China

Mechanical alloying method was applied to fabricate coating with amorphous structure on pure Cu *** microstructure,the phase composition and the mechanical properties including microhardness and wear resistance of the coating were,respectively,characterized and *** results show that the coating is rough but *** has favorable adhesion to the *** coating is made up of an inner composite layer and an outer amorphous *** microhardness and the wear resistance of the pure Cu substrate are improved because of the bilayer *** formation mechanism of the coating was *** as-synthesized coating is considered to be effective to strengthen the surface of pure Cu substrate.

关键词： Coating Amorphous Mechanical alloying Surface reinforcement

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Boundedness of fractional integral operators on α-modulation spaces

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Applied Mathematics(A Journal of Chinese Universities) 2014年第3期29卷 339-351页

作者： WU xiao-mei CHEN Jie-cheng Xingzhi Colledge Zhejiang Normal University Department of Mathematics Zhejiang Normal University

In this paper, we obtain the boundedness of the fractional integral operators, the bilineax fractional integral operators and the bilinear Hilbert transform on α-modulation spaces.

关键词： α-modulation space fractional integral operator bilinear fractional integral operator bilinearHilbert transform.

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Synthesis,Crystal Structure and Bioactivity Evaluation of a Heterocyclic Compound

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Chinese Journal of Structural Chemistry 2020年第10期39卷 1892-1897,1745页

作者： ZHANG Peng ZHAO xiao-mei School of Pharmacy Shaanxi University of Chinese MedicineXianyangShaanxi 712046China

The heterocyclic compound 2-amino-N-(2-chloro-6-methylphenyl)thiazole-5-carboxamide(1),designed using 2-chloro-6-methylaniline(2)as the start material,was successfully obtained via multiple synthesis route and finally characterized by IR,1H NMR,and single-cystal X-ray *** select the suitable candidates for tissue regeneration,the induction activity of the compound on the dental pulp mesenchymal stem cells(DP-MSCs)was ***,the DP-MSCs cells were isolated and the cell colon formation ability was measured after compound treatment with cell colony *** that,the RT-PCT assay was conducted and the relative expression level of the genes related with cell osteogenesis and proliferation was further detected.

关键词： heterocycles X-ray DP-MSCs RT-PCT assay

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INVESTIGATION OF SPECIFIC AB_2 TYPE HYPERBRANCHED POLYESTERIFICATION REACTION WITH MONTE CARLO SIMULATION

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Chinese Journal of Polymer Science 2013年第3期31卷 371-371,372-376页

作者： Long Wang xiao-mei Yang 何学浩 Department of Polymer Science and Engineering School of Chemical Engineering and TechnologyTianjin University Department of Chemistry School of ScienceTianjin University

The AB2 type bulk polymerization of 3,5-bis（trimethylsiloxy）benzoyl chloride is studied by the reactive 3d bond fluctuation lattice model （3d-BFLM）. Through tuning the reactivity parameters, the experimental data are fitted well via an iterative dichotomy method. By using the optimized reactivity parameters, the number-average degree of polymerization and degree of branching obtained in simulation are very close to experimental data. Meanwhile, the information about the weightaverage degree of polymerization and the polydispersity index is provided, and the internal structural properties of hyperbranched polyesters are investigated. Simulation results demonstrate that the 3d-BFLM can be used to study specific hyperbranched polymerizations semi-quantitatively which is helpful to deep understand the kinetics of reactions and make predictions for specific polymerization systems.

关键词： Hyperbranched polyesterification Monte Carlo Iterative dichotomy method.

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Entanglement wedge cross-section with Gauss-Bonnet corrections and thermal quench

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Science China(Physics,Mechanics & Astronomy) 2021年第12期64卷 90-103页

作者： Yong-Zhuang Li Cheng-Yong Zhang xiao-mei Kuang School of Science Jiangsu University of Science and TechnologyZhenjiang 212003China Department of Physics and Siyuan Laboratory Jinan UniversityGuangzhou 510632China Center for Gravitation and Cosmology College of Physical Science and TechnologyYangzhou UniversityYangzhou 225009China

The entanglement wedge cross section(EWCS) is numerically investigated statically and dynamically in a five-dimension Ad SVaidya spacetime with Gauss-Bonnet(GB) corrections, focusing on two identical rectangular strips on the boundary. In the static case, EWCS increases as the GB coupling constant α increases and disentangles at small separation between two strips for smaller α. For the dynamic case, such a monotonic relationship between EWCS and α holds but the two strips no longer disentangle monotonically as in the static case. In the early thermal quenching stage, the disentanglement occurs at smaller αwith larger separations. Two strips then disentangle at larger separation with larger α as time evolves. Our results indicate that the higher-order derivative corrections, like the entanglement measure in the dual boundary theory, also have nontrivial effects on the EWCS evolution.

关键词： Ad S/CFT correspondence holographic entanglement entropy Gauss-Bonnet gravity entanglement wedge cross section

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The holographic fermions dual to massive gravity

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Science China(Physics,Mechanics & Astronomy) 2016年第10期59卷 49-57页

作者： Li-Qing Fang[[ xiao-mei Kuang Jian-Pin Wu School of Physics and Electronic Information Shangrao Normal UniversityShangrao 334000China Department of Physics and Astronomy Shanghai Jiao Tong UniversityShanghai 200240China Shanghai Key Laboratory of High Temperature Superconductors Shanghai 200444China Instituto de Fisica Pontificia Universidad Catolica de ValparaisoCasilla 4059ValparaisoChile Institute of Gravitation and Cosmology Department of PhysicsSchool of Mathematics and PhysicsBohai UniversityJinzhou 121013China

We investigate the properties of the spectral function of the fermionic operator in the field theory which is dual to a 4-dimensional massive gravity. We first study the Fermi surface and the dispersion relation in the dual boundary theory. We find that as the massive parameters is decreased, the Fermi momentum becomes lower and the low energy excitation near Fermi surface behaves more like non-Fermi liquid. Then, we introduce a dipole coupling in the bulk theory and explore the emergence of a gap in the fermionic spectral function. It is found that larger critical dipole coupling is needed to open the gap than that in Einstein gravity. Accordingly,in the field theory dual to massive gravity, it requires stronger negative dipole coupling to generate the marginal Fermi liquid.

关键词： holography duality AdS/CFT correspondence holographic fermions

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