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A functional tacrolimus-releasing nerve wrap for enhancing nerve regeneration following surgical nerve repair

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Neural Regeneration Research 2025年第1期20卷 291-304页

作者： Simeon C.Daeschler Katelyn J.W.So Konstantin Feinberg Marina Manoraj Jenny Cheung Jennifer Zhang kaveh Mirmoeini JPaul Santerre Tessa Gordon Gregory HBorschel SickKids Research Institute Neuroscience and Mental Health ProgramTorontoONCanada Institute of Biomaterials and Biomedical Engineering University of TorontoTorontoONCanada Indiana University School of Medicine IndianapolisINUSA Division of Plastic and Reconstructive Surgery the Hospital for Sick ChildrenTorontoONCanada Translational Biology and Engineering Program Ted Rogers Centre for Heart ResearchInstitute of Biomedical EngineeringFaculty of DentistryUniversity of TorontoTorontoONCanada

Axonal regeneration following surgical nerve repair is slow and often incomplete,resulting in poor functional recovery which sometimes contributes to lifelong ***,there are no FDA-approved therapies available to promote nerve *** accelerates axonal regeneration,but systemic side effects presently outweigh its potential benefits for peripheral nerve *** authors describe herein a biodegradable polyurethane-based drug delivery system for the sustained local release of tacrolimus at the nerve repair site,with suitable properties for scalable production and clinical application,aiming to promote nerve regeneration and functional recovery with minimal systemic drug *** is encapsulated into co-axially electrospun polycarbonate-urethane nanofibers to generate an implantable nerve wrap that releases therapeutic doses of bioactive tacrolimus over 31 *** and drug loading are adjustable for applications in small and large caliber nerves,and the wrap degrades within 120 days into biocompatible *** released from the nerve wrap promotes axon elongation in vitro and accelerates nerve regeneration and functional recovery in preclinical nerve repair models while off-target systemic drug exposure is reduced by 80%compared with systemic *** its surgical suitability and preclinical efficacy and safety,this system may provide a readily translatable approach to support axonal regeneration and recovery in patients undergoing nerve surgery.

关键词： biodegradable local drug delivery nerve injury nerve regeneration nerve wrap tacrolimus

Physicochemical properties of silver carp(Hypophthalmichthys molitrix)mince sausages as influenced by washing and frozen storage

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Aquaculture and Fisheries 2023年第4期8卷 403-409页

作者： kaveh Rahmanifarah Joe M.Regenstein mehdi Nikoo Department of Pathobiology and Quality Control Artemia and Aquaculture Research InstituteUrmia UniversityUrmiaWest Azerbaijan57179-44514Iran Department of Food Science Cornell UniversityIthacaNY14853-7201USA

Frozen storage of emulsion-type sausages may be one approach to avoid or reduce the use of sodium nitrite,which is associated with health *** carp(Hypophthalmichthys molitrix)mince(M_(0))was washed for 1(M_(1))or 3(M_(3))times and the impact of washing on the properties frozen storage(−18℃)during 4 months were determined and results were compared to those of conventional silver carp sausages(Mt).Lipid oxidation,as evidenced by changes in thiobarbituric acid reactive substances and FFAs,took place during storage in the order of M_(0)>M_(1)=M_(3)=Mt with M_(0)being highly oxidized(P≤0.05).Total volatile base nitrogen formed during storage and the ranking for the quality loss was as follows M_(0)>M_(1)>M_(3)=***(M_(1)=M_(3))led to less hardness(P≤0.05).Mt had better redness,while M_(1)and M_(3)led to higher expressible moisture,water release and lightness(P≤0.05).Results indicated the lower sensory and consumer-liking properties of frozen M_(1)and M_(3)***,washing and frozen storage influenced silver carp mince sausages.

关键词： Frozen storage Emulsion-type sausages Hypophthalmichthys molitrix Minced fish

Cutaneous leishmaniasis in Iran: Results from an epidemiological study in urban and rural provinces

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Asian Pacific Journal of Tropical Biomedicine 2016年第7期6卷 614-619页

作者： Faezeh Norouzinezhad Fatemeh Ghaffari Abbas Norouzinejad Farzad kaveh Mohammad mehdi Gouya Babol University of Medical Sciences BabolMazandaranIran Center for Disease Control Ministry of Health and Medical EducationTehranIran

Objective: To examine the prevalence and clinical manifestations of cutaneous leishmaniasis(CL) in ***: This study was conducted in Iran between 2011 and 2013. Sampling, preparing, developing, and fixing of suspicious skin lesions were completed in healthcare centers in 31 Iranian provinces as well as in the Academic Reference Laboratory and the National Reference Laboratory. The information was then analyzed at the Ministry of Health's Information Management Center of Contagious ***: Over a three-year period, the number of people identified with CL was 56 *** highest incidence was reported in 2011(27.5 per 100 000). Wet CL accounted for 43.7% of cases while 43.3% resulted from sporotrichoid leishmaniasis. The results showed that there was a higher incidence of CL due to Leishmania major(50.2%) than to Leishmania tropica. The results of this study found that the highest incidence of CL had happened respectively in Ilam, Fars and, Khorasan Razavi Provinces between 2011 and ***: Although the incidence of the disease is declining, CL is still a public health concern and disease control protocols need to be established. Therefore, further studies are needed to identify the vectors, reservoirs, and disease species as well as to develop appropriate disease control strategies.

关键词： Cutaneous leishmaniasis Epidemiology Iran Leishmania

Comprehensive AIDS prevention programs in prisons:A review study

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Family Medicine and Community Health 2018年第4期6卷 200-207页

作者： Somayeh Zare mehdi Kargar Jeyran Ostovarfar Mohammad Hossein kaveh Health Education and Health Promotion Department Health SchoolRazi StreetShirazIran

Objective:Since prisoners may acquire AIDS and transmit HIV because of highly risky be-haviors,implementation of educational and therapeutic programs is important in decreasing the prevalence of AIDS and transmission of *** study was conducted to recognize different types of interventions and compare their effectiveness regarding prevention of AIDS and its control in ***:The ISI,PubMed,Google Scholar,databases were searched with use of“AIDS,”“prison,”“HIV,”and“incarceration”as keywords from January 2000 to March 2017,with ac-cess to free full text and English language as *** articles,including observational,epidemiological,case,and interventional studies,were extracted and those inconsistent with the study’s goals were ***:Forty-three studies were finally *** effectiveness of interventions related to AIDS prevention and control in prisons was ***:It seems that theory-based studies conducted with stakeholders participation and evaluated summatively are more successful,because they give a sense of *** addition,considering prison as a setting can lead to more success of these programs.

关键词： AIDS prison intervention prevention

Topology optimization of shear wall structures under seismic loading

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Earthquake Engineering and Engineering Vibration 2020年第1期19卷 105-116页

作者： Pooya Zakian Ali kaveh Department of Civil Engineering Faculty of EngineeringArak UniversityArak 38156-8-8349Iran Centre of Excellence for Fundamental Studies in Structural Engineering Iran University of Science and TechnologyNarmakTehran-16Iran

A topology optimization formulation is developed to find the stiffest structure with desirable material distribution subjected to seismic loads. Finite element models of the structures are generated and the optimality criteria method is modified using a simple penalty approach and introducing fictitious strain energy to simultaneously consider both material volume and displacement constraints. Different types of shear walls with/without opening are investigated. Additionally, the effects of shear wall-frame interaction for single and coupled shear walls are studied. Gravity and seismic loads are applied to the shear walls so that the definitions provide a practical approach for locating the critical parts of these structures. The results suggest new viewpoints for architectural and structural engineering for placement of openings.

关键词： topology optimization seismic loads shear wall minimum compliance multiple constraints fi nite element analysis

Mechanical characterization of Mg-B4C nanocomposite fabricated at different strain rates

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International Journal of Minerals,Metallurgy and Materials 2020年第2期27卷 252-263页

作者： Gholam Hossein Majzoobi kaveh Rahmani Mechanical Engineering Department Bu-Ali Sina University

Magnesium has wide application in *** main purpose of this investigation was to improve the properties of magnesium by reinforcing it using B4C *** reinforced nanocomposites were fabricated using a powder compaction technique for 0,1.5vol%,3vol%,5vol%,and 10vol% of *** compaction was conducted using a split Hopkinson bar(SHB),drop hammer(DH),and Instron to reach different compaction loading *** compressive stress–strain curves of the samples were captured from quasi-static and dynamic tests carried out using an Instron and split Hopkinson pressure bar,*** revealed that,to achieve the highest improvement in ultimate strength,the contents of B4C were 1.5vol%,3vol%,and 3vol% for Instron,DH,and SHB,*** results also indicated that the effect of compaction type on the quasi-static strength of the samples was not as significant,although its effect on the dynamic strength of the samples was *** improvement in ultimate strength obtained from the quasi-static stress–strain curves of the samples(compared to pure Mg)varied from 9.9% for DH to 24% for *** dynamic strength of the samples was improved(with respect to pure Mg)by 73%,116%,and 141%for the specimens compacted by Instron,DH,and SHB,*** improvement in strength was believed to be due to strengthening mechanisms,friction,adiabatic heating,and shock waves.

关键词： powder compaction B4C magnesium strain rate ultimate strength sintering

Flood risk on arid alluvial fans:a case study in the Joghatay Mountains,Northeast Iran

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Journal of Mountain Science 2023年第5期20卷 1183-1200页

作者： kaveh GHAHRAMAN Balázs NAGY Department of Physical Geography Eotvos Loránd UniversityPázmány Péter stny.1/CH-1117 BudapestHungary

Among the common hazards related to alluvial fans,flooding is one of the most ***,in populated alluvial fans,not only the natural processes are effective in floods,but the artificial structures and modifications can change the behavior of flooding and its potential *** study aims to indicate the flood-prone landforms in a set of populated alluvial fans in an arid region and investigate the role of anthropogenic activities in controlling/exacerbating flooding in alluvial *** achieve this goal,15 Ground Range Detected in High resolution(GRDH)SAR Sentinel-1 images,covering a total of 24 alluvial fans,were ***-processing and post-processing steps were applied to all images to identify flood-prone sections of the studied alluvial *** results showed that feeder channels,spreading sites,and wide interfluves are the most flood-prone landforms of alluvial *** terms of anthropogenic modifications to mitigate flooding,a rampart system is distributed in the study *** are levee like structures formed from the fan *** aim to mitigate flood hazard on residential areas,infrastructures,and agricultural lands of the study *** show that the rampart system can reduce the danger of floods,but it cannot be considered a long-term ***,a comprehensive flood protection system distributed throughout the whole alluvial fan system is *** also reveal that in regions where flood monitoring is challenging,SAR images can be used as a freely available data set to monitor and identify flooding hotspots.

关键词： Alluvial fan Flood Anthropogenic activities Rampart Sentineli SAR

Spherical Tropical Geometry:a Survey of Recent Developments

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Acta Mathematica Sinica,English Series 2018年第3期34卷 454-465页

作者： Kiumars kaveh Christopher MANON Department of Mathematics University of PittsburghPittsburghPAUSA Department of Mathematics Univcrsity of KentuckyLexingtonKYUSA

This is a survey of some recent results on spherical tropical geometry.

关键词： Tropical geometry reductive group action spherical variety Grbner theory

Green,mild and efficient bromination of aromatic compounds by HBr promoted by trans-3,5-dihydroperoxy-3,5-dimethyl-1,2-dioxolane in water as a solvent

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Chinese Chemical Letters 2012年第4期23卷 387-390页

作者： kaveh Khosravi Samira Kazemi Department of Chemistry Faculty of ScienceUniversity of Arak Department of Chemistry Shahr-e-Rey branchIslamic Azad University

A combination of HBr and trans-3,5-dihydroperoxy-3,5-dimethyl-1,2-dioxolane as anew and powerful oxidant was found effective for facile brotnination of different aromatic compounds at room temperature in water as a green *** reaction conditions,high selectivity and yield,high reaction rate and non-toxicity are some of the major advantages of this synthetic protocol.

关键词： Trans-3 5-dihydroperoxy-3 5-dimethyl-1 2-dioxolane HBr Bromination Anilines Phenoles