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Applications of SMILE-extracted lenticules in ophthalmology

International Journal of Ophthalmology(English edition) 2024年第1期17卷 173-187页

作者： Hossein Aghamollaei Hassan Hashemi Mahsa Fallahtafti Seyed-Hashem Daryabari mehdi Khabazkhoob Khosrow Jadidi Chemical Injuries Research Center Systems Biology and Poisonings InstituteBaqiyatallah University of Medical SciencesTehran ***Iran Noor Research Center for Ophthalmic Epidemiology Noor Eye HospitalTehran ***Iran Vision Health Research Center Semnan University of Medical SciencesSemnan ***Iran Department of Basic Sciences School of Nursing and MidwiferyShahid Beheshti University of Medical SciencesTehran ***Iran

AIM:To review recent innovations,challenges,and applications of small incision lenticule extraction(SMILE)extracted lenticule for treating ocular ***:A literature review was performed in the PubMed database,which was last updated on 30 December *** was no limit regarding *** authors evaluated the reference lists of the collected papers to find any relevant ***:Due to the simplicity and accuracy of modern femtosecond lasers and the extensive development of SMILE surgery,many healthy human corneal stromal lenticules were extracted during surgery,motivating some professionals to investigate the SMILE lenticule reusability in different ocular *** addition,new approaches had been developed to preserve,modify,and bioengineer the corneal stroma,leading to the optimal use of discarded byproducts such as lenticules from SMILE *** lenticules can be effectively re-implanted into the autologous or allogenic corneas of human subjects to treat refractive errors,corneal ectasia,and corneal perforation and serve as a patch graft for glaucoma drainage devices with better cosmetic ***:SMILE-extracted lenticules could be a viable alternative to human donor corneal tissue.

关键词： small incision lenticule extraction corneal lenticule implantation keratoconus corneal perforation femtosecond laser stromal keratophakia

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Niosome-encapsulated auraptene reduced the mRNA expression of VEGF-A and PDGFs genes in human retinaderived RPE cell line

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International Journal of Ophthalmology(English edition) 2024年第6期17卷 1028-1035页

作者： Akram Vahidi Teymoor Khosravi Farzad Dastaviz mehdi Sheikh arabi Ayyoob Khosravi Morteza Oladnabi Student Research Committee Golestan University of Medical SciencesGorgan ***Iran Department of Medical Nanotechnology Faculty of Advanced Medical TechnologiesGolestan University of Medical SciencesGorgan ***Iran Stem Cell Research Center Golestan University of Medical SciencesGorgan ***Iran Department of Molecular Medicine Faculty of Advanced Medical TechnologiesGolestan University of Medical SciencesGorgan ***Iran Gorgan Congenital Malformations Research Center Golestan University of Medical SciencesGorgan ***Iran

AIM:To evaluate the effect of auraptene(AUR)treatment in forms of free and encapsulated in niosome nanoparticles by investigating the mRNA expression level of vascular endothelium growth factor(VEGF)-A and platelet-derived growth factors(PDGFs)in human retinal pigment epithelium(RPE)cell ***:Niosome nanocarriers were produced using two surfactants Span 60 and Tween *** cell line was treated with both free AUR and *** dosage of treatments was calculated using 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide(MTT)*** of VEGF-A and PDGF-A,PDGF-B,PDGF-C,PDGF-D genes was measured after total RNA extraction and cDNA synthesis,using real-time polymerase chain reaction(RT-PCR).RESULTS:The highest entrapment efficiency(EE)was achieved by Span 60:cholesterol(1:1)with 64.3%.The half maximal inhibitory concentration(IC50)of free and niosome-encapsulated AUR were 38.5 and 27.78µg/mL,*** study revealed that niosomal AUR had more gradual delivery to the ***-PCR results showed reduced expression levels of VEGF-A,PDGF-A,PDGF-B,PDGF-C,and PDGF-D after treatment with both free and niosomal ***:Niosomal formulation of Span 60:cholesterol(1:1)is an effective drug delivery approach to transfer AUR to RPE ***-A,PDGF-A,PDGF-B,PDGF-C,and PDGF-D are four angiogenic factors,inhibiting which by niosomal AUR may be effective in age-related macular degeneration.

关键词： auraptene niosome age-related macular degeneration angiogenesis nanocarrier

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Late-onset Very long-chain acyl-CoA dehydrogenase deficiency diagnosis complicated by fulminant myocarditis in adult patient

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Journal of Intensive Medicine 2024年第3期4卷 400-402页

作者： Martin Gérard Clair Douillard Julien Poissy mehdi Marzouk Christophe Vinsonneau Intensive Care Unit Centre Hospitalier de Bethune-BeuvryBethuneFrance Endocrinology diabetologymetabolism departmentLille reference centre of inborn errors of metabolismLille University HospitalLilleFrance Inserm U1285 CHU LillePôle de réanimationCNRSUMR 8576-UGSF-Unitéde Glycobiologie Structurale et FonctionnelleUniv.LilleLilleFrance

Introduction A 21-year-old woman presented to the emergency department with fatigue,abdominal pain and *** physical activity in school was strictly *** had no family medical history and no personal history but reported frequent episodes of nausea and vomiting lasting 2 to 7 days during the past two years,as well as a weight loss of 9 kg due to reactive anorexia(Body Mass Index 17.5),without triggering factors or *** gastrointestinal symptoms led to the detection of isolated elevated transaminases(aspartate aminotransferase[AST]190 U/L and alanine aminotransferase[ALT]170 U/L);however,the patient did not pursue the proposed etiological *** has been using cannabis once a day for several years,with an increase in consumption over the past year,but no *** reported no other recent change in her habits.

关键词： diagnosis patient elevated

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Impacts of radiation therapy on quality of life and pain relief in patients with bone metastases

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World Journal of Orthopedics 2024年第9期15卷 841-849页

作者： Armin Hoveidaei mehdi Karimi Vida Khalafi Patrick Fazeli Amir Human Hoveidaei Students’Scientific Research Center Exceptional Talents Development CenterTehran University of Medical SciencesTehran ***Iran Bogomolets National Medical University Kyiv 01601Ukraine Student Research Committee Jahrom University of Medical SciencesJahrom ***Iran Brown University ProvidenceRI 02912United States International Center for Limb Lengthening Rubin Institute for Advanced OrthopedicsSinai Hospital of BaltimoreBaltimoreMD 21215United States

Bone metastases(BM)are a common complication in advanced cancer patients,significantly contributing to morbidity and mortality due to their ability to cause pain,fractures,and spinal cord *** therapy(RT)is vital in managing these complications by targeting metastatic lesions to ease pain,improve mobility,and reduce the risk of skeletal-related events such as *** supports the effectiveness of RT in pain relief,showing its ability to provide significant palliation and lessen the need for opioid painkillers,thereby enhancing the overall quality of life(QoL)for patients with ***,optimizing RT outcomes involves considerations such as the choice of radiation technique,dose fractionation schedules,and the integration of supportive care measures to mitigate treatment-related side effects like fatigue and skin *** factors highlight the importance of personalized treatment planning tailored to individual patient needs and tumor *** mini-review aims to provide comprehensive insights into the multifaceted impacts of RT on pain management and QoL enhancement in BM patients,with implications for refining clinical practices and advancing patient care through the synthesis of findings from various studies.

关键词： Radiation therapy Radiotherapy Quality of life Pain relief Bone metastases Bone cancer

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Assessment of laryngologists'ratings on physician review websites

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World Journal of Otorhinolaryngology-Head and Neck Surgery 2024年第1期10卷 1-6页

作者： Meleeka Akbarpour Karen Tawk Madelyn Frank Alizah S.Gomez Navid Mostaghni mehdi Abouzari Department of Otolaryngology-Head and Neck Surgery University of CaliforniaIrvineUSA

Objective:To assess and characterize online ratings and comments on laryngologists and determine factors that correlate with higher ***:All the American Laryngological Association(ALA)members were queried across several online *** were normalized for comparison on a five-point Likert *** were categorized based on context and for positive/negative ***:Of the 331 ALA members,256(77%)were rated on at least one online *** all platforms,the average overall rating was 4.39±0.61(range:1.00-5.00).Specific positive ratings including“bedside manners,”“diagnostic accuracy,”“adequate time spent with patient,”“appropriate follow-up,”and“physician timeliness”had significant positive correlations to overall ratings,by Pearson's correlation(P<0.001).Long wait times had significant negative correlations to overall ratings(P<0.001).Conclusion:Online ratings and comments for laryngologists are significantly influenced by patient perceptions of bedside manner,physician competence,and time spent with the patient.

关键词： laryngologist online rating patient rating physician review website

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Two-dimensional Parameter Relationships for W UMa-type Systems Revisited

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Research in Astronomy and Astrophysics 2024年第1期24卷 51-58页

作者： Atila Poro Ehsan Paki Ailar Alizadehsabegh mehdi Khodadadilori Selda Ranjbar Salehian Mahya Hedayatjoo Fatemeh Hashemi Yasaman Dashti Fatemeh Mohammadizadeh Astronomy Department of the Raderon AI Lab. BurnabyBCCanada Faculty of Electrical and Computer Engineering Department of PhotonicsUniversity of TabrizTabriz 51664Iran Department of Electrical Engineering Amirkabir University of TechnologyTehranIran Astronomy Students'Scientific Association University of TabrizTabriz 51664Iran Department of Physics Iran University of Science and TechnologyTehranIran Institute for the Intellectual Development(Kanoon) Astronomy GroupBojnordIran Department of Mechanical Engineering Amirkabir University of TechnologyTehranIran Aerospace Engineering Department Science and Research Branch of Islamic Azad UniversityTehranIran

Reviewing the empirical and theoretical parameter relationships between various parameters is a good way to understand more about contact binary *** this investigation,two-dimensional(2D)relationships for P–MV(system),P–L1,2,M1,2–L1,2,and q–Lratiowere *** sample used is related to 118 contact binary systems with an orbital period shorter than 0.6 days whose absolute parameters were estimated based on the Gaia Data Release 3 *** reviewed previous studies on 2D relationships and updated six parameter ***,Markov chain Monte Carlo and Machine Learning methods were used,and the outcomes were *** selected 22 contact binary systems from eight previous studies for comparison,which had light curve solutions using spectroscopic *** results show that the systems are in good agreement with the results of this study.

关键词： (stars:)binaries(including multiple):close stars:fundamental parameters methods:data analysis

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Effectiveness of aromatherapy with lavender compared to progressive muscle relaxation on anxiety and vital signs in patients under spinal anesthesia:A randomized clinical trial

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Journal of Integrative Nursing 2024年第2期6卷 90-95页

作者： Nazanin AMINI Safoora OMIDVAR Masoomeh Noruzi ZAMENJANI mehdi HARORANI Hesameddin MODIR Department of Paramedicine Arak University of Medical SciencesArakIran Department of Nursing Shazand School of NursingArak University of Medical SciencesArakIran Department of Anesthesiology Arak University of Medical SciencesArakIran

Objective:This study aimed to determine the effectiveness of aromatherapy with lavender essential oil compared to progressive muscle relaxation(PMR)on anxiety and vital signs of patients under spinal *** and Methods:This clinical trial was conducted on 120 spinal anesthesia candidates who were randomly assigned into three groups of 40 including control,PMR(Jacobsen group),and *** state-trait anxiety inventory was completed on surgery day and 15 min after the end of the intervention by the samples of all three groups,and at the same time as completing the questionnaire,vital signs were also measured and ***:The mean score of anxiety after intervention was lower than that before the intervention in the aromatherapy group(P<0.001).The mean score of anxiety in the aromatherapy group was significantly lower than that in the Jacobsen group(P<0.001).Moreover,data analysis showed a significant decrease in the mean arterial blood pressure scores of the PMR(P=008)and aromatherapy(P<0.001)groups and a statistically significant increase in the mean heart rate scores in the control group(P=0.002).Conclusion:The use of aromatherapy with lavender is more effective than PMR therapy in reducing the anxiety level of patients undergoing spinal *** to the high level of anxiety and its serious effects on the patient’s hemodynamics,aromatherapy with lavender can be used as an easy and cheap method to reduce anxiety in operation rooms.

关键词： Anxiety aromatherapy lavender essential oil massage progressive muscle relaxation spinal anesthesia vital signs

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Impact of umbelliprenin-containing niosome nanoparticles on VEGF-A and CTGF genes expression in retinal pigment epithelium cells

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International Journal of Ophthalmology(English edition) 2024年第1期17卷 7-15页

作者： Farzad Dastaviz Akram Vahidi Teymoor Khosravi Ayyoob Khosravi mehdi Sheikh arabi Abouzar Bagheri Mohsen Rashidi Morteza Oladnabi Stem Cell Research Center Golestan University of Medical SciencesGorgan ***Iran Department of Medical Genetics School of Advanced Technologies in MedicineGolestan University of Medical SciencesGorgan ***Iran Student Research Committee Golestan University of Medical SciencesGorgan ***Iran Department of Molecular Medicine Faculty of Advanced Medical TechnologiesGolestan University of Medical SciencesGorgan ***Iran Department of Medical Nanotechnology Faculty of Advanced Medical TechnologiesGolestan University of Medical SciencesGorgan ***Iran Department of Clinical Biochemistry and Genetics Faculty of MedicineMazandaran University of Medical SciencesSari ***Iran Department Pharmacology Faculty of MedicineMazandaran University of Medical SciencesSari ***Iran Gorgan Congenital Malformations Research Center Golestan University of Medical SciencesGorgan ***Iran

AIM:To investigate the impact of niosome nanoparticles carrying umbelliprenin(UMB),an anti-angiogenic and anti-inflammatory plant compound,on the expression of vascular endothelial growth factor(VEGF-A)and connective tissue growth factor(CTGF)genes in a human retinal pigment epithelium(RPE)-like retina-derived cell ***:UMB-containing niosomes were created,optimized,and ***-like cells were treated with free UMB and UMB-containing *** IC_(50)values of the treatments were determined using an MTT *** expression of VEGF-A and CTGF was evaluated using real-time polymerase chain reaction after RNA extraction and cDNA ***’characteristics,including drug entrapment efficiency,size,dispersion index,and zeta potential were *** UMB had an IC_(50)of 96.2μg/mL,while UMB-containing niosomes had an IC_(50)of 25μg/***:Treatment with UMB-containing niosomes and free UMB resulted in a significant reduction in VEGF-A expression compared to control cells(P=0.001).Additionally,UMB-containing niosomes demonstrated a significant reduction in CTGF expression compared to control cells(P=0.05).However,there was no significant reduction in the expression of both genes in cells treated with free ***:Both free UMB and niosome-encapsulated UMB inhibits VEGF-A and CTGF genes ***,the latter demonstrates significantly greater efficacy,potentially due to the lower UMB dosage and gradual *** findings have implications for anti-angiogenesis therapeutic approaches targeting age-related macular degeneration.

关键词： umbelliprenin niosome age-related macular degeneration vascular endothelial growth factor-A connective tissue growth factor

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Effect of prisms on visual acuity,contrast sensitivity and nystagmus in patients with albinism

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International Journal of Ophthalmology(English edition) 2024年第10期17卷 1864-1868页

作者： Maryam Dashti Abbas Riazi Majid Ashrafi Saeed Rahmani Seyyed mehdi Tabatabaei Department of Optometry School of RehabilitationShahid Beheshti University of Medical SciencesTehran ***Iran Department of Optometry School of RehabilitationIran University of Medical SciencesTehran ***Iran Department of Audiology School of RehabilitationShahid Beheshti University of Medical SciencesTehran ***Iran School of Rehabilitation Shahid Beheshti University of Medical SciencesTehran ***Iran

AIM:To investigate the effect of using base-out prisms on nystagmus,visual acuity and contrast sensitivity in patients with ***:In this interventional study,patients with albinism who had nystagmus were enrolled.A comprehensive eye exam was conducted,which included refraction,assessment of far and near vision acuity,and contrast sensitivity *** check for the nystagmus,a videonystagmography was *** tests were carried out in three modes:without any correction,with optical correction,and with correction using base-out prisms in three different powers,including 4,6,and 8 prism ***:Totally 23 patients with average age of 28.65±12.13 were *** was found that the use of optical correction and optical correction with prisms resulted in a statistically significant improvement in both far(at least:P<0.006)and near visual acuity(at least:P<0.001 except for prism 8;P<0.02).In addition,contrast sensitivity significantly improved at all low and medium frequencies except for correction with prism 8 in frequency 1.5(at least:P<0.01 except for prism 4,frequency 6;P=0.04).no significant improvement was observed in the evaluation of nystagmus ***:Optical correction with a prism can improve visual acuity and some spatial frequencies,but failed to improve nystagmus parameters.

关键词： nystagmus albinism prism

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Oxygen vacancy promoting artificial atom(RuPd)by d-orbital coupling for efficient water dissociation

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Nano Research 2024年第8期17卷 7045-7052页

作者： Ruofan Shen Yanyan Liu Shuling Liu Shuyan Guan Huanhuan Zhang Sehrish mehdi Saima Ashraf Ting-Hui Xiao Erjun Liang Jianchun Jiang Yongfeng Wang Baojun Li Laboratory of Zhongyuan Light School of PhysicsZhengzhou UniversityZhengzhou 450001China Key Laboratory of Materials Physics Ministry of EducationSchool of PhysicsZhengzhou UniversityZhengzhou 450001China College of Chemistry Zhengzhou UniversityZhengzhou 450001China College of Science Henan Agricultural UniversityZhengzhou 450002China Department of Chemistry Tsinghua UniversityBeijing 100084China National Engineering Lab.for Biomass Chemical Utilization Institute of Chemical Industry of Forest ProductsCAFNanjing 210042China Center for Carbon-based Electronics and Key Laboratory for the Physics and Chemistry of Nanodevices Department of ElectronicsPeking UniversityBeijing 100871China

Rational design of highly active catalysts for breaking hydrogen-oxygen bonds is of great significance in energy chemical reactions involving ***,an efficient strategy for the artificial atom(RuPd)established by d-orbital coupling and adjusted by oxygen vacancy(V_(O))is verified for water *** an experimental verification,the turnover frequency of RuPd-TiO_(2)-VO(RuPdTVO)catalyst in ammonia borane hydrolysis reaches up to 2750 min^(−1)(26,190 min−1 based on metal dispersion)in the absence of alkali,exceeding the highest active catalysts(Rh-based catalysts).The d-orbital coupling effect between Ru and Pd simulates the outer electronic structure of *** transfer from V_(O) to(RuPd)constructs an electron-rich state of active sites that further enhances the ability of the artificial atom to dissociate *** work provides an effective electronic regulation strategy from V_(O) and artificial atom constructed by d-orbital coupling effect for efficient water dissociation.

关键词： ammonia borane hydrolysis d-orbital coupling oxygen vacancy artificial atom water dissociation

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