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Induction of osteoblast apoptosis stimulates macrophage efferocytosis and paradoxical bone formation

Bone Research 2024年第3期12卷 634-647页

作者： Lena Batoon Amy Jean Koh Susan Marie Millard Jobanpreet Grewal Fang Ming Choo Rahasudha Kannan Aysia Kinnaird megan avey Tatyana Teslya Allison Robyn Pettit Laurie K.McCauley Hernan Roca Department of Periodontics and Oral Medicine University of MichiganSchool of DentistryAnn ArborMI 48109USA Mater Research Institute The University of QueenslandBrisbaneQLD 4102Australia Department of Pathology University of MichiganMedical SchoolAnn ArborMI 48109USA

Apoptosis is crucial for tissue homeostasis and organ *** bone,apoptosis is recognized to be a main fate of osteoblasts,yet the relevance of this process remains *** our murine model with inducible Caspase 9,the enzyme that initiates intrinsic apoptosis,we triggered apoptosis in a proportion of mature osteocalcin(OCN^(+))osteoblasts and investigated the impact on postnatal bone development.

关键词： development homeostasis bone

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Recent advances in the study of Kaposi's sarcoma-associated herpesvirus replication and pathogenesis

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Virologica Sinica 2015年第2期30卷 130-145页

作者： Denis avey Brittany Brewers Fanxiu Zhu Department of Biological Science Florida State University Tallahassee 32306 USA

It has now been over twenty years since a novel herpesviral genome was identified in Kaposi's sarcoma biopsies. Since then, the cumulative research effort by molecular biologists, virologists, clinicians, and epidemiologists alike has led to the extensive characterization of this tumor virus, Kaposi's sarcoma-associated herpesvirus(KSHV; also known as human herpesvirus 8(HHV-8)), and its associated diseases. Here we review the current knowledge of KSHV biology and pathogenesis, with a particular emphasis on new and exciting advances in the field of epigenetics. We also discuss the development and practicality of various cell culture and animal model systems to study KSHV replication and pathogenesis.

关键词： Kaposi’s sarcoma-associated herpesvirus(KSHV) Kaposi’s sarcoma epigenetic epigenome herpesvirus oncovirus chromatin

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Magnesium research and applications: Past, present and future

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Journal of Magnesium and Alloys 2023年第11期11卷 3867-3895页

作者： Jianyue Zhang Jiashi Miao Nagasivamuni Balasubramani Dae Hyun Cho Thomas avey Chia-Yu Chang Alan A.Luo Department of Materials Science and Engineering The Ohio State UniversityColumbusOH 43210USA Department of Integrated Systems Engineering The Ohio State UniversityColumbusOH 43210USA

As the lightest structural metal and one of the most abundant metallic elements on earth, magnesium(Mg) has been used as an "industrial metal" for lightweighting in the transportation and electronics industries, in addition to other traditional applications in aluminum alloying,steel desulfurization and protective anodes. In recent years, research has shown significant potential for Mg to become a "technology metal"in a variety of new applications from energy storage/battery to biomedical products. However, global Mg production has shown steady but moderate growth in the last three decades. Mg applications as an industry metal are still limited due to some sustainability concerns of primary Mg production, as well as a number of technical issues related to the structural and corrosion performance of commercial Mg *** Mg applications as an industrial or technology metal face tremendous technical challenges, which have been reflected in the intensified global research efforts in the last twenty years. This paper will review some past and present applications, and discuss future opportunities and challenges for Mg research and applications for the global Mg community.

关键词： Magnesium alloys Structural applications Lightweighting Biomedical applications Energy applications

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三个冬小麦杂交组合抽穗期的高代分析

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麦类作物学报 1985年第1期 14-16页

作者： D.P.avey 田笑明

培育丰产而又早熟的品种对于减少因病害造成的损失和对小麦、大豆两熟地区是有重要意义的.有人发现,是单基因控制小麦成熟的,它对早熟性是显性或部分显性;另一些人则认为,更有可能是两个基因控制熟性,并证明它

关键词：冬小麦品种杂交组合衍生系早熟性染色体代换基因控制加性效应上位性春化处理遗传变异性

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