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Aortic Neocuspidization with Autologous Pericardium: Initial Experience of Single Center

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World Journal of Cardiovascular Surgery 2021年第6期11卷 51-60页

作者： Kubilay Karabacak Emre Kubat Gökhan Erol Murat Kadan Furkan Burak Akyol Elgin Hacızade Suat Doganci mehmet Emin Ince Uygar Cagdas Yuksel Murat Celik Cengiz Bolcal Department of Cardiovascular Surgery Gülhane School of Medicine Health Sciences University Ankara Turkey Department of Anesthesiology Gülhane School of Medicine Health Sciences University Ankara Turkey Department of Cardiology Gülhane School of Medicine Health Sciences University Ankara Turkey

Background: Aortic neo-cuspidization (AVNeo) procedure has been adopted by limited centers with the publication of the mid-long term successful results. The aim of this study was to present initial experience of the AVNeo procedure of a single center. Methods: The medical records of 24 patients who underwent AVNeo with or without concomitant cardiac surgery between February 2019 and February 2021 at our tertiary hospital were scanned retrospectively. Results: The mean age of patients was aged 58.21 ± 13.14 years and 16 (66.7%) of them were men. 16 patients were operated on for aortic stenosis (66.67%). Morphology of the aortic valve was tricuspid in 21 (87.5%) and bicuspid in 3 (12.5%) of the patients. Additional cardicac surgery was performed in 13 (54.17%) patients. No patients needed reoperation for bleeding, pacemaker implantations, conversion to classical prosthetic aortic valve replacement, or infective endocarditis. Two patients died due to non-cardiac reasons. Preoperative peak and mean aortic valve pressures improved significantly at 1st and 6th months (Preop: 89.06 ± 21.88 mmHg and 56.38 ± 15.09 mmHg 1st month: 22.00 ± 3.93 mmHg and 8.73 ± 2.60 mmHg, 6th month: 18.13 ± 3.02 mmHg and 6.93 ± 1.83 mmH

关键词： Ozaki Procedure Aortic Valve Repair Autologous Pericardium

Synapsin Polymorphisms Could Be Correlated with Stroop Simple Reaction Time Scores

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American Journal of Molecular Biology 2016年第1期6卷 25-32页

作者： Ahmet Buber Burge Kabukcu Basay Omer Basay Onder Ozturk Huseyin Alacam Kemal Utku Yazici Ali Bacanli Mustafa Ertan Ay mehmet Emin Erdal Hasan Herken Eyup Sabri Ercan Child and Adolescent Psychiatry Department Pamukkale University Medical Faculty Denizli Turkey Psychiatry Department Pamukkale University Medical Faculty Denizli Turkey Child and Adolescent Psychiatry Department Firat University Medical Faculty Elazig Turkey Child and Adolescent Psychiatry Department Gaziantep Children Hospital Gaziantep Turkey Medical Biology and Genetics Department Mersin University Medical Faculty Mersin Turkey Child and Adolescent Psychiatry Department Ege University Medical Faculty Izmir Turkey

Objective: The aim of this study was to research the relationship between Attention Deficit Hyperactivity Disorder (ADHD) and the synapsin III -196G>A and -631C>G polymorphisms and study their impact on neurocognition and behavior in Turkish children and adolescents. Methods: A total of 201 ADHD-diagnosed children and 100 control subjects aged between 8 and 15 years were recruited, and genetic material was obtained from saliva. In the diagnostic assessments, the KSADS- PL semi-structured interview was applied. Children with any comorbid psychiatric diagnosis (with the exclusion of oppositional defiant disorder (ODD)), medical conditions, prior psychotropic drug use history or IQ score below 80 were excluded. For the behavioral and ADHD symptom assessments, the Turgay DSM-IV Disruptive Behaviors Rating Scale, Teacher Report Form (TRF) and Child Behavior Checklist (CBCL) were completed by the parents and teachers. Neurocognitive profiles were evaluated with the CNS-Vital Signs computerized neurocognitive test battery. Results: No significant difference in ADHD prevalence was observed between subjects with the synapsin III gene -196G>A polymorphism and -631C>G polymorphisms. These polymorphisms were also not associated with subtypes of ADHD. We found a relationship between both polymorphisms and Stroop simple reaction time. Conclusion: Synapsin’s effect could be limited during childhood, but synapsin polymorphisms could be associated with Stroop simple reaction time.

关键词： Attention Deficit Hyperactivity Disorder Synapsin III Association Cognitive Function

A novel preoperative inflammatory marker prognostic score in patients with localized and metastatic renal cell carcinoma

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Asian Journal of Urology 2017年第4期4卷 230-238页

作者： Rishi R.Sekar Dattatraya Patil Yoram Baum Jeffrey Pearl Anna Bausum mehmet A.Bilen Omer Kucuk Wayne B.Harris Bradley C.Carthon Mehrdad Alemozaffar Christopher P.Filson John G.Pattaras Peter T.Nieh Kenneth Ogan Viraj A.Master Department of Urology Emory University School of MedicineAtlantaGAUSA Department of Hematology and Medical Oncology Emory University School of MedicineAtlantaGAUSA Winship Cancer Institute of Emory University Emory University School of MedicineAtlantaGAUSA The Atlanta VA Medical Center Emory University School of MedicineAtlantaGAUSA

Objective:Several inflammatory markers have been studied as potential biomarkers in renal cell carcinoma(RCC),however few reports have analyzed their prognostic value in aggregate and in non-clear cell *** hypothesize that a combination of specific inflammatory markers into an RCC Inflammatory Score(RISK)could serve as a rigorous prognostic indicator of overall survival(OS)in patients with clear cell and non-clear cell ***:Combination of preoperative C-reactive protein(CRP),albumin,erythrocyte sedimentation rate(ESR),corrected calcium,and aspartate transaminase to alanine transaminase(AST/ALT)ratio was used to develop *** was developed using grid-search methodology,receiver-operating-characteristic(ROC)analysis,and sensitivity-specificity trade-off *** value of RISK was analyzed using the KaplaneMeier method and Cox proportional regression *** accuracy was compared with RISK to Size,Size,Grade,and Necrosis(SSIGN)score,University of California-LOS Angeles(UCLA)Integrated Staging System(UISS),and Leibovich Prognosis Score(LPS).

关键词： Renal cell carcinoma Inflammation Prognosis Biomarker

Rapidly destructive arthrosis of the hip joint

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Chinese Medical Journal 2013年第16期126卷 3195-3195页

作者： Alparslan Bayram Carl(i) Selim Akarsu Levent Tekin mehmet Zeki Kiralp Department of Physical Medicine and Rehabilitation. Bursa Military Hospital Bursa Turkey Department of Physical Medicine and Rehabilitation Gialhane Military MedicalAcademy Haydarpa~a Training Hospital lstanbul Turkey

To the editor：A 67-year-old man presented with left hip pain for the last one *** detailed questioning,he declared that he had been under chemotherapy for prostate cancer for one *** medical/family history was otherwise *** physical examination,he had pain and mild limitation in his left hip *** demonstrated slight joint space narrowing and sclerosis,consistent with *** tests including erythrocyte sedimentation rate and C-reactive protein were *** evidence of infection or inflammatory arthropathies was *** was given a non-steroidal anti-inflammatory *** the second visit （3 months later）,he needed to use a *** complaints got worse and he could not *** was no history of *** revealed severe collapse and destruction of the femoral *** patient was consulted to the urology department;and as he was not considered to have any metastasis,he underwent hip arthroplasty.

关键词： Rapidly destructive arthrosis

Molecular epidemiology of HIV-1 strains in the south-east and east of Turkey

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Asian Pacific Journal of Tropical Biomedicine 2015年第9期5卷 743-747页

作者： Mustafa Kemal elen Murat Sayan Tuba Dal Celal Ayaz Alicem Tekin Tuncer zekinci Suda Tekin Koruk Tunga Barcin Recep Tekin mehmet Sinan Dal Sevgi Kalkanl Dicle University Clinical Laboratory Kocaeli University Research Center of Experimental Health Sciences Near East University Yildirim Beyazit University Harran University Kiziltepe State Hospital Abdurrahman Yurtaslan Ankara Oncology Training and Research Hospital

Objective:To detect the subtype characterization and drug-resistant mutations in HIV-1 strains after the refugee movement from Syria to Turkey between 2011 and 2014 in south east border lines. Methods: A total of 65 patients were included in this study, of which 57(88%) patients were antiretroviral therapy-naive patients. HIV-1 RNA was detected and quantii ed by realtime PCR assay. HIV-1 subtypes and circulating recombinant forms(CRFs) were identii ed by phylogenetic analysis(neighbor-joining method), and drug-resistant mutations were ***: Three major HIV groups were indicated. Two of these groups were located in subtype B. The other group showed heterogeneity. Subtype B(48/65, 73.8%), followed by CRFs(12/65, 18.5%) was the most common strain. Subtype of CRFs consisted of CRF01_AE(9/65, 13.8%) and CRF02_AG(3/65, 4.6%). Subtype C(1/65, 1.5%), sub-subtypes A1(2/65, 3.1%) and F1(2/65, 3.1%) were also detected with low prevalence. The rate of overall primary antiretroviral resistance was 4.9%(3/61). Drug-resistant rate for non-nucleoside reverse transcriptase inhibitors was 4.9%. The thymidine analogue mutation rate was 13.1%(8/61).Conclusions: HIV molecular epidemiology studies are necessary to determine transmission patterns and spread. Subtype B and CRF01_AE, CRF02_AG are the most prevalent strains in the south-east of Turkey. However, subtype C, sub-subtypes A1 and F1 are of low prevalence but persist in the south-east of Turkey. In the near future, changing of HIV epidemiology will be possible in Turkey due to migration movement in border lines and resistance testing will play an important role in HIV management.

关键词： HIV-1 Turkey Molecular epidemiology Refugee

Screening of Class 1 and Class 2 Integrons in Clinical Isolates of Pseudomonas aeruginosa Collected from Seven Hospitals in Turkey:A Multicenter Study

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Open Journal of Medical Microbiology 2013年第4期3卷 227-233页

作者： Aysegul Copur Cicek Aysegul Saral Azer Ozad Duzgun Zeynep Cizmeci Tuba Kayman Pervin Ozlem Balci Tuba Dal mehmet Firat Yelda Yazici Metin Sancaktar Osman Birol Ozgumus Cemal Sandalli Department of Medical Microbiology Faculty of MedicineRecep Tayyip Erdogan UniversityRizeTurkey Department of Biology Faculty of Arts and SciencesArtvin Coruh UniversityArtvinTurkey Department of Genetics and Bioengineering Faculty of Engineering and Natural SciencesGumushane UniversityGumushaneTurkey Clinical Microbiology Laboratory Kecioren Research and Training HospitalAnkaraTurkey Clinical Microbiology Laboratory Research and Training HospitalKayseriTurkey Clinical Microbiology Laboratory General State HospitalTokatTurkey Department of Medical Microbiology Faculty of MedicineDicle UniversityDiyarbakirTurkey Clinic of Infectious Diseases and Clinical Microbiology Private OSM Ortadogu HospitalSanliurfaTurkey Clinical Microbiology Laboratory Ahi Evren Chest and Cardiovascular Surgery Research and Training HospitalTrabzonTurkey Clinical Microbiology Laboratory Akcaabat Hackali Baba General State HospitalTrabzonTurkey Department of Biology Faculty of Arts and SciencesRecep Tayyip Erdogan UniversityRizeTurkey

Pseudomonas aeruginosa is one of the leading nosocomial pathogens worldwide, and their infections are difficult to treat due to acquired resistance to many antibiotics. This study aimed to detect class 1 and 2 integrons and antibiotic susceptibility of clinical isolates of P. aeruginosa. Two hundred and five P. aeruginosa strains were collected from the seven general state hospitals in Turkey. They were characterized by antimicrobial susceptibility testing, screened for class 1 and class 2 integrons, and evaluated for the association between antibiotic resistance phenotypes and the presence of integrons. intI gene was amplified in 10 isolates (4.87%) by PCR and in seven isolates of them (70%) were found different gene cassettes. The aadA gene integrated into the class 1 integrons was most frequently found and it was followed by aac genes and blaOXA family genes. Sequence analysis of variable regions of the class 1 integrons showed five gene cassette arrays;aadA1(99%), aac(3)-Id(82%)-orf-aac(3”)-Ia(99%), aac(3)-Ie(83%)-blaoxa10(100%)- aadA1 (100%), aadA6(99%, 100%), aac(6’)-I(97%)-orf-aadA2(99%). No class 2 integron was detected. This study is the first multicenter study for class 1 integrons and it indicates the low rate of presence of class 1 gene cassette in P. aeruginosa.

关键词： Pseudomonas aeruginosa Antibiotic Resistance Class 1 Integron AadA Multicenter Study

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一种新型可重复利用荫罩掩膜技术

一种新型可重复利用荫罩掩膜技术

Effects of Melatonin on Ischemia-Reperfusion Injury in Rat Ovary:Histopathologic and Immunohistochemical Study

真空电子与专用金属材料、陶瓷——金属封接第十一届技术研讨会

作者：李兴辉 Selvapraba Selvarasah mehmet R. Dokmeci 北京真空电子技术研究所大功率微波电真空器件技术国防科技重点实验室 Department of Electrical and Computer Engineering Northeastern University

利用化学气相沉积、光刻和反应离子刻蚀等微细加工技术,可以制作柔性、低成本、结实耐用、生物科技和半导体技术兼容、可重复使用的聚对二甲苯-C荫罩掩膜。利用这种透明的惰性材料掩膜,可以制作出传统平面微加工技术难以实现的曲面微图... 详细信息

利用化学气相沉积、光刻和反应离子刻蚀等微细加工技术,可以制作柔性、低成本、结实耐用、生物科技和半导体技术兼容、可重复使用的聚对二甲苯-C荫罩掩膜。利用这种透明的惰性材料掩膜,可以制作出传统平面微加工技术难以实现的曲面微图形,同时在多次使用场合,可以实现其它柔性荫罩掩膜材料难以达到的微米级特征尺寸,并能保持很好的图形复制特性。

关键词：荫罩掩膜聚对二甲苯微细加工

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Open Journal of Obstetrics and Gynecology 2015年第11期5卷 639-645页

作者： Deniz Balsak Cihan Togrul Cenap Ekinci Kerem Doga Seckin mehmet Fatih Karsli Aysun Ekinci Ali Emre Tahaoglu Hanefi Bademkiran Zuat Acar Senem Yaman Tunc Engin Deveci Günsen Kirman Department of Obstetrics and Gynecology School of Medicine Hospital University of Halic Istanbul Turkey Department of Obstetrics and Gynecology School of Medicine University of Hitit Corum Turkey Department of Histology and Embryology School of Medicine Hospital University of Dicle Diyarbakir Turkey Department of Obstetrics and Gynecology Kanuni Sultan Süleyman Education and Research Hospital Istanbul Turkey Department of Obstetrics and Gynecology Dr. Sami Ulus Education and Research Hospital Ankara Turkey Department of Biochemistry Faculty of Medicine University of Dicle Diyarbakir Turkey Department of Obstetrics and Gynecology Diyarbakir Gazi Yasargil Education and Research Hospital Diyarbakir Turkey Department of Obstetrics and Gynecology Diyarbakir Obstetrics and Gynecology Hospital Diyarbakir Turkey Department of Obstetrics and Gynecology Memory Hospital Diyarbakir Turkey Department of Obstetrics and Gynecology School of Medicine Hospital University of Dicle Diyarbakir Turkey

Aim: To investigate the effect of melatonin on ischemia–reperfusion (I/R) injury in rat ovary. Material and Method: A total of 24 Wistar rats were divided into four groups. The rats were first numbered randomly and then randomly divided into four equal groups: sham, torsion, detorsion and melatonin groups. In group I (n = 6) sham, as well as in group II ovary torsion was not performed and no drug was administered. In group III, 1 hour of ischemia and 2 hours of reperfusion were performed and no drug was given. In group IV, melatonin was dissolved in 1% ethanol just before use. Melatonin was injected 1 hour before torsion to the torsion plus melatonin group. Right ovaries were surgically removed in all groups. Result: Malondialdehyde (MDA) levels were measured. We suggested that administration of melatonin would be in treating ovaries from torsion/detorsion induced damage in humans. The histopathological changes such as vascular congestion, edema, hemorrhage, and follicular degeneration were found to be decreased in the melatonin + ischemia-reperfusion group. Ischemia-reperfusion group: PECAM-I expression is positive in vessel of the stromal area. The follicles and interfolicular area infiltrated with CD68 positive cells were increased in a time of ischemia-reperfusion exposure dependent manner. Conclusions: Melatonin after ischemia-reperfusion CD31 and CD68 expressions is weak, due to the reduction of the inflammatory effects and hemorrhage is thought that melatonin is effective.

关键词： Ischemia-Reperfusion Ovary Rat CD31 CD68

Prognostic puzzle： which strategy in determining prognosis of patients with acutecoronary syndrome？

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Chinese Medical Journal 2014年第6期127卷 1169-1169页

作者： Murat Atalay Gokhan Deg(i)rmenc(i)oglu mehmet Dogan Ejder Kardesoglu Merz(i)fon M(i)l(i)tary Hosp(i)tal Sofular Mah.Merz(i)fon Amasya 05300 Turkey Gulhane Military Academy Haydarpasa Training Hospital Turkey(Deg(i)rmenc(i)oglu

To the editor:We read with great interest an article by Zhang et al.1The soluble ST2 level was shown to be increased in the early period and an independent predictor of *** additionally proposed that it might contribu...

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