检索结果-南通市图书馆

英国医学杂志中文版 2019年第5期22卷 281-282页

作者： David McCartney Richard J mcmanus 梁平平(译) 杨军(校) Nuffield Department of Primary Care Health Sciences Universityof OxfordOxfordUK 山东烟台毓璜顶医院心内科

背景收缩压干预试验(SPRINT)是发布于2015年的一项大型、多中心、随机对照试验这项试验将9 361名患有心血管疾病高危风险(但没有糖尿病或卒中)的高血压患者随机分为强化治疗组(控制收缩压低于120 mmHg)和标准治疗组(控制收缩压低于140 m... 详细信息

背景收缩压干预试验(SPRINT)是发布于2015年的一项大型、多中心、随机对照试验这项试验将9 361名患有心血管疾病高危风险(但没有糖尿病或卒中)的高血压患者随机分为强化治疗组(控制收缩压低于120 mmHg)和标准治疗组(控制收缩压低于140 mmHg)。由于强化治疗组的心血管事件和病死率显著降低,试验被提前停止。最初的试验研究报道,在强化治疗组,发生与治疗相关的严重不良事件增加了一倍,包括症状性低血压、晕厥和急性肾损伤后续的病例研究进一步分析了有关患者的身心健康和对治疗依从性方面的情况2。

关键词：高血压患者心血管疾病标准降压随机对照试验预后干预试验症状性低血压

Real-time PCR diagnosis of Schistosoma japonicum in low transmission areas of China

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Infectious Diseases of Poverty 2018年第1期7卷 87-97页

作者： Pei He Catherine A.Gordon Gail M.Williams Yuesheng Li Yuanyuan Wang Junjian Hu Darren J.Gray Allen G.Ross Donald Harn Donald P.mcmanus Hunan Institute of Parasitic Diseases YueyangPeople’s Republic of China Molecular Parasitology Laboratory Infectious Diseases DivisionQIMR Berghofer Medical Research InstituteBrisbaneAustralia Discipline of Epidemiology and Biostatistics School of Population HealthUniversity of QueenslandBrisbaneAustralia Research School of Population Health The Australian National UniversityCanberraAustralia Menzies Health Institute Queensland Griffith UniversityGold CoastQLDAustralia University of Georgia College of Veterinary MedicineAthensGAUSA.

Background:Schistosomiasis in the People’s Republic of China(PRC)can be traced back to *** the past 60 years,the Chinese government has made great efforts to control this persistent disease with elimination slated by 2020 through the implementation of a comprehensive control *** strategy aims to reduce the role of bovines and humans as sources of infection as a pre-requisite for elimination through transmission *** goal of elimination will be achievable only by the implementation of a sustainable surveillance and control system,with sensitive diagnosis a key feature so that the true disease burden is not *** used diagnostics lack the necessary sensitivity to accurately determine the prevalence of Schistosoma japonicum infection in areas with low infection *** is of critical importance to find and treat people and to identify animals with low-level infections if the National Control Programme for China is to achieve schistosomiasis ***:We evaluated a real-time polymerase chain reaction(qPCR)assay using 633 human stool samples collected from five villages in Hunan,Anhui,Hubei,and Jiangxi provinces,and 182 bovine(70 cattle and 112 buffalo)stool samples obtained from four villages in Hunan,Anhui,and Jiangxi provinces in the *** stool samples were subjected to the miracidium hatching test(MHT,a diagnostic procedure used in the National Schistosomiasis Control Programme)and the qPCR *** positive by MHT were subjected to either the Kato-Katz technique for humans,or the formalin-ethyl acetate sedimentation-digestion(FEA-SD)procedure for bovines,to determine infection ***:The qPCR assay exhibited a high level of sensitivity in the detection of *** *** both the human and bovine samples,a significantly higher prevalence was determined using the qPCR assay(11.06%humans,24.73%bovines)than with the MHT(0.93%humans,7.69%bovines).The animal contamination

关键词： Schistosomiasis Schistosoma Japonicum China Real-time PCR Miracidium hatching test Kato-Katz FEA-SD Bovine Human

维普期刊数据库

青藏高原青海田鼠体内囊尾蚴分类学地位的初步研究

在线全文

学校读者我要写书评

暂无评论

中国兽医科学 2014年第8期44卷 789-793页

作者：范彦雷娄忠子李立闫鸿斌韩秀敏李建秋刘聪暖杨玉荣 mcmanus D P 贾万忠中国农业科学院兰州兽医研究所家畜疫病病原生物学国家重点实验室甘肃省动物寄生虫病重点实验室农业部兽医公共卫生重点开放实验室甘肃兰州730046 青海省地方病预防控制所青海西宁811602 宁夏医科大学宁夏银川主750004 Molecular Parasitology Laboratory Infectious Diseases Division Queensland Institute of Medical ResearchBrisbaneQLD 4006Australia

在青藏高原青海田鼠(Microtus fuscus)体内首次发现了一带属绦虫新种的幼虫。形态学研究表明,该囊尾蚴头节具有带属绦虫典型的特征,头节上有2圈钩和4个吸盘。利用线粒体cox1基因序列构建的分子系统发育树分析结果表明,该囊尾蚴与其他带... 详细信息

在青藏高原青海田鼠(Microtus fuscus)体内首次发现了一带属绦虫新种的幼虫。形态学研究表明,该囊尾蚴头节具有带属绦虫典型的特征,头节上有2圈钩和4个吸盘。利用线粒体cox1基因序列构建的分子系统发育树分析结果表明,该囊尾蚴与其他带属绦虫的遗传距离相对较远。依据形态学和分子生物学数据,加之其特有的中间宿主和地理分布,该囊尾蚴可明确被鉴定为带属绦虫一新种囊尾蚴,遂将其命名为田氏囊尾蚴(Cysticercus tianguangfui ***.或者Taenia tianguangfui larva ***.)。

关键词：田氏囊尾蚴青藏高原青海田鼠 cox1基因系统发育分析

维普期刊数据库

在线全文

学校读者我要写书评

暂无评论

临床证据(13) 血栓栓塞

英国医学杂志中文版 2003年第2期6卷 109-114页

作者： David Fitzmaurice FD Richard Hobbs Richard mcmanus 荆志成吴娜琼 Senior Lecturer Professor Clinical Research Fellow Department of Primary Care and General Practice The Medical School University of Birmingham BirminghamUK

背景知识定义静脉血栓栓塞是指发生于静脉系统的任何血栓栓塞事件,包括深静脉血栓形成和肺栓塞。深静脉血栓形成(DVT)是指经放射学证实的下肢静脉系统发生足以引起疼痛或肿胀症状的部分或完全性血栓阻塞。近端DVT是指累及膝盖以上静脉... 详细信息

背景知识定义静脉血栓栓塞是指发生于静脉系统的任何血栓栓塞事件,包括深静脉血栓形成和肺栓塞。深静脉血栓形成(DVT)是指经放射学证实的下肢静脉系统发生足以引起疼痛或肿胀症状的部分或完全性血栓阻塞。近端DVT是指累及膝盖以上静脉的DVT(腘静脉,股浅静脉,股总静脉以及髂静脉)。孤立腓静脉血栓血栓形成部位限腓深静脉而不累及膝盖以上的静脉。肺栓塞是指经放射学证实的肺动脉内发生足以引起气短、胸痛或二者兼有等症状的部分或完全性血栓阻塞。血栓后综合征是指下肢发生DVT后出现水肿、溃疡形成和皮下组织活力受损。

关键词：临床证据静脉血栓栓塞深静脉血栓形成肺栓塞病因学危险因素预后

维普期刊数据库

Intracystic bleeding of a solitary hydatid cyst: A rare complication of a rare disease in central Africa. A case report

在线全文

学校读者我要写书评

暂无评论

Case Reports in Clinical Medicine 2013年第2期2卷 163-166页

作者： Ankouane Andoulo Firmin Ngo Nonga Bernadette Monabang Catherine Djapa Roger Tchoumi Eric Njoya Oudou Ndjitoyap Ndam Elie Claude D. P. mcmanus Malonga Eimo Department of Internal Medicine Faculty of Medicine and Biomdical Sciences University of Yaounde I Yaounde Cameroon Department of Radiology Faculty of Medicine and Biomdical Sciences University of Yaounde I Yaounde Cameroon Department of Surgery Faculty of Medicine and Biomdical Sciences University of Yaounde I Yaounde Cameroon Donald Peter mcmanus Infectious Disease Division Queensland Institute of Medical Research Brisbane Australia

Splenic cysts are rare lesions and most of them are hydatid in origin. Hydatid disease is very rare in central Africa although it is cosmopolitan in North Africa. We are presenting a case of intracystic bleeding complicated with shock in a rural based Cameroonian and owner of hunting dogs treated in our university teaching hospital.

关键词： Hydatid Disease Cyst Bleeding Splenectomy

The genome and transcriptome of the hydatid tapeworm Echinococcus granulosus

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

The genome and transcriptome of the hydatid tapeworm Echinoc...

The effect of global warming on beef production in developing countries of the southern hemisphere

第四届全国人畜共患病学术研讨会 2014年中国狂犬病年会中国畜牧兽医学会兽医公共卫生学分会第四次学术研讨会

作者： Wenbao Zhang Zhuangzhi Zhang Huajun Zhen Jun Li Hui Wang Baoxin Shi Yan Zhou Shengyue Wang Donald P.mcmanus Hao Wen Clinical Medical Research Institute The First Affiliated Hospital of Xinjiang Medical University Veterinary Research Institute Xinjiang Academy of Animal Sciences Shanghai–Ministry of Science and Technology Key Laboratory of Health and Disease Genomics Chinese National Human Genome Center at Shanghai

Cystic echinococcosis (hydatid disease),caused by the tapeworm Echinococcus granulosus,is responsible for considerable human morbidity and *** cosmopolitan disease is difficult to diagnose,treat and *** sequenced the whole genomic sequence for the worm comprising 151.6 Mb encoding 11,325 *** with the genome sequences from other taxa show that *** has acquired a spectrum of genes,including the EgAgB family,whose products are secreted by the parasite to interact and redirect host immune *** also found that genes in bile salt pathways may control the bidirectional development of E

关键词：

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

Natural Science 2013年第1期5卷 106-119页

作者： M.M.Scholtz C.mcmanus K-J.Leeuw H.Louvandini L.Seixas C.B.de Melo A.Theunissen F.W.C.Neser ARC-Animal Production Institute IreneSouth Africa University of the Free State BloemfonteinSouth Africa Insituto Nacional de Ciencia e Tecnologia-InformacaoGenetico-Sanitaria da Pecuaria Brasileira Brazil Departamento de Zootecnia Universidade Federal de Rio Grande do SulPorto AlegreBrazil Centro de Energia Nuclear na Agricultura Universidade de Sao PauloPiracicabaBrazil Faculdade de Agronomia e Medicina Veterinaria Universidade de BrasiliaBrasiliaBrazil Northern Cape Department of Agricultural Land Reform and Rural DevelopmentJan KempdorpSouth Africa

Developing countries from the southern hemisphere will be confronted by the same beef production challenges caused by global warming, because these countries are at the same geographical positions in southern latitudes. Global warming is expected to have a more extreme effect on the southern hemisphere than on other continents and will have a negative effect on the beef production environments in these countries. The negative effects will include high ambient temperatures, nutritional stress and altered patterns of animal diseases. Heat stress in beef cattle on veld/savannah is expected to increase as a result of changing weather patterns on a global and regional scale. This may negatively influence food production from beef cattle for the human food chain. Negative effects of increased temperatures and thus heat stress can include lower reproductive rates and weaning weights. The effect of heat stress can be partly addressed by nutritional strategies, such as replacing rapid fermentable carbohydrates with saturated fatty acids and the feeding of more by-pass protein and dietary electrolytes. Global warming will also alter the distribution pattern of animal diseases and the vectors of some of these diseases. This may even include the spread to South American countries. Likewise the nutritional value of natural pastures may be influenced. The effect of global warming on the quality of pastures will depend on whether the global warming is a result of increased carbon dioxide levels or not. An improved understanding of the adaptation of beef cattle to their production environments is important, but adaptation is complex and thus difficult to measure. Fortunately, several proxy-indicators for adaptation such as reproductive, production and health traits are available. The selection of animals and genotypes that are better adapted to the production system, including heat stress, is possible and should be persuade to ensure sustainable beef production in hotter climates.

关键词： Adaptation Animal diseases Heat Stress Mitigation Strategies Nutritional Stress

高血压的目标和自我监测:随机对照试验和成本效益分析

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

世界核心医学期刊文摘(心脏病学分册) 2006年第2期 17-18页

作者： mcmanus R .J. Mant J. Roalfe A. 王亭忠 Department of Primary Care and General Practice University of Birmingham Birmingham B15 2TT United Kingdom

Objectives: To assess whether blood pressure control in primary care could be improved with the use of patient held targets and self monitoring in a practice setting, and to assess the impact of these on health behaviours, anxiety, prescribed antihypertensive drugs, patients' preferences, and costs. Design: Randomised controlled trial. Setting: Eight general practices in south Birmingham. Participants: 441 people receiving treatment in primary care for hypertension but not controlled below the target of< 140/85 mm Hg. Interventions: Patients in the intervention group received treatment targets along with facilities to measure their own blood pressure at their general practice; they were also asked to visit their general practitioner or practice nurse if their blood pressure was repeatedly above the target level. Patients in the control group received usual care(blood pressure monitoring by their practice). Main outcome measures: Primary outcome: change in systolic blood pressure at six months and one year in both intervention and control groups. Secondary outcomes: change in health behaviours, anxiety, prescribed antihypertensive drugs, patients' preferences of method of blood pressure monitoring, and costs. Results: 400(91% ) patients attended follow up at one year. Systolic blood pressure in the intervention group had significantly reduced after six months(mean difference 4.3 mm Hg(95% confidence interval 0.8 mm Hg to 7.9 mm Hg)) but not after one year(mean difference 2.7 mm Hg(-1.2 mm Hg to 6.6 mm Hg)). No overall difference was found in diastolic blood pressure, anxiety, health behaviours, or number of prescribed drugs. Patients who self monitored lost more weight than controls(as evidenced by a drop in body mass index), rated self monitoring above monitoring by a doctor or nurse, and consulted less often. Overall, self monitoring did not cost significantly more than usual care(￡ 251(＄ 437; 364)(95% confidence interval ￡ 233 to ￡ 275) versus ￡ 240(￡ 217 to ￡ 263

关键词：自我监测高血压随机对照试验

冠心病患者中的抑郁症筛查:来自心脏与精神研究的资料

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

世界核心医学期刊文摘(心脏病学分册) 2006年第3期 27-28页

作者： mcmanus D. Pipkin S.S. Whooley M.A. 姜朝晖 Department of Medicine University of California San Francisco CA United States Dr.

Major depression is associated with adverse outcomes in patients who have coronary heart disease. How best to identify depression in busy cardiology practices is unknown. We compared the test characteristics of 4 depression screening instruments with an interview diagnosis of depression(Diagnostic Interview Schedule) in 1,024 outpatients who had coronary heart disease. Screening instruments were the 10-item Center for Epidemiologic Studies Depression Scale-10, the Patient Health Questionnaire-9, the Patient Health Questionnaire-2, and a simple 2-item instrument that asks(1) “ During the past month, have you often been bothered by feeling down, depressed, or hopeless?” and(2) “ During the past month, have you often been bothered by little interest or pleasure in doing things?” Of the 1,024 participants, 224(22% ) had major depression based on the Diagnostic Interview Schedule. Areas under the receiver-operating characteristic curves were similar for all instruments(range 0.84 to 0.87). In conclusion, a positive response to 1 of the 2 items was 90% sensitive and 69% specific for depression, with a negative likelihood ratio of 0.14. Thus, negative responses to the 2 items effectively ruled out depression. A score < 10 on the Patient Health Questionnaire-9 was 54% sensitive and 90% specific, with a positive likelihood ratio of 5.4. Thus, a cutpoint< 10 was virtually diagnostic for depression.

关键词：抑郁症忧郁症情感性精神病冠心病患者筛查工具