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Current updates on the epidemiology,pathogenesis and development of small molecule therapeutics for the treatment of Ebola virus infections

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Asian Pacific Journal of Tropical Medicine 2024年第7期17卷 285-298,I0001-I0007页

作者： Shah Alam Khan Neelima Shrivastava mdjawaid akhtar Aftab Ahmad Asif Husain Department of Pharmaceutical Chemistry College of PharmacyNational University of Science and TechnologyPO Box 620Postal code 130MuscatSultanate of Oman Centre of Molecular Medicine and Diagnostics(COMMAND) Saveetha Dental College&HospitalsSaveetha Institute of Medical&Technical SciencesSaveetha UniversityChennai 600077India Department of Pharmaceutical Chemistry School of Pharmaceutical Education and ResearchJamia HamdardNew Delhi-110062India Department of Health Information Technology the Applied CollegeKing Abdulaziz UniversityJeddah-21589Kingdom of Saudi Arabia

Ebola virus disease(EVD)is a rare,highly contagious and a deadly disease with a variable fatality rate ranging from 30%to 90%.Over the past two decades,Ebola pandemic has severely affected the sub-Sahara region including Democratic Republic of the Congo(DRC),and *** causative agents of the most EVD cases are three distinct species out of six Ebolaviruses namely Zaire Ebolavirus(ZEBOV),Sudan Ebolavirus(SUDV)and Bundibugyo Ebolavirus(BDBV).In recent years,significant strides have been made in therapeutic ***,the US Food and Drug Administration has approved two monoclonal antibodies:InmazebTM(REGN-EB3)and Ansuvimab or ***,many small molecules are currently in the developmental stage,promising further progress in medical *** the critical need for preventive measures,this review provides an in-depth analysis of the licensed Ebola vaccines-Ervebo and the combination of Zabdeno(***)and Mvabea(MVA-BN-Filo)as well as the vaccines which are currently being tested for their efficacy and safety in clinical *** vaccines might play an important role in curbing the spread and mitigating the impact of this lethal *** current treatment landscape for EVD encompasses both nutritional(supportive)and drug *** review comprehensively details the origin,pathogenesis,and epidemiology of EVD,shedding light on the ongoing efforts to combat this devastating *** explores small molecules in various stages of the development,discusses patents filed or granted,and delves into the clinical and supportive therapies that form the cornerstone of EVD *** review aims to provide the recent developments made in the design and synthesis of small molecules for scientific community to facilitate a deeper understanding of the disease and fostering the development of effective strategies for prevention,treatment,and control of EVD.

关键词： Ebola Epidemic Vaccine Ebola virus diseas

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Energy management of buildings with energy storage and solar photovoltaic:A diversity in experience approach for deep reinforcement learning agents

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Energy and AI 2024年第1期15卷 1-14页

作者： akhtar Hussain Petr Musilek Department of Electrical and Computer Engineering University of AlbertaEdmontonT6G 2G2ABCanada Department of Applied Cybernetics University of Hradec Králové50003Hradec KrálovéCzech Republic

Deep reinforcement learning(DRL)is a suitable approach to handle uncertainty in managing the energy consumption of buildings with energy storage ***,DRL agents are trained by randomly selecting samples from a data set,which can result in overexposure to some data categories and under/no exposure to other data ***,the trained model may be biased towards some data groups and underperform(provide suboptimal results)for data groups to which it was less *** address this issue,diversity in experience-based DRL agent training framework is proposed in this *** approach ensures the exposure of agents to all types of *** proposed framework is implemented in two *** the first step,raw data are grouped into different clusters using the K-means clustering *** clustered data is then arranged by stacking the data of one cluster on top of *** the second step,a selection algorithm is proposed to select data from each cluster to train the DRL *** frequency of selection from each cluster is in proportion to the number of data points in that cluster and therefore named the proportional selection *** analyze the performance of the proposed approach and compare the results with the conventional random selection method,two indices are proposed in this study:the flatness index and the divergence *** model is trained using different data sets(1-year,3-year,and 5-year)and also with the inclusion of solar *** simulation results confirmed the superior performance of the proposed approach to flatten the building’s load curve by optimally operating the energy storage system.

关键词： Battery energy storage Building demand management Deep reinforcement learning Diversity in experience Energy management

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Thermal properties and high-temperature ablation of high-entropy (Ti_(0.25)V_(0.25)Zr_(0.25)Hf_(0.25))B_(2) coating on graphite substrate

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Journal of Advanced Ceramics 2024年第8期13卷 1268-1281页

作者： Ana C.Feltrin Daniel Hedman Farid akhtar Division of Materials Science Lulea University of TechnologyLulea 97187Sweden Center for Multidimensional Carbon Materials(CMCM) Institute for Basic Science(IBS)Ulsan 44919Republic of Korea

An entropy-stabilized multicomponent ultrahigh-temperature ceramic(UHTC)coating,(Ti_(0.25)V_(0.25)Zr_(0.25)Hf_(0.25))B_(2),on a graphite substrate was in-situ sintered by spark plasma sintering(SPs)from constituent transition metal diboride ***(Ti_(0.25)V_(0.25)Zr_(0.25)Hf_(0.25))B_(2) coating had a hardness of 31.2±2.1 GPa and resisted 36.9 GPa of stress before delamination,as observed at the *** temperature-dependent thermal properties of the multicomponent diboride(Ti_(0.25)V_(0.25)Zr_(0.25)Hf_(0.25))B_(2) were obtained by molecular dynamics(MD)simulations driven by a machine learning force field(MLFF)trained on density functional theory(DFT)*** thermal conductivity,density,heat capacity,and coefficient of thermal expansion obtained by the MD simulations were used in time-dependent thermal stress finite element model(FEM)*** low thermal conductivity(<6.52 W·m^(-1)·K^(-1))of the multicomponent diboride coupled with its similar coefficient of thermal expansion to that of graphite indicated that stresses of less than 10 GPa were generated at the interface at high temperatures,and therefore,the coating was mechanically resistant to the thermal stress induced during *** experiments at 220℃ showed that the multicomponent diboride coating was resistant to thermal stresses with no visible cracking or *** ablation mechanisms were mechanical denudation and evaporation of B_(2)O_(5) and light V-Ti oxides,which caused a decrease in the mass and thickness of the coating and resulted in mass and linear ablation rates of-0.51 mg·s^(-1) and -1.38μm·s^(-1),respectively,after 60 *** findings demonstrated the thermal and mechanical stability of multicomponent entropy-stabilized diborides as coatings for carbon materials in engineering components under extreme environments.

关键词： entropy-stabilized diborides ultrahigh temperature ceramics molecular dynamics(MD)simulations density functional theory(DFT) ablation properties

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A new class of generalized quasi-variational inequalities with applications to Oseen problems under nonsmooth boundary conditions

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Science China Mathematics 2024年第2期67卷 315-338页

作者： Shengda Zeng akhtar A.Khan Stanislaw Migórski Guangxi Colleges and Universities Key Laboratory of Complex System Optimization and Big Data Processing Yulin Normal UniversityYulin 537000China Faculty of Mathematics and Computer Science Jagiellonian University in Krak´owKrak´ow 30348Poland Center for Applied and Computational Mathematics School of Mathematical SciencesRochester Institute of TechnologyRochesterNY 14623USA College of Sciences Beibu Gulf UniversityQinzhou 535000China

In this paper, we study a generalized quasi-variational inequality (GQVI for short) with twomultivalued operators and two bifunctions in a Banach space setting. A coupling of the Tychonov fixedpoint principle and the Katutani-Ky Fan theorem for multivalued maps is employed to prove a new existencetheorem for the GQVI. We also study a nonlinear optimal control problem driven by the GQVI and givesufficient conditions ensuring the existence of an optimal control. Finally, we illustrate the applicability of thetheoretical results in the study of a complicated Oseen problem for non-Newtonian fluids with a nonmonotone andmultivalued slip boundary condition (i.e., a generalized friction constitutive law), a generalized leak boundarycondition, a unilateral contact condition of Signorini’s type and an implicit obstacle effect, in which themultivalued slip boundary condition is described by the generalized Clarke subgradient, and the leak boundarycondition is formulated by the convex subdifferential operator for a convex superpotential.

关键词： generalized quasi-variational inequality existence theorem optimal control Kakutani-Ky Fan theorem Oseen problem non-Newtonian fluid nonmonotone slip boundary condition

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Effect of rotating gliding discharges on the lean blow-off limit of biogas flames

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Plasma Science and Technology 2024年第10期26卷 116-122页

作者： Muhammad Saqib akhtar Mhedine ALICHERIF Bing WANG Deanna A.LACOSTE School of Aerospace Engineering Tsinghua UniversityBeijing 10084People’s Republic of China King Abdullah University of Science and Technology Physical Science and Engineering DivisionClean Combustion Research CenterThuwal 23955-6900Saudi Arabia

This study investigates the effect of a rotating gliding discharge on synthetic biogas combustion at atmospheric *** biogas was produced by mixing methane and carbon *** mixtures were considered:100%/0%,70%/30%,and 50%/50%of methane and carbon dioxide,*** plasma effect was investigated in a low-swirl-number burner equipped with a high-voltage electrode to produce gliding *** effect of plasma on the stability limits of the flame is reported for several electrical *** plasma-assisted combustion,the lean blow-off limits of biogas-air flames were significantly improved,which agrees with what can be found in the literature for other *** electrical parameters of the discharge and the plasma emissions were measured using electric probes and emission spectroscopy,*** mixture with the CO_(2)dilution was associated with a higher reduced electric field and higher ion production.A better understanding of the excited-species concentration evolution during plasma is necessary and will be investigated in future work.

关键词： plasma-assisted combustion non-equilibrium plasma methane carbon dioxide

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The Application of Artificial Intelligence in Alzheimer’s Research

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Tsinghua Science and Technology 2024年第1期29卷 13-33页

作者： Qing Zhao Hanrui Xu Jianqiang Li Faheem akhtar Rajput Liyan Qiao Faculty of Information Technology Beijing University of TechnologyBeijing 100124China School of Medicine Tsinghua UniversityBeijing 100084China Department of Computer Science Sukkur IBA UniversitySukkur 65200Pakistan Department of Neurology Tsinghua University Yuquan HospitalBeijing 100040China

Alzheimer's disease(AD)is an irreversible and neurodegenerative disease that slowly impairs memory and neurocognitive function,but the etiology of AD is still *** the explosive growth of electronic health data,the application of artificial inteligence(Al)in the healthcare setting provides excellent potential for exploring etiology and personalized treatment approaches,and improving the disease's diagnostic and prognostic *** paper first briefly introduces Al technologies and applications in medicine,and then presents a comprehensive review of Al in *** simple,it includes etiology discovery based on genetic data,computer-aided diagnosis(CAD),computer-aided prognosis(CAP)of AD using multi-modality data(genetic,neuroimaging and linguistic data),and pharmacological or non-pharmacological approaches for treating ***,some popular publicly available AD datasets are introduced,which are important for advancing Al technologies in AD ***,core research challenges and future research directions are discussed.

关键词： Alzheimer's disease artificial intelligence etiology discovery computer-aided diagnosis computer-aided prognosis treatment

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Landau quantization effects on damping Kawahara solitons in electron–positron–ion plasma in rotating ionized medium

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Communications in Theoretical Physics 2024年第10期76卷 143-152页

作者： E I El-Awady S Hussain N akhtar Department of Physics Faculty of Science Port Said University Theoretical Physics Division (TPD) PINSTECH

For the dynamics of three-dimensional electron–positron–ion plasmas, a fluid quantum hydrodynamic model is proposed by considering Landau quantization effects in dense ***–neutral collisions in the presence of the Coriolis force are also considered. The application of the reductive perturbation technique produces a wave evolution equation represented by a damped Korteweg–de Vries equation. This equation, however, is insufficient for describing waves in our system at very low dispersion coefficients. As a result, we considered the highest-order perturbation, which resulted in the damped Kawahara equation. The effects of the magnetic field, Landau quantization, the ratio of positron density to electron density, the ratio of positron density to ion density, and the direction cosine on linear dispersion laws as well as soliton and conoidal solutions of the damped Kawahara equation are explored. The understanding from this research can contribute to the broader field of astrophysics and aid in the interpretation of observational data from white dwarfs.

关键词： Coriolis force Kawahara equation Landau quantization magnetoplasmas quantum plasma solitary and cnoidal waves

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Tuning structural,electrical,dielectric and magnetic properties of Mg-Cu-Co ferrites via dysprosium(Dy^(3+))doping

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Journal of Rare Earths 2024年第1期42卷 137-146,I0005页

作者： Maria akhtar M.S.Hasan Nasir Amin N.A.Morley Muhammad Imran Arshad Department of Physics Government College UniversityFaisalabad38000Pakistan Department of Physics The University of Lahore53700Pakistan Department of Materials Science and Engineering The University of SheffieldS13JDUK Department of Physics&Astronomy University College LondonUK

In current research work,Dy3+substituted Mg0.5Cu0.25Co0.25Fe2-xDyxO4(0.0≤x≤0.04 with the step interval of 0.01)soft ferrites were synthesized by the sol-gel auto combustion *** prepared samples were characterized by the techniques using X-ray diffraction(XRD),scanning electron microscopy(SEM),energy dispersive X-ray spectroscopy(EDS),Fourier transform infrared(FTIR)spectroscopy,curre nt-voltage(Ⅰ-Ⅴ)measurement,LCR meter,vibrating sample magnetometer(VSM)and *** data reveal that the average crystallite size is 49.71 nm and the lattice constant is 0.83703 nm for sample x=*** non-uniform grain growth was demonstrated by micrographs and impurity-free elemental composition was observed from EDX *** DC resistivity has an increasing and decreasing trend in ferromagnetic and paramagnetic regions with an increase in ***,the high resistivity is observed with the order of 1010Ω·cm,and the activation energy is 0.944 eV for samples x=*** dielectric parameters including dielectric constant,dielectric losses,and impedance gradually decrease with the increase in frequency from 8 Hz to 8 *** minimum dielectric loss at high frequency is found for sample x=*** coercivity(Hc)and saturation magnetization(Ms)are found in the ranges of 520.82-544.02 Oe and 20.5841-21.1473 emu/g,*** observations confirm that dysprosium(x=0.03)doped MCC-soft ferrites may be applicable in transformer cores,microwave absorbance,and telecommunication devices.

关键词： Soft ferrites DC resistivity Dielectric loss Impedance Coercivity Rare earths

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Base Pressure Control with Semi-Circular Ribs at Critical Mach Number

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Fluid Dynamics & Materials Processing 2024年第9期20卷 2007-2028页

作者： Ambareen Khan Sher Afghan Khan Mohammed Nishat akhtar Abdul Aabid Muneer Baig School of Aerospace Engineering Universiti Sains MalaysiaPenang11600Malaysia Department of Mechanical and Aerospace Engineering Faculty of EngineeringInternational Islamic University MalaysiaKuala Lumpur59000Malaysia Department of Engineering Management College of EngineeringPrince Sultan UniversityP.O.Box 66833Riyadh11586Saudi Arabia

When better fuel-air mixing in the combustion chamber or a reduction in base drag are required in vehicles,rockets,and aeroplanes,the base pressure control is *** the base pressure and drag is necessary in both *** this work,semi-circular ribs with varying diameters(2,4,and 6 mm)positioned at six distinct positions(0.5D,1D,1.5D,2D,3D,and 4D)inside a square duct with a side of 15 mm are proposed as an efficient way to apply the passive control ***-depth research is done on optimising rib size for various rib *** to this study,the base pressure rises as rib height ***,the optimal location for the semi-circular ribs with a diameter of 2 mm is at *** 1D location appears to be optimal for the 4 mm size as *** the 6 mm size,however,the 4D position fills this function.

关键词： Base pressure nozzle pressure ratio base drag sonic Mach number passive control

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Assessing forest cover changes and fragmentation in the Himalayan temperate region: implications for forest conservation and management

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Journal of Forestry Research 2024年第4期35卷 128-141页

作者： Kaleem Mehmood Shoaib Ahmad Anees akhtar Rehman Aqil Tariq Qijing Liu Sultan Muhammad Fazli Rabbi Shao’an Pan Wesam Atef Hatamleh College of Forestry Beijing Forestry UniversityBeijing 100083People’s Republic of China Institute of Agriculture Sciences and Forestry University of SwatSwatPakistan Department of Forestry The University of AgricultureDera Ismail Khan 29050Pakistan Key Laboratory for Silviculture and Conservation of Ministry of Education Beijing Forestry UniversityBeijing 100083People’s Republic of China Beijing Key Laboratory of Precision Forestry Forestry CollegeBeijing Forestry UniversityBeijing 100083People’s Republic of China School of Environmental Studies China University of GeosciencesWuhan 430074People’s Republic of China Department of Wildlife Fisheries and AquacultureCollege of Forest ResourcesMississippi State UniversityStarkvilleMS 39762‑9690USA School of Management Tianjin University of CommerceTianjin 300134People’s Republic of China Department of Computer Science College of Computer and Information SciencesKing Saud UniversityP.O.Box 5117811543 RiyadhSaudi Arabia

This study comprehensively assessed long-term vegetation changes and forest fragmentation dynamics in the Himalayan temperate region of Pakistan from 1989 to *** satellite images,including Landsat-5 TM and Landsat-8 Operational Land Imager(OLI),were chosen for subsequent assessments in October 1989,2001,2011 and *** classified maps of 1989,2001,2011 and 2019 were created using the maximum likelihood ***-classification comparison showed an overall accuracy of 82.5%and a Kappa coefficient of 0.79 for the 2019 *** revealed a drastic decrease in closed-canopy and open-canopy forests by 117.4 and 271.6 km^(2),respectively,and an increase in agriculture/farm cultivation by 1512.8 km^(2).The two-way ANOVA test showed statistically significant differences in the area of various cover *** fragmentation was evaluated using the Landscape Fragmentation Tool(LFT v2.0)between 1989 and *** large forest core(>2.00 km^(2))decreased from 149.4 to 296.7 km^(2),and a similar pattern was observed in medium forest core(1.00-2.00 km^(2))*** the contrary,the small core(<1.00 km^(2))forest increased from 124.8 to 145.3 km^(2) in *** perforation area increased by 296.9 km^(2),and the edge effect decreased from 458.9 to 431.7 km^(2).The frequency of patches also increased by 119.1 km^(2).The closed and open canopy classes showed a decreasing trend with an annual rate of 0.58%and 1.35%,*** broad implications of these findings can be seen in the studied region as well as other global ecological *** serve as an imperative baseline for afforestation and reforestation operations,highlighting the urgent need for efficient management,conservation,and restoration *** on these findings,sustainable land-use policies may be put into place that support local livelihoods,protect ecosystem services,and conserve biodiversity.

关键词： Natural catastrophes Landsat Change detection Forest fragmentation Landscape fragmentation tool(LFT) Afforestation Reforestation

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