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英语沙龙（高中） 2014年第9期 48-49,58页

作者： megan Clements George Tuggle

Mojave desert tortoise(Gopherus agassizii)thermal ecology and reproductive success along a rainfall cline

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Integrative Zoology 2015年第3期10卷 282-294页

作者： Annette E.SIEG megan M.GAMBONE Bryan P.WALLACE Susana CLUSELLATRULLAS James R.SPOTILA Harold W.AVERY Department of Natural Sciences University of Michigan-DearbornDearbornMichiganUSA HDR Plymouth MeetingPennsylvaniaUSA Nicholas School of the Environment Duke University Marine LaboratoryBeaufortNorth CarolinaUSA Stratus Consulting BoulderColoradoUSA Centre for Invasion Biology Department of Botany and ZoologyStellenbosch UniversityPrivate Bag X1Matieland 7602South Africa Department of Biodiversity Earth and Environmental ScienceDrexel UniversityPhiladelphiaPennsylvaniaUSA Department of Biology The College of New JerseyEwingNew JerseyUSA

Desert resource environments(***,food)are tied to limited,highly localized rainfall regimes which generate microgeographic variation in the life histories of ***,enhanced growth rates,reproduction and survivorship are observed in response to increased resource availability in a variety of desert plants and short-lived *** examined the thermal ecology and reproduction of US federally threatened Mojave desert tortoises(Gopherus agassizii),long-lived and large-bodied ectotherms,at opposite ends of a 250-m elevation-related rainfall cline within Ivanpah Valley in the eastern Mojave Desert,California,*** operative environments in both the upper-elevation,“Cima,”and the lower-elevation,“Pumphouse,”plots corresponded with daily and seasonal patterns of incident solar *** received 22%more rainfall and contained greater perennial vegetative cover,which conferred 5°C-cooler daytime shaded *** a monitored average rainfall year,Cima tortoises had longer potential activity periods by up to several hours and greater ephemeral *** resource availability in Cima was associated with larger-bodied females producing larger eggs,while still producing the same number of eggs as Pumphouse ***,reproductive success was lower in Cima because 90%of eggs were depredated versus 11%in Pumphouse,indicating that predatory interactions produced counter-gradient variation in reproductive success across the rainfall ***-use impacts on deserts(*** energy generation)are increasing rapidly,and conservation strategies designed to protect and recover threatened desert inhabitants,such as desert tortoises,should incorporate these strong ecosystem-level responses to regional resource variation in assessments of habitat for prospective development and mitigation efforts.

关键词： Gopherus agassizii operative environments reproductive ecology resource gradient

High fat diet dysregulates microRNA-17-5p and triggers retinal inflammation:Role of endoplasmic-reticulum-stress

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World Journal of Diabetes 2017年第2期8卷 56-65页

作者： Maha Coucha Islam N Mohamed Sally L Elshaer Osinakachuk Mbata megan L Bartasis Azza B El-Remessy Clinical and Experimental Therapeutics College of PharmacyUniversity of GeorgiaAugustaGA 30912United States

AIM To elucidate how high diet-induced endoplasmic reticulum-stress upregulates thioredoxin interacting protein expression in Müller cells leading to retinal inflammation. METHODS Male C57Bl/J mice were fed either normal diet or 60% high fat diet for 4-8 wk. During the 4 wk study, mice received phenyl-butyric acid(PBA); endoplasmic reticulum-stress inhibitor; for 2 wk. Insulin resistance was assessed by oral glucose tolerance. Effects of palmitate-bovine serum albumin(BSA)(400 μmol/L) were examined in retinal Müller glial cell line and primary Müller cells isolated from wild type and thioredoxin interacting protein knock-out mice. Expression of thioredoxin interacting protein, endoplasmic reticulum-stress markers, mi R-17-5p m RNA, as well as nucleotide-binding oligomerization domain-like receptor protein(NLRP3) and IL1β protein was *** High fat diet for 8 wk induced obesity and insulin resistance evident by increases in body weight and impaired glucose tolerance. By performing quantitative real-time polymerase chain reaction, we found that high fat diet triggered the expression of retinal endoplasmic reticulum-stress markers(P < 0.05). These effects were associated with increased thioredoxin interacting protein and decreased mi R-17-5p expression, whichwere restored by inhibiting endoplasmic reticulumstress with PBA(P < 0.05). In vitro, palmitate-BSA triggered endoplasmic reticulum-stress markers, which was accompanied with reduced mi R-17-5p and induced thioredoxin interacting protein m RNA in retinal Müller glial cell line(P < 0.05). Palmitate upregulated NLRP3 and IL1β expression in primary Müller cells isolated from wild type. However, using primary Müller cells isolated from thioredoxin interacting protein knock-out mice abolished palmitate-mediated increase in NLRP3 and IL1β.CONCLUSION Our work suggests that targeting endoplasmic reticulumstress or thioredoxin interacting protein are potential therapeutic strategies for early intervention of ob

关键词： High fat diet Palmitate Endoplasmic-reticulum-stress Inflammation Thioredoxin-interacting protein Micro-RNA 17-5p

Tough Times Mean Time Together for Some Families

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英语画刊（初三版） 2009年第10期 28-29页

作者： megan K. Scott

A New Dimension In Retail Analysis

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成功营销 2007年第7期 66-67页

作者： Ken Harris megan Margraff

Eggshell as a Source of Novel Bioactive Molecules

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Journal of Food Science and Engineering 2013年第5期3卷 219-225页

作者： megan Rose-Martel Maxwell Hincke Department of Cellular and Molecular Medicine University of Ottawa Ottawa Ontario K1H 8M5 Canada

This review will focus on the more abundant eggshell specific matrix proteins localized in the chicken eggshell （cuticle layer eggshell matrix and shell membranes） that are involved in eggshell mineralization and protecting the egg against microbial contamination, including ovocalyxin-36, ovocleidin-17, ovocalyxin-32 and ovocalyxin-25. Further understanding of these proteins and their mechanisms in egg defence could lead to the development of novel neutraceuticals for human health, additives to animal feed for healthy flocks, or enhanced eggs for human consumption.

关键词： Ovocalyxin Ovocleidin antimicrobial protease inhibitor cuticle eggshell shell membranes review

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Labour of Love

英语学习 1997年第2期 3-6页

作者： megan Rule 云芳

二月是情人的季节。红红的玫瑰、缠绵的情书、甜蜜的巧克力给爱增添了许多浪漫。读一读下面这篇短文,你一定会惊叹于威尔士男子对爱的想象力。

关键词： Labour of Love 威尔士

Endosomal trafficking defects in patient cells with KIAA1109 biallelic variants

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Genes & Diseases 2019年第1期6卷 56-67页

作者： megan S.Kane Callie J.Diamonstein Natalie Hauser John F.Deeken John E.Niederhuber Thierry Vilboux Inova Translational Medicine Institute Inova Health SystemFairfaxVAUnited States Department of Medicine Virginia Commonwealth UniversityRichmondVAUnited States Department of Public Health Sciences University of Virginia School of MedicineCharlottesvilleVAUnited States Department of Oncology and Surgery Johns Hopkins University School of MedicineBaltimoreMDUnited States

The uncharacterized gene KIAA1109 has recently been associated with a congenital neurological malformation disorder that variably presents with arthrogryposis,craniofacial and/or cardiac *** have identified two additional patients with compound heterozygous KIAA1109 variants presenting with the same neurological *** mechanism whereby KIAA1109 loss of function causes this spectrum of disorders was the primary focus of our *** hypothesized that KIAA1109 function could be conserved relative to the fly gene tweek and examined endocytosis and endosome recycling in patient ***,we examined the structure of the cytoskeleton and cilia based on functional overlap with endocytosis and several known etiologies for neuronal migration *** primary dermal fibroblasts from one patient and a healthy donor,we performed immunofluorescence and endocytosis assays to examine the endosomal,cytoskeletal,and ciliary cellular *** found notable abnormalities in endosomal trafficking and endosome recycling *** also observed changes in the actin cytoskeleton and cilia structural *** conclude that the function of KIAA1109 in humans may indeed overlap with the function of the Drosophila ortholog,resulting in perturbations to endosomal trafficking and the actin *** alterations have ripple effects,altering many pathways that are critical for proper neuronal migration and embryonic development.

关键词： Cilia Endocytosis KIAA1109 Neurological malformation Vesicular trafficking

Brain-Derived Neurotrophic Factor (BDNF) Genomic Variants and Salivary Progesterone Levels in Female Patients with a History of Idiopathic Scoliosis: An Historical Cross-Sectional Study

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Open Journal of Clinical Diagnostics 2022年第2期12卷 27-37页

作者： Mark W. Morningstar megan Strauchman Natural Wellness & Pain Relief Center Grand Blanc MI USA

Purpose: Adolescent idiopathic scoliosis is a condition characterized by a three-dimensional curvature of the spine. However, in addition to the spinal curvature, it has also been reported that patients with idiopathic scoliosis can display other abnormal physiologic parameters, such as hormone imbalances, genetic variants, and micronutrient deficiencies. The present study evaluated the salivary progesterone levels, as well as the results of brain-derived neu-rotrophic factor (BDNF) genomic testing, from a historical cohort of patients seeking treatment at a single integrative medicine clinic. Method: A group of female patients with a history of adolescent idiopathic scoliosis was compared to a group of non-scoliosis female patients. Results: Salivary progesterone lev-els were 41% higher in non-scoliosis patients compared to the scoliosis group (P Conclusion: These results suggest a potential relationship between salivary progesterone, BDNF, and adolescent idiopathic scoliosis among female patients. Prospective studies are needed for data extrapolation. The current data warrants further investigation.

关键词： Genomics Hormone Progesterone Scoliosis

Bedside diagnosis of hemoperitoneum by characteristics of fluid visualized on focused assessment with sonography in trauma exam in a patient in non-traumatic shock

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World Journal of Emergency Medicine 2022年第2期13卷 144-146页

作者： Margarita S.Popova Khai-El Johnson Daniel R.King megan T.Quintana Kendarius Talton Keith S.Boniface Department of Emergency Medicine George Washington UniversityWashingtonDC 20037USA Department of Family Medicine George Washington UniversityWashingtonDC 20037USA Department of Anesthesia and Critical Care Medicine George Washington UniversityWashingtonDC 20037USA Center for Trauma and Critical Care Department of SurgeryGeorge Washington UniversityWashingtonDC 20037USA

Dear editor,Focused Assessment with Sonography in Trauma(FAST)enables clinicians to identify injury at the bedside in patients who are too unstable for computed tomography(CT).FAST is most commonly used for the evaluation of trauma,but is also essential to evaluate undifferentiated shock,as in the Rapid Ultrasound for Shock and Hypotension(RUSH)exam.[1]

关键词： diagnosis unstable trauma