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Effects of Melandrium firmum methanolic extract on testosterone-induced benign prostatic hyperplasia in Wistar rats

Asian Journal of Andrology 2012年第2期14卷 320-324页

作者： mee-young lee In-Sik Shin Chang-Seob Seo Nam-Hun lee Hye-Kyung Ha Jong-Keun Son Hyeun-Kyoo Shin Herbal Medicine EBM Research Center Korea institute of Oriental MedicineExporo 483Yusung-guDaejeon 305-811Koreaand Coilege of Pharmacy Yeungnam UniversityGyonsan 712-749Korea

Benign prostatic hyperplasia （BPH） is an age-related disease of unknown aetiology characterized by prostatic enlargement coincident with distinct alterations in tissue histomorphology. Instead of therapeutic agents that can cause severe side effects, plant extracts are frequently used to treat BPH. In this study, we investigated whether the Melandrium firmum methanolic extract （MFME） improves BPH, using the testosterone propionate （TP）-induced BPH rat model. Castration was performed via the scrotal route under sodium pentobarbital anaesthesia. BPH in castrated rats was generated via daily subcutaneous injections of TP （3 mg kg-1） dissolved in corn oil, for 4 weeks. MFME was administered daily by oral garage at a dose of 200 mg kg-1 for 4 weeks, along with the TP injections. The control group received injections of corn oil subcutaneously. At the scheduled termination of the experiment, all rats were killed and their prostates weighed; the relative prostate weight （prostate/body weight ratio） was calculated, and histomorphological changes in the prostate were examined. Additionally, we measured the levels of testosterone and dihydrotestosterone （DHT） in the serum and the prostate. Experimentally induced BPH led to marked decreases in the relative prostate weight and the DHT levels in the serum and the prostate. Histologically, BPH was evident in the ventral lobe of the prostate, and MFME treatment suppressed the severity of the lesions. These results indicate that MFME effectively inhibits the development of BPH induced by testosterone in a rat model. Further studies will be needed to identify the compound（s） responsibility for inducing the protective effect against BPH and determine its mechanism of action,

关键词： benign prostatic hyperplasia dihydrotestosterone Melandrium firmum (S. et Z.)RoHRB prostate testosterone

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辣椒素受体介导热休克诱导人表皮角质形成细胞金属蛋白酶1的表达

辣椒素受体介导热休克诱导人表皮角质形成细胞金属蛋白酶1的表达

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2006中国中西医结合皮肤性病学术会议

作者：李文海 young mee lee Jee Youn KIM Seokwon KANG Jin Ho CHUNG 北京大学人民医院皮肤科 Department of Dermatology Laboratory of Cutaneous Aging ResearchClinical Research InstituteSeoul National University HospitalSeoulKorea

背景:金属蛋白酶1(MMP-1)是炎症反应中降解胶原的主要内肽酶。近来发现辣椒素受体(TR- PV1,一种非特异性离子通道)存在于人类角质形成细胞上,表皮的辣椒素受体激活后可以释放炎症前介质,然而在生理活动和病理状态下皮肤辣椒素受体的调...

背景:金属蛋白酶1(MMP-1)是炎症反应中降解胶原的主要内肽酶。近来发现辣椒素受体(TR- PV1,一种非特异性离子通道)存在于人类角质形成细胞上,表皮的辣椒素受体激活后可以释放炎症前介质,然而在生理活动和病理状态下皮肤辣椒素受体的调节功能所知甚少。

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Diagnostic accuracy of administrative database for bile duct cancer by ICD-10 code in a tertiary institute in Korea

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Hepatobiliary & Pancreatic Diseases International 2020年第6期19卷 575-580页

作者： young-Jae Hwang Seon mee Park Soomin Ahn Jongchan lee young Soo Park Nayoung Kim Department of Internal Medicine Seoul National University Bundang HospitalSeongnamKorea Department of Internal Medicine Chungbuk National University College of Medicine and Medical Research InstituteCheongjuKorea Department of Pathology Seoul National University Bundang HospitalSeoungnamKorea Department of Internal Medicine and Institute of Liver Research Seoul National University College of MedicineSeoulKorea Tumor Microenvironment Global Core Research Center Seoul National UniversitySeoulKorea

Background:Administrative database provides valuable information for large cohort studies,especially when tissue diagnosis is rather difficult such as the diagnosis for bile duct cancer(BDC).The aim of this study was to evaluate the diagnostic accuracy of administrative database for BDC by International Classification of Diseases(ICD)-10 codes in a tertiary ***:BDC and control groups were collected from 2003 to 2016 at Seoul National University Bundang *** of BDC were identified in the National Health Insurance Service(NHIS)database by ICD 10-code supported by V *** control group was selected from cases without ICD-10 codes for BDC.A definite or possible diagnosis was defined according to pathologic *** records,images,and pathology reports were analyzed to evaluate ICD-10 codes for ***,specificity,positive predictive value,and negative predictive value for BDC were analyzed according to diagnostic criteria and cancer ***:A total of 1707 patients with BDC and 1707 controls were *** those with BDC,1320(77.3%)were diagnosed by definite ***(99.4%)of them had *** of definite diagnosis was the highest for ampulla of Vater(88.9%),followed by that for extrahepatic(84.9%)and intrahepatic(68.3%)*** positive cases commonly had hepatocellular *** overall diagnosis of BDC,sensitivity,specificity,positive predictive value,and negative predictive value were 99.94%,98.33%,98.30%,and 99.94%,*** accuracies were similar regardless of diagnostic criteria or tumor ***:Administrative database for BDC collected according to ICD-10 code with V code shows good accuracy.

关键词： National Health Insurance Service Bile duct cancer ICD-10

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p73 G4C14 to A4T14 polymorphism is associated with colorectal cancer risk and survival

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World Journal of Gastroenterology 2010年第35期16卷 4448-4454页

作者： Kyung-Eun lee young-Seoub Hong Byoung-Gwon Kim Na-young Kim Kyoung-Mu lee Jong-young Kwak mee-Sook Roh Department of Clinical Laboratory Science College of Health Sciences Catholic University of Pusan Department of Preventive Medicine Dong-A University College of Medicine Clinical Research Institute Seoul National University College of Medicine Medical Research Center for Cancer Molecular Therapy Dong-A University College of Medicine Department of Pathology Dong-A University College of Medicine

AIM:To analyze the association between the p73 G4C14-to-A4T14 polymorphism(a.k.a.,the GC/AT variation) and colorectal cancer risk and survival in the Korean population,and to evaluate the relationships between p73 polymorphism and the p73 protein expression or clinicopathological characteristics of colorectal ***:Three hundred and eighty-three histologically confirmed cases and 469 healthy controls,recruited at one teaching hospital in Pusan,Korea from 2001 and 2007,were genotyped for p73 G4C14-to-A4T14 by PCR with confronting two-pair primers(PCR-CTPP) and the expression profile of p73 in cancer tissues(n=383) was analyzed by ***:Odds ratios(ORs) and 95% confidence intervals(CIs) were calculated by unconditional logistic regression model adjusted for age and *** with the GC/GC genotypes,the GC/AT and AT/AT genotypes were significantly associated with colorectal cancer risk(GC/AT vs GC/GC:OR = 1.46,95% CI:1.10-1.94;AT/AT vs GC/GC:1.72,0.98-3.03;Ptrend=0.01).When stratified by age and gender,the association was restricted to those less than 60 years of age(GC/AT or AT/AT vs GC/GC:2.22,1.39-3.55) and male(GC/AT or AT/AT vs GC/GC:1.91,1.31-2.77).The expression of p73 was associated with invasion depth(P = 0.003) and advanced Duke's stage(P = 0.06) of colorectal *** patients with the GC/GC genotype were associated with worse survival compared with those with the other genotypes(P = 0.02).However,no signif icant relationship was observed between the p73 G4C14-to-A4T14 polymorphism and p73 protein expression in cancer ***:Our results suggest that the p73 GC/AT polymorphism is associated with an increased colorectal cancer risk and survival in the Korean population.

关键词： p73 G4C14 to A4T14 polymorphism Colorectal cancer

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pH-induced structural changes of surface immobilized poly (L-lysine) by two-dimensional (2D) infrared correlation study

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Chinese Chemical Letters 2015年第2期26卷 173-176页

作者： Eun Joo Yoo Boknam Chae young mee Jung Seung Woo lee School of Chemical Engineering Yeungnam University Pohang Accelerator Laboratory Department of Chemistry Kangwon National University

This paper reports the pH-induced structural changes in the surface immobilized poly（L-lysine）（PLL）***-dimensional（2D） correlation analysis was applied to the Fourier transform infrared（FTIR）spectra of the surface-immobilized PLL film to examine the spectral changes induced by the alternations of the protonation state of the amino group in the side *** spectral changes in the FTIR spectra of the PLL film were observed between pH 7 and *** decrease in the protonation state of the amino group in the side chain induced spectral changes in the amino group as well as conformational changes in the alky]group in the side *** pH 1-8,the spectral changes in the amino and alkyl groups in the side chain occurred before those of the amide group in the main chain of the surface immobilized PLL film.

关键词： Poly(L-lysine)(PLL) Surface-immobilized polypeptide FT-IR spectroscopy 2D correlation spectroscopy

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Collision tumor of the rectum: A case report of metastatic gastric adenocarcinoma plus primary rectal adenocarcinoma

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World Journal of Gastroenterology 2006年第34期12卷 5569-5572页

作者： young-Hoon Roh Hyoun-Wook lee Min-Chan Kim Kyeong-Woo lee mee-Sook Roh Department of Surgery Dong-A University College of Medicine Busan 602-715 South Korea Department of Pathology Dong-A University College of Medicine Busan 602-715 South Korea Department of Rehabilitation Medicine Dong-A University College of Medicine Busan 602-715 South Korea Department of Pathology Dong-A University College of Medicine Busan 602-715 South Korea Medical Research Center for Cancer Molecular Therapy Dong-A University College of Medicine Busan 602-715 South Korea

Collision tumors are thought to arise from the accidental meeting and interpenetration of two independent tumors. We report here a highly unusual case of a 61-year old man who had a unique tumor that was composed of a metastatic adenocarcinoma from the stomach to the rectum, which harbored a collision tumor of primary rectal adenocarcinoma. The clonalities of the two histologically distinct lesions of the rectal mass were confirmed by immunohistochemical and molecular analysis. Although histologic examination is the cornerstone in pathology, immunohistochemical and molecular analysis can provide evidence regarding whether tumors originate from the same clone or different clones. To the best of our knowledge, this is the fi rst reported case of such an occurrence.

关键词： Collision tumor Rectum Clonality

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Interleukin-24 is correlated with differentiation and lymph node numbers in rectal cancer

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World Journal of Gastroenterology 2011年第9期17卷 1167-1173页

作者： youngmin Choi mee-Sook Roh young-Seoub Hong Hyung-Sik lee Won-Joo Hur Department of Radiation Oncology Dong-A University School of Medicine Department of Pathology Dong-A University School of Medicine Department of Preventive Medicine Dong-A University School of Medicine

AIM:To assess the significance of interleukin(IL)-24 and vascular endothelial growth factor(VEGF)expression in lymph-node-positive rectal cancer. METHODS:Between 1998 and 2005,90 rectal adenocarcinoma patients with lymph node involvement were *** patients received radical surgery and postoperative pelvic chemoradiotherapy of 50.4-54.0 *** of 5-fluorouracil and leucovorin or levamisole was given intravenously during the first and last week of radiotherapy,and then monthly for about 6 *** of IL-24 and VEGF was evaluated by immunohistochemical staining of surgical specimens, and their relations with patient characteristics and survival were *** median follow-up of surviving patients was 73 mo(range:52-122 mo). RESULTS:IL-24 expression was found in 81 out of 90 patients;31 showed weak intensity and 50 showedstrong *** expression was found in 64 out of 90 *** and weak intensities of IL-24 expression were classified as negative expression for ***-24 expression was significantly reduced in poorly differentiated tumors in comparison with well or moderately differentiated tumors(P=0.004),N2b to earlier N stages(P=0.016),and stageⅢc to stageⅢ a orⅢb(P=0.028).The number of involved lymph nodes was also significantly reduced in IL-24-positive patients in comparison with IL-24-negative ones. There was no correlation between VEGF expression and patient *** of IL-24 and VEGF was not correlated with survival,but N stage and stages were significantly correlated with survival. CONCLUSION:IL-24 expression was significantly correlated with histological differentiation,and inversely correlated with the degree of lymph node involvement in stageⅢrectal cancer.

关键词： Interleukin-24 Rectal cancer Lymph node Histological differentiation Vascular endothelial growth factor

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Prognosis of hepatocellular carcinoma expressing cytokeratin 19:Comparison with other liver cancers

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World Journal of Gastroenterology 2012年第34期18卷 4751-4757页

作者： Jung Il lee Jin-Woo lee Joon mee Kim Ja Kyung Kim Hyun Jung Chung young Soo Kim Department of Internal Medicine School of MedicineInha UniversityIncheon 400-711South Korea Department of Pathology School of MedicineInha UniversityIncheon 400-711South Korea Department of Internal Medicine Yonsei University College of MedicineGangnam Severance HospitalSeoul 135-720South Korea

AIM:To investigate whether expressing biliary phenotype predicted poor outcome after the surgical treatment in primary liver cancers. METHODS:Out of 204 patients that underwent liver resection due to hepatocellular carcinoma (HCC), liver specimens of 70 patients with HCC were evaluated for biliary components by cytokeratin (CK) 19 immunostain (CK19 - HCC and CK19 + HCC). CK19 positivity was defined as membranous and/or cytoplasmic expression in ≥ 5% of tumor cells with moderate or strong intensity. Patients with other primary liver cancers, such as com- bined HCC and cholangiocarcinoma (cHCC-CC), intrahe- patic cholangiocarcinoma (ICC) who received curative liver resection, were also included in the study. Clinical characteristics of CK19-HCC and CK19 + HCC patients, including survival outcome after curative liver resection, were compared with that of cHCC-CC and ICC patients. RESULTS: The overall survival (OS) rate of CK19 - HCC(n = 49) after the curative surgical treatment was 90.7%, and 80.4% at 1 and 5 years after the resection. OS rate of CK19 + HCC (n = 21) was 74.3%, 28.9% and OS rate of cHCC-CC (n = 22) was 66.7%, 32.2% at 1 and 5 years after the surgery. For ICC (n = 19), 1 and 5-year-OS rate was 50.2% and 14.3% after the cura-tive resection. The OS rates of CK19 + HCC and cHCC-CC were significantly lower than that of CK19-HCC, but higher than the OS rate of ICC (P = 0.000). There was no statistically significant difference in OS rate between CK19 + HCC and cHCC-CC. The disease free survival (DFS) rate of CK19-HCC was 72.0% and 54.5% at 1 and 3 years after the surgical treatment. DFS rate of CK19 + HCC was 53.3%, 34.3% and DFS rate of cHCC- CC was 51.5%, 39.2% at 1 and 3 years after the resection. For ICC, 1 and 3-year-DFS rate was 28.0% and 14.0% after the curative resection. DFS rate of CK19-HCC was significantly higher than that of ICC (P = 0.017), but marginally higher than DFS rate of either CK19 + HCC or cHCC-CC (P = 0.097, P = 0.089, respec-tively).

关键词： Cytokeratin 19 Hepatocellular carcinoma Intrahepatic cholangiocarcinoma Liver cancers Hepa-tectomy

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Systematic review on the surgical treatment for T1 gallbladder cancer

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World Journal of Gastroenterology 2011年第2期17卷 174-180页

作者： Seung Eun lee Jin-young Jang Chang-Sup Lim mee Joo Kang Sun-Whe Kim Department of Surgery Chung-Ang University College of Medicine Department of Surgery Seoul National University College of Medicine

AIM:To evaluate the efficacy of simple and extended cholecystectomy for mucosa(T1a) or muscularis(T1b) gallbladder(GB) cancer. METHODS:Original studies on simple and extended cholecystectomy for T1a or T1b GB cancer were searched from MEDLINE(PubMed) ,Cochrane Library,EMBase,and CancerLit using the search terms of GB,cancer/carcinoma/tumor/neoplasm. RESULTS:Twenty-nine out of the 2312 potentially relevant publications met the eligibility *** the 1266 patients with GB cancer included in the publications,706(55.8%) and 560(44.2%) had T1a and T1b GB cancer,*** cholecystectomy for T1a and T1b GB cancer was performed in 590(83.6%) and 375(67.0%) patients,respectively(P<0.01) .In most series,the treatment of choice was simple cholecystectomy for T1a GB cancer patients with a 5-year survival rate of 100%.Lymph node metastasis was detected in 10.9% of the T1b GB cancer patients and in 1.8%of the T1a GB cancer patients,respectively(P<0.01) .Eight patients(1.1%) with T1a GB cancer and 52 patients(9.3%) with T1b GB cancer died of recurrent GB cancer(P<0.01) . CONCLUSION:Simple cholecystectomy represents the adequate treatment of T1a GB *** is no definite evidence that extended cholecystectomy is advantageous over simple cholecystectomy for T1b GB cancer.

关键词： Gallbladder Cancer Cholecystectomy Simple Extended

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Accuracy of an administrative database for pancreatic cancer by international classification of disease 10th codes: A retrospective large-cohort study

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World Journal of Gastroenterology 2019年第37期25卷 5619-5629页

作者： young-Jae Hwang Seon mee Park Soomin Ahn Jong-Chan lee young Soo Park Nayoung Kim Departments of Internal Medicine Seoul National University Bundang HospitalSeoungnam 13620South Korea Department of Internal Medicine Chungbuk National University College of Medicine and Medical Research InstituteCheongju 28644South Korea Departments of Pathology Seoul National University Bundang HospitalSeoungnam 13620South Korea Department of Internal Medicine and Institute of Liver Research and Tumor Microenvironment Global Core Research Center Seoul National University College of MedicineSeoul 08826South Korea

BACKGROUND Korean National Health Insurance(NHI)claims database provides ***,studies regarding accuracy of administrative database for pancreatic cancer(PC)have not been *** aimed to identify accuracy of NHI database regarding PC classified by international classification of disease(ICD)-10 *** To identify the accuracy and usefulness of administrative database in PC and the accurate ICD codes for PC with *** Study and control groups were collected from 2003 to 2016 at Seoul National University Bundang *** of PC were identified in NHI database by international classification of diseases,10th revision edition(ICD-10 codes)supported with V codes.V code is issued by medical doctors for covering 95%of medical cost by Korean *** to pathologic reports,definite or possible diagnoses were defined using medical records,images,and *** A total of 1846 cases with PC and controls were *** PC,only 410(22.2%)cases were identified as specific cancer sites including head in 234(12.7%)cases,tail in 104(5.6%)cases and body in 72(3.9%)*** PC,910(49.3%)cases were diagnosed by definite *** of these were adenocarcinoma(98.0%).The rates of definite diagnosis of PC were highest in head(70.1%)followed by body(47.2%)and tail(43.3%).False-positive cases were pancreatic cystic neoplasm and metastasis to the *** terms of the overall diagnosis of PC,sensitivity,specificity,positive predictive value,and negative predictive value were 99.95%,98.72%,98.70%,and 99.95%,*** accuracy was similar both in terms of diagnostic criteria and tumor *** Korean NHI claims database collected according to ICD-10 code with V code for PC showed good accuracy.

关键词： Korean national health insurance Accuracy Pancreatic cancer International classification of disease Sensitivity Specificity

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