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Red honeybush(Cyclopia genistoides)tea mitigates oxidative imbalance and hyperlipidemia,while improving glucose homeostasis in type 2 diabetic rats

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Food Science and Human Wellness 2023年第6期12卷 2029-2039页

作者： Xin Xiao Ochuko L.Erukainure md.shahidul Islam Department of Biochemistry University of KwaZulu-NatalWestville CampusDurban 4000South Africa Department of Pharmacology University of the Free StateBloemfontein 9300South Africa

Red honeybush tea(RHT)is a tea product developed from Cyclopia *** is endemic to South *** refreshment,RHT has over the years been used traditionally in the treatment of various diseases including type 2 *** study investigated the in vivo antioxidant and anti-diabetic activity of RHT concentrated hot water extract in type 2 diabetes(T2D)model of rats.T2D was induced starting with feeding 10%fructose solution ad libitum for 2 weeks followed by a single intraperitoneal injection of streptozotocin(40 mg/kg body weight(BW)).Five weeks of treatment of RHT led to significant(PmdA levels and enhanced level of GSH,activity of SOD,catalase,GR in most of organs(pancreas,liver,kidneys,and heart).Signifi cantly(P<0.05)improved morphological changes in the islets andβ-cells were observed in rats treated with *** data of this study suggest that RHT demonstrates an outstanding antioxidant and anti-diabetic effects in STZ-induced T2D model of rats.

关键词： Red honeybush tea(Cyclopia genistoides) Antioxidants Anti-diabetes Type 2 diabetes

Contribution of non-timber forest products to the livelihoods of the forest-dependent communities around the Khadimnagar National Park in northeastern Bangladesh

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Regional Sustainability 2021年第3期2卷 280-295页

作者： md.Habibur RAHMAN Bishwajit ROY md.shahidul ISLAM Laboratory of Tropical Forest Resources and Environments Division of Forest and Biomaterials ScienceGraduate School of AgricultureKyoto UniversityKyoto606-8502Japan Bangladesh Institute of Social Research Trust LalmatiaDhaka1207Bangladesh Climate Change andSustainable Development Policies Faculty of ScienceUniversity of LisbonLisbon1749-016Portugal Research and Development Cell Bangladesh Knitwear Manufacturers and Exporters AssociationDhaka1000Bangladesh

Non-timber forest products(NTFPs)play a significant role in the improvement of the forest-dependent people’s livelihoodsaround the world,strengthening protection for the sustainable use of *** purpose of this research was to evaluate the influence of occupational category-wise(fuelwood collectors,farmers,small-scale businessmen,day labourers,and tea estate labourers)dependencyon NTFPsand the role of NTFPs on household income around the Khadimnagar National Park(KNP)in northeastern *** 2014,178purposively selected respondents from four villages(out of 22 villagesaround the KNP)were interviewed face-to-face using a semi-structured *** study observed that these forest-dependent communities utilized resources of the KNP mainly for domestic energy supply,household income,and house *** showed that income from NTFPs made a significant contribution to family *** data analysis indicated that small-scale businessmen earned relatively more income from NTFPs,followed by tea estate labourersand day *** study revealed significant negative relationships of the distance of households from the forest with the amount of NTFPs collected(P<0.01)and monthly income from NTFPs(P<0.01).Positive significant relationships were found between the amount of NTFPs collected and the time spent in NTFP collection(P<0.001),as well as betweenmonthly income from NTFPs and family size(P<0.001).The fuelwood collectors and farmers collected significantly greater amounts of NTFPs per trip(P<0.001)than other occupational *** households that were moderately to highly dependent on NTFPs collected significantly higher amounts of NTFPs pertrip(P<0.01)than the households that were moderately dependent and less dependent on *** dependence on KNP’sresources,community’sappreciation of the KNP’s ecosystem services for villagers’livelihoods,and community’s high levels of concern for forest conservation provided a foundation

关键词： Forest dependency Household income Non-timber forest products Forest sustainability Occupational categories Khadimnagar National Park

Harpephyllum caffrum stimulates glucose uptake,abates redox imbalance and modulates purinergic and glucogenic enzyme activities in oxidative hepatic injury

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Asian Pacific Journal of Tropical Biomedicine 2022年第1期12卷 9-19页

作者： Kolawole A.Olofinsan Ochuko L.Erukainure Beseni K.Brian md.shahidul Islam Department of Biochemistry School of Life SciencesUniversity of KwaZulu-Natal(Westville Campus)Durban 4000South Africa Department of Pharmacology University of the Free StateBloemfontein 9300South Africa

Objective:To investigate the antioxidative and antidiabetic effects of Harpephyllum caffrum bark infusion as well as its effects on glucogenic and nucleotide hydrolyzing enzyme activities in FeSO4-induced oxidative stress in rat hepatic ***:Harpephyllum caffrum infusion was prepared from dried plant materials(40 g)infused in boiling water(400 mL)for 20 min at room *** antioxidative and inhibitory activities against carbohydrate digestive enzymes of the infusion were determined using established *** liver tissues of rats were used for glucose uptake assay and to evaluate the infusion’s effect on endogenous antioxidant,glucogenic,and nucleotide hydrolyzing enzyme activities in FeSO4-induced hepatic ***:The Harpephyllum caffrum infusion significantly reduced ferric iron(FRAP)and free radicals(OH•and DPPH)in a dose-dependent *** inhibitedα-amylase andα-glucosidase activities and increased glucose uptake in hepatic ***4 significantly decreased glutathione concentration,catalase,and superoxide dismutase activities while increasing malondialdehyde level,glycogen phosphorylase,fructose-1,6-bisphosphatase,and adenosine triphosphatase ***,treatment with Harpephyllum caffrum infusion reversed FeSO4-induced *** of the infusion revealed the presence of catechol,O-pyrocatechuic acid,mequinol,maltol,and glycoside ***:The Harpephyllum caffrum infusion demonstrates antidiabetic and antioxidative potentials in in vitro models of type 2 diabetes as depicted by its ability to inhibit carbohydrate digestive enzymes,mitigate oxidative imbalance,and regulate glucogenic and nucleotide hydrolyzing enzyme activities in oxidative hepatic injury.

关键词： Harpephyllum caffrum Antioxidant Oxidative injury Carbohydrate dysmetabolism

Comparative effects of xylitol and erythritol on modulating blood glucose;inducing insulin secretion;reducing dyslipidemia and redox imbalance in a type 2 diabetes rat model

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Food Science and Human Wellness 2023年第6期12卷 2052-2060页

作者： Nontokozo Z.Msomi Ochuko L.Erukainure Veronica F.Salau Kolawole A.Olofinsan md.shahidul Islam Department of Biochemistry University of KwaZulu-NatalWestville CampusDurban 4000South Africa Department of Pharmacology University of the Free StateBloemfontein 9300South Africa

Xylitol and erythritol have been reported in numerous previous and recent studies as potential antidiabetic sweeteners,however,it is not certain which one is most effective in this *** the present study,the effects of xylitol and erythritol were comparatively investigated on blood glucose,insulin level,dyslipidemia,pancreatic islet morphology andβ-cell function,and redox imbalance in a type 2 diabetes(T2D)model of ***-week-old male Sprague-Dawley rats were randomly divided into 8 groups:Normal Control(NC),Diabetic Control(DC),Diabetic Xylitol 5%(DX5),Diabetic Xylitol 10%(DX10),Diabetic Xylitol 20%(DX20),Diabetic Erythritol 5%(DE5),Diabetic Erythritol 10%(DE10),and Diabetic Erythritol 20%(DE20).T2D was induced in the diabetic groups initially by feeding 10%fructose solution to induce insulin resistance followed by an intraperitoneal injection of streptozotocin(40 mg/kg body weight)dissolved in citrate buffer(pH 4.5)to induce partial pancreaticβ-cells *** animals in NC group were fed with normal drinking water and injected with citrate buffer *** the confi rmation of diabetes,the xylitol and erythritol with above-mentioned concentrations were supplied to the respective animal groups when the animals in NC and DC groups were supplied with normal drinking *** 8 weeks intervention period,the body weight,fl uid and water intake,blood glucose,serum alanine aminotransferase,aspartate aminotransferase,CK-MB and creatinine were signifi cantly decreased,while the serum insulin level,serum lipids,glucose tolerance ability,pancreatic islet morphology andβ-cell function,pancreatic and serum redox imbalance were improved in the most xylitol and erythritol fed groups compared to the DC group,when effects were better for xylitol compared to *** data of this study suggests that xylitol has better antioxidant and antidiabetic effects compared to ***,xylitol can be used as a preferrable dietary anti-diabetic sweetener

关键词： Xylitol Erythritol Sweeteners Type 2 diabetes Oxidative stress

Senna petersiana inhibits key digestive enzymes and modulates dysfunctional enzyme activities in oxidative pancreatic injury

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Asian Pacific Journal of Tropical Biomedicine 2022年第7期12卷 300-311页

作者： Kolawole A.Olofinsan Ochuko L.Erukainure Nontokozo Z.Msomi md.shahidul Islam Department of Biochemistry University of KwaZulu-NatalWestville CampusDurban 4000South Africa Department of Pharmacology University of the Free StateBloemfontein 9300South Africa

Objective:To evaluate the effect of Senna petersiana leaf extracts on key digestive enzymes and FeSO_(4)-induced oxidative ***:Dried Senna petersiana leaf powder(60 g)was defatted in n-hexane and then extracted sequentially at room temperature with dichloromethane,methanol,and distilled *** total phytochemical content of the extracts was estimated using established *** in vitro antioxidant,anti-lipase,and antidiabetic activities and the effect of the extracts on intestinal glucose absorption and FeSO_(4)-induced pancreatic oxidative injury were determined using different ***,GC-MS analysis was performed to identify the main compounds of the plant *** docking analysis was also carried out to evaluate the binding energy of compounds with digestive ***:Senna petersiana leaf extracts showed significant antioxidant activities in FRAP,DPPH,and hydroxyl radical scavenging *** also inhibited pancreatic lipase and lowered intestinal glucose absorption by suppressing activities ofα-amylase andα-*** with the extracts also lowered lipid peroxidation(malondialdehyde),nitric oxide level,acetylcholinesterase,and ATPase activities with simultaneous improvement of antioxidant(catalase,superoxide dismutase,glutathione)capacity in the type 2 diabetes model of oxidative pancreatic ***-MS characterization of the extracts revealed the presence of stilbenoids,alkaloids,and other *** docking screening assay indicated the extract phytochemicals showed strong interaction with the active site amino acids of the targeted digestive *** the Senna petersiana compounds,veratramine had the highest affinity forα-amylase and lipase,whereas dihydrostilbestrol was most attracted toα-***:Senna petersiana inhibits carbohydrate digestive enzymes,reduces intestinal glucose absorption,and exerts ameliorative effects on FeSO_(4)-induced oxidative pancreatic injury wi

关键词： Senna petersiana Antioxidant Digestive enzymes Oxidative pancreatic injury Type 2 diabetes

Rhus longipes (Engl.) infusions improve glucose metabolism and mitigate oxidative biomarkers in ferrous sulfate-induced renal injury

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Asian Pacific Journal of Tropical Biomedicine 2022年第11期12卷 453-465页

作者： Brian K.Beseni Kolawole AOlofinsan Veronica F.Salau Ochuko L.Erukainure md.shahidul Islam Department of Biochemistry University of KwaZulu-NatalWestville CampusDurban 4000South Africa Department of Pharmacology University of the Free StateBloemfontein 9300South Africa

Objective:To explore the antioxidant and antidiabetic activities of Rhus longipes(***)leaf and stem bark aqueous ***:*** leaf and stem bark infusions were characterized via gas-chromatography mass-spectroscopy(GC-MS)*** vitro antioxidant and carbohydrate and lipid digestive enzyme inhibitory activities of *** infusions were ***,the modulatory effects of *** infusions on intestinal glucose absorption,muscle glucose uptake,and biomarkers of renal oxidative injury were *** docking was performed to determine the binding affinities of the identified compounds from the leaf and stem bark infusions on carbohydrate and lipid digestive ***:GC-MS analysis revealed the presence of several phytocompounds,including palmitoleic acid,octadecanamide,24,25-dihydroxyvitamin D and L-ascorbic *** bark infusion had significantly higher total phenolic contents compared with the leaf infusion,with better DPPH scavenging[IC_(50):(10.50±1.03)μg/mL]and ferric reducing[IC_(50):(9.85±0.32)μg/mL]activities(P<0.05).Both *** infusions at their highest concentrations significantly increased glucose uptake in yeast suspension and rat psoas muscle with marked suppression of glucose absorption in the rat jejunum(P<0.05).With no cytotoxicity on Vero cells,the infusions lowered lipid peroxidation,increased cellular reduced glutathione concentration,and the activities of superoxide dismutase and catalase in renal homogenate treated with FeSO_(4).Conclusions:*** shows antioxidant and antidiabetic activities and could be a potential therapeutic candidate for diabetes.

关键词： Antioxidant Oxidative biomarkers Enzyme inhibition Antidiabetic Rhus longipes Searsia longipes

Sorbitol-based osmotic diarrhea:Possible causes and mechanism of prevention investigated in rats

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World Journal of Gastroenterology 2006年第47期12卷 7635-7641页

作者： md.shahidul Islam Ei Sakaguchi Laboratory of Animal Nutri-tion Faculty of Agriculture Okayama University 1-1-1 Tsushima-naka Okayama City 700-8530 Japan

AIM: To study the possible causes of sorbitol (S)-based diarrhea and its mechanism of reduction by rice gruel (RG) in cecectomized rats. METHODS: S was dissolved either in distilled water or in RG (50 g/L) and ingested as a single oral dose (1.2 g/kg body mass, containing 0.5 g/L phenol red as a re-covery marker) by S (control) and S + RG groups (n = 7), respectively. This dose is over the laxative dose for hu-mans. Animals were sacrificed exactly 1 h after dose in-gestion, without any access to drinking water. The whole gastro-intestinal tract was divided into seven segments and sampled to analyze the S and marker remaining in its ***: Gastric-emptying and intestinal transit were comparatively slower in the S + RG group. Also, the S absorption index in the 3rd and last quarter of the small intestine (24.85 ± 18.88% vs 0.0 ± 0.0% and 39.09 ± 32.75% vs 0.0 ± 0.0%, respectively, P < 0.05) was sig-nificantly higher in the S + RG group than in the control group. The S absorption index and the intestinal fluid volume are inversely related to each other. CONCLUSION: The intestinal mal-absorption of S is the main reason for S-based osmotic diarrhea. Where RG en-hanced the absorption of S through passive diffusion, the degree of diarrhea was reduced in cecectomized rats.

关键词： Cecectomized rat Sorbitol Diarrhea Rice gruel Phenol red

Whole Leea macrophylla ethanolic extract normalizes kidney deposits and recovers renal impairments in an ethylene glycol-induced urolithiasis model of rats

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Asian Pacific Journal of Tropical Medicine 2012年第7期5卷 533-538页

作者： Abu Nasim Nizami md Atiar Rahman Nazim Uddin Ahmed md.shahidul Islam Department of Biochemistry and Molecular Biology University of ChittagongChittagong-4331Bangladesh Department of Biochemistry School of BiochemistryGenetics and MicrobiologyUniversity of KwaZulu-NatalDurban 4000South Africa Bangladesh Council of Scientific and Industrial Research(BCSIR) Chittagong-4220Bangladesh

Objective:To investigate the antilithiatic effect of the whole Leea macrophylla(L macrophylla) Roxb(Leeaeeae) ethanol extract in ediylene glycol-induced urolithiasis model of ***: Forty two seven weeks old male wistar albino rats were randomly divided into two major groups namely:preventive(n=18) and therapeutic(n=24).Preventive group was further subdivided into 3 groups of 6 rats namely:preventive control(PC),preventive lithiatic control(PLC) and preventive lithiatic ***(PLLM).Similarly,therapeutic group was also subdivided into 4 groups of 6 rats namely:therapeutic control(TC),therapeutic lithiatic control(TLC).therapeutic lithitatic L macrophylla(TLLM) and therapeutic lithiatic cystone(TLCYS).The lithiasis was induced by 0.75%(v/v) ethylene glycol in the drinking water of all groups except the PC and TC *** urinary ionic parameters such as calcium,inorganic phosphate,oxalate,magnesium & creatinine and renal morphology were altered by ediylene glycol,which were partially recovered by 14 d preventive and almost fully recovered by 28 d therapeutic intervention trials with L macrophylla extract(500 mg/kg BW daily).Results:Significant difference on recovery was observed between preventive and dierapeutic interventional ***-urolithiatic effect of cystone was significantly(P<0.001) higher than extracts.L macrophylla extract was found nontoxic in the acute toxicity ***:The results of this study demonstrated very promising antiurolithiatic effect of *** extract with preventive and therapeutic treatments in this experimental condition.

关键词： Urolithiasis Ethylene glycol Leea macrophylla Urinary parameter Rats

Glucagon-like-peptide-1 receptor agonists and the management of type 2 diabetes-backwards and forwards

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World Journal of Diabetes 2024年第3期15卷 326-330页

作者： Michael Horowitz Lu Cai md.shahidul Islam Department of Medicine University of AdelaideAdelaide 5005Australia Pediatric Research Institute University of LouisvilleLouisvilleKY 40202United States Department of Biochemistry School of Life SciencesUniversity of KwaZulu-NatalDurban 4000KwaZulu-NatalSouth Africa

This editorial is stimulated by the article by Alqifari et al published in the World Journal of Diabetes(2024).Alqifari et al focus on practical advice for the clinical use of glucagon-like-peptide-1(GLP-1)receptor agonists(GLP-1RAs)in the management of type 2 diabetes and this editorial provides complementary *** initially give a brief historical perspective of the development of GLP-1RAs stimulated by recognition of the‘incretin effect’,the substantially greater insulin increase to enteral when compared to euglycaemic intravenous glucose,and the identification of the incretin hormones,GIP and *** addition to stimulating insulin,GLP-1 reduces postprandial glucose levels by slowing gastric ***-1RAs were developed because native GLP-1 has a very short plasma *** majority of current GLP-1RAs are administered by subcutaneous injection once a *** are potent in glucose lowering without leading to hypoglycaemia,stimulate weight loss in obese individuals and lead to cardiovascular and renal *** landscape in relation to GLP-1RAs is broadening rapidly,with different formulations and their combination with other peptides to facilitate both glucose lowering and weight *** is a need for more information relating to the effects of GLP-1RAs to induce gastrointestinal symptoms and slow gastric emptying which is likely to allow their use to become more effective and personalised.

关键词： Glucagon-like-peptide-1 Glucose-dependent insulinotropic peptide Gastric emptying Type 2 diabetes