检索结果-南通市图书馆

Degradation of kanamycin from production wastewater with high-concentration organic matrices by hydrothermal treatment

在线全文

学校读者我要写书评

暂无评论

Journal of Environmental Sciences 2020年第11期32卷 11-18页

作者： Mei Tang Fan Li Min Yang Yu Zhang State Key Laboratory of Environmental Aquatic Chemistry Research Center for Eco-Environmental SciencesUniversity of Chinese Academy of SciencesChinese Academy of ScienceBeijing 100085China Key Laboratory of Drinking Water Science and Technology Research Center for Eco-Environmental SciencesUniversity of Chinese Academy of SciencesChinese Academy of ScienceBeijing 100085China National Engineering Laboratory for Industrial Wastewater Treatment Research Center for Eco-Environmental SciencesChinese Academy of SciencesBeijing 100085China

It is known that many kinds of fermentative antibiotics can be removed by temperatureenhanced hydrolysis from production wastewater based on their easy-to-hydrolyze characteristics.However,a few aminoglycosides are hard to hydrolyze below 100℃ because of their stability expressed by high molecular energy gap(E).Herein,removal of hard-to-hydrolyze kanamycin residue from production wastewater by hydrothermal treatment at subcritical temperatures was investigated.The results showed the reaction temperature had a significant impact on kanamycin degradation.The degradation half-life(t1/2)was shortened by 87.17-fold when the hydrothermal treatment temperature was increased from 100℃ to 180℃.The t1/2 of kanamycin in the N2 process was extended by 1.08-1.34-fold compared to that of the corresponding air process at reaction temperatures of 140-180℃,indicating that the reactions during hydrothermal treatment process mainly include oxidation and hydrolysis.However,the contribution of hydrolysis was calculated as 75%-98%,which showed hydrolysis played a major role during the process,providing possibilities for the removal of kanamycin from production wastewaters with high-concentration organic matrices.Five transformation products with lower antibacterial activity than kanamycin were identified using UPLC-QTOF-MS analysis.More importantly,hydrothermal treatment could remove 97.9%of antibacterial activity(kanamycin EQ,1,109 mg/L)from actual production wastewater with CODCr around 100,000 mg/L.Furthermore,the methane production yield in anaerobic inhibition tests could be increased about 2.3 times by adopting the hydrothermal pretreatment.Therefore,it is concluded that hydrothermal treatment as a pretreatment technology is an efficient method for removing high-concentration hard-to-hydrolyze antibiotic residues from wastewater with high-concentration organic matrices.

关键词： Pharmaceutical wastewater Hydrothermal process Antibiotic antibacterial activity Hydrolysis Refractory organic wastewater

Macrophage membrane-mediated targeted drug delivery for treatment of spinal cord injury regardless of the macrophage polarization states

在线全文

学校读者我要写书评

暂无评论

Asian Journal of Pharmaceutical Sciences 2021年第4期16卷 459-470页

作者： Wei tang Yi Yang Ling Yang Mei Tang Ying Chen Chong Li Medical Research Institute College of Pharmaceutical SciencesSouthwest UniversityChongqing 400715China

Targeted delivery of therapeutics for spinal cord injury(SCI)has been a long-term challenge due to the complexity of the pathological procession.Macrophage,as an immune cell,can selectively accumulate at the trauma site after SCI.This intrinsic targeting,coupled with good immune-escaping capacity makes macrophages an ideal source of biomimetic delivery carrier for SCI.Worth mentioning,macrophages have multiple polarization states,which may not be ignored when designing macrophage-based delivery systems.Herein,we fabricated macrophage membrane-camouflaged liposomes(RM-LIPs)and evaluated their abilities to extend drug circulation time and target the injured spinal cord.Specially,we detected the expression levels of the two main targeted receptors Mac-1 and integrinα4 in three macrophage subtypes,including unactivated(M0)macrophages,classically activated(M1)macrophages and alternatively activated(M2)macrophages,and compared targeting of these macrophage membrane-coated nanoparticles for SCI.The macrophage membrane camouflage decreased cellular uptake of liposomes in RAW264.7 immune cells and strengthened binding of the nanoparticle to the damaged endothelial cells in vitro.RM-LIPs can prolong drug circulation time and actively accumulate at the trauma site of the spinal cord in vivo.Besides,RM-LIPs loaded with minocycline(RM-LIP/MC)showed a comprehensive therapeutic effect on SCI mice,and the anti-pyroptosis was found to be a novel mechanism of RM-LIP/MC treatment of SCI.Moreover,the levels of Mac-1 and integrinα4 in macrophages and the targeting of RM-LIP for SCI were found to be independent of macrophage polarization states.Our study provided a biomimetic strategy via the biological properties of macrophages for SCI targeting and treatment.

关键词： Spinal cord injury Pyroptosis Macrophage polarization Minocycline Actively targeted delivery

Elastic properties of disordered binary hcp-Fe alloys under high pressure: Effects of light elements

在线全文

学校读者我要写书评

暂无评论

ChemPhysMater 2023年第2期2卷 155-163页

作者： Zhenwei Niu Shuqiong Zeng Mei Tang Zaixiu Yang Laboratory for Extreme Conditions Matter Properties Southwest University of Science and TechnologyMianyang 621010China Fundamental Science on Nuclear Wastes and Environmental Safety Laboratory Southwest University of Science and TechnologyMianyang 621010China Key Laboratory of Science and Technology on Wear and Protection of Materials Lanzhou Institute of Chemical PhysicsChinese Academy of SciencesLanzhou 730000China

The effects of light elements on the elastic properties of disordered binary hcp-Fe alloys were investigated at high pressures using plane-wave density functional theory combined with the Monte Carlo special quasi-random structure method.We found that the increase in the O content in hcp-Fe had a more pronounced effect on the sound velocity than Si,S,and C.The longitudinal wave velocity was decreased by∼6%with 2%O content,which was a much greater decrease than the values of 0.6%and 2%induced by the same content of Si and S,respectively,under high pressures.Compared with the other three light elements,the longitudinal wave velocity of the Fe-C alloy exhibited the most gradual decreasing with increasing C content.In addition,the effects of different O and S contents on the anisotropy of hcp-Fe alloys strongly depended on the variation in pressure,whereas the pressure only slightly affected the anisotropy of Fe-Si alloy systems.

关键词： hcp-Fe alloys Elastic property Sound velocity Light elements

Intestinal microcirculation dysfunction in sepsis: pathophysiology, clinical monitoring, and therapeutic interventions

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Emergency Medicine 2022年第5期13卷 343-348页

作者： A-ling tang mei-jia Shen Guo-qiang Zhang Graduate School Beijing University of Chinese MedicineBeijing 100029China Graduate School Peking Union Medical CollegeBeijing 100730China Department of Emergency China-Japan Friendship HospitalBeijing 100029China

BACKGROUND:Intestinal microcirculation dysfunction is an important factor that causes poor prognosis in sepsis patients and is an important pathophysiological basis for the occurrence and development of sepsis.DATA RESOURCES:PubMed,Web of Science,and China National Knowledge Infrastructure(CNKI)were searched from inception to August 1,2021.The search was limited to the English language only.Two reviewers independently identified studies related to intestinal microcirculation dysfunction in sepsis.Exclusion criteria were duplicate articles according to multiple search criteria.RESULTS:Fifty articles were included,and most of them were animal studies.These studies reported pathogenesis,including endothelial dysfunction,leukocyte recruitment and adhesion,microthrombus formation,microcirculation hypoperfusion,and redistribution of intestinal wall blood flow.The monitoring methods of intestinal microcirculation were also diverse,including handheld microscopes,intravital microscopy(IVM),laser Doppler blood flow instruments,laser speckle contrast imaging,tissue refl ectance spectrophotometry,biochemical markers of intestinal ischemia,and histopathological examination.In view of the related pathogenesis of intestinal microcirculation disorder in sepsis,existing studies also have diff erent opinions on its treatment.CONCLUSIONS:Limited by monitoring,there are few clinical studies on intestinal microcirculation dysfunction in sepsis.Related research mainly focuses on basic research,but some progress has also been made.Therefore,this review may provide a reference for future research on intestinal microcirculation dysfunction in sepsis.

关键词： Sepsis Microcirculation Intestinal barrier Intestinal ischemia Review

Role of endothelial cells in the regulation of mechanical microenvironment on tumor progression

在线全文

学校读者我要写书评

暂无评论

Acta Mechanica Sinica 2021年第2期37卷 218-228页

作者： Changling Wei Mei Tang Zhiling Xu Li Yang Yonggang Lv Mechanobiology and Regenerative Medicine Laboratory Bioengineering CollegeChongqing UniversityChongqing 400044China Key Laboratory of Biorheological Science and Technology(Chongqing University) Ministry of EducationBioengineering CollegeChongqing UniversityChongqing 400044China

Majority of cancer patients die from cancer metastases.The physical stimulation produced by microenvironment regulates invasive behavior of cancer cells.Blood vessel is one of the“pathways”for cancer to metastasize,in which tumor cells need to cross the endothelial barrier for intravasation and extravasation.Tumor vessels are arranged in untraditional hierarchies and characterized with rupture,bend,swell and high permeability that are beneficial to intravasation of cancer cell.Abnormal vessels are accompanied with uneven blood flow,increased compression and interstitial fluid pressure.Meanwhile,excessive proliferation of tumor leads to low oxygen pressure in solid tumor.The aberrant tumor mechanical microenvironment changes the biochemical and mechanical signal transduction of endothelial cells and participates in tumor progression.Many current researches focus on how chemical signals regulate endothelial cell function while the role of physical cues is unclear.In this review,the role of endothelial cells in the regulation of shear stress,intercellular force,extracellular matrix and pressure on tumor progression is summarized.

关键词： Endothelial cells.Cancer metastases Mechanical microenvironment Matrix stiffness Shear stress

An efficient 3D cell-based discrete fracture-matrix flow model for digitally captured fracture networks

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

International Journal of Coal Science & Technology 2023年第5期10卷 87-106页

作者： Lei Sun mei Li Aly Abdelaziz Xuhai tang Quansheng Liu Giovanni Grasselli Department of Civil and Mineral Engineering University of TorontoTorontoON M5S 1A4Canada School of Civil Engineering Wuhan UniversityWuhan 430072China

Complex hydraulic fracture networks are critical for enhancing permeability in unconventional reservoirs and mining indus-tries.However,accurately simulating the fluid flow in realistic fracture networks(compared to the statistical fracture net-works)is still challenging due to the fracture complexity and computational burden.This work proposes a simple yet efficient numerical framework for the flow simulation in fractured porous media obtained by 3D high-resolution images,aiming at both computational accuracy and efficiency.The fractured rock with complex fracture geometries is numerically constructed with a cell-based discrete fracture-matrix model(DFM)having implicit fracture apertures.The flow in the complex fractured porous media(including matrix flow,fracture flow,as well as exchange flow)is simulated with a pipe-based cell-centered finite volume method.The performance of this model is validated against analytical/numerical solutions.Then a lab-scale true triaxial hydraulically fractured shale sample is reconstructed,and the fluid flow in this realistic fracture network is simu-lated.Results suggest that the proposed method achieves a good balance between computational efficiency and accuracy.The complex fracture networks control the fluid flow process,and the opened natural fractures behave as primary fuid pathways.Heterogeneous and anisotropic features of fluid flow are well captured with the present model.

关键词： Fractured porous medium-Flow simulation Digital image Cell-based DFM Finite volume method

Synthesis of Piperazic Acid-Containing Cyclodepsipeptide Core of Verucopeptin

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Chinese Journal of Chemistry 2023年第17期41卷 2077-2081页

作者： Yuanjun Sun Wenhao tang mei Wang Huxin Ni Ya-Qiu Long Laboratory of Medicinal Chemical Biology College of Pharmaceutical SciencesJiangsu Province Engineering Research Centerof Precision Diagnostics and Therapeutics DevelopmentSoochow UniversitySuzhouJiangsu 215123China

Comprehensive SummaryChemically,N1 nitrogen of piperazic acid is more nucleophilic than N2 nitrogen,but amide bonds predominantly formed at N2 nitrogen are prevalent in piperazic acid-containing natural products,with only one exception of sanglifehrin.Thus two orthogonal protecting groups of nitrogen are often employed to realize selective coupling of N2 nitrogen,resulting in increased synthetic steps and low synthetic efficiency.However,we develop selective deprotection of N2-Cbz from the N1,N2-diCbz-piperazic acid-containing peptide to form the N2 amide exclusively,avoiding the tedious orthogonal protection strategy which is commonly applied when the easily-accessible N1,N2-diCbz-piperazic acid is used as the synthetic module.We employ this selective-deprotection strategy to achieve an efficient synthesis of piperazic acid-containing cyclodepsipeptide core of verucopeptin with an overall yield of 21%from commercially/readily available building blocks.

关键词： Natural products Piperazic acid Verucopeptin Total synthesis Regioselectivity

Effects of surfactants on the combined toxicity of TiO_2 nanoparticles and cadmium to Escherichia coli

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Environmental Sciences 2018年第12期30卷 126-133页

作者： mei Li Jianchuan Pei Xiaomeng tang Xiaoli Guo School of Environmental and Resource Sciences Zhejiang A & F University

The combined ecological toxicity of TiO2 nanoparticles（nano-TiO2） and heavy metals has been paid more attention. As the common pollutants in water environment, surfactants could affect the properties of nanoparticles and heavy metals, and thus further influence the combined toxicity of nano-TiO2 and heavy metals. In this study, the effects of sodium dodecyl benzene sulfonate（SDBS） and Tween 80 on the single and combined toxicities of Cd2＋ and nano-TiO2 to Escherichia coli（E. coli） were examined, and the underlying influence mechanism was further discussed. The results showed both SDBS and Tween 80 enhanced the toxicity of Cd2＋ to E. coli in varying degrees. The reaction of SDBS and Cd2＋ could increase the outer membrane permeability and the bioavailability of Cd, while Tween 80 itself could enhance the outer membrane permeability. The combined toxicity of nano-TiO2 and Cd2＋ to E. coli in absence of surfactant was antagonistic because of the adsorption of Cd2＋ to nanoTiO2 particles. However, in the presence of SDBS, both SDBS and nano-TiO2 influenced the toxicity of Cd2＋ , and also SDBS could adsorb to nano-TiO2 by binding to Cd2＋ . The combined toxicity was reduced at Cd2＋ lower than 4 mg/L and enhanced at Cd2＋ higher than 4 mg/L under multiple interactions. Tween 80 enhanced the combined toxicity of nano-TiO2 and Cd2＋ by increasing the outer membrane permeability. Our study firstly elucidated the effects of surfactants on the combined toxicity of nano-TiO2 and Cd2＋ to bacteria, and the underlying influencing mechanism was proposed.

关键词： Nano-TiO2 Heavy metal Surfactant Combined toxicity Bacteria

SwinFusion: Cross-domain Long-range Learning for General Image Fusion via Swin Transformer

在线全文

学校读者我要写书评

暂无评论

IEEE/CAA Journal of Automatica Sinica 2022年第7期9卷 1200-1217页

作者： Jiayi Ma Linfeng tang Fan Fan Jun Huang Xiaoguang mei Yong Ma The authors are with the Electronic Information School Wuhan UniversityWuhan 430072China IEEE

This study proposes a novel general image fusion framework based on cross-domain long-range learning and Swin Transformer,termed as SwinFusion.On the one hand,an attention-guided cross-domain module is devised to achieve sufficient integration of complementary information and global interaction.More specifically,the proposed method involves an intra-domain fusion unit based on self-attention and an interdomain fusion unit based on cross-attention,which mine and integrate long dependencies within the same domain and across domains.Through long-range dependency modeling,the network is able to fully implement domain-specific information extraction and cross-domain complementary information integration as well as maintaining the appropriate apparent intensity from a global perspective.In particular,we introduce the shifted windows mechanism into the self-attention and cross-attention,which allows our model to receive images with arbitrary sizes.On the other hand,the multi-scene image fusion problems are generalized to a unified framework with structure maintenance,detail preservation,and proper intensity control.Moreover,an elaborate loss function,consisting of SSIM loss,texture loss,and intensity loss,drives the network to preserve abundant texture details and structural information,as well as presenting optimal apparent intensity.Extensive experiments on both multi-modal image fusion and digital photography image fusion demonstrate the superiority of our SwinFusion compared to the state-of-theart unified image fusion algorithms and task-specific alternatives.Implementation code and pre-trained weights can be accessed at https://***/Linfeng-tang/SwinFusion.

关键词： Cross-domain long-range learning image fusion Swin transformer