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Potential benefit of lymph node dissection during radical nephrectomy for kidney cancer:A review and critical analysis of current literature

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Asian Journal of Urology 2022年第3期9卷 215-226页

作者： Michele Marchioni Daniele Amparore Igino Andrea Magli Riccardo Bertolo Umberto Carbonara Selcuk Erdem Alexandre Ingels Constantijn H.J.Muselaers Onder Kara Marco Mascitti Tobias Klatte maximilian kriegmair Nicola Pavan Eduard Roussel Angela Pecoraro Laura Marandino Riccardo Campi Luigi Schips Department of Urology SS Annunziata Hospital“G.D’Annunzio”University of ChietiChietiItaly Division of Urology Department of OncologySchool of MedicineSan Luigi HospitalUniversity of TurinOrbassanoTurinItaly Department of Urology San Carlo Di Nancy HospitalRomeItaly Department of Emergency and Organ Transplantation-Urology Andrology and Kidney Transplantation UnitUniversity of BariBariItaly Division of Urologic Oncology Department of UrologyIstanbul University Istanbul Faculty of MedicineIstanbulTurkey Department of Urology University Hospital Henri MondorAPHPCreteilFrance Department of Urology Radboud University Medical CenterNijmegenthe Netherlands Department of Urology Kocaeli University School of MedicineKocaeliTurkey Department of Urology Royal Bournemouth HospitalBournemouthUK Department of Urology University Medical Centre MannheimMannheimGermany Urology Clinic Department of MedicalSurgical and Health ScienceUniversity of TriesteTriesteItaly Department of Urology University Hospitals LeuvenLeuvenBelgium Department of Medical Oncology Fondazione IRCCS Istituto Nazionale dei TumoriMilanItaly Unit of Urological Robotic Surgery and Renal Transplantation University of FlorenceCareggi HospitalFlorenceItaly

Objective:The role of lymph node dissection(LND)is still controversial in patients with renal cell carcinoma undergoing *** aimed to provide a comprehensive review of the literature about the effect of LND on survival,prognosis,surgical outcomes,as well as patient selection and available LND ***:Recent literature(from January 2011 to December 2021)was assessed through PubMed and MEDLINE databases.A narrative review of most relevant articles was ***:The frequencies in which LNDs are being carried out are decreasing due to an increase in minimally invasive and nephron sparing ***,randomized clinical trials and meta-analyses failed to show any survival advantage of LND versus no ***,retrospective studies suggest a survival benefit of LND in high-risk patients(bulky tumors,T3-4 stage,and cN1 patients).Moreover,extended LND might provide important staging information,which could be of interest for adjuvant treatment ***:No level 1 evidence of any survival advantage deriving from LND is currently available in ***,the role of LND is limited to staging ***,low grade evidence suggests a possible role of LND in high-risk *** clinical trials are warranted to corroborate these findings.

关键词： Renal cell carcinoma Lymph node dissection Radical nephrectomy Salvage lymph node dissection

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NUMERICAL APPROXIMATION OF THE SMOLUCHOWSKI EQUATION USING RADIAL BASIS FUNCTIONS

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Journal of Computational Mathematics 2020年第1期38卷 176-194页

作者： Christiane Helzel maximilian Schneiders Institut of Mathematics Heinrich-Heine-Universitat DusseldorfGermany formerly Institut of Mathematics Heinrich-Heine-Universitat DusseldorfGermany

The goal of this paper is to present a numerical method for the Smoluchowski equation,a drift-diffusion equation on the sphere,arising in the modelling of particle *** numerical method uses radial basis functions(RBF).This is a relatively new approach,which has recently mainly been used for geophysical *** a simplified model problem we compare the RBF approach with a spectral method,*** standard approach used in related physical *** comparison as well as our other accuracy studies show that RBF methods are an attractive alternative for these kind of models.

关键词： Smoluchowski equation Spectral method Radial basis function method

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Self-supervised optimization of random material microstructures in the small-data regime

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npj Computational Materials 2022年第1期8卷 435-445页

作者： maximilian Rixner Phaedon-Stelios Koutsourelakis Professorship of Data-driven Materials Modeling Department of Engineering Physics and ComputationTechnical University of MunichBoltzmannstr.15D-85748Garching bei MünchenGermany Munich Data Science Institute(MDSI-Core Member) Garching bei MünchenGermany

While the forward and backward modeling of the process-structure-property chain has received a lot of attention from the materials’ community,fewer efforts have taken into consideration *** arise from a multitude of sources and their quantification and integration in the inversion process are essential in meeting the materials design *** first contribution of this paper is a flexible,fully probabilistic formulation of materials’ optimization problems that accounts for the uncertainty in the process-structure and structure-property linkages and enables the identification of optimal,high-dimensional,process *** employ a probabilistic,data-driven surrogate for the structure-property link which expedites computations and enables handling of non-differential *** couple this with a problem-tailored active learning strategy,i.e.,a self-supervised selection of training data,which significantly improves accuracy while reducing the number of expensive model *** demonstrate its efficacy in optimizing the mechanical and thermal properties of two-phase,random media but envision that its applicability encompasses a wide variety of microstructure-sensitive design problems.

关键词： microstructure property optimization

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Novel pathomechanistic insights into lysosomal storage disorders:how neuron-intrinsic cGAS-STING signaling drives disease progression

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Signal Transduction and Targeted Therapy 2024年第9期9卷 3548-3549页

作者： maximilian Frosch Marco Prinz Institute of Neuropathology University of FreiburgFaculty of MedicineFreiburgGermany Signalling Research Centres BIOSS and CIBSS University of FreiburgFreiburgGermany

In their recent paper published in Nature Cell Biology,1 Wang and colleagues defined a pathogenetic mechanism among a variety of lysosomal storage disorders(LSDs)mediating neuronal death and disease *** authors observed neuron-intrinsic activated cGAS-STING signaling triggered by accumulating cytosolic dsDNA,and thus,they provide a valuable target for directed therapies.

关键词： disorders intrinsic death

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“Wood-nacre”:Development of a Bio-inspired Wood-Based Composite for Beam and 3D-Surface Elements with Improved Failure Mechanisms

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Journal of Bionic Engineering 2023年第4期20卷 1701-1711页

作者： Ulrich Müller Peter Halbauer Alexander Stadlmann maximilian Grabner Hajir Al-musawi Bernhard Ungerer maximilian Pramreiter Department of Material Science and Process Engineering Institute of Wood Technology and Renewable MaterialsUniversity of Natural Resources and Life SciencesKonrad-Lorenz-Straße 243430Tulln an der DonauAustria Hycobility Engineering&Technologies GmbH Stadiongasse 6-8/Top281010ViennaAustria

Following the natural structure of the nacre,the material studied consists of a multitude of hexagonal tiles that are glued together in an offset manner with a ductile *** so-called“wood nacre”consists of macroscopic tiles of birch wood veneer with a thickness of 0.8 mm and a size of 20 or 10 mm in diameter in order to mimic the aragonite tiles and the ductile PUR-adhesive corresponds to the layers of collagen in between.E-modulus(MOE),bending strength(MOR)and impact bending strength of the samples were determined and compared with reference samples of birch laminated *** hierarchical layered structure of the tiles does not cause any relevant loss in *** nacre,“wood nacre”also shows tough fracture behaviour and a high homogenization ***,strain hardening and high fracture toughness of the natural model could not be fully *** reason for this is the insufficient ratio between the strength and stiffness of the veneer layers and the *** adjusting the size of the tiles,increasing the strength and surface roughness of the veneers,*** densification,and using more ductile adhesives that can be applied in smaller layer thicknesses,it should be possible to better reproduce the natural ratios of nacre and thus achieve a significant improvement in the material properties of“wood nacre”.In addition to the mechanical properties,the high potential of the new material lies in the possibility of producing 3D shell-shaped elements for lightweight wood hybrid construction.

关键词： Bio-inspired Damage tolerance Failure behaviour Hierarchical structure Nacre Work of fracture

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Transient thermal analysis as measurement method for IC package structural integrity

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Chinese Physics B 2015年第6期24卷 47-64页

作者： Alexander Han maximilian Schmid E Liu Gordon Elger Technische Hochschule Ingolstadt

Practices of IC package reliability testing are reviewed briefly, and the application of transient thermal analysis is examined in great depth. For the design of light sources based on light emitting diode （LED） efficient and accurate reliability testing is required to realize the potential lifetimes of 105 h. Transient thermal analysis is a standard method to determine the transient thermal impedance of semiconductor devices, e.g. power electronics and LEDs. The temperature of the semiconductor junctions is assessed by time-resolved measurement of their forward voltage （Vf）. The thermal path in the IC package is resolved by the transient technique in the time domain. This enables analyzing the structural integrity of the semiconductor package. However, to evaluate thermal resistance, one must also measure the dissipated energy of the device （i.e., the thermal load） and the k-factor. This is time consuming, and measurement errors reduce the accuracy. To overcome these limitations, an innovative approach, the relative thermal resistance method, was developed to reduce the measurement effort, increase accuracy and enable automatic data evaluation. This new way of evaluating data simplifies the thermal transient analysis by eliminating measurement of the k-factor and thermal load, i.e. measurement of the lumen flux for LEDs, by normalizing the transient Vf data. This is especially advantageous for reliability testing where changes in the thermal path, like cracks and delaminations, can be determined without measuring the k-factor and thermal load. Different failure modes can be separated in the time domain. The sensitivity of the method is demonstrated by its application to high- power white InGaN LEDs. For detailed analysis and identification of the failure mode of the LED packages, the transient signals are simulated by time-resolved finite element （FE） simulations. Using the new approach, the transient thermal analysis is enhanced to a powerful tool for reliability

关键词： transient thermal analysis thermal resistance reliability light emitting diode

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Light and sound- emerging imaging techniques for inflammatory bowel disease

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World Journal of Gastroenterology 2016年第25期22卷 5642-5654页

作者： Ferdinand Knieling maximilian J Waldner Clinic for Children and Adolescent Medicine Friedrich-Alexander-Universitat Erlangen-Nurnberg91054 ErlangenGermany Medical Department 1 Friedrich-Alexander-Universitat Erlangen-Nurnberg91054 ErlangenGermany Erlangen Graduate School of Advanced Optical Technologies Friedrich-Alexander-Universitat Erlangen-Nurnberg91054 ErlangenGermany

Patients with inflammatory bowel disease are known to have a high demand of recurrent evaluation for therapy and disease activity. Further, the risk of developing cancer during the disease progression is increasing from year to year. New, mostly non-radiant, quick to perform and quantitative methods are challenging, conventional endoscopy with biopsy as gold standard. Especially, new physical imaging approaches utilizing light and sound waves have facilitated the development of advanced functional and molecular modalities. Besides these advantages they hold the promise to predict personalized therapeutic responses and to spare frequent invasive procedures. Within this article we highlight their potential for initial diagnosis, assessment of disease activity and surveillance of cancer development in established techniques and recent advances such as wide-view full-spectrum endoscopy, chromoendoscopy, autofluorescence endoscopy, endocytoscopy, confocal laser endoscopy, multiphoton endoscopy, molecular imaging endoscopy, B-mode and Doppler ultrasound, contrast-enhanced ultrasound, ultrasound molecular imaging, and elastography.

关键词： Ulcerative colitis Crohn’ s disease Endoscopy Chromoendoscopy Autofluorescence endoscopy Full-view full-spectrum endoscopy Confocal endomicroscopy Multiphoton endoscopy High-definition endoscopy Ultrasound molecular imaging B-mode ultrasound Doppler ultrasound

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Cooling China： The Weather Dependence of Air Conditioner Adoption

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Frontiers of Economics in China-Selected Publications from Chinese Universities 2014年第1期9卷 70-84页

作者： maximilian Auffhammer Agricultural and Resource Economics Department University of California Berkeley. Berke-ley CA 94720-3310 USA National Bureau of Economic Research (NBER)

One of the major adaptation mechanisms to climate change is increased demand for cooling via the air conditioning of indoor environments. China＇s demand for air conditioners has displayed explosive growth since 1995. This paper provides estimates of the income and short run weather sensitivity of air conditioner adoption across urban areas for 29 Chinese provincial entities. We show that the adoption decision displays significant income and weather sensitivity in the short run, with adoption being higher the year following a hot summer.

关键词： climate change air conditioning weather

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Perspective on ultramicroporous carbon as sulphur host for Li-S batteries

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Journal of Energy Chemistry 2021年第8期30卷 242-256,I0006页

作者： Helen Maria Joseph maximilian Fichtner Anji Reddy Munnangi ASTUTE 2020 College of EngineeringSwansea UniversityFabian WaySA18EN SwanseaUnited Kingdom Helmholtz Institute Ulm(HIU)Electrochemical Energy Storage Helmholtzstraße 1189081 UlmGermany Institute of Nanotechnology Karlsruhe Institute of TechnologyP.O.Box 3640D-76021 KarlsruheGermany College of Engineering Swansea UniversityFabian WaySA18EN SwanseaUnited Kingdom

Lithium-sulphur(Li-S)batteries are currently considered as next-generation battery *** is an attractive positive electrode for lithium metal batteries,mainly due to its high capacity(1675 m Ah g^(-1))and high specific energy(2600 Wh kg^(-1)).The electrochemical reaction of lithium with sulphur in non-aqueous electrolytes results in the formation of electrolyte soluble intermediate *** dissolved polysulphides shuttle to the anode and get reduced at the anode resulting in Li metal *** solubility of polysulphide gradually reduces the amount of sulphur in the cathode,thereby limiting the cycle life of Li-S *** strategies have been proposed to improve the cycling stability of Li-S batteries.A unique approach to eliminate the polysulphide shuttle is to use ultramicroporous carbon(UMC)as a host for *** pore size of UMC which is below 7A,is the bottleneck for carbonate solvents to access sulphur/polysulphides confined in the pores,thereby preventing the polysulphide *** perspective article will emphasise the role of UMC host in directing the lithiation mechanism of sulphur and in inhibiting polysulphide dissolution,including the resulting parasitic reaction on the lithium ***,the challenges that need to be addressed by UMC-S based Li-S batteries,and the strategies to realise high power density,high Coulombic efficiency,and resilient Li-S batteries will be discussed.

关键词： Lithium-sulphur batteries Ultramicroporous carbon Sulphur Cathode Composites

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Scalable Deposition Methods for Large-Area Production of Perovskite Thin Films

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Energy & Environmental Materials 2019年第2期2卷 119-145页

作者： Richard Swartwout maximilian T.Hoerantner Vladimir Bulovic Department of Electrical Engineering and Computer Science Massachusetts Institute of Technology77 Massachusetts AvenueCambridge MA 02139USA

The recent steady improvements in the performance of the nascent hybrid perovskite photovoltaic(PV)devices have led to power conversion efficiencies that rival the best-performing established PV ***,to scale these laboratory demonstrations to PV module-scale production will require development of scalable deposition methods for perovskite thin *** record result for perovskite PVs so far was achieved via spin coating,a technique that is popular in research laboratories for thin-film coating over relatively small device areas,but not considered to be a method that could be used to scale up the manufacturing of perovskite *** larger thin-film areas are needed for future commercial PV ***,some researchers have focused their efforts on perovskite deposition techniques that can be considered as scalable for mass production and have achieved notable results even on large ***,we present an overview of the solution-based and vapor-based deposition processes;we explain their influence on the molecular crystal growth behavior of perovskite thin films and discuss the morphology as well as other material quality *** presenting a comprehensive comparison of the deposition techniques and the corresponding performance parameters for different device sizes,we intent to guide the growing research community through the methods that might enable mass production of perovskite solar products.

关键词： perovskite solar cells scalable deposition solution processing vapor deposition

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