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The efficacy of vitamin E in preventing arthrofibrosis after joint replacement

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Animal Models and Experimental Medicine 2024年第2期7卷 145-155页

作者： Yingfang Fan Jean Yuh Sashank Lekkala mehmet D.Asik Andrew Thomson Madeline McCanne Mark A.Randolph Antonia F.Chen Ebru Oral Harris Orthopaedic Laboratory Department of Orthopaedic SurgeryMassachusetts General HospitalBostonMassachusettsUSA Department of Orthopaedic Surgery Harvard Medical SchoolBostonMassachusettsUSA Department of Surgery Harvard Medical SchoolBostonMassachusettsUSA Department of Orthopaedic Surgery Brigham and Women's HospitalBostonMassachusettsUSA

Background:Arthrofibrosis is a joint disorder characterized by excessive scar formation in the joint *** E is an antioxidant with potential anti-fibroblastic *** aim of this study was to establish an arthrofibrosis rat model after joint replacement and assess the effects of vitamin E supplementation on joint ***:We simulated knee replacement in 16 male Sprague–Dawley *** immobilized the surgical leg with a suture in full *** control groups were killed at 2 and 12 weeks(n=5 per group),and the test group was supplemented daily with vitamin E(0.2 mg/mL)in their drinking water for 12 weeks(n=6).We performed histological staining to investigate the presence and severity of *** staining andα2-macroglobulin(α2M)enzyme-linked immunosorbent assay(ELISA)were used to assess local and systemic *** weight bearing(total internal reflection)and range of motion(ROM)were collected for functional ***:The ROM and weight-bearing symmetry decreased after the procedure and recovered slowly with still significant deficit at the end of the study for both *** analysis confirmed fibrosis in both lateral and posterior periarticular *** E supplementation showed a moderate anti-inflammatory effect on the local and systemic *** vitamin E group exhibited significant improvement in ROM and weight-bearing symmetry at day 84 compared to the control ***:This model is viable for simulating arthrofibrosis after joint *** E may benefit postsurgical arthrofibrosis,and further studies are needed for dosing requirements.

关键词： arthrofibrosis range of motion total knee arthroplasty vitamin E

Radical vs conservative surgery for hydatid liver cysts:Experience from single center

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World Journal of Gastroenterology 2010年第8期16卷 953-959页

作者： Sami Akbulut Ayhan Senol Arsenal sezgin Bahri Cakabay mehmet Dursun Omer Satici Department of Surgery Diyarba-kir Education and Research Hospital Department of Radiology Diyarbakir Education and Research Hospital Department of Pathology Diyarbakir Education and Research Hospital Department of Gastroenterology Veni Vidi Hospital Department of Biostatistics Dicle University Faculty of Medicine

AIM:To compare the efficacy and safety of radical and conservative surgical interventions for liver hydatid ***:The study comprised 59 patients in two groups who had undergone radical and conservative surgical procedures for liver hydatid disease in our department between 2004 and 2009. Preoperative diagnostic tools,medical treatments,demographic and clinical characteristics,postoperative follow-up,and recurrence were compared in both groups. RESULTS:This non-randomized retrospective studyincluded 59 patients who had undergone liver hydatid disease surgery. The radical technique was used in 18 patients (mean age:42.1 ± 13.5 years,seven male,11 female),and the conservative technique was used in 41 patients (mean age:43.5 ± 13.9 years,17 male,24 female). The follow-up period ranged from 3 to 58 mo. Although operative time was significantly shorter in the conservative group (P < 0.001),recurrence was significantly reduced in the radical group (P = 0.045). No statistically significant differences were found in terms of hospitalization duration,cyst count and size,location,postoperative complications,scolicidal solution usage,or follow-up duration between the two ***:The more effective method for pre-venting postoperative recurrence is radical surgery. En-doscopic retrograde cholangiopancreatography for bile leakage in the early postoperative period may decrease the requirement for repeat surgery.

关键词： Echinococcosis Endoscopic retrograde chol-angiopancreatography Digestive system surgery

Effect of acetyl L-carnitine on human retinal pigment epithelium-19 cells in hypoxic conditions

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国际眼科杂志 2024年第10期24卷 1515-1521页

作者： Ali Dal Onur Catak Murat Erdag mehmet Canleblebici Ebru Onalan Ilay Buran Department of Ophthalmology Faculty of MedicineFirat UniversityElazig 23119Turkey Department of Ophthalmology Ata Sokmen Faculty of MedicineMustafa Kemal UniversityHatay 31100Turkey Department of Ophthalmology Kayseri State HospitalKayseri 38200Turkey Department of Medical Biology Faculty of MedicineFirat UniversityElazig 23100Turkey

AIM:To investigate the effect of acetyl-L-carnitine(ALCAR)on cell viability,morphological integrity,and vascular endothelial growth factor(VEGF)expression in human retinal pigment epithelium(ARPE-19)cells using a hypoxic ***:In the first set of experiments,the optimal CoCl_(2) dose was determined by exposing ARPE-19 cell cultures to different *** evaluate the effect of ALCAR on cell viability,five groups of ARPE-19 cell culture were established that included a control group,a sham group(200μM CoCl_(2)),and groups that received 1,10 and 100 mM doses of ALCAR combined with 200μM CoCl_(2),*** cell viability was measured by MTT *** morphological characteristics of cells were observed by an inverted phase contrast *** levels of VEGF and HIF-1α secretion by ARPE-19 cells were detected by enzyme linked immunosorbent assay(ELISA)***:ARPE-19 cells were exposed to different doses of CoCl_(2) in order to create a hypoxia ***,when exposed to a concentration of 200μM CoCl_(2),a notable decrease in viability to 83% was *** was found to increase the cell viability at 1 mM and 10 mM concentrations,while the highest concentration(100 mM)did not have an added *** cell viability was found to be significantly higher in the groups treated with a concentration of 1 mM and 10 mM ALCAR compared to the Sham group(P=0.041,P=0.019,respectively).The cell viability and morphology remained unaffected by the greatest dose of ALCAR(100 mM).The administration of 10 mM ALCAR demonstrated a statistically significant reduction in the levels of VEGF and HIF-1α compared with the Sham group(P=0.013,P=0.033,respectively).CONCLUSION:The findings from the current study indicate that ALCAR could represent a viable therapeutic option with the potential to open up novel treatment pathways for retinal diseases,particular relevance for age-related macular degeneration(AMD).However,to fully elucidate ALCAR’s application

关键词： acetyl-L-carnitine(ALCAR) human retinal pigment epithelium(ARPE-19) vascular endothelial growth factor(VEGF) hypoxia-inducible factor 1(HIF-1α)

Clinical and hemodynamic profiles of elderly patients with pulmonary arterial hypertension： a single center, prospective study

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Journal of Geriatric Cardiology 2017年第1期14卷 20-27页

作者： Ebru Ozpelit Bahri Akdeniz Dilek sezgin Can Sevinc Kemal Can Tertemiz mehmet Emre Ozpelit Mustafa Baris Nezihi Baris Department of Cardiology School of Medicine Dokuz Eylul University Izmir Turkey Department of lnternal Medicine Faculty of Nursing Dokuz Eylul University Izmir Turkey Department of Chest Disease School of Medicine Dokuz Eylul University Izmir Turkey Department of Cardiology Medicalpark Hospital Izmir Turkey Department of Radiology School of Medicine Dokuz Eylul University Izmir Turkey

Backgrounds Pulmonary arterial hypertension （PAH） was previously considered an illness that affects mostly the young, but now it is also increasingly recognized in the elderly. The aim of this study was to compare the features of elderly versus younger patients diagnosed with PAH, and to define the prognostic factors which affect their long-term survival. Methods In this prospective, single center study, the clinical, echocardiographic, hemodynamic characteristics, and the outcomes of younger （18-65 years） and elderly （〉 65 years） patients with definitive diagnosis of precapillary PAIl were compared. Results A total of 119 patients were analyzed in this study; 43 were elderly （mean age： 71.5 ± 5.5 years）, while 76 were non-elderly （mean age 44.5 ±15.2 years）. During the mean follow-up duration of 26.8 ±25.0 months, 43 deaths occurred, 17 of which were among the elderly group, with 28 among non-elderly group. Comparison of baseline parameters showed that 6 min walking distance, hemoglobin levels, pulmonary artery pressures and pulmonary vascular resistance were significantly lower; and estimated glomerular filtration rate, body mass index, E/e＇ and pulmonary capillary wedge pressure were significantly higher in the elderly group than in the younger group. Survival analysis demonstrated that the independent predictors of death were tricuspid plane annular systolic excursion （TAPSE; HR： 1.272, 95% CI： 1.079-1.499, P = 0.004） and uric acid （HR： 1.291, 95% CI： 1.042-1.600, P = 0.019） in the elderly group. In contrast, in the non-elderly group, higher brain natriuretic peptide （HR： 1.002, 95% CI： 1.001-1.004, P 〈 0.001） and higher right atrial pressure （HR： 1.128, 95% CI： 1.026-1.241, P = 0.013） values were the only parameters associated with mortality. Conclusions Our data suggest that elderly PAH patients have a unique clinical and hemodynamic profile, with totally different prognostic markers compared to younger PAH patients.

关键词： Clinical characteristics Prognosis Pulmonary hypertension The elderly

群体饲养生命表:资料分析理论与转化为个体生命表的方法

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昆虫学报 2024年第8期67卷 1147-1162页

作者：马敏任芳旭王怡孔维娜魏明峰齐心 mehmet Salih ÖZGÖKCE 马瑞燕山西农业大学植物保护学院农业有害生物综合治理山西省重点实验室太原030031 山西农业大学棉花研究所运城044000 山东农业大学植物保护学院泰安271018 福建农林大学应用生态研究所闽台作物有害生物生态防控国家重点实验室福州350002 福建省农业科学院农业质量标准与检测技术研究所福州350003 Department of Plant Protection Faculty of AgricultureVan YüzüncüY l UniversityVan 65080Türkiye

本文介绍群体饲养生命表的资料分析基本原理及转换为个体生命表的方法。每日群体饲养生命表的记录实际上即年龄-龄期两性生命表的矩阵N,而每日所有雌虫的总繁殖力记录即为矩阵F_(total)。利用矩阵N与矩阵F_(total)可以计算年龄-龄期存... 详细信息

本文介绍群体饲养生命表的资料分析基本原理及转换为个体生命表的方法。每日群体饲养生命表的记录实际上即年龄-龄期两性生命表的矩阵N,而每日所有雌虫的总繁殖力记录即为矩阵F_(total)。利用矩阵N与矩阵F_(total)可以计算年龄-龄期存活率矩阵S、繁殖力矩阵F及各种群参数。以桃蚜Myzus persicae和马铃薯块茎蛾Phthorimaea operculella为例,阐明群体饲养生命表分析的理论依据,证明群体饲养生命表得到的各项参数可靠,并介绍了一种将群体饲养生命表转化为个体生命表的方法。比较了群体饲养生命表和个体饲养生命表的特点。利用群体饲养研究昆虫生命表可以节省大量人力、时间与经费,群体饲养生命表可用于设计大量饲养生物防治天敌、鱼与鸟的饲料昆虫以及可供人类食用的昆虫。

关键词：年龄-龄期两性生命表群体饲养电脑模拟种群预测生物防治

Coupling Interactions and Trapped Effects for a Triple-Well Potential

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Journal of Modern Physics 2011年第8期2卷 898-907页

作者： sezgin Aydin mehmet Simsek Department of Physics Faculty of SciencesGazi UniversityAnkaraTurkey

Weak and strong coupling interactions and trapped effects have always played a significant role in understanding physical and chemical properties of materials. Triple-well anharmonic potential may be modeled for interpretation of energy spectra from the nuclear to macro molecular systems, and also crystalline systems. Exact periods of a trapped particle in each well of the potential are explicitly derived. For the extended Duffing system, it is predicted that infinite series of both frequency and spatial trajectory approach to exact results in the limit of weak-coupling cases (g→0).

关键词： Perturbation Method Triple-Well Potential Duffing Equation Weak and Strong Couplings

Dura Mater: Anatomy and Clinical Implication

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Journal of Behavioral and Brain Science 2021年第10期11卷 239-247页

作者： mehmet Ünal Ahmet Burak sezgin Flex & Form Kocaeli Turkey ABS holistik sa&gbreve l&imath k &Idot stanbul Turkey

The dura mater is of similar embryological origin to the fascial organ. It contains several fibroblasts which make the dura mater a flexible structure. Dura mater is the outermost of the three layers of meninges, a thick and rigid inelastic membrane that covers the brain and spinal cord and that is impermeable to the cerebrospinal fluid. The cranial dura mater in certain respects differs anatomically from the dura material in the spinal cord, and it is important to classify them separately. This article reviews the anatomical structure of spinal and cranial dura mater and its anatomy with muscle, fascia, bone structure and ligaments. Dura mater is a structure in the body that is connected with systemic functions.

关键词： Dura Mater Osteopathy Physiotherapy

Compensating the effects of DC bias lines on terahertz photomixer antennas using resistively loaded lines

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红外与毫米波学报 2015年第4期34卷 420-426页

作者： Adem Yilmaz mehmet Unlu Electrical and Electronics Engineering Department Yildirim Beyazit University Ankara Turkey Cankiri Caddesi Cicek Sokak No: 3 Ulus Ankara 06030 Turkey

This paper proposed a method,namely resistively loaded lines(RLL),to compensate the effects of the DC bias lines after investigating its effects on several types of antennas for terahertz *** RLL is formed by placing lumped resistances periodically on the DC bias line in order to cease the leakage current virtually,w hich cause a significant amount of distortion on the antenna *** simulation results of the dipole,folded dipole,log-periodic,and spiral antennas show that RLL almost removes the effects of the bias lines and improves the antenna radiation resistance and radiation pattern notably compared w ith that of the commonly used bias line types,such as coplanar stripline and photonic bandgap type bias lines.

关键词：红外技术毫米波技术光电技术应用

Fuzzy rule based seismic risk assessment of one-story precast industrial buildings

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Earthquake Engineering and Engineering Vibration 2019年第3期18卷 631-648页

作者： mehmet Palanci Istanbul Arel University Department of Civil Engineering

Effi cient tools capable of using uncertain data to produce fast and approximate results are more practical in rapid decision-making applications when compared to conventional methods. From this point of view, this study introduces a risk assessment model for one-story precast industrial buildings by fuzzy logic which builds a bridge between uncertainty and precision. The input, output and relations of the fuzzy based risk assessment model (FBRAM) were determined by reference buildings. The Monte Carlo simulation method was used to handle uncertainties associated with the structural characteristics of the reference buildings. Section dimension, longitudinal reinforcement ratio, column height related to building elevation, confi nement ratio and seismic hazard are regarded as input and the plastic demand ratio is considered as the output parameter by the mathematical formulation of strength and deformation capacity of the buildings. The supervised learning method was used to determine the membership function of fuzzy sets. Fuzzy rules of FBRAM were constructed from Monte Carlo simulation by mapping of inputs and output. FBRAM was evaluated by a group of simulated buildings and two existing precast industrial buildings. Comparisons have shown signifi cant agreement with analytical model results in both cases. Consequently, it is anticipated that the proposed model can be used for the seismic risk mitigation of precast buildings.

关键词： fuzzy logic supervised learning precast buildings risk assessment Monte Carlo simulation