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Adipose tissue-derived mesenchymal stem cells and chitosan/poly(vinyl alcohol)nanofibrous scaffolds for cartilage tissue engineering

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Cell Regeneration 2020年第1期9卷 62-73页

作者： Ghada Nour-Eldeen mazen abdel-rasheed Amira M.EL-Rafei Osama Azmy Gehan T.El-Bassyouni Molecular Genetics and Enzymology Department National Research CentreDokkiCairo 12622Egypt Stem Cell Research group Medical Research Centre of ExcellenceNational Research CentreCairo 12622Egypt Reproductive Health Research Department National Research Centre33 El-Buhouth StDokkiCairo 12622Egypt Refractories Ceramics and Building Materials DepartmentNational Research CentreDokkiCairo 12622Egypt

Osteoarthritis(OA)has been defined as a chronic inflammatory joint disease characterized by progressive articular cartilage *** growing interest in regenerative medicine,using cell therapy and tissue engineering,where cellular components in combination with engineered scaffolds and bioactive materials were used to induce functional tissue *** the present study,nanofibrous scaffold based on chitosan(CS)/poly(vinyl alcohol)(PVA)were used to develop biologically functionalized biomaterial to mimic the extracellular matrix,allowing the human adipose tissue derived mesenchymal stem cells(ADSCs)to proliferate and differentiate to chondrogenic *** morphology of the nanofibrous mat was examined using field emission scanning electron microscope(FE/SEM).The characteristic functional groups and the nature of the chemical bonds between atoms were evaluated using Fourier transform infrared spectroscopy(FTIR)*** of the seeded cells was morphologically evaluated by scanning electron microscopy and by flow cytometry for the expression of the stem cell surface *** differentiation potential was verified after chondrogenic induction by analyzing the expression of chondrogenic marker genes using real-time(RT PCR).Current study suggest significant potential for the use of ADSCs with the nanofibrous scaffolds in improving the osteoarthritis pathology.

关键词： Adipose tissue Mesenchymal stem cells Nanofibrous scaffolds Osteoarthritis Cartilage tissue engineering

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Immunomodulatory and Antioxidativepotentials of adipose-derived Mesenchymalstem cells isolated from breast versusabdominal tissue: a comparative study

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Cell Regeneration 2020年第1期9卷 190-203页

作者： Nourhan Abu-Shahba Marwa Mahmoud mazen abdel-rasheed Yasmine Darwish Ahmad abdelKhaliq Eman Mohammed Mahmoud ElHefnawi Osama Azmy Stem Cell Research Group Centre of Excellence for Medical ResearchNational Research CentreCairoEgypt Medical Molecular Genetics Department Human Genetics and Genome Research DivisionNational Research CentreCairo 12622Egypt Department of Reproductive Health Research Medical Research Division.National Research CentreCairoEgypt Plastic and Reconstructive Surgery Unit General Surgery DepartmentKasr Al Ainy School of MedicineCairo UniversityCairoEgypt Biomedical Informatics and Chemoinformatics Group Centre of Excellence for Medical ResearchInformatics and Systems DepartmentNational Research CentreCairoEgypt

Background: Adipose-derived stem cells (ASCs) are considered ideal candidates for both research and cellular therapydue to ease of access, large yield, feasibility, and efficacy in preclinical and clinical studies. Unlike the subcutaneousabdominal fat depot, breast ASCs features are still not well recognized, limiting their possible therapeutic use. ASCswere found to exert immunomodulatory and antioxidative activities for maintaining homeostasis and functionality ofdiseased/damaged tissues. This study aims to investigate the immunomodulatory and antioxidative potentials of breastversus abdominal isolated ASCs to find out which anatomical site provides ASCs with better immunoregulatory andoxidative stress resistance ***: ASCs were isolated from abdominal and breast tissues. Gene expression analysis was conducted for a panelof immunomodulatory and antioxidative genes, as well as adipokines and proliferation genes. Flow cytometric analysisof a group of immunomodulatory surface proteins was also performed. Finally, the significantly expressed genes haveundergone protein-protein interaction and functional enrichment in silico ***: Our results revealed similar morphological and phenotypic characteristics for both breast and abdominalASCs. However, a significant elevation in the expression of two potent immunosuppressive genes, IL-10 and IDO aswell as the expression of the multifaceted immunomodulatory adipokine, visfatin, was detected in breast versusabdominal ASCs. Moreover, a significant overexpression of the antioxidative genes, GPX1, SIRT5, and STAT3 and theproliferation marker, Ki67, was also observed in breast ASCs relative to abdominal ones. In silico analysis showed thatboth of the differentially upregulated immunomodulatory and antioxidative mediators integratively involved inmultiple biological processes and pathways indicating their functional ***: Breast ASCs possess superior immunomodulatory and antioxidative c

关键词： Adipose-derived stem cells(ASCs) Breast adipose tissue Abdominal adipose tissue Immunomodulatory potential Antioxidative potential

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Calculation of ship motions in steep waves with restoring and Froude-Krylov forces on an adaptive panel mesh with Gauss and analytic integration methods

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Journal of Hydrodynamics 2024年第2期36卷 275-289页

作者： Malwin Wermbter Moustafa abdel-Maksoud Institute for Fluid Dynamics and Ship Theory Hamburg University of TechnologyHamburgGermany

The impulse response method is a frequently used method to calculate ship seakeeping *** this paper,the restoring and Froude-Krylov calculation is conducted with constant evaluation of panel pressures as well as Gauss quadrature and an analytical *** applied panel grid is coarsened by an adaptive algorithm which is based on a normal vector *** comparison of methods is based on grid convergence studies which are followed by a verification of forces with computational fluid dynamics(CFD)results on the fixed duisburg test case in *** with experimental results in head,oblique and following waves show that all integration methods are *** exact integration is numerically sensitive in some *** quadrature is highly accurate;however,the additional effort is not beneficial since the geometrical accuracy has-stronger influence on the force amplitudes than the integration *** grid coarsening reduces the simulation time and is accurate up to a level,where the panel length comes close the *** added resistance at the investigated Froude number of 0.05 shows higher uncertainty levels,this applies to the results of both the numerical methods and model tests.

关键词： Ship hydrodynamics seakeeping impulse response method added resistance wave loads

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Computational Analysis of Novel Extended Lindley Progressively Censored Data

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Computer Modeling in Engineering & Sciences 2024年第3期138卷 2571-2596页

作者： Refah Alotaibi mazen Nassar Ahmed Elshahhat Department of Mathematical Sciences College of SciencePrincess Nourah bint Abdulrahman UniversityP.O.Box 84428Riyadh11671Saudi Arabia Department of Statistics Faculty of ScienceKing Abdulaziz UniversityJeddah21589Saudi Arabia Department of Statistics Faculty of CommerceZagazig UniversityZagazigEgypt Faculty of Technology and Development Zagazig UniversityZagazig44519Egypt

A novel extended Lindley lifetime model that exhibits unimodal or decreasing density shapes as well as increasing,bathtub or unimodal-then-bathtub failure rates, named the Marshall-Olkin-Lindley (MOL) model is *** this research, using a progressive Type-II censored, various inferences of the MOL model parameters oflife are introduced. Utilizing the maximum likelihood method as a classical approach, the estimators of themodel parameters and various reliability measures are investigated. Against both symmetric and asymmetric lossfunctions, the Bayesian estimates are obtained using the Markov Chain Monte Carlo (MCMC) technique with theassumption of independent gamma priors. From the Fisher information data and the simulatedMarkovian chains,the approximate asymptotic interval and the highest posterior density interval, respectively, of each unknownparameter are calculated. Via an extensive simulated study, the usefulness of the various suggested strategies isassessedwith respect to some evaluationmetrics such as mean squared errors, mean relative absolute biases, averageconfidence lengths, and coverage percentages. Comparing the Bayesian estimations based on the asymmetric lossfunction to the traditional technique or the symmetric loss function-based Bayesian estimations, the analysisdemonstrates that asymmetric loss function-based Bayesian estimations are preferred. Finally, two data sets,representing vinyl chloride and repairable mechanical equipment items, have been investigated to support theapproaches proposed and show the superiority of the proposed model compared to the other fourteen lifetimemodels.

关键词： Marshall-Olkin-Lindleymodel reliability inference Bayesian and classical inference progressive Type-II censoring

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An extensive analytical and numerical study of the generalized q-deformed Sinh-Gordon equation

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Journal of Ocean Engineering and Science 2024年第3期9卷 232-239页

作者： Khalid K.Ali abdel-Haleem abdel-Aty Mathematics Department Faculty of ScienceAl-Azhar UniversityNasr-CityCairoEgypt Department of Physics College of SciencesUniversity of BishaPO Box 344Bisha 61922Saudi Arabia Physics Department Faculty of ScienceAl-Azhar UniversityAssiut 71524Egypt

In this paper,the q-deformed Sinh-Gordon equation is solved analytically using a new general form based on the extended tanh *** numerical solutions of the equation is obtained using a b-spline finite element ***,we present numerous figures to demonstrate the various solitons propagation *** type of equation has not been previously dealt with in such ways,whether analytical or *** study is very useful in studying several physical systems that have lost their symmetry.

关键词： q-Deformed equation Solitos solutions The extended tanh method Finite element method q-Calculus

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Ultralong hydroxyapatite-based forward osmosis membrane for freshwater generation

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Frontiers of Chemical Science and Engineering 2024年第9期18卷 37-49页

作者： Mohamed Gamal Gomaa Hamdy Maamoun abdel-Ghafar Francesco Galiano Francesca Russo Alberto Figoli El-Sayed Ali abdel-Aal abdel-Hakim Taha Kandil Bahaa Ahmed Salah Central Metallurgical Research and Development Institute(CMRDI) 11421 CairoEgypt Chemistry Department Faculty of ScienceHelwan University11795 CairoEgypt Institute on Membrane Technology(CNR-ITM) 87036 RendeItaly

Increasing global water shortages are accelerating the pace of membrane manufacturing,which generates many environmentally harmful *** challenges need a radical rethink of developing innovative membranes that can address freshwater production without generating environmentally harmful *** work utilized the synthesized ultra-long hydroxyapatite(UHA)by the solvothermal method using the green solvent oleic acid in preparing UHA-based forward osmosis *** membranes were developed using different loading ratios of graphene oxide(GO)by vacuum-assisted filtration *** prepared GO/UHA membranes were identified using X-ray diffraction,scanning electron microscope,Fourier-transform infrared spectroscopy,and X-ray photoelectron *** contact angle and pore size distribution were determined for the obtained GO/UHA *** obtained hierarchical porous structure in the prepared membranes with interconnected channels results in a stable water flux with reverse salt *** best water flux rate of 42±2 L·m^(–2)·h^(–1)was achieved using the 50 mg GO/UHA membrane,which is 3.3 times higher than the pristine membrane,and a reverse salt flux of 67 g·m^(-2)·h^(–1).The obtained results showed a promising capability of a new generation of sustainable inorganic-based membranes that can be utilized in freshwater generation by energy-efficient techniques such as forward osmosis.

关键词： forward osmosis ultra-long hydroxyapatite graphene oxide inorganic-based membrane

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Geochemistry of island arc assemblage in the Eastern Desert of Egypt and the role of Pan-African magmatism in crustal growth of the Arabian–Nubian Shield:A review

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Acta Geochimica 2024年第3期43卷 588-622页

作者： abdel-Aal Mabdel-Karim Mohamed MHamdy Adel A.Surour Geology Department Faculty of ScienceZagazig UniversityZagazig 44519Egypt Geology Department Faculty of ScienceTanta UniversityTanta 31527Egypt Department of Geological Sciences Faculty of ScienceNew Galala City 43511Egypt Geology Department Faculty of ScienceCairo UniversityGiza 12613Egypt

Neoproterozoic island arc assemblage of the Arabian–Nubian Shield(ANS)in the Eastern Desert(ED)of Egypt comprises juvenile suites of metavolcanics(MV),large amounts of meta-sedimentary rocks(MS),and voluminous metagabbros-diorites(MGD)and syn-tectonic intrusions of older granitoids(OG).We report here the updates of these four rock units in terms of classification,distribution,chemical characteristics,geodynamic evolution,metamorphism,and *** addition,we discuss these integrated data to elucidate a reasonable and reliable model for crustal evolution in the *** main features of these rock units indicate their relation to each other and the geodynamic environment dominated by early immature oceanic island arcs to primitive continental *** information of the island arc metavolcanic and plutonic rocks(gabbros,diorites,tonalites,and granodiorites)furnish evidence of the genetic *** include proximity and a coeval nature in the field;all protolith magmas are subalkaline in nature following calc-alkaline series with minor tholeiitic affinities;common geochemical signature of the arc rocks and subduction-related magmatism;their similar enrichment in LREEs;and similar major element compositions with mafic melts derived from metasomatized mantle *** volcano-sedimentary and the OG rocks underwent multiphase deformation events whereas the MGD complexes deformed *** on the magmatic,sedimentological,and metamorphic evolutions constrained by geochronological data as well as the progressive evolutionary trend from extensional to compressional regimes,a possible gradual decrease in the subducted slab dip angle is the most infl uential in any geodynamic model for arc assemblage in the ED of Egypt.

关键词： Island arc assemblage Magmatism Crustal growth Neoproterozoic Arabian–Nubian Shield Eastern Desert Egypt

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Orchestrating seed storage protein and starch accumulation toward overcoming yield–quality trade-off in cereal crops

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Journal of Integrative Plant Biology 2024年第3期66卷 468-483页

作者： Shuanghe Cao Bingyan Liu Daowen Wang Awais rasheed Lina Xie Xianchun Xia Zhonghu He State Key Laboratory of Crop Gene Resources and Breeding/National Wheat Improvement Center Institute of Crop SciencesBeijing 100081China College of Agronomy Henan Agricultural UniversityZhengzhou 450002China International Maize and Wheat Improvement Center(CIMMYT)China Office Chinese Academy of Agricultural SciencesBeijing 100081China

Achieving high yield and good quality in crops is essential for human food security and ***,there is usually disharmony between yield and *** storage protein(SSP)and starch,the predominant components in cereal grains,determine yield and quality,and their coupled synthesis causes a yield–quality ***,dissection of the underlying regulatory mechanism facilitates simultaneous improvement of yield and ***,we summarize current findings about the synergistic molecular machinery underpinning SSP and starch synthesis in the leading staple cereal crops,including maize,rice and *** further evaluate the functional conservation and differentiation of key regulators and specify feasible research approaches to identify additional regulators and expand *** also present major strategies to leverage resultant information for simultaneous improvement of yield and quality by molecular ***,future perspectives on major challenges are proposed.

关键词： cereal crops grain yield and quality seed storage protein starch synergistic regulation

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Entrepreneurship training:its influences on innovation potentials among nursing students

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Frontiers of Nursing 2024年第1期11卷 85-98页

作者： Asmaa abdel Rahman abdel Rahman Dalia Abdallah abdelatief Medical Surgical Nursing Department Faculty of NursingAin Shams UniversityCairoEgypt

Objective:To evaluate the influences of entrepreneurship training on the innovation potential among nursing ***:A quasi-experimental design was utilized to conduct this *** study was conducted in the classroom at the faculty of nursing,and the“i Hub”center at Ain Shams University(ASU)in Cairo,Egypt.A purposive sample of 42 nursing students who participated in the“Ain Shams University-innovate”competition from the Faculty of Nursing of ASU were included in this *** collection tools included(1)Nursing students'innovation skills assessment questionnaire and(2)Innovative projects evaluation ***:There was a statistically significant difference between the mean scores of nursing students'total innovation skills pre-and post-implementation of entrepreneurship training,where P-value<***:The results of the current study support the research hypothesis because the implementation of entrepreneurship training positively affects nursing students'innovation *** entrepreneurship education in nursing and integrating it into nursing programs will stimulate creativity,innovation,and entrepreneurship among nursing students and health care services.

关键词： entrepreneurship training innovation potentials nursing students creative skills energy/motivation

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New soliton solutions of Dual mode Sawada Kotera equation using a new form of modified Kudryashov method and the finite difference method

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Journal of Ocean Engineering and Science 2024年第3期9卷 207-215页

作者： Khalid K.Ali M.S.Mehanna abdel-Haleem abdel-Aty Abdul-Majid Wazwaz Department of Mathematics Faculty of ScienceAl-Azhar UniversityNasr City 11884CairoEgypt Faculty of Engineering MTI UniversityCairoEgypt Department of Physics College of SciencesUniversity of BishaPO Box 344Bisha 61922Saudi Arabia Physics Department Faculty of ScienceAl-Azhar UniversityAssiut 71524Egypt Department of Mathematics Saint Xavier UniversityChicagoIL 60655USA

In this article,we suggest a new form of modified Kudryashov’s method(NMK)to study the Dual-mode Sawada Kotera *** know very well that the more the solutions depend on many constants,the easier it is to study the model better by observing the change in the constants and what their impact is on the *** this point of view,we developed the modified Kudryashov method and put it in a general form that contains more than one controllable *** have studied the model in this way and presented figures showing the correctness of what we hoped to reach from the proposed *** addition to the results we reached,they were not sufficient,so we presented an extensive numerical study of this model using the finite differences *** also came up with the local truncation error for the difference scheme is h^(6) k^(2)(1+k^(2)).In addition,the analytical solutions we reached were compared with the numerical solutions,and we presented many forms that show that the results we reached are a clear contribution to this field.

关键词： Soliton solution A new form of analytical method Local truncation error Numerical solutions

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