Synthesis,Crystal Structure and Bioactivity Evaluation of a Heterocyclic Compound

作     者：ZHANG Peng ZHAO Xiao-Mei 张朋;赵小梅

作者机构：School of PharmacyShaanxi University of Chinese MedicineXianyangShaanxi 712046China 

出 版 物：《Chinese Journal of Structural Chemistry》 (结构化学（英文）)

年 卷 期：2020年第39卷第10期

页      面：1892-1897,1745页

核心收录：

学科分类：1007[医学-药学(可授医学、理学学位)] 081704[工学-应用化学] 07[理学] 08[工学] 0817[工学-化学工程与技术] 070303[理学-有机化学] 0703[理学-化学] 100701[医学-药物化学] 10[医学] 

主　　题：heterocycles X-ray DP-MSCs RT-PCT assay 

摘      要：The heterocyclic compound 2-amino-N-(2-chloro-6-methylphenyl)thiazole-5-carboxamide(1),designed using 2-chloro-6-methylaniline(2)as the start material,was successfully obtained via multiple synthesis route and finally characterized by IR,1H NMR,and single-cystal X-ray *** select the suitable candidates for tissue regeneration,the induction activity of the compound on the dental pulp mesenchymal stem cells(DP-MSCs)was ***,the DP-MSCs cells were isolated and the cell colon formation ability was measured after compound treatment with cell colony *** that,the RT-PCT assay was conducted and the relative expression level of the genes related with cell osteogenesis and proliferation was further detected.