Reactive oxygen species promote endurance exercise-induced adaptations in skeletal muscles

作     者：Scott K.Powers Zsolt Radak Li Li Ji Malcolm Jackson Scott K.Powers;Zsolt Radak;Li Li Ji;Malcolm Jackson

作者机构：Department of Applied PhysiologyUniversity of FloridaGainesvilleFL 32608USA Research Institute of Sport ScienceHungarian University of Sport ScienceBudapest 1123Hungary Department of KinesiologyUniversity of MinnesotaSt.PaulMN 55455USA Department of Musculoskeletal and Ageing ScienceInstitute of Life Course and Medical SciencesUniversity of LiverpoolLiverpool L78TXUK 

出 版 物：《Journal of Sport and Health Science》 (运动与健康科学（英文）)

年 卷 期：2024年第13卷第6期

页      面：780-792页

核心收录：

学科分类：0403[教育学-体育学] 040302[教育学-运动人体科学(可授教育学、理学、医学学位)] 04[教育学] 

基　　金：supported by a grant from the National Institutes of Health(R21AR063956 to SKP) 

主　　题：Antioxidants Mitochondrial biogenesis Radicals Redox signaling 

摘      要：The discovery that contracting skeletal muscle generates reactive oxygen species(ROS)was first reported over 40 years *** prevailing view in the 1980s was that exercise-induced ROS production promotes oxidation of proteins and lipids resulting in muscle ***,a paradigm shift occurred in the 1990s as growing research revealed that ROS are signaling molecules,capable of activating transcriptional activators/coactivators and promoting exercise-induced muscle *** evidence supports the notion that reduction-oxidation(redox)signaling pathways play an important role in the muscle remodeling that occurs in response to endurance exercise *** review examines the specific role that redox signaling plays in this endurance exercise-induced skeletal muscle *** begin with a discussion of the primary sites of ROS production in contracting muscle fibers followed by a summary of the antioxidant enzymes involved in the regulation of ROS levels in the *** then discuss which redox-sensitive signaling pathways promote endurance exercise-induced muscle adaptation and debate the strength of the evidence supporting the notion that redox signaling plays an essential role in muscle adaptation to endurance exercise *** hopes of stimulating future research,we highlight several important unanswered questions in this field.