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World Journal of Gastroenterology 2006年第34期12卷 5569-5572页

作者： Young-Hoon roh Hyoun-Wook Lee Min-Chan Kim Kyeong-Woo Lee mee-sook roh Department of Surgery Dong-A University College of Medicine Busan 602-715 South Korea Department of Pathology Dong-A University College of Medicine Busan 602-715 South Korea Department of Rehabilitation Medicine Dong-A University College of Medicine Busan 602-715 South Korea Department of Pathology Dong-A University College of Medicine Busan 602-715 South Korea Medical Research Center for Cancer Molecular Therapy Dong-A University College of Medicine Busan 602-715 South Korea

Collision tumors are thought to arise from the accidental meeting and interpenetration of two independent tumors. We report here a highly unusual case of a 61-year old man who had a unique tumor that was composed of a metastatic adenocarcinoma from the stomach to the rectum, which harbored a collision tumor of primary rectal adenocarcinoma. The clonalities of the two histologically distinct lesions of the rectal mass were confirmed by immunohistochemical and molecular analysis. Although histologic examination is the cornerstone in pathology, immunohistochemical and molecular analysis can provide evidence regarding whether tumors originate from the same clone or different clones. To the best of our knowledge, this is the fi rst reported case of such an occurrence.

关键词： Collision tumor Rectum Clonality

Interleukin-24 is correlated with differentiation and lymph node numbers in rectal cancer

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World Journal of Gastroenterology 2011年第9期17卷 1167-1173页

作者： Youngmin Choi mee-sook roh Young-Seoub Hong Hyung-Sik Lee Won-Joo Hur Department of Radiation Oncology Dong-A University School of Medicine Department of Pathology Dong-A University School of Medicine Department of Preventive Medicine Dong-A University School of Medicine

AIM:To assess the significance of interleukin(IL)-24 and vascular endothelial growth factor(VEGF)expression in lymph-node-positive rectal cancer. METHODS:Between 1998 and 2005,90 rectal adenocarcinoma patients with lymph node involvement were *** patients received radical surgery and postoperative pelvic chemoradiotherapy of 50.4-54.0 *** of 5-fluorouracil and leucovorin or levamisole was given intravenously during the first and last week of radiotherapy,and then monthly for about 6 *** of IL-24 and VEGF was evaluated by immunohistochemical staining of surgical specimens, and their relations with patient characteristics and survival were *** median follow-up of surviving patients was 73 mo(range:52-122 mo). RESULTS:IL-24 expression was found in 81 out of 90 patients;31 showed weak intensity and 50 showedstrong *** expression was found in 64 out of 90 *** and weak intensities of IL-24 expression were classified as negative expression for ***-24 expression was significantly reduced in poorly differentiated tumors in comparison with well or moderately differentiated tumors(P=0.004),N2b to earlier N stages(P=0.016),and stageⅢc to stageⅢ a orⅢb(P=0.028).The number of involved lymph nodes was also significantly reduced in IL-24-positive patients in comparison with IL-24-negative ones. There was no correlation between VEGF expression and patient *** of IL-24 and VEGF was not correlated with survival,but N stage and stages were significantly correlated with survival. CONCLUSION:IL-24 expression was significantly correlated with histological differentiation,and inversely correlated with the degree of lymph node involvement in stageⅢrectal cancer.

关键词： Interleukin-24 Rectal cancer Lymph node Histological differentiation Vascular endothelial growth factor

p73 G4C14 to A4T14 polymorphism is associated with colorectal cancer risk and survival

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World Journal of Gastroenterology 2010年第35期16卷 4448-4454页

作者： Kyung-Eun Lee Young-Seoub Hong Byoung-Gwon Kim Na-Young Kim Kyoung-Mu Lee Jong-Young Kwak mee-sook roh Department of Clinical Laboratory Science College of Health Sciences Catholic University of Pusan Department of Preventive Medicine Dong-A University College of Medicine Clinical Research Institute Seoul National University College of Medicine Medical Research Center for Cancer Molecular Therapy Dong-A University College of Medicine Department of Pathology Dong-A University College of Medicine

AIM:To analyze the association between the p73 G4C14-to-A4T14 polymorphism(a.k.a.,the GC/AT variation) and colorectal cancer risk and survival in the Korean population,and to evaluate the relationships between p73 polymorphism and the p73 protein expression or clinicopathological characteristics of colorectal ***:Three hundred and eighty-three histologically confirmed cases and 469 healthy controls,recruited at one teaching hospital in Pusan,Korea from 2001 and 2007,were genotyped for p73 G4C14-to-A4T14 by PCR with confronting two-pair primers(PCR-CTPP) and the expression profile of p73 in cancer tissues(n=383) was analyzed by ***:Odds ratios(ORs) and 95% confidence intervals(CIs) were calculated by unconditional logistic regression model adjusted for age and *** with the GC/GC genotypes,the GC/AT and AT/AT genotypes were significantly associated with colorectal cancer risk(GC/AT vs GC/GC:OR = 1.46,95% CI:1.10-1.94;AT/AT vs GC/GC:1.72,0.98-3.03;Ptrend=0.01).When stratified by age and gender,the association was restricted to those less than 60 years of age(GC/AT or AT/AT vs GC/GC:2.22,1.39-3.55) and male(GC/AT or AT/AT vs GC/GC:1.91,1.31-2.77).The expression of p73 was associated with invasion depth(P = 0.003) and advanced Duke's stage(P = 0.06) of colorectal *** patients with the GC/GC genotype were associated with worse survival compared with those with the other genotypes(P = 0.02).However,no signif icant relationship was observed between the p73 G4C14-to-A4T14 polymorphism and p73 protein expression in cancer ***:Our results suggest that the p73 GC/AT polymorphism is associated with an increased colorectal cancer risk and survival in the Korean population.

关键词： p73 G4C14 to A4T14 polymorphism Colorectal cancer

Microscopic characteristics of the inferior tarsal muscle and its surroundings in Korean

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International Journal of Ophthalmology(English edition) 2013年第2期6卷 126-130页

作者： Jung Min Park mee sook roh Moo Hyun Kim Woo Jin Jeung Won Yeol Ryu Yoon Hyung Kwon Hee Bae Ahn Department of Ophthalmology Maryknoll Hospital Department of Pathology College of Medicine Dong-A University Department of Cardiology College of Medicine Dong-A University Department of Ophthalmology College of Medicine Dong-A University

AIM: To investigate the detailed microscopic anatomic structures of the lower eyelid in Korean cadavers. METHODS: Eight lower eyelids of 4 formalin-fixed Asian cadavers (4 males; age range, 48-69 years; mean age, 60.2 years) were examined. Three perpendicular dissected sections with a 2mm thickness were obtained from each eyelid to investigate anatomic shapes, size and relationship with surrounding structures. One section was obtained from the midline and 2 the other sections were obtained from a 3mm apart from the lateral and medial tarsus margins. RESULTS: The inferior tarsal muscle fibers were not directly attached to the tarsus but were only linked to the tarsus with enclosed fibrous fascia. The inferior tarsal muscles connected loosely with the capsulopalpebral fascia anteriorly and the conjunctiva posteriorly. The inferior tarsal muscle runs horizontally to the tarsus according to the shape of muscle fibers. The capsulopalpebral fascia consisted of an anterior and posterior layer. The anterior layer reached the orbital septum and subcutaneous fat but the posterior layer forwarded into the tarsus. Lockwood’s ligament was separated from the inferior tarsal muscle and capsulopalpebral fascia or fused into the capsulopalpebral ***: This study suggests that the inferior tarsal muscle which runs horizontally and doesn’t insert directly into the tarsus, plays an important role in the movement and localization of the lower eyelid.

关键词： capsulopalpebral fascia inferior tarsal muscle lower eyelid

Operational Implementation of the ATOVS Processing Procedure in KMA and Its Validation

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Advances in Atmospheric Sciences 2003年第3期20卷 398-414页

作者： Myoung-Hwan AHN mee-Ja KIM Chu-Yong CHUNG Ae-sook SUH RemoteSensing Research Laboratory/Meteorological Research Institute RemoteSensing Research Laboratory/Meteorological Research InstituteRemoteSensing Research Laboratory/Meteorological Research InstituteRemoteSensing Research Laboratory/Meteorological Research Institute Seoul 156-720KoreaSeoul 156-720KoreaSeoul 156-720KoreaSeoul 156-720Korea

The Korea Meteorological Administration (KMA) has processed the data from the advanced TOVS (ATOVS) onboard NOAA-16 satellite since May 2001. The operational production utilizes the AAPP (ATOVS and AVHRR Processing Package) of EUMETSAT and IAPP (International ATOVS Processing Package) of the University of Wisconsin. For the initial guess profiles, the predicted fields (usually 6 to 12 hour forecasted fields) from the global aviation model of NOAA/NCEP are used. The average number of profiles retrieved from the ATOVS data is about 1,300 for each morning and afternoon orbit at about 18 and 06 UTC, respectively. The retrieved temperature and dew point temperatures are provided to forecasters in real time and used for initialization of prediction models. With the advanced microwave sensor (AMSU; Advanced Microwave Sounding Unit), accuracy of the ATOVS products is expected to be better than that of the TOVS products, especially in cloudy conditions. Indeed, the preliminary results from a validation study with the collocated radiosonde data during a 8-month period, from May to December 2001, for the East Asia region show an improved accuracy of the ATOVS products for cloudy skies versus the TOVS, especially for higher altitudes. The RMS (Root Mean Square) difference between the ATOVS products and radiosonde data is about 1.3°C for both clear and cloudy conditions, except for near the ground and at higher altitudes, at around 200 hPa. There is no significant temporal variation of the error statistics at all pressure levels. In case of the water vapor mixing ratio, the largest difference is shown at lower altitudes, while the accuracy is much better for the clear sky cases than the cloudy sky cases. The bias and RMSE at lower altitudes is about 0.557 g kg−1 and 2.5 g kg−1 and decrease significantly with increasing altitude.

关键词： ATOVS Processing and validation temperature and humidity profiles

The secretory products of Trichomonas vaginalis decrease fertilizing capacity of mice sperm in vitro

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Asian Journal of Andrology 2015年第2期17卷 319-323,I0012页

作者： Jaesook roh Young-Su Lim Min-Young Seo Yuri Choi Jae-sook Ryu Department of Anatomy and Cell Biology Laboratory of Reproductive Endocrinology College of Medicine Hanyang University Seoul Korea Department of Anesthesiology and Pain Medicine St. Mary's Hospital Catholic University Incheon Korea Department of Environmental Biology and Medical Parasitology College of Medicine Hanyang University Seoul Korea.

Trichomonas vaginalis infection is one of the most prevalent sexually transmitted infections in humans and is now recognized as an important cause of infertility in men. There is little information about the effect of extracellular polymeric substances （EPS） from T. vaginalis on sperm, but previous reports do not provide a conclusive description of the functional integrity of the sperm. To investigate the impact of EPS on the fertilizing capacity of sperm, we assessed sperm motility, acrosomal status, hypo-osmotic swelling, and in vitro fertilization rate after incubating the sperm with EPS in vitro using mice. The incubation of sperm with EPS significantly decreased sperm motility, viability, and functional integrity in a concentration and time-dependent manner. These effects on sperm quality also resulted in a decreased fertilization rate in vitro. This is the first report that demonstrates the direct negative impact of the EPS of T. vaginalis on the fertilization rate of sperm in vitro. However, further study should be performed using human sperm to determine if EPS has similar negative impact on human sperm fertilizing capacity in vitro.

关键词： extracellular polymeric substances fertilization sperm Trichomonas vaginalis

Identification of Tsuga Germplasm by Morphological Characters and RAPD Markers

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应用与环境生物学报 2007年第2期13卷 145-151页

作者： roh Mark S DE BENEDETTI Laura JOUNG Young Hee LEE Nam sook US Department of Agriculture Agricultural Research ServiceNational ArboretumFloral and Nursery Plants Research UnitBeltsvilleMD 20705USA Istituto Sperimentale per la Floricoltura SanremoImperiaItaly Chonnam National University School of Biological Sciences and TechnologyGwangjuKorea Ewha Womans University Department of Life SciencesSeoulKorea

Germplasm collection is important to preserve and maximize genetic diversity for germplasm *** dumosa(***)Eichler in Engler & *** *** ***(Downie)Silba germplasm was collected from three localities in China:***,Wenfeng Temple and ***,Yunnan *** were identified based on morphological characters and RAPD *** shapes of the apices and margins of needles were examined,and the length and width of needles,cones and seeds from accessions of mature plants were used to compare the morphological differences and to identify the *** markers generated by randomly amplified polymorphic DNA(RAPD)were also used to characterize the *** the clustering based on RAPD markers was inconsistent with the morphological characters of the needles,based on the overall morphological characters and on RAPD markers,the accessions from *** and Wenfeng Temple were identified as *** ***,and those from *** identified as *** identification of the accessions was made based on morphology and by RAPD markers *** results indicate that the shapes of the apices and margins of needles particularly from young plants could not be used as a possible key to identify *** and *** *** 6,Tab 3,Ref

关键词：形态特征 RAPD分子标记种质鉴定云南铁杉华铁杉

Efficacy of Seprafilm~ graft with adhesiolysis in experimentally induced lid adhesion in rabbits

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International Journal of Ophthalmology(English edition) 2013年第1期6卷 44-49页

作者： Sang Wook Jin Hee Bae Ahn Mi sook roh Yoon Hyung Kwon Won Yeol Ryu Department of Ophthalmology College of MedicineDong-A University Department of Pathology College of MedicineDong-A University

AIM:To evaluate the efficacy of Seprafilm transplantation following adhesiolysis for preventing postoperative readhesion and improving surgical outcomes. METHODS:Primary blepharoplasty was carried out on both eyelids of 18 albino rabbits. After 2 weeks, a new skin incision was made, and adhesiolysis was performed on both eyelids. The rabbits were categorized into two groups, one with adhesiolysis alone in the left eyelid (control group), and the other with adhesiolysis with a Seprafilm graft in the right eyelid (Seprafilm group). The degrees of inflammation and fibrosis were examined with hematoxylin-eosin (HE) and Masson’s trichrome stains. Expression of α-smooth muscle actin (α-SMA) was also immunohistochemically examined. RESULTS:Eyelid examination immediately after the operation revealed mild swelling and hemorrhage in both groups, but these symptoms resolved after 1 week-2 weeks, and eyelid shape had recovered completely in both groups. Microscopic assessments demonstrated that the Seprafilm group showed less inflammation and fibrosis than the control group. The Seprafilm group also exhibited fewer α-SMA-positive cells than the control group. CONCLUSION:Based on these findings, we conclude that Seprafilm graft with adhesiolysis is an effective method for preventing postoperative readhesions after eyelid surgery.

关键词： Seprafilm adhesion adhesiolysis

Bile-derived circulating extracellular mi R-30d-5p and mi R-92a-3p as potential biomarkers for cholangiocarcinoma

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Hepatobiliary & Pancreatic Diseases International 2020年第1期19卷 41-50页

作者： Hye sook Han Mi Jin Kim Joung-Ho Han Jieun Yun Hee Kyung Kim Yaewon Yang Ki Bae Kim Seon mee Park Department of Internal Medicine Chungbuk National University HospitalCheongju 28644Korea Departments of Internal Medicine Chungbuk National University College of MedicineCheongju 28644Korea Department of Pharmaceutical Engineering College of Science EngineeringCheongju UniversityCheongju 28644Korea

Background: Cholangiocarcinoma (CCA) is from cholangiocytes, and therefore bile is a potentially rich source of biomarkers for CCA. The aim of the study was to identify and validate microRNAs (miRNAs) in bile samples that are differentially expressed between benign biliary disease (BBD) and CCA. Methods: Bile samples from 106 patients with obstructive biliary disease were allocated consecutively to a discovery set (10 patients with BBD and 11 with CCA) and then a validation set (48 patients with BBD and 37 with CCA). An miRNA microarray platform was used to screen 1209 miRNAs in the discovery set. Quantitative real-time reverse transcription polymerase chain reaction (qRT-PCR) was used to validate the pro ling results in the discovery and validation sets. In addition, the levels of carbohydrate antigen 19-9 (CA19-9) and carcinoembryonic antigen (CEA) were determined from patient serum samples. Results: Microarray pro ling showed that miR-30d-5p and miR-92a-3p were signi cantly upregulated in bile from the CCA group compared with those from the BBD group. qRT-PCR results indicated that the expression levels of miR-30d-5p and of miR-92a-3p were signi cantly upregulated in the CCA group compared to the BBD group, validating the miRNA microarray results. Pathway analysis suggested that putative target genes of miR-30d-5p and of miR-92a-3p were involved in CCA-associated signalling path- ways, such as Hippo, Wnt, p53, MAPK, and EGFR. Receiver operating curve analysis revealed that the areas under the curve for bile miR-30d-5p, miR-92a-3p, serum CA19-9, and CEA were 0.730, 0.652, 0.675, and 0.603, respectively, and bile miR-30d-5p showed the best diagnostic performance with a sensitivity of 81.1% and a speci city of 60.5%. Conclusions: The levels of extracellular miR-30d-5p and miR-92a-3p in bile were signi cantly higher in patients with CCA than those in patients with BBD. Bile-derived circulating extracellular miR-30d-5p and miR-92a-3p are potential biomarkers for discr

关键词： Bile Biomarkers Cholangiocarcinoma MicroRNA

SIMULA在Cu/ZnO/Al_2O_3催化剂上进行甲醇部分氧化蒸气重整制备氢气的模拟研究(英文)

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燃料化学学报 2001年第3期29卷 207-213页

作者：蒋元力黄强王福安 mee sook Lim Dong Hyun Kim 郑州工业大学化工学院 DepartmentofChemicalEngineering KyungpookNationalUniversityTaegu702701Korea

两个大气压下 ,对管状填充床反应器中在Cu ZnO Al2 O3催化剂上甲醇部分氧化蒸气重整制备氢气进行了实验研究。在Cu ZnO Al2 O3催化剂上进行该反应体系动力学研究的基础上 ,建立了该反应器内的稳态质量和热量衡算方程 ,同时考虑了颗粒内... 详细信息

两个大气压下 ,对管状填充床反应器中在Cu ZnO Al2 O3催化剂上甲醇部分氧化蒸气重整制备氢气进行了实验研究。在Cu ZnO Al2 O3催化剂上进行该反应体系动力学研究的基础上 ,建立了该反应器内的稳态质量和热量衡算方程 ,同时考虑了颗粒内的扩散限制。模型的预测结果与实验结果吻合较好。

关键词：氢气制备模拟质量衡算热量衡算部分氧化蒸气重整甲醇铜氧化锌氧化铝催化剂