Role of endothelial cells in the regulation of mechanical microenvironment on tumor progression
作者机构：Mechanobiology and Regenerative Medicine LaboratoryBioengineering CollegeChongqing UniversityChongqing 400044China Key Laboratory of Biorheological Science and Technology(Chongqing University)Ministry of EducationBioengineering CollegeChongqing UniversityChongqing 400044China
出 版 物：《Acta Mechanica Sinica》 (力学学报（英文版）)
年 卷 期：2021年第37卷第2期
页 面：218-228页
核心收录：
学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 0802[工学-机械工程] 0701[理学-数学] 10[医学] 0801[工学-力学（可授工学、理学学位）] 0702[理学-物理学]
基 金：This work was supported in part by the National Natural Science Foundation of China(Grants Nos.11872134 and 12072054) the Natural Science Foundation of Chongqing,China(Grant cstc2020jcyj-msxmX0035).
主 题：Endothelial cells.Cancer metastases Mechanical microenvironment Matrix stiffness Shear stress
摘 要：Majority of cancer patients die from cancer metastases.The physical stimulation produced by microenvironment regulates invasive behavior of cancer cells.Blood vessel is one of the“pathwaysfor cancer to metastasize,in which tumor cells need to cross the endothelial barrier for intravasation and extravasation.Tumor vessels are arranged in untraditional hierarchies and characterized with rupture,bend,swell and high permeability that are beneficial to intravasation of cancer cell.Abnormal vessels are accompanied with uneven blood flow,increased compression and interstitial fluid pressure.Meanwhile,excessive proliferation of tumor leads to low oxygen pressure in solid tumor.The aberrant tumor mechanical microenvironment changes the biochemical and mechanical signal transduction of endothelial cells and participates in tumor progression.Many current researches focus on how chemical signals regulate endothelial cell function while the role of physical cues is unclear.In this review,the role of endothelial cells in the regulation of shear stress,intercellular force,extracellular matrix and pressure on tumor progression is summarized.
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