Comparative effects of xylitol and erythritol on modulating blood glucose;inducing insulin secretion;reducing dyslipidemia and redox imbalance in a type 2 diabetes rat model

作     者：Nontokozo Z.Msomi Ochuko L.Erukainure Veronica F.Salau Kolawole A.Olofinsan Md.Shahidul Islam Nontokozo Z.Msomi;Ochuko L.Erukainure;Veronica F.Salau;Kolawole A.Olofinsan;Md.Shahidul Islam

作者机构：Department of BiochemistryUniversity of KwaZulu-NatalWestville CampusDurban 4000South Africa Department of PharmacologyUniversity of the Free StateBloemfontein 9300South Africa 

出 版 物：《Food Science and Human Wellness》 (食品科学与人类健康（英文）)

年 卷 期：2023年第12卷第6期

页      面：2052-2060页

核心收录：

学科分类：0832[工学-食品科学与工程（可授工学、农学学位）] 1004[医学-公共卫生与预防医学(可授医学、理学学位)] 08[工学] 083201[工学-食品科学] 

基　　金：supported by funding from the Research office,University of KwaZulu-Natal,Durban the National Research Foundation,Pretoria,South Africa(112430) 

主　　题：Xylitol Erythritol Sweeteners Type 2 diabetes Oxidative stress 

摘      要：Xylitol and erythritol have been reported in numerous previous and recent studies as potential antidiabetic sweeteners,however,it is not certain which one is most effective in this *** the present study,the effects of xylitol and erythritol were comparatively investigated on blood glucose,insulin level,dyslipidemia,pancreatic islet morphology andβ-cell function,and redox imbalance in a type 2 diabetes(T2D)model of ***-week-old male Sprague-Dawley rats were randomly divided into 8 groups:Normal Control(NC),Diabetic Control(DC),Diabetic Xylitol 5%(DX5),Diabetic Xylitol 10%(DX10),Diabetic Xylitol 20%(DX20),Diabetic Erythritol 5%(DE5),Diabetic Erythritol 10%(DE10),and Diabetic Erythritol 20%(DE20).T2D was induced in the diabetic groups initially by feeding 10%fructose solution to induce insulin resistance followed by an intraperitoneal injection of streptozotocin(40 mg/kg body weight)dissolved in citrate buffer(pH 4.5)to induce partial pancreaticβ-cells *** animals in NC group were fed with normal drinking water and injected with citrate buffer *** the confi rmation of diabetes,the xylitol and erythritol with above-mentioned concentrations were supplied to the respective animal groups when the animals in NC and DC groups were supplied with normal drinking *** 8 weeks intervention period,the body weight,fl uid and water intake,blood glucose,serum alanine aminotransferase,aspartate aminotransferase,CK-MB and creatinine were signifi cantly decreased,while the serum insulin level,serum lipids,glucose tolerance ability,pancreatic islet morphology andβ-cell function,pancreatic and serum redox imbalance were improved in the most xylitol and erythritol fed groups compared to the DC group,when effects were better for xylitol compared to *** data of this study suggests that xylitol has better antioxidant and antidiabetic effects compared to ***,xylitol can be used as a preferrable dietary anti-diabetic sweetener