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Correlations between hippocampal functional connectivity,structural changes,and clinical data in patients with relapsing-remitting multiple sclerosis:a case-control study using multimodal magnetic resonance imaging

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Neural Regeneration Research 2022年第5期17卷 1115-1124页

作者： Xin-Quan Gu Ying Liu Jie-Bing Gu Lin-Fang Li Ling-Ling Fu Xue-mei han China-Japan Union Hospital of Jilin University ChangchunJilin ProvinceChina First Department of Neurology China-Japan Union Hospital of Jilin UniversityChangchunJilin ProvinceChina Cardre’s Ward Changchun Central hospitalChangchunJilin ProvinceChina

Multiple sclerosis is associated with structural and functional brain alterations leading to cognitive impairments across multiple domains including attention,memory,and the speed of information *** hippocampus,which is a brain important structure involved in memory,undergoes microstructural changes in the early stage of multiple *** this study,we analyzed hippocampal function and structure in patients with relapsing-remitting multiple sclerosis and explored correlations between the functional connectivity of the hippocampus to the whole brain,changes in local brain function and microstructure,and cognitive function at *** retrospectively analyzed data from 20 relapsing-remitting multiple sclerosis patients admitted to the Department of Neurology at the China-Japan Union Hospital of Jilin University,China,from April 2015 to November *** healthy volunteers were recruited as the healthy control *** participants were evaluated using a scale of extended disability status and the Montreal cognitive assessment within 1 week before and after head diffusion tensor imaging and functional magnetic resonance *** with the healthy control group,the patients with relapsing-remitting multiple sclerosis had lower Montreal cognitive assessment scores and regions of simultaneously enhanced and attenuated whole-brain functional connectivity and local functional connectivity in the bilateral *** diffusion tensor imaging data showed that,compared with the healthy control group,patients with relapsing-remitting multiple sclerosis had lower hippocampal fractional anisotropy values and higher mean diffusivity values,suggesting abnormal hippocampal *** left hippocampus whole-brain functional connectivity was negatively correlated with the Montreal cognitive assessment score(r=-0.698,P=0.025),and whole-brain functional connectivity of the right hippocampus was negatively correlated with extended disability stat

关键词： cognitive impairment diffusion tensor imaging fractional anisotropy functional connectivity functional magnetic resonance imaging hippocampus local consistency low frequency oscillation amplitude mean diffusivity multiple sclerosis neurodegeneration

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Prevalence and Factors Associated with Female Sexual Dysfunction in Beijing, China

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Chinese Medical Journal 2017年第12期130卷 1389-1394页

作者： Wen-Jia Lou Bo Chen Lan Zhu Shao-mei han Tao Xu Jing-He Lang Lei Zhang Department of Obstetrics and Gynecology Peking Union Medical College Hospital Chinese Academy of Medical Sciences Beijing 100730 China Department of Clinical Medicine Peking Union Medical College Chinese Academy of Medical Sciences Beijing 100005 China Department of Epidemiology and Statistics Institute of Basic Medical Sciences Peking Union Medical College Chinese Academy of Medical Sciences and School of Basic Medicine Beijing 100005 China

Background： Female sexual dysfunction （FSD） is a highly prevalent and often underestimated problem. However, large-scale, population-based epidemiological surveys of FSD are scarce in China. The present study was conducted to evaluate the prevalence and the potential risk factors of FSD across a selection of social groups in Beijing, China, based on the Female Sexual Function Index （FSFI）. Methods： A cross-sectional study based on the multiple-stage cluster sampling was performed with adult women throughout the Dongcbeng and Shunyi districts of Beijing. The Chinese version of FSFI was used, as well as questions on demographic characteristics, the disease-related context, and social relationships. Results： A total of 6000 consecutive women entered this study, with an actual response from 5024 women, corresponding to a response rate of 83.7%. A total of 4697 （78.3%） questionnaires were effective. The prevalence of adult FSD in Beijing was 2973 （63.3%） using a score of 26.55 as the boundary value, whereas the total mean FSFI score was 23.92 ~ 6.37. However, 1423 （30.3%） women did not seek help. By multivariate logistic regression analysis, the possible potential risk factors included age （odds ratio [OR] = 1.051 ）, dissatisfaction with the spouse＇s sexual ability （OR = 3.520）, poor marital affection （OR = 2.087）, spouse sexual difficulties （OR = 1.720）, dissatisfaction with married life （OR = 1.476）, living in a rural area （OR = 1.292）, chronic pelvic pain （OR = 1.261）, chronic disease （OR = 1.534）, previous pelvic surgery （OR = 1.605）, vaginal delivery （OR = 2.285）, lower education （OR = 3.449） and postmenopausal （OR = 3.183）. Conclusions： As suggested by the FSFI scores, female sexual problems are highly prevalent in Beijing. Dissatisfaction with the spouse＇s sexual ability, poor marital affection, sexual difficulties of the spouse, dissatisfaction with the marriage, rural life, CPP, and postmenopausal were conceivable risk factors for FSD in Beijing women.

关键词： Beijing, Female Sexual Dysfunction Female Sexual Function Index Potential Risk Factors Prevalence

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甘肃省临夏州2型糖尿病患者糖尿病视网膜病变影响因素分析

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河北北方学院学报（自然科学版） 2024年第4期40卷 10-15页

作者：段红涛董祖焱孔宝焕韩梅天津市眼科医院、南开大学附属眼科医院、天津医科大学眼科临床学院、天津市眼科学与视觉科学重点实验室、天津市眼科研究所天津300020 临夏州人民医院眼科甘肃临夏731100

目的分析甘肃省临夏回族自治州糖尿病(diabetes mellitus,DM)患者中糖尿病视网膜病变(diabetic retinopathy,DR)患病率及影响因素。方法选取甘肃省临夏回族自治州人民医院确诊的230例2型DM患者作为研究对象,开展横断面现场调查。通过调... 详细信息

目的分析甘肃省临夏回族自治州糖尿病(diabetes mellitus,DM)患者中糖尿病视网膜病变(diabetic retinopathy,DR)患病率及影响因素。方法选取甘肃省临夏回族自治州人民医院确诊的230例2型DM患者作为研究对象,开展横断面现场调查。通过调查问卷记录患者性别、年龄、民族、身高体质量指数(BMI)、收缩压、舒张压、空腹血糖及血脂水平等临床资料。所有患者接受详细的眼底检查,确诊为DR的患者,同时行眼底荧光素血管造影(fluorescein fundus angiography,FFA)检查。根据有无DR分为NDR组和DR组,比较2组患者的临床资料、饮食偏好,并通过Logistic回归分析DR发病的危险因素。结果230例DM患者中,DR组患者102例,NDR组患者128例。2组DM病程、DM病程大于10年、吸烟史、空腹血糖、总胆固醇、LDL比较差异有统计学意义(P0.05)。NDR组与DR组在饮食偏好方面有显著差异(P<0.05)。Logistic回归分析显示DM病程大于10年和LDL的OR值分别为2.470(P=0.003)、1.607(P=0.002)。结论临夏回族自治州DR发病率无种族差异。DM病程大于10年、LDL是临夏回族自治州2型DM患者发生DR的主要危险因素。

关键词：糖尿病视网膜病变 DM病程 LDL

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Inflammation and atherosclerosis: signaling pathways and therapeutic intervention

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Signal Transduction and Targeted Therapy 2022年第5期7卷 1467-1490页

作者： Peng Kong Zi-Yang Cui Xiao-Fu Huang Dan-Dan Zhang Rui-Juan Guo mei han Department of Biochemistry and Molecular Biology College of Basic MedicineKey Laboratory of Medical Biotechnology of Hebei ProvinceKey Laboratory of Neural and Vascular Biology of Ministry of EducationHebei Medical UniversityShijiazhuang 050017PR China

Atherosclerosis is a chronic inflammatory vascular disease driven by traditional and nontraditional risk ***-wide association combined with clonal lineage tracing and clinical trials have demonstrated that innate and adaptive immune responses can promote or quell *** signaling pathways,that are associated with the inflammatory response,have been implicated within atherosclerosis such as NLRP3 inflammasome,toll-like receptors,proprotein convertase subtilisin/kexin type 9.

关键词： NLRP3 atherosclerosis clinical

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Content analysis of systematic reviews on effectiveness ofTraditional Chinese Medicine

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Journal of Traditional Chinese Medicine 2013年第2期33卷 156-163页

作者： Junwen Wang Meng Cui Hongguan Jiao Yuanyuan Tong Jun Xu Yingkai Zhao mei han Jianping Liu Institute of Information onTraditional Chinese Medicine China Academy of Chinese Medical SciencesCACMS Center for Evidence Based Chinese Medicine Beijing University of Chinese Medicine

OBJECTIVE:To evaluate evidence for the efficacy of Traditional Chinese Medicine(TCM) in systematic ***:Chinese(TCM Periodical Literature Database,Chinese Biological Medicine database,Chinese Medical Current Contents,China Hospital Knowledge Database journal fulltext database,Virtual Machining and Inspection System,and Wanfang) and English(Cochrane Database of Systematic Reviews,PubMed and Embase) databases were ***:Three thousand,nine hundred and fifty-five articles were initially identified,606 of which met the inclusion criteria,including 251 in English(83 from the Cochrane Database) and 355 in *** number of articles published each year increased between 1989 and *** disease was the most studied target *** measures included TCM preparations(177 articles),acupuncture(133 articles) and combinations of TCM and Western Medicine(38 articles).Control measures included positive medical(177 articles),basic treatment(100 articles),placebo(219 articles),and blank and mutual(107 articles).All articles included at least one reference;the greatest number was *** of 10 articles with high quality references demonstrated curative effectsagainst target diseases including upper respiratory tract infection,dementia and *** that were not recommended were tripterygium for rheumatoid arthritis and TCM syndrome differentiation for pediatric *** 10.4% of the studies,the authors concluded that the intervention had a curative *** assessors agreed with the authors' conclusions in 88.32% of cases,but rejected 8.94%(54 articles).CONCLUSION:1) Training in systematic review methods,including topic selection,study design,methods and technology,should be improved.2) Upper respiratory tract infection,dementia and depression may become the predominant diseases treated by TCM,and the corresponding interventions could be developed into practical applications.3) Use of non-recommended inter

关键词： Evidence-based medicine Systematicreview Traditional Chinese Medicine Curative ef-fect Content analysis

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2型糖尿病患者非酒精性脂肪肝及肝纤维化与骨骼肌质量关系的研究

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中华内分泌代谢杂志 2024年第8期40卷 660-668页

作者：郭馨远韩梅马邓荣昝晓晖赵阳婷吕小羽李凯陈重阳王亚雯刘靖芳兰州大学第一临床医学院兰州兰州大学第一医院内分泌科兰州

目的探讨2型糖尿病患者(type 2 diabetes mellitus, T2DM)非酒精性脂肪性肝病(non-alcoholic fatty liver disease, NAFLD)及肝纤维化与骨骼肌质量之间的关系。方法 2022年4月至2023年5月兰州大学第一医院内分泌科确诊的685例T2DM患者... 详细信息

目的探讨2型糖尿病患者(type 2 diabetes mellitus, T2DM)非酒精性脂肪性肝病(non-alcoholic fatty liver disease, NAFLD)及肝纤维化与骨骼肌质量之间的关系。方法 2022年4月至2023年5月兰州大学第一医院内分泌科确诊的685例T2DM患者根据是否伴有NAFLD分为NAFLD组和Non-NAFLD组, NAFLD人群根据天冬氨酸转氨酶(aspartate aminotransferase, AST)/丙氨酸转氨酶(alanine aminotransferase, ALT)水平分为肝纤维化和无肝纤维化组, 比较各组之间四肢骨骼肌质量(appendicular skeletal muscle mass, ASM)、四肢骨骼肌质量指数(appendicular skeletal muscle mass index, ASMI)水平及肌肉质量减少患病率的差异。二元logistic回归分析T2DM患者ASMI与NAFLD、肝纤维化的独立相关性。结果男性T2DM患者NAFLD组ASMI水平低于Non-NAFLD组, 肌肉质量减少患病率高于Non-NAFLD组;女性NAFLD组ASM、ASMI水平均低于Non-NAFLD组, 肌肉质量减少患病率高于Non-NAFLD组。男性、女性T2DM患者ASMI水平与NAFLD患病风险独立负相关(OR=-0.696, 95%CI 0.579～0.837;OR=-0.757, 95%CI 0.629～0.911)。NAFLD患者肝纤维化组ASM、ASMI水平低于无肝纤维化组;肌肉质量减少患病率差异无统计学意义。男性NAFLD患者肝纤维化组ASM水平、ASMI水平低于无肝纤维化组, 女性患者ASM及ASMI水平组间差异无统计学意义。男性NAFLD患者ASMI水平与肝纤维化患病风险独立负相关(OR=-0.726, 95%CI 0.537～0.983), 女性患者ASMI水平与肝纤维化患病风险无相关性。结论男性或女性T2DM患者肌肉质量减少与T2DM患者NAFLD患病风险独立相关。男性T2DM患者肌肉质量减少与其肝脏纤维化患病风险独立相关。

关键词：糖尿病, 2型四肢骨骼肌质量非酒精性脂肪肝肝纤维化

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Heat Capacity and Thermodynamic Properties of Crystalline 2-Chloro- N, N-dimethylnicotinamide

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Chinese Journal of Chemistry 2005年第11期23卷 1490-1494页

作者： SUN, Xiao-Hong LIU, Yuan-Fa TAN, Zhi-Cheng JI, Peng-Ju WANG, mei-han College of Chemical Engineering Chemical Research Institute Northwest University Xi'an Shaanxi 710069 China Department of Chemistry Northwest University Xi'an Shaanxi 710069 China Thermochemistry Laboratory Dalian Institute of Chemical Physics Chinese Academy of Sciences Dalian Liaoning 116023 China

Low-temperature heat capacities of 2-chloro-N,N-dimethylnicotinamide were precisely measured with a high-precision automated adiabatic calorimeter over the temperature range from 82 K to 380 K. The compound was observed to melt at （342.15±0.04） K. The molar enthalpy AfusionHm, and entropy of fusion, △fusionSm, as well as the chemical purity of the compound were determined to be （21387±7） J·mol^-1, （62.51±0.01） J·mol^-1·K^-1, （0.9946±0.0005） mass fraction, respectively. The extrapolated melting temperature for the pure compound obtained from fractional melting experiments was （342.25±0.024） K. The thermodynamic function data relative to the reference temperature 298.15 K were calculated based on the heat capacity measurements in the temperature range from 82 to 325 K. The thermal behavior of the compound was also investigated by different scanning calorimetry.

关键词： 2-chloro-N,N-dimethylnicotinamide heat capacity adiabatic calorimetry

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Construction of the Core of Pseudolaric Acid A and Mechanistic Studies on Intramolecular [4+3] Cycloaddition

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Chinese Chemical Letters 2001年第2期12卷 113-116页

作者： Xun Tian JIANG Li Gong OU Dong mei han Yu Feng ZHAI Dong Lu BAI Shanghai Institute of Materia Medica Chinese Academy of Sciences294 Taiyuan RoadShanghai200031

This paper describes the construction of hemiacetal 2, the core of pseudolaric acid A via oxidative cleavage of acetonide 6 or 7 and enolization-hemiacetalization of aldehyde 8. A plausible general mechanism for thc i... 详细信息

关键词： pseudolaric acid A 5, 7-membered fused ring hemiacetal intramolecular [4+3] cycloaddition mechanism

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肛门直肠测压联合生物反馈技术治疗先天性肛门直肠畸形患儿术后排便功能障碍中的效果观察

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四川生理科学杂志 2024年第1期46卷 31-33页

作者：徐美汉李周旋陈快樊纬陈小清江西省儿童医院小儿外科江西南昌330000

目的:观察肛门直肠测压联合生物反馈技术治疗先天性肛门直肠畸形(Anorectal malformation,ARM)患儿术后排便功能障碍(Function defecation disorder,FDD)中的效果。方法:选取2021年10月至2023年1月江西省儿童医院收治的ARM患儿62例,随... 详细信息

目的:观察肛门直肠测压联合生物反馈技术治疗先天性肛门直肠畸形(Anorectal malformation,ARM)患儿术后排便功能障碍(Function defecation disorder,FDD)中的效果。方法:选取2021年10月至2023年1月江西省儿童医院收治的ARM患儿62例,随机将患儿分为对照组(31例)和观察组(31例),对照组接受生物反馈技术干预,观察组在对照组基础上联合肛门直肠测压,两组均治疗3 m,比较两组出院6 m后肛门直肠测压指标、肛门功能及生活质量。结果:出院6 m后,观察组平均及最大静息压、初始排便阈值均高于对照组(P<0.05);观察组Rintala评分及儿童生活质量普适性核心量表优于对照组(P<0.05)。结论:肛门直肠测压联合生物反馈技术可改善ARM患儿术后FDD,提高初始排便阈值,提升肛门功能及生活质量。

关键词：先天性肛门直肠畸形排便功能障碍小儿肛门直肠测压生物反馈技术

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Diastereoselective Michael Addition of (4'S)-Ethyl-3-(2',2'-Dimethyl-1',3'- dioxolan-4'-yl) acrylate with Furyl Lithium

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Chinese Chemical Letters 2001年第5期12卷 403-406页

作者： Dong mei han Xun Tian JIANG Jian Hong CHEN Bin WANG Dong Lu BAI Shanghai Institute of Meteria Medica Shanghai Institutes for Biological SciencesChinese Academy of SciencesShanghai 200031

Michael addition of the chiral alpha,beta -unsaturated ester 2 with furyl lithium proceeded in syn manner with excellent diastereoselectivity. The diastereoselectivity was not affected by the configuration of the doub... 详细信息

关键词： Michael addition configuration determination syn addition.

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