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Current updates on the epidemiology,pathogenesis and development of small molecule therapeutics for the treatment of Ebola virus infections

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Asian Pacific Journal of Tropical Medicine 2024年第7期17卷 285-298,I0001-I0007页

作者： Shah Alam Khan Neelima Shrivastava mdjawaid akhtar Aftab Ahmad Asif Husain Department of Pharmaceutical Chemistry College of PharmacyNational University of Science and TechnologyPO Box 620Postal code 130MuscatSultanate of Oman Centre of Molecular Medicine and Diagnostics(COMMAND) Saveetha Dental College&HospitalsSaveetha Institute of Medical&Technical SciencesSaveetha UniversityChennai 600077India Department of Pharmaceutical Chemistry School of Pharmaceutical Education and ResearchJamia HamdardNew Delhi-110062India Department of Health Information Technology the Applied CollegeKing Abdulaziz UniversityJeddah-21589Kingdom of Saudi Arabia

Ebola virus disease(EVD)is a rare,highly contagious and a deadly disease with a variable fatality rate ranging from 30%to 90%.Over the past two decades,Ebola pandemic has severely affected the sub-Sahara region including Democratic Republic of the Congo(DRC),and *** causative agents of the most EVD cases are three distinct species out of six Ebolaviruses namely Zaire Ebolavirus(ZEBOV),Sudan Ebolavirus(SUDV)and Bundibugyo Ebolavirus(BDBV).In recent years,significant strides have been made in therapeutic ***,the US Food and Drug Administration has approved two monoclonal antibodies:InmazebTM(REGN-EB3)and Ansuvimab or ***,many small molecules are currently in the developmental stage,promising further progress in medical *** the critical need for preventive measures,this review provides an in-depth analysis of the licensed Ebola vaccines-Ervebo and the combination of Zabdeno(***)and Mvabea(MVA-BN-Filo)as well as the vaccines which are currently being tested for their efficacy and safety in clinical *** vaccines might play an important role in curbing the spread and mitigating the impact of this lethal *** current treatment landscape for EVD encompasses both nutritional(supportive)and drug *** review comprehensively details the origin,pathogenesis,and epidemiology of EVD,shedding light on the ongoing efforts to combat this devastating *** explores small molecules in various stages of the development,discusses patents filed or granted,and delves into the clinical and supportive therapies that form the cornerstone of EVD *** review aims to provide the recent developments made in the design and synthesis of small molecules for scientific community to facilitate a deeper understanding of the disease and fostering the development of effective strategies for prevention,treatment,and control of EVD.

关键词： Ebola Epidemic Vaccine Ebola virus diseas

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Evaluating Wharton’s jelly-derived stem cell therapy in autism:Insights from a case study

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World Journal of Methodology 2025年第2期15卷 174-176页

作者： Muzamil akhtar Abdulqadir J Nashwan College of Medicine Gujranwala Medical CollegeGujranwala 52250PunjabPakistan Department of Nursing and Midwifery Research Hamad Medical CorporationDoha 3050Qatar

Autism spectrum disorder(ASD)is a complex neurodevelopmental disorder affecting over 2%of the global population,marked by social communication deficits and repetitive *** et al explored the efficacy and safety of Wharton’s jelly-derived mesenchymal stem cell(WJ-MSC)therapy in a 4-year-old child with *** the childhood autism rating scale and Denver II develop-mental screening test,significant improvements were seen after six WJ-MSC sessions,with no adverse events over 2 *** promising results,the study’s single-case design limits ***,multi-center trials are needed to validate the findings and assess long-term effects of WJ-MSC therapy in ASD.

关键词： Autism spectrum disorder Stem cell therapy Neuroinflammation Neuro-developmental disorders Wharton jelly derived mesenchymal stem cell

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Optimization and Sizing for Propulsion System of Liquid Rocket Using Genetic Algorithm

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Chinese Journal of Aeronautics 2007年第1期20卷 40-46页

作者： Saqlain akhtar School of Astronautics Beijing University of Aeronautics and Astronautics

Flight vehicle conceptual design appears to be a promising area for application of the Genetic Algorithm （GA） as an approach to help to automate part of the design process. This computational research effort strives to develop a propulsion system design strategy for liquid rocket to optimize take-off mass, satisfying the mission range under the constraint of axial overload. The method by which this process is accomplished by using GA as optimizer is outlined in this paper. Convergence of GA is improved by introducing initial population based on Design of Experiments Technique.

关键词： liquid rocket propulsion system genetic algorithm design of experiments

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Pressureless infiltration of Si_3N_4 preforms with an Al-2wt%Mg alloy

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Journal of University of Science and Technology Beijing 2005年第4期12卷 351-356页

作者： akhtar Farid Materials Science and Engineering School

The pressureless infiltration process to synthesize a silicon nitride composite was investigated. An Al-2wt%Mg alloy was infiltrated into silicon nitride preforms in the atmosphere of nitrogen. It is possible to infiltrate the Al-2wt%Mg alloy in silicon nitride preforms, The growth of the composite with useful thickness was facilitated by the presence of magnesium powder at the interface and by flowing nitrogen. The microstructure of the Si3N4-Al composite has been characterized using scanning electron microscope. During the infiltration of Si3N4 preforms, Si3N4 reacted with aluminium to form silicon and AIN. The silicon produced during the growth consumed in the formation of MgSiAIO, MgSiAlN and Al3.27Si0.47 type phases. The growth of the composite was found to proceed in two ways, depending on the oxide content in the initial preforms, First, less oxide content preforms gave rise to MgAlSiO and MgAlSiN type phases after infiltration. Second, more oxide content preforms gave rise to AlN-Al2O3 solid solution phase （AlON）, The AlON phase was only present in the composite, containing 10% aluminium in the silicon nitride preforms before infiltration.

关键词： Si3N4 composite infiltration AlON AlN-Al2O3 solid solution

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Effect of inner oxidant on self-propagating high-temperature synthesis of MnZn-ferrite powder

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Rare Metals 2006年第Z1期25卷 553-556页

作者： akhtar Farid School of Materials Science and Engineering University of Science and Technology Beijing

Using KClO3 as an inner oxidant, MnZn-ferrite powder was synthesized by a self-propagating high-temperature synthesis (SHS) process in normal air atmosphere. The effects of the inner oxidant on combustion temperature, combustion velocity, microstructure and the phase of the product were investigated by XRD and SEM,respectively. The results show that a highly ferritized powder can be obtained as well as the highest combustion temperature and the highest combustion velocity when the inner oxidant content m equals 54(k-16).

关键词： inner oxidant self-propagating high-temperature synthesis (SHS) MnZn-ferrite powder

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Development of Si_3N_4/Al composite by pressureless melt infiltration

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中国有色金属学会会刊：英文版 2006年第3期16卷 629-632页

作者： akhtar Farid Institute of Powder Metallurgy University of Scien ce and Technology Beijing Beijing 100083 China

Pressureless infiltration process to synthesize Si3N4/Al composite was investigated. Al-2%Mg alloy was infiltrated into Si3N4 and Si3N4 containing 10% Al2O3 preforms in the atmosphere of nitrogen. It is possible to infiltrate Al-2%Mg alloy in Si3N4 and Si3N4 containing 10% Al2O3 preforms. The growth of the dense composite of useful thickness was facilitated by the presence of magnesium powder at the interface and by flowing nitrogen. During infiltration Si3N4 reacted with aluminium to form Si and AlN, the growth of composite was found to proceed in two ways, depending on the Al2O3 content in the initial preform. Firstly, preform without Al2O3 content gives rise to AlN, Al3.27Si0.47 and Al type phases after infiltration. Secondly, perform with 10% Al2O3 content gives rise to AlN-Al2O3 solid solution phase (AlON), MgAl2O4, Al and Si type phases. AlON phase was only present in composite, containing 10% Al2O3 in the Si3N4 preforms before infiltration.

关键词： Si3N4 无压渗透铝复合材料

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Lubrication effectiveness of composite lubricants during P/M electrostatic die wall lubrication and warm compaction

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Journal of University of Science and Technology Beijing 2006年第6期13卷 528-531页

作者： Farid akhtar Materials Science and Engineering School University of Science and Technology BeijingBeijing 100083China

The lubrication effectiveness of the composite lubricants, 50wt% ethylene bis-stearamide （EBS） wax ＋50wt% graphite and 50wt% EBS wax ＋ 50wt% BN, during the powder metallurgy （P/M） electrostatic die wall lubrication and warm compaction was studied. The results show that the combination of 50wt% EBS wax and 50wt% graphite has excellent lubrication performance, resulting in fairly high green densities, but the mixture of 50wt% EBS wax and 50wt% BN has less beneficial effect. In addition, corresponding die temperatures should be applied when different die wall lubricants are used to achieve the highest green densities.

关键词： powder metallurgy composite lubricant electrostatic die wall lubrication warm compaction

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Stainless steel binder for the development of novel TiC-reinforced steel cermets

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Journal of University of Science and Technology Beijing 2006年第6期13卷 546-550页

作者： akhtar Farid Materials Science and Engineering School University of Science and Technology BeijingBeijing 100083 China

Steel reinforced TiC composites are an attractive choice for wear resistance and corrosion resistance applications. TiC- reinforced 17-4PH maraging stainless matrix composites were processed by conventional powder metallurgy （P/M）. TiC-reinforced maraging stainless steel composites with 〉97% of theoretical density were fabricated. The microstructure, mechanical and wear properties of the composites were evaluated. The microstructure of these composites consisted of spherical and semi-spherical TiC particles. A few microcracks appeared in the composites, showing the presence of tensile stress in the composites produced during sintering. Typical properties, namely, hardness and bend strength were reported for the sintered composites. After heat treatment and aging, the increase of hardness was observed. The increase of hardness was attributed to the aging reaction in the 17-4PH stainless steel. The precipitates appeared in the microstructure and were responsible for the increase in hardness. The specific wear behavior of the composites was strongly dependent on the content of TiC particles, the interparticle spacing, and the presence of hard precipitates in the binder phase.

关键词： TiC-based cermets binder phase maraging stainless steel aging microcracks

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Effect of Additive Cu-10Sn Alloy on Sintering Behavior of Elemental Powders in Composition of 465 Stainless Steel

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Journal of Iron and Steel Research International 2007年第4期14卷 61-64,74页

作者： Farid akhtar Department of Metallurgical and Materials Engineering University of Engineering and TechnologyLahore 54890PakistanInstitute of Powder MetallurgyUniversity of Science and Technology BeijingBeijing 100083China

The addition of Cu-10Sn alloy for developing the high strength 465 maraging stainless steel from elemental powders was studied. The sintering parameters investigated include the sintering temperature, the sintering time, and the mass percent of Cu-10Sn. For vacuum sintering, effective sintering occurs at temperature between 1 250 ℃ and 1 300 ℃. The maximum sintered density was achieved at 1 300 ℃ for 60 min with 3% （in mass percent） Cu- 10Sn alloy. More than 3% （in mass percent） Cu-10Sn content and temperature above 1 300 ℃ caused slumping of the samples. A maximum density of 7.4 g/cm^3 was achieved with 3% （in mass percent） Cu-10Sn content at a sintering temperature of 1 300 ＂C for 60 rain. A maximum ultimate tensile strength （UTS） of 517 MPa was achieved with 3% （in mass percent） Cu-10Sn content. With content higher than 2% （in mass percent） Cu-10Sn, a maximum increase in the density was observed. The fracture morphologies of the sintered samples are also reported.

关键词： 465 maraging stainless steel sintering UTS Cu-10Sn alloy

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The influence of Landau quantization on the propagation of solitary structures in collisional plasmas

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Communications in Theoretical Physics 2020年第8期72卷 148-153页

作者： S Hussain N akhtar Theoretical Physics Division(TPD) PINSTECHPO NiloreIslamabad 44000Pakistan

In this work, we study damped ion acoustic solitary wave structures in magnetized dense plasmas. The collisional effects of ions with electrons and neutrals are considered. The trapping effects of electrons and Landau quantization are included in the plasma model under consideration. We assume that magnetic field is quantized such that the condition■ is satisfied. We have derived the damped Korteweg–de Vries(dKdV) equation by using small amplitude reductive perturbation technique. The time-dependent analytical and numerical solutions of the dKdV equation are presented. For numerical solutions we apply a two level finite difference scheme with the help of the Runge Kutta method. The effects of variations of different plasma parameters on the propagation characteristics of damped solitary structures in the presence of collisions are discussed.

关键词： soliton collisional plasmas finite difference method reductive perturbation method

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