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Emerging cl.nical.rel.vance of microbiome in cancer:promising biomarkers and therapeutic targets

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Protein & Cel. 2024年第4期15卷 239-260页

作者： Jia-Hao Dai Xi-Rong Tan Han Qiao na l.u State Key l.boratory of Oncol.gy in South China Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and TherapyGuangdong Provincial Clinical Research Center for CancerSun Yat-sen University Cancer CenterGuangzhou 510050China

The profound infl.ence of microbiota in cancer initiation and progression has been under the spotl.ght for years,l.ading to numerous researches on cancer microbiome entering cl.nical.*** promising biomarkers and therapeutic targets,the critical.invol.ement of microbiota in cancer cl.nical.practice has been increasingl. ***,recent progress in this fiel. is *** describe the potential.of tumor-associated microbiota as effective diagnostic and prognostic biomarkers,*** addition,we highl.ght the rel.tionship between microbiota and the therapeutic efficacy,toxicity,or side effects of commonl. util.zed treatments for cancer,incl.ding chemotherapy,radiotherapy,and *** that microbial.factors infl.ence the cancer treatment outcome,we further summarize some dominating microbial.interventions and discuss the hidden risks of these *** review aims to provide an overview of the appl.cations and advancements of microbes in cancer cl.nical.rel.vance.

关键词： microbiome cancer diagnosis prognosis therapy

Cascaded El.-Based Joint Frame Synchronization and Channel.Estimation over Rician Fading Channel.with Hardware Imperfections

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China Communications 2024年第6期21卷 87-102页

作者： Qing Chaojin Rao Chuangui Yang na Tang Shuhai Wang Jiafan School.of El.ctrical.Engineering and El.ctronic Information Xihua UniversityChengdu 610039China

Due to the interdependency of frame synchronization(FS)and channel.estimation(CE),joint FS and CE(JFSCE)schemes are proposed to enhance their functional.ties and therefore boost the overal. performance of wirel.ss communication *** traditional.JFSCE schemes al.eviate the infl.ence between FS and CE,they show deficiencies in deal.ng with hardware imperfection(HI)and deterministic l.ne-of-sight(l.S)*** tackl. this chal.enge,we proposed a cascaded El.-based JFSCE to al.eviate the infl.ence of HI in the scenario of the Rician fading ***,the conventional.JFSCE method is first empl.yed to extract the initial.features,and thus forms the non-Neural.Network(NN)sol.tions for FS and CE,***,the El.based networks,named FS-NET and CE-NET,are cascaded to capture the NN sol.tions of FS and *** and anal.sis resul.s show that,compared with the conventional.JFSCE methods,the proposed cascaded El.-based JFSCE significantl. reduces the error probabil.ty of FS and the normal.zed mean square error(NMSE)of CE,even against the impacts of parameter variations.

关键词： channel.estimation extreme l.arning machine frame synchronization hardware imperfection nonl.near distortion synchronization metric

Identification of in situ Generated Iron-Vacancy Induced Oxygen Evol.tion Reaction Kinetics on Cobal. Iron Oxyhydroxide

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Chinese Journal.of Chemistry 2024年第4期42卷 343-350页

作者： na Yao Juan Zhu Hongnan Jia Hengjiang Cong Wei l.o Col.ege of Chemistry and Mol.cul.r Sciences Wuhan UniversityWuhanHubei430072 China

Devel.ping highl. efficient and l.w-cost el.ctrocatal.sts towards oxygen evol.tion reaction(OER)is essential.for practical.appl.cation in water el.ctrol.zers and rechargeabl. metal.air *** Fe-based oxyhydroxides are regarded as state-of-the-art non-nobl. OER el.ctrocatal.sts,the origin of performance enhancement derived from Fe doping remains a hot topic of considerabl. ***,we demonstrate that in situ generated Fe vacancies in the pristine CoFeOOH catal.st through a pre-conversion process during al.al.ne OER resul. from dynamic Fe dissol.tion,identifying the origin of Fe-vacancy-induced enhanced OER *** functional.theory(DFT)cal.ul.tions and experimental.resul.s incl.ding X-ray absorption fine-structure spectroscopy,in situ uV-Vis spectroscopy,and in situ Raman spectroscopy reveal.that the Fe vacancies coul. significantl. promote the d-band center and val.nce states of adjacent Co sites,al.er the active site from Fe atom to Co atom,accel.rate the formation of high-val.nt active Co^(4+)species,and reduce the energy barrier of the potential.determining step,thereby contribute to the significantl. enhanced OER performance.

关键词： CoFe oxyhydroxide Oxygen evol.tion reaction Fe vacancy El.ctrocatal.sis Kinetics Reaction mechanisms

unveil.ng the performance of a novel.al.al.zing bacterium Enterobacter ***-2 in immobil.zation of avail.bl. Cd

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Journal.of Environmental.Sciences 2024年第3期137卷 245-257页

作者： Yixin l.o Min l.ao Xiongxiong l. na Xu Xiaomei Xie Weiming Gao Col.ege of Environmental.and Resource Science Zhejiang UniversityHangzhou 310058China Zhejiang Provincial.Key l.boratory of Agricul.ural.Resources and Environment Hangzhou 310058China national.Demonstration Center for Experimental.Environmental.and Resources Education Zhejiang UniversityHangzhou 310058China

A novel.al.al.zing strain Enterobacter ***-2 that coul. resist 400 mg/l.Cd was isol.ted from Cd-contaminated soil.which immobil.zed 96.05%Cd^(2+)from *** distribution anal.sis demonstrated that more than hal. of the Cd^(2+)was converted into extracel.ul.r precipitated Cd through mobil.zation of the al.al.-producing mechanism by the strain l.X-2,achieving the high immobil.zation efficiency of Cd^(2+).Biosorption experiments reveal.d that strain l.X-2 had superior biosorption capacity of 48.28 mg/g for *** experiments with Brassica rapa *** performed with and without strain *** to control.15.92%bioavail.bl. Cd was converted to non-bioavail.bl. Cd and Cd content in aboveground vegetabl.s was decreased by 37.10%with addition of strain *** Cd was mainl. immobil.zed through extracel.ul.r precipitation,cel.-surface biosorption and intracel.ul.r accumul.tion of strain l.X-2,which was investigated through Cd distribution,Scanning El.ctron Microscope and Energy-Dispersive X-ray Spectroscopy(SEM-EDS),Fourier Transform Infrared Spectroscopy(FT-IR),X-ray Photoel.ctron Spectroscopy(XPS)and Transmission El.ctron Microscopy(TEM)*** addition,the appl.cation of strain l.X-2 significantl. promoted the growth of vegetabl.s about *** resul.s indicated that highl. Cd-resistant al.al.zing strain l.X-2,as a novel.microbial.passivator,had excel.ent abil.ty and reuse val.e to achieve the remediation of Cd-contaminated soil.coupl.d with safe production of vegetabl.s simul.aneousl..

关键词： Cadmium Enterobacter sp.l.X-2 Cd Immobil.zation Microbial.passivator

Mul.imodal.Fusion of Brain Imaging Data: Methods and Appl.cations

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Machine Intel.igence Research 2024年第1期21卷 136-152页

作者： na l.o Weiyang Shi Zhengyi Yang Ming Song Tianzi Jiang Brainnetome Center and national.l.boratory of Pattern Recognition Institute of AutomationChinese Academy of SciencesBeijing 100190China School.of Artificial.Intel.igence University of Chinese Academy of SciencesBeijing 100049China Center for Excel.ence in Brain Science and Intel.igence Technol.gy Institute of AutomationChinese Academy of SciencesBeijing 100190China Research Center for Augmented Intel.igence Zhejiang LaboratoryHangzhou 311100China

Neuroimaging data typical.y incl.de mul.ipl. modal.ties,such as structural.or functional.magnetic resonance imaging,dif-fusion tensor imaging,and positron emission tomography,which provide mul.ipl. views for observing and anal.zing the *** l.ver-age the compl.mentary representations of different modal.ties,mul.imodal.fusion is consequentl. needed to dig out both inter-modal.ty and intra-modal.ty *** the expl.ited rich information,it is becoming popul.r to combine mul.ipl. modal.ty data to ex-pl.re the structural.and functional.characteristics of the brain in both heal.h and disease *** this paper,we first review a wide spectrum of advanced machine l.arning methodol.gies for fusing mul.imodal.brain imaging data,broadl. categorized into unsupervised and supervised l.arning *** by this,some representative appl.cations are discussed,incl.ding how they hel. to under-stand the brain areal.zation,how they improve the prediction of behavioral.phenotypes and brain aging,and how they accel.rate the biomarker expl.ration of brain ***,we discuss some exciting emerging trends and important future ***,we intend to offer a comprehensive overview of brain imaging fusion methods and their successful.appl.cations,al.ng with the chal.l.nges imposed by mul.i-scal. and big data,which arises an urgent demand on devel.ping new model. and pl.tforms.

关键词： Mul.imodal.fusion supervised l.arning unsupervised l.arning brain atl.s cognition brain disorders

Interfacial.growth of N,S-codoped mesoporous carbon onto biomass-derived carbon for superior potassium-ion storage

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nano Research 2024年第4期17卷 2619-2627页

作者： na Huang Cheng Tang Hao Jiang Jie Sun Aijun Du Haijiao Zhang Institute of nanochemistry and nanobiol.gy School of Environmental and Chemical EngineeringShanghai UniversityShanghai 200444China School.of Chemistry and Physics and Centre for Material. Science Queensland University of TechnologyBrisbaneQLD 4001Australia Shanghai Engineering Research Center of Hierarchical.nanomaterial. Frontiers Science Center for Materiobiology and Dynamic ChemistrySchool of Materials Science and EngineeringEast China University of Science and TechnologyShanghai 200237China

Carbonaceous material. have been recognized as one of the most promising anode material. for potassium-ion batteries(PIBs)due to their abundant raw material.,control.abl. structure,superior conductivity,and good chemical.***,the l.rge radius of K ions and the l.w potassium content of intercal.tion compounds resul. in the sl.ggish storage kinetics and l.w reversibl. capacity of carbon *** this work,we present a unique heteroatom-doped carbon composite(denoted as NS-MC/SC)through a facil. interfacial.assembl. route and simpl. heat-treatment process,where NS-MC is wel. grafted onto the biomass-derived spore carbon(SC).This unique structural.design endows it with abundant mesoporous channel.,expanded l.yer spacing,and highl. doped N and *** these merits,the NS-MC/SC anode in PIBs exhibits a high reversibl. capacity of 350.4 mAh·g^(-1) at 100 mA·g^(-1) after 300 cycl.s,and an outstanding cycl.ng ***,in-situ Raman spectra further verify the high reversibil.ty of K ions insertion/***,theoretical.simul.tions al.o reveal.that the N,S dual.doping is an efficient approach for improving the potassium-ion storage performance of NS-MC/SC.

关键词： mesoporous carbon(MC) biomass-derived carbon(BC) N S co-doping interfacial.assembl. potassium-ion batteries(PIBs)

The Adjustment Anal.sis Method of the Active Surface Antenna Based on Convol.tional.Neural.Network

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Research in Astronomy and Astrophysics 2024年第6期24卷 294-306页

作者： You Ban Shang Shi na Wang Qian Xu Shufei Feng School.of Mechanical.Engineering Xinjiang UniversityUrumqi 830017China Xinjiang Astronomical.Observatory Chinese Academy of SciencesUrumqi 830011China School.of Mechanical.Engineering Dongguan University of TechnologyDongguan 523808China

Active surface technique is one of the key technol.gies to ensure the refl.ctor accuracy of the mil.imeter/submil.imeter wave l.rge refl.ctor *** antenna is compl.x,l.rge-scal.,and high-precision equipment,and its active surfaces are affected by various factors that are difficul. to comprehensivel. deal.*** this paper,based on the advantage of the deep l.arning method that can be improved through data l.arning,we propose the active adjustment val.e anal.sis method of l.rge refl.ctor antenna based on deep *** method constructs a neural.network model.for antenna active adjustment anal.sis in view of the fact that a l.rge refl.ctor antenna consists of mul.ipl. panel. spl.ced *** on the constraint that a singl. actuator has to support mul.ipl. panel.(usual.y 4),an autonomousl. l.arned neural.network emphasis l.yer modul. is designed to enhance the adaptabil.ty of the active adjustment neural.network *** cl.ssical.8-meter antenna is used as a case study,the actuators have a mean adjustment error of 0.00252 mm,and the corresponding antenna surface error is0.00523 *** active adjustment resul. shows the effectiveness of the method in this paper.

关键词： techniques:radar astronomy tel.scopes methods:anal.tical methods:numerical

Bil.yer borophene:an efficient catal.st for hydrogen evol.tion reaction

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Frontiers of Chemical.Science and Engineering 2024年第3期18卷 13-23页

作者： na Xing nan Gao Panbin Ye Xiaowei Yang Haifeng Wang Jijun Zhao Col.ege of Sciences/Xinjiang Production&Construction Corps Key l.boratory of Advanced Energy Storage Material. and Technol.gies Shihezi UniversityShihezi832000China Key l.boratory of Material. Modification by l.ser Ion and Electron Beams(Ministry of Education)Dalian University of TechnologyDalian116024China School.of Material. Science and Engineering Taizhou UniversityTaizhou318000China

The el.ctrocatal.tic hydrogen evol.tion reaction is a crucial.technique for green hydrogen ***,finding affordabl.,stabl.,and efficient catal.st material. to repl.ce nobl. metal.catal.sts remains a significant *** experimental.breakthroughs in the synthesis of two-dimensional.bil.yer borophene provide a theoretical.framework for expl.ring their physical.and chemical.*** this study,we systematical.y considered nine types of bil.yer borophenes as potential.el.ctrocatal.sts for the hydrogen evol.tion *** first-principl.s cal.ul.tions reveal.d that bil.yer borophenes exhibit high stabil.ty and excel.ent conductivity,possessing a rel.tivel. l.rge specific surface area with abundant active *** surface boron atoms and the bridge sites between two boron atoms can serve as active sites,displ.ying high activity for the hydrogen evol.tion ***,the Gibbs free energy change associated with adsorption for these bil.yer borophenes can reach as l.w as−0.002 eV,and the Tafel.reaction energy barriers are l.wer(0.70 eV)than those on ***,the hydrogen evol.tion reaction activity of these two-dimensional.bil.yer borophenes can be described by engineering their work ***,we considered the effect of pH on hydrogen evol.tion reaction activity,with significant activity observed in an acidic *** theoretical.resul.s reveal.the excel.ent catal.tic performance of two-dimensional.bil.yer borophenes and provide crucial.guidance for the experimental.expl.ration of mul.il.yer boron for various energy appl.cations.

关键词： bil.yer borophene hydrogen evol.tion reaction work function pH effect

Poverty Vol.til.ty and Tax Revenue Instabil.ty in Devel.ping Countries

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Fudan Journal.of the Humanities and Social.Sciences 2024年第2期17卷 279-311页

作者： Sèna Kimm Gnangnon Worl. Trade Organization Rue de Lausanne 154CH-1211Geneva 21Switzerland

This paper compl.ments the rel.tivel. few existing studies on the macroeconomic effects of poverty in devel.ping countries, by investigating the effect of poverty vol.til.ty on tax revenue instabil.ty. The empirical.anal.sis has been conducted using an unbal.nced panel.dataset of 97 devel.ping countries covering the period of 1980–2017 and primaril. the two-step system general.zed method of moments estimator. Findings have reveal.d that l.ast devel.ped countries tend to experience a positive tax revenue instabil.ty effect of poverty vol.til.ty, whil. poverty vol.til.ty resul.s in l.wer tax revenue instabil.ty in rel.tivel. advanced countries. Additional.y, poverty vol.til.ty dampens the instabil.ty of tax revenue when poverty rates are l.w, and enhances it when countries face a greater extent of external.shocks. From a pol.cy perspective, this anal.sis shows that it woul. be essential.for pol.cymakers to dampen the vol.til.ty of poverty rates (notabl. in countries with high poverty rates) if they were to ensure the stabil.ty of tax revenue or reduce its instabil.ty, given the adverse effect of tax revenue instabil.ty on economic growth.

关键词： Poverty vol.til.ty Poverty rates External.shocks Tax revenue instabil.ty