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Microglial complex I activity: a crucial factor for smoldering inflammation in the central nervouss system

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Signal Transduction and Targeted Therapy 2024年第8期9卷 3165-3166页

作者： Jana k.Sonner Christina Mayer Manuel A.Friese Institute of Neuroimmunology and Multiple Sclerosis University Medical Center Hamburg-EppendorfHamburgGermany

In their article published in Nature,Peruzotti-Jametta et *** metabolic reprogramming of microglia as a defining characteristic of their persistent and harmful activation during inflammatory neurodegeneration,which is observable in conditions like multiple sclerosis(MS).Subsequently,the authors demonstrate how mitigating mitochondrial dysregulation in microglia alleviates disease progression in an animal model of MS,thereby unveiling a potential novel target for the treatment of MS(Fig.1).

关键词： inflammation al. thereby

Microstructure transformations and improving wear resistance of austenitic stainless steel additively fabricated by arc-based DED process

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Defence Technology（防务技术） 2024年第8期38卷 194-204页

作者： Ashish Yadav Manu Srivastava Prashant k.Jain Sandeep Rathee Hybrid Additive Manufacturing Laboratory Mechanical Engineering DepartmentPDPM Indian Institute of Information TechnologyDesign&ManufacturingJabalpur482005Madhya PradeshIndia FFF Laboratory Mechanical Engineering DepartmentPDPM Indian Institute of Information TechnologyDesign&ManufacturingJabalpur482005Madhya PradeshIndia Department of Mechanical Engineering National Institute of TechnologySrinagarIndia

In this study, austenitic stainless steel(ASS) was additively fabricated by an arc-based direct energy deposition(DED) technique. Macrostructure, microstructure, mechanical characteristics at different spatial orientations(0°, 90°, and 45°), and wear characteristics were evaluated at the deposited structure top, middle, and bottom regions. Results show that austenite(γ) and delta-ferrite(δ) phases make up most of the microstructure of additively fabricated SS316LSi steel. Within γ matrix, δ phase is dispersed both(within and along) grain boundaries, exhibiting a fine vermicular morphology. The bottom, middle,and top regions of WAAM deposited ASS exhibit similar values to those of wrought SS316L in the tensile and impact test findings. Notably, a drop in hardness values is observed as build height increases. During SEM examinations of fractured surfaces from tensile specimen, closed dimples were observed, indicating good ductility of as-built structure. Wear test findings show signs of mild oxidation and usual adhesive wear. By depositing a mechanically mixed composite layer, an increase in the oxidation percentage was discovered to facilitate healing of worn surfaces. The findings of this study will help in design, production and renovation of products/components that are prone to wear. WAAM-deposited ASS has remarkable strength and ability to withstand impacts;it can be used in the production of armour plates for defence applications, mainly military vehicles and aircraft.

关键词： Metal additive deposition Defence applications Arc-based DED Characterization Wear behaviour Fractography

Joint Rain Streaks & Haze Removal Network for Object Detection

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Computers, Materials & Continua 2024年第6期79卷 4683-4702页

作者： Ragini Thatikonda Prakash kodali Ramalingaswamy Cheruku Eswaramoorthy k.V Department of Electronics and Communication Engineering National Institute of TechnologyWarangal506004India Department of Computer Science and Engineering National Institute of TechnologyWarangal506004India Department of Electronics and Communication Engineering Indian Institute of Information TechnologyDesign and ManufacturingKurnool518008India

In the realm of low-level vision tasks,such as image deraining and dehazing,restoring images distorted by adverse weather conditions remains a significant *** emergence of abundant computational resources has driven the dominance of deep Convolutional Neural Networks(CNNs),supplanting traditional methods reliant on prior ***,the evolution of CNN architectures has tended towards increasing complexity,utilizing intricate structures to enhance performance,often at the expense of computational *** response,we propose the Selective kernel Dense Residual M-shaped Network(SkDRMNet),a flexible solution adept at balancing computational efficiency with network accuracy.A key innovation is the incorporation of an M-shaped hierarchical structure,derived from the U-Net framework as M-Network(M-Net),within which the Selective kernel Dense Residual Module(SDRM)is introduced to reinforce multi-scale semantic feature *** methodology employs two sampling techniques-bilinear and pixel unshuffled and utilizes a multi-scale feature fusion approach to distil more robust spatial feature map *** the reconstruction phase,feature maps of varying resolutions are seamlessly integrated,and the extracted features are effectively merged using the Selective kernel Fusion Module(SkFM).Empirical results demonstrate the comprehensive superiority of SkDRMNet across both synthetic and real rain and haze datasets.

关键词： Image deraining Selective Dense Residual Module(SDRM) Selective kernel Fusion Module(SkFM) Selective kernelDense Residual M-Shaped Network(SkDRMNet)

Performance and combustion study of a low heat rejection engine running with biogas–diethyl ether–diesel

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Waste Disposal and Sustainable Energy 2024年第1期6卷 151-162页

作者： Sanjaya k.Mishra Premananda Pradhan Shakti P.Jena Department of Mechanical Engineering S‘O’A Deemed to be UniversityBhubaneswar751030India

The present research focuses on addressing the faster depletion of fossil fuels and environmental pollution in addition to the energy crisis that hinders the progress of a *** the current research,waste banana leaves were considered as substrates for biogas *** is taken as the primary fuel in dual fuel(DF)operations to maximize possible diesel *** performance and combustion assessment were executed in a low heat rejection(LHR)engine using 5%diethyl ether by volume blended with diesel(5DEE)as pilot *** combustion attributes of the engine reveal that the apex of net heat release rate(NHRR)curve retarded a bit as compared to apex of base *** peak cylinder pressure was noted to be 6.19 MPa in the LHR engine running with 5DEE+biogas at 11.7°crank angle(CA)after top dead center(aTDC)compared to 5.23 MPa for the diesel alone operation at the same *** apex point for NHRR was observed to be 54.51 J(°)^(−1)for 5DEE+biogas in LHR engine positioned at 3.2°*** brake thermal efficiency at full engine load operation decreased by 12.7%and 5.2%for biogas substitutions of 0.8 kg h^(−1)with diesel and 5DEE,respectively,compared to the base *** smoke opacity and nitric oxide emissions were reduced during the DF run accompanied by diethyl ether as a fuel additive.

关键词： Biogas Banana leaves Coating Diesel engine Diethyl ether Exhaust emissions

Anti-methanogenic potential of seaweeds and seaweed-derived compounds in ruminant feed:current perspectives,risks and future prospects

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Journal of Animal Science and Biotechnology 2024年第2期15卷 463-489页

作者： Ailbhe McGurrin Julie Maguire Brijesh k.Tiwari Marco Garcia-Vaquero Section of Food and Nutrition School of Agriculture and Food ScienceUniversity College DublinDublin 4BelfieldIreland TEAGASC Food Research CentreDublin 15AshtownIreland Bantry Marine Research Station Ltd BantryCo.CorkP75 AX07GearhiesIreland

With methane emissions from ruminant agriculture contributing 17%of total methane emissions worldwide,there is increasing urgency to develop strategies to reduce greenhouse gas emissions in this *** of the proposed strategies is ruminant feed intervention studies focused on the inclusion of anti-methanogenic compounds which are those capable of interacting with the rumen microbiome,reducing the capacity of ruminal microorganisms to produce ***,seaweeds have been investigated for their ability to reduce methane in ruminants in vitro and in vivo,with the greatest methane abatement reported when using the red seaweed Asparagopsis taxiformis(attributed to the bromoform content of this species).From the literature analysis in this study,levels of up to 99%reduction in ruminant methane emissions have been reported from inclusion of this seaweed in animal feed,although further in vivo and microbiome studies are required to confirm these results as other reports showed no effect on methane emission resulting from the inclusion of seaweed to basal *** review explores the current state of research aiming to integrate seaweeds as anti-methanogenic feed additives,as well as examining the specific bioactive compounds within seaweeds that are likely to be related to these *** effects of the inclusion of seaweeds on the ruminal microbiome are also reviewed,as well as the future challenges when considering the largescale inclusion of seaweeds into ruminant diets as anti-methanogenic agents.

关键词： Asparagopsis Bromoform Methanogenesis Phlorotannin Saponin Tannin

On the existence and stability of traversable wormhole solutions with novel shapefunctions in the framework of F(R,L_(m))gravity

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Communications in Theoretical Physics 2024年第5期76卷 114-127页

作者： Sourav Chaudhary Jitendra kumar S k Maurya Sweeti kiroriwal Abdul Aziz Department of Mathematics Central University of HaryanaJant-PaliMahendergarhIndia Department of Mathematical and Physical Sciences College of Arts and ScienceUniversity of NizwaP.O.Box 33Nizwa 616Oman

In this work,we have explored wormhole(WH)solutions in F(R,L_(m))gravity by assuming the Morris-Thorne WH metric and F(R,Lm)=R/2+(1+γR)L_(m),whereγis the free model *** determined the WH solutions by utilizing two newly developed shape functions(SF)that satisfy all basic conditions for a WH’s physical *** also observe that the null energy condition(NEC)behaves ***,for both models,we use the volume integral quantifier(VIQ)and Tolman-Oppenheimer-Volkoff(TOV)equation to determine how much exotic matter is needed near the WH throat and the stability of the *** extensive detailed discussions of the matter components have been done via graphical *** obtained WH geometries meet the physically acceptable conditions for a stable wormhole.

关键词： energy conditions wormhole exotic matter F(R L_(m))gravity

Exploring the synergy of the eyebrain connection:neuromodulation approaches for neurodegenerative disorders through transcorneal electrical stimulation

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Neural Regeneration Research 2024年第10期19卷 2097-2098页

作者： Antara Verma Stephen k.Agadagba Leanne Lai-Hang Chan Department of Electrical Engineering City University of Hong KongKowloonHong Kong Special Administrative RegionChina Centre for Eye and Vision Research Ltd. Hong Kong Special Administrative RegionChina Pennsylvania State University University ParkPAUSA

The connection and interaction between the eye and the brain are crucial to understanding brain disorders(Marchesi et al.,2021).Both the eye and the brain have a limited regenerative capacity as there are few progenitor cells,and nerve cells do not ***,neurodegeneration implicates irreversible damage to the central nervous system,as observed in several neurodegenerative diseases(Marchesi et al.,2021).

关键词： stimulation degenerative

Reactive oxygen species promote endurance exercise-induced adaptations in skeletal muscles

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Journal of Sport and Health Science 2024年第6期13卷 780-792页

作者： Scott k.Powers Zsolt Radak Li Li Ji Malcolm Jackson Department of Applied Physiology University of FloridaGainesvilleFL 32608USA Research Institute of Sport Science Hungarian University of Sport ScienceBudapest 1123Hungary Department of kinesiology University of MinnesotaSt.PaulMN 55455USA Department of Musculoskeletal and Ageing Science Institute of Life Course and Medical SciencesUniversity of LiverpoolLiverpool L78TXUK

The discovery that contracting skeletal muscle generates reactive oxygen species(ROS)was first reported over 40 years *** prevailing view in the 1980s was that exercise-induced ROS production promotes oxidation of proteins and lipids resulting in muscle ***,a paradigm shift occurred in the 1990s as growing research revealed that ROS are signaling molecules,capable of activating transcriptional activators/coactivators and promoting exercise-induced muscle *** evidence supports the notion that reduction-oxidation(redox)signaling pathways play an important role in the muscle remodeling that occurs in response to endurance exercise *** review examines the specific role that redox signaling plays in this endurance exercise-induced skeletal muscle *** begin with a discussion of the primary sites of ROS production in contracting muscle fibers followed by a summary of the antioxidant enzymes involved in the regulation of ROS levels in the *** then discuss which redox-sensitive signaling pathways promote endurance exercise-induced muscle adaptation and debate the strength of the evidence supporting the notion that redox signaling plays an essential role in muscle adaptation to endurance exercise *** hopes of stimulating future research,we highlight several important unanswered questions in this field.

关键词： Antioxidants Mitochondrial biogenesis Radicals Redox signaling

Inclusive quasielastic neutrino-nucleus scattering with energy density functional nuclear models

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Chinese Physics C 2024年第8期48卷 153-158页

作者： k.S.kim Soonchul Choi Hana Gil Chang Ho Hyun School of liberal arts and science korea aerospace universitygoyang 10540korea Center for exotic nuclear studies institute for basic sciencedaejeon 34126korea Center for extreme nuclear matters korea universityseoul 02841korea Department of physics education daegu universitygyeongsan 38453korea

In this study,we calculated the inclusive charged-current neutrino-nucleus scattering from ^(40)Ar in the quasielastic *** explore the effect of uncertainties stemming from the nuclear structure,we used the kIDS(korea-IBS-Daegu-SkkU)nuclear energy density functional and Skyrme force models,namely SLy4,SkI3,and *** models were selected to have distinct behavior in terms of the density dependence of the symmetry energy and the effective mass of the *** the charged-current neutrino scattering,the single-and double-differential cross sections were calculated for various *** cross sections are reported as a function of the incident neutrino *** theoretical cross sections were compared with experimental data,and the roles of the effective mass and symmetry energy were investigated in terms of charged-current neutrino-nucleus scattering.

关键词： energy density functional neutrino-nucleus scattering symmetry energy effective mass of the nucleon