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ENTPD1-AS1-miR-144-3p-mediated high expression of COL5A2 correlates with poor prognosis and macrophage infiltration in gastric cancer

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World Journal of Gastrointestinal Oncology 2023年第7期15卷 1182-1199页

作者： han-mei Yuan Xiao-Feng Pu Hui Wu Chao Wu Department of Laboratory Medicine The Eighth Affiliated HospitalSun Yat-sen UniversityShenzhen 518033Guangdong ProvinceChina Department of Clinical Laboratory The General Hospital of Western Theater CommandChengdu 610000Sichuan ProvinceChina

BACKGROUND Gastric cancer(GC)is a malignant tumor with high morbidity and mortality.Expression of COL5A2 is significantly elevated in GC.Abnormal expression of noncoding RNAs(ncRNAs)have been found in GC,including microRNA(miRNA)and long noncoding RNA(lncRNA).Competing endogenous RNA network plays an important regulatory role in GC.However,its specific regulatory mechanism has not been elucidated.AIM To gain insight into the ncRNA regulatory mechanism and immune microenvironment related to COL5A2 in GC.METHODS RNA sequencing data and clinical information from The Cancer Genome Atlas data portal were used to analyze the expressions of COL5A2,miRNA and lncRNA related to the prognosis of GC.Cox regression analysis and Kyoto Encyclopedia of Genes and Genomes analysis were performed to assess the risk factors and relevant function of COL5A2.StarBase was used to predict the interaction of miRNA–lncRNA or miRNA–mRNA in GC.The relationship between COL5A2,miR-144-3p and ENTPD1-AS1 were verified by dual luciferase reporter assay.The association of COL5A2 with immune cell infiltration were analyzed using the Tumor Immune Estimation Resource database and single sample gene set enrichment analysis.The expression of COL5A2 and macrophages in paired GC tissues were detected by immunohistochemical staining.RESULTS We verified that the upregulation of COL5A2 expression was associated with the prognosis of GC and was an independent risk factor for GC.miR-144-3p was downregulated and correlated with the prognosis of GC.miR-144-3p regulated the expression of COL5A2 through direct interaction with COL5A2.ENTPD1-AS1 was elevated in GC and competitively bound to miR-144-3p,thus inhibiting the expression of miR-144-3p.ENTPD1-AS1 enhanced the expression of COL5A2 through sponging miR-144-3p.Compared to paired normal tissue,COL5A2 expression was upregulated at the protein level,especially in the middle and late stages of GC.The high expression of COL5A2 was positively linked to macrophage infiltration in GC.CONCLUSION COL5A2 regulated by

关键词： COL5A2 Noncoding RNAs Macrophage infiltration Prognosis Gastric cancer

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Mussel-inspired approach towards heparin immobilized cellulose hydrogel for ive removal of low density lipoprotein from whole blood

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中国循环杂志 2018年第S1期33卷 126-127页

作者： Yupei Li Baihai Su Qiang Liu Yuqin Xiong mei han Si Sun Liping Lin Jiameng Li Liya Wang West China Hospital Sichuan UniversityChengduSichuanChina

Objective This work is designed to fabricate a new low density lipoprotein(LDL)absorbent through a mussel-inspired approach and to evaluate the blood compatibility and adsorption clearance,capacity and selectivity of this technique in vitro.Methods Heparin immobilized cellulose(HeTaCe)hydrogels were fabricated through a mussel-inspired approach.Fourier transform infrared spectroscopy,X-ray photoelectron spectroscopy,thermo gravimetric analysis were used to characterize the chemical compositions of the hydrogels.

关键词： low density lipoprotein(LDL) Heparin immobilized cellulose(HeTaCe) blood

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仿生物电刺激联合认知行为疗法对女性压力性尿失禁患者的效果评价

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中国医药 2024年第7期19卷 1047-1051页

作者：郝伶俐韩梅赫永磊王素巍首都医科大学附属北京康复医院中医康复中心北京100144 北京大学第三医院泌尿外科北京100191

目的观察仿生物电刺激联合认知行为疗法对女性压力性尿失禁(SUI)患者的效果。方法本研究为前瞻性随机对照研究。选取2019年3月至2023年6月北京大学第三医院收治的160例女性SUI患者为研究对象,采用随机数字表法分为观察组和对照组,各80... 详细信息

目的观察仿生物电刺激联合认知行为疗法对女性压力性尿失禁(SUI)患者的效果。方法本研究为前瞻性随机对照研究。选取2019年3月至2023年6月北京大学第三医院收治的160例女性SUI患者为研究对象,采用随机数字表法分为观察组和对照组,各80例。对照组给予单纯认知行为疗法干预,观察组在对照组基础上增加盆底仿生物电刺激治疗,均干预8周。比较2组干预前后的盆底功能超声指标、盆底肌电值、尿失禁问卷简表(ICI-Q-SF)评分、焦虑自评量表(SAS)评分和抑郁自评量表(SDS)评分,并比较干预后2组总有效率。结果研究过程中,对照组脱落1例,观察组脱落3例,最终对照组79例、观察组77例完成本研究。干预后,2组膀胱尿道后角、膀胱颈移动度、ICI-Q-SF、SAS和SDS评分均小于/低于干预前且观察组均小于/低于对照组,盆底快速收缩阶段、持续收缩阶段和耐力收缩阶段肌电值均高于干预前且观察组均高于对照组(均P<0.05)。干预后,观察组总有效率明显高于对照组[97.4%(75/77)比88.6%(70/79)](P<0.05)。结论仿生物电刺激联合认知行为疗法可有效改善女性SUI患者的盆底功能,减少尿失禁症状和负面情绪。

关键词：压力性尿失禁仿生物电刺激认知行为疗法盆底肌功能

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Median arcuate ligament syndrome with retroperitoneal haemorrhage:A case report

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World Journal of Clinical Cases 2022年第21期10卷 7509-7516页

作者： Xiao-Chen Lu Jian-Guo Pei Guang-Hua Xie Yong-Yu Li Hong-mei han Department of Gastroenterology Affiliated Hospital of Yanbian UniversityYanji 133000Jilin ProvinceChina Department of Imaging Affiliated Hospital of Yanbian UniversityYanji 133000Jilin ProvinceChina Department of Hepatobiliary Surgery Affiliated Hospital of Yanbian UniversityYanji 133000Jilin ProvinceChina

BACKGROUND Median arcuate ligament syndrome(MALS)is relatively rare and is due to extraluminal compression of the coeliac artery by the median arcuate ligament of the diaphragm.Here,we report a case of MALS found in a patient with abdominal pain and retroperitoneal haemorrhage for education and dissemination.CASE SUMMARY This article describes a 46-year-old female patient who was admitted to our hospital with abdominal pain as her chief complaint.She had experienced no obvious symptoms but had retroperitoneal bleeding during the course of the disease.Contrast-enhanced computed tomography(CT)and noninvasive CT angiography(CTA)led to an initial misdiagnosis of pancreaticoduodenal artery aneurysm(PDAA)causing retroperitoneal hemorrhage.After intraoperative exploration and detailed analysis of enhanced CT and CTA images,a final diagnosis of MALS was made.The cause of the haemorrhage was bleeding from a branch of the gastroduodenal artery,not rupture of a PDAA.The prognosis of MALS combined with PDAA treated by laparoscopy and interventional therapy is still acceptable.The patient was temporarily treated by gastroduodenal suture haemostasis and was referred for further treatment.CONCLUSION MALS is very rare and usually has postprandial abdominal pain,upper abdominal murmur,and weight loss.It is diagnosed by imaging or due to complications.When a patient has abdominal bleeding or PDAA,we should consider whether the patient has celiac trunk stenosis(MALS or other etiology).When abdominal bleeding is combined with an aneurysm,we generally think of aneurysm rupture and hemorrhage first,but it may also be collateral artery rupture and hemorrhage.

关键词： Median arcuate ligament syndrome Retroperitoneal haemorrhage Pancreaticoduodenal artery aneurysm Case report

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电感耦合等离子体发射光谱法测定土壤中有效磷的不确定度评价

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四川环境 2024年第3期43卷 162-166页

作者：韩梅韩文红张伯研贾娜张威孔祥科中国地质科学院水文地质环境地质研究所石家庄050001 河北省地质矿产勘查开发局第六地质大队石家庄050086

为准确测定土壤中有效磷的含量,采用电感耦合等离子体光谱仪进行测定,并对测定过程中相关因素引起的不确定度进行评定。整个实验过程中不确定度来源主要包括以下5个方面:(1)样品称量时引入的不确定度u(m);(2)加入浸提液时浸提液体积V引... 详细信息

为准确测定土壤中有效磷的含量,采用电感耦合等离子体光谱仪进行测定,并对测定过程中相关因素引起的不确定度进行评定。整个实验过程中不确定度来源主要包括以下5个方面:(1)样品称量时引入的不确定度u(m);(2)加入浸提液时浸提液体积V引入的不确定度u(V);(3)标准溶液配置时引入的不确定度u(C_(s));(4)标准曲线拟合引入的不确定度u(C0);(5)样品测量重复性引入的不确定度u(R)。结果表明,样品测量重复性、标准溶液配置、标准曲线拟合在整个实验中引入的不确定度影响较大。因此,在实际样品测定过程中,一定要注意对结果有影响的不确定度因素,加强质量控制,使结果准确可靠。

关键词：电感耦合等离子体发射光谱法土壤有效磷不确定度

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院内制剂红花浸提液在增强CT对比剂外渗中的应用效果

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河南医学研究 2024年第6期33卷 1104-1107页

作者：白娟张海宇段世英韩玫朱兴来河南中医药大学第一附属医院体检中心河南郑州450000 河南中医药大学第一附属医院放射科河南郑州450000 中国人民解放军联勤保障部队第九八八医院影像医学科河南郑州450042

目的本研究旨在探讨院内制剂红花浸提液在对比剂外渗治疗中的应用效果,并与硫酸镁湿敷治疗进行对比。方法由于部分患者对硫酸镁湿敷治疗不能耐受,本研究试图寻找一种有效的替代药物,因此本文纳入60例研究对象,分别接受红花浸提液(30例)... 详细信息

目的本研究旨在探讨院内制剂红花浸提液在对比剂外渗治疗中的应用效果,并与硫酸镁湿敷治疗进行对比。方法由于部分患者对硫酸镁湿敷治疗不能耐受,本研究试图寻找一种有效的替代药物,因此本文纳入60例研究对象,分别接受红花浸提液(30例)和硫酸镁湿敷治疗(30例),并对治疗效果进行评估,对比治疗24 h、72 h、1周后临床总有效率、患肢肿胀值及疼痛等级评分的差异。结果红花浸提液治疗24 h、72 h、1周后临床总有效率分别为80.0%、90.0%、100.0%;硫酸镁湿敷治疗24 h、72 h、1周后临床总有效率分别为80.0%、86.6%、96.6%;红花浸提液各治疗时间点患肢肿胀值分别为(22.79±0.56)、(18.24±0.01)、(17.38±0.46)cm;硫酸镁湿敷各治疗时间点患肢肿胀值分别为(23.35±0.44)、(18.11±0.15)、(17.53±0.27)cm。红花浸提液各治疗时间点患肢疼痛等级评分分别为(8.34±0.04)、(4.81±0.31)、(3.68±0.51)分。硫酸镁湿敷各治疗时间点患肢疼痛等级评分分别为(8.22±0.01)、(4.78±0.15)、(3.56±0.06)分。两组治疗24 h、72 h、1周后临床总有效率、患肢肿胀值及疼痛等级评分差异无统计学意义(P>0.05)。结论在对硫酸镁湿敷不能耐受患者,可利用红花浸提液替代治疗,能达到相同临床效果。

关键词：红花浸提液临床疗效对比剂外渗

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Fever glove hand-shake method safe blood collection from children's fingertips in COVID-19 fever clinic

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World Journal of Clinical Cases 2023年第33期11卷 7965-7971页

作者： Ling Luo Wei-Li Qin han-mei Huang Zhi-Hong Ou Zhi-Hua Peng Department of Infectious Diseases Guilin Municipal Hospital of Traditional Chinese MedicineGuilin 541000Guangxi Zhuang Autonomous RegionChina Department of Emergency Guilin Municipal Hospital of Traditional Chinese MedicineGuilin 541000Guangxi Zhuang Autonomous RegionChina Laboratory Guilin Municipal Hospital of Traditional Chinese MedicineGuilin 541000Guangxi Zhuang Autonomous RegionChina Department of Nursing Guilin Traditional Chinese Medicine HospitalGuilin 541000Guangxi Zhuang Autonomous RegionChina

BACKGROUND During the coronavirus disease 2019(COVID-19)epidemic,the fever clinic is an important link for screening and diagnosing whether a patient is infected with the novel coronavirus.Blood collection from children’s fingertips is a commonly used detection method;however,in children,the blood collection process may cause discomfort and resistance.To address this problem,the use of heating gloves combined with hand swinging can be considered for fingertip blood collection in children.AIM To explore the application of fever gloves with the handshaking method for fingertip blood collection from children in fever clinics during the COVID-19 epidemic.METHODS A total of 100 children were selected for fingertip blood collection at the fever clinic of our hospital from June 2022 to June 2023 and were divided into two groups using a randomized numerical table method,with 50 cases in each group,including the control and observation groups.The patients in the control group followed the doctor's instructions to cooperate with the routine fingertip blood collection method,and the patients in the observation group followed the doctor's instructions to cooperate with the static fever gloves with the shaking hands method of children's fingertip blood collection.The level of the six blood routine and collection indexes,and the satisfaction of the examination of the patients in the peripheral blood group and the fever gloves with the shaking hands method of the children's fingertip blood collection group were compared.RESULTS The red and white blood cell count,hemoglobin,and red blood cell pressure volume in the observation group were higher than those in the control group(Phan that in the observation group(Phan those in the control group(P<0.05);and satisfaction with the routine blood examination

关键词： Fever gloves Shaking hands method Peripheral blood Index Puncture Satisfactio

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血府逐瘀口服液对狼疮性肾炎患者疗效和安全性评估及血清胸腺肽β4的影响

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中国药师 2024年第3期27卷 455-462页

作者：徐娜韩梅封锦慧孙垚任占芬杨悦河北北方学院附属第二医院药剂科河北张家口075100 河北北方学院附属第二医院手术室河北张家口075100 河北北方学院附属第一医院风湿免疫科河北张家口075100

目的探究血府逐瘀口服液(XZOL)对狼疮性肾炎(LN)患者临床疗效和安全性及血清胸腺肽β4的影响。方法纳入2021年10月至2022年10月河北北方学院附属第二医院诊治的患者为研究对象。采用随机数字表法,将LN患者分为对照组[泼尼松(PDN)+环磷酰... 详细信息

目的探究血府逐瘀口服液(XZOL)对狼疮性肾炎(LN)患者临床疗效和安全性及血清胸腺肽β4的影响。方法纳入2021年10月至2022年10月河北北方学院附属第二医院诊治的患者为研究对象。采用随机数字表法,将LN患者分为对照组[泼尼松(PDN)+环磷酰胺(CTX)]和血府逐瘀组(XZOL联合PDN+CTX),连续治疗6个月。比较两组治疗有效率、系统性红斑狼疮疾病活动指数(SLEDAI)评分、免疫指标[抗双链DNA抗体(dsDNA)、血清免疫球蛋白(Ig)G和血清补体C3水平]、肾功能指标[血肌酐(Scr)、白蛋白(ALB)、红细胞沉降率(ESR)、谷丙转氨酶(ALT)、24 h尿蛋白和C-反应蛋白(CRP)水平]、血清胸腺肽β4水平和不良反应发生率。结果研究共纳入60例LN患者,每组各30例。血府逐瘀组治疗总有效率明显高于对照组(P0.05)。治疗6个月后,两组患者SLEDAI评分、血清IgG、抗dsDNA抗体、血清Scr、ALT、24 h尿蛋白和CRP水平均较治疗前显著下降(P0.05)。结论XZOL治疗LN临床效果显著,未见明显不良反应,值得在临床推广使用。

关键词：血府逐瘀口服液狼疮性肾炎临床疗效安全性胸腺肽β4

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基于UPLC-QTOF-MS解析苦荞黄酮组成及药理学网络分析

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核农学报 2024年第5期38卷 911-918页

作者：董玲张凤菊赵驰杨文渊韩梅黄巧莲阿木布哈李治华四川省农业科学院农产品加工研究所四川成都610066 四川省农业科学院园艺研究所四川成都610066 四川省农业科学院农业质量标准与检测技术研究所四川成都610066 甘洛县教育体育和科学技术局四川凉山615100

为优化苦荞黄酮提取工艺并明确其具体成分结构和含量及药理作用,本研究以四川省凉山彝族自治州甘洛县优质苦荞为研究对象,对超声提取苦荞黄酮工艺进行了优化,采用超高效液相色谱-四级杆-飞行时间质谱(UPLC-QTOF-MS)对主要黄酮成分进行... 详细信息

为优化苦荞黄酮提取工艺并明确其具体成分结构和含量及药理作用,本研究以四川省凉山彝族自治州甘洛县优质苦荞为研究对象,对超声提取苦荞黄酮工艺进行了优化,采用超高效液相色谱-四级杆-飞行时间质谱(UPLC-QTOF-MS)对主要黄酮成分进行结构鉴定,并采用超高效液相色谱-三重四级杆质谱联用仪对鉴定到的黄酮进行准确定量,同时利用中药系统药理学(TCMSP)系统分析其网络药理学特性。结果表明,超声辅助乙醇提取苦荞黄酮的最优条件为乙醇浓度90%(V/V)、超声功率140 W、超声温度70℃、超声时间60 min、提取溶剂与苦荞原料比50∶1(mL·g^(-1)),该条件下,提取液中共鉴定到黄酮16种,其中芦丁、表儿茶素和儿茶素含量分别达到115.81、72.99和23.08μg·mL^(-1)。这16种黄酮在防治心血管疾病、慢性炎症性疾病上具有重要作用。本研究可为苦荞精深加工综合利用尤其是功能性苦荞产品开发利用奠定基础。

关键词：苦荞黄酮超高效液相色谱-四级杆-飞行时间质谱芦丁

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Influence of structural damage on evaluation of microscopic pore structure in marine continental transitional shale of the Southern North China Basin:A method based on the low-temperature N2 adsorption experiment

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Petroleum Science 2022年第1期19卷 100-115页

作者： mei-Ling han Xiao-Liang Wei Jin-Chuan Zhang Yang Liu Xuan Tang Pei Li Zi-Yi Liu Key Laboratory of Strategy Evaluation for Shale Gas of Ministry of Land and Resources China University of GeosciencesBeijing100083China Exploration and Development Institute of Shengli Oilfield Company SinopecDongyingShandong 257015China Petroleum Exploration and Production Research Institute China Petroleum and Chemical Corporation(Sinopec)No.197 Baisha RoadChangping DistrictBeijing102206China State Key Laboratory of Petroleum Resources and Prospecting China University of PetroleumBeijing102200China

Structural damage from sample preparation processes such as cutting and polishing may change the pore structure of rocks.However,changes in pore structure caused by this structural damage from crushing and its effect on marine continental transitional shale have not been well documented.The changes of microscopic pore structure in marine continental transitional shale during the sample preparation have important research value for subsequent exploration and development of shale gas.In this study,the pore structures of transitional shale samples from the Shanxi-Taiyuan Formation of the Southern North China Basin under different degrees of damage were analyzed through low-temperature N;adsorption experiments,combined with X-ray diffraction,total organic carbon,vitrinite reflectance analysis,and scanning electron microscopy.The results showed that(1)With increasing structural damage,the specific surface area(SSA)changed within relatively tight bounds,while the pore volume(PV)varied significantly,and the growth rate(maximum)exhibited a certain critical value with the crushing mesh number increasing from 20 to 200.(2)The ratio of SSA to PV can be used as a potential proxy for evaluating the influence of changes in the pore structure.(3)Correlation analysis revealed that the microscopic pore structure of marine continental transitional shale from the Shanxi-Taiyuan Formations is mainly controlled by organic matter and clay minerals.Clay minerals play a leading role in the development of microscopic pores and changes in pore structure.

关键词： Marine continental transitional shale N_(2)adsorption Structural damage Crushing mesh Pore structure parameters

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