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Variability of platelet aggregation in patients with clopidogrel treatment and hip fracture: A retrospective case-control study on 112 patients

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World Journal of Orthopedics 2015年第5期6卷 439-445页

作者： Anna Clareus Inga Fredriksson Hkan Wallén max gordon André Stark Olof Skldenberg Division of Orthopaedics Department of Clinical Sciences at Danderyd Hospital Karolinska Institutet Division of Anesthesiology Department of Clinical Sciences at Danderyd Hospital Karolinska Institutet Division of Cardiology Department of Clinical Sciences at Danderyd Hospital Karolinska Institute

AIM: To identify the rate of non-responders to clopidogrel treatment in hip fracture patients and study how non-responders differ from ***: In a retrospective case-control study we included 28 cases of acute proximal femoral fracture with clopidogrel treatment 2011 to 2013. Eighty-four controls from the same time period were included. Data collected included response to clopidogrel measured with multiple electrode aggregometry(MEA), intraoperative bleeding, erythrocyte transfusion, time to surgery and the incidence of adverse events up to 3 mo after surgery. RESULTS: Eight(29%) of the 28 cases were nonresponders. The median intraoperative bleeding was 300 mL(range, 0-1500), and was lower for non-responders(50 m L) but did not reach statistical significance. Erythrocyte transfusions did not differ between responders, non-responders and controls. Forty-five(40%) of 112 patients had adverse events postoperatively but the rate did not differ between patients with and without clopidogrel ***: Almost one-third of patients withclopidogrel treatment and an acute proximal femoral fracture are non-responders to antiplatelet therapy and can be operated without delay.

关键词： Proximal femoral fracture Clopidogrel Variability Bleeding Adverse events

Stimulated Brillouin scattering in chiral photonic crystal fiber

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Photonics Research 2022年第3期10卷 711-718页

作者： Xinglin Zeng Wenbin He Michael HFrosz Andreas Geilen Paul Roth gordon K.L.Wong Philip St.J.Russell Birgit Stiller max-Planck Institute for the Science of Light 91058 ErlangenGermany Department of Physics Friedrich-Alexander-Universität91058 ErlangenGermany

Stimulated Brillouin scattering(SBS)has many applications;for example,in sensing,microwave photonics,and signal ***,we report the first experimental study of SBS in chiral photonic crystal fiber(PCF),which displays optical activity and robustly maintains circular polarization states against external *** a result,circularly polarized pump light is cleanly backscattered into a Stokes signal with the orthogonal circular polarization state,as is required by angular momentum *** comparison,untwisted PCF generates a Stokes signal with an unpredictable polarization state,owing to its high sensitivity to external *** use chiral PCF to realize a circularly polarized continuous-wave Brillouin *** results pave the way for a new generation of stable circularly polarized SBS systems with applications in quantum manipulation,optical tweezers,optical gyroscopes,and fiber sensors.

关键词： polarization fiber scattering

Long-range optical trapping and binding of microparticles in hollow-core photonic crystal fibre

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Light(Science & Applications) 2018年第1期7卷 865-871页

作者： Dmitry S.Bykov Shangran Xie Richard Zeltner Andrey Machnev gordon K.L.Wong Tijmen G.Euser Philip St.J.Russell max Planck Institute for the Science of Light Staudtstr.291058 ErlangenGermany Department of Physics University of Erlangen-Nuremberg91058 ErlangenGermany NanoPhotonics Centre Cavendish LaboratoryUniversity of CambridgeCambridge CB30HEUK

Optically levitated micro-and nanoparticles offer an ideal playground for investigating photon–phonon interactions over macroscopic *** we report the observation of long-range optical binding of multiple levitated microparticles,mediated by intermodal scattering and interference inside the evacuated core of a hollow-core photonic crystal fibre(HC-PCF).Three polystyrene particles with a diameter of 1μm are stably bound together with an inter-particle distance of~40μm,or 50 times longer than the wavelength of the trapping *** levitated boundparticle array can be translated to-and-fro over centimetre distances along the *** evacuated to a gas pressure of 6 mbar,the collective mechanical modes of the bound-particle array are able to be *** measured interparticle distance at equilibrium and mechanical eigenfrequencies are supported by a novel analytical formalism modelling the dynamics of the binding *** HC-PCF system offers a unique platform for investigating the rich optomechanical dynamics of arrays of levitated particles in a well-isolated and protected environment.

关键词： optical scattering fibre

Outcome of Assisted Reproduction Treatment in Women with Extremely Low Antimullerian Hormone (AMH) Levels

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Open Journal of Obstetrics and Gynecology 2014年第15期4卷 961-966页

作者： Munawar Hussain David J. Cahill Valentine Akande Uma gordon St. Michael’s Hospital University Hospital Bristol NHS Foundation Trust Bristol UK Academic Unit of Obstetrics and Gynaecology School of clinical sciences University of Bristol & St. Michael’s Hospital Bristol UK Bristol Centre for Reproductive Medicine North Bristol NHS Trust Bristol UK

Purpose: To evaluate age related ovarian response to controlled ovarian hyperstimulation, clinical pregnancy and ongoing pregnancy rates beyond 20 weeks in women undergoing assisted reproduction treatment (ART) with antimullerian hormone (AMH) levels of 38 years of age. Non parametric variables were expressed as median (Interquartile range) and compared by Kruskal-Wallis test. Categorical variables were expressed as numbers with proportions (%) and compared by Fisher’s exact test. Results: There was no statistical difference in body max index, level of antimullerian hormone (AMH), follicle stimulating hormone (FSH), dose of gonadotrophins used and cycles cancellation rate in two groups. Although number of oocytes retrieved (median 5), clinical pregnancy (18.4%) and ongoing pregnancy rate beyond 20 weeks (18.4%) was higher in group 1, there was no statistical difference between the two groups. There was one miscarriage in group 2. Conclusion: Women with extremely low-serum AMH levels can still have clinical pregnancy and ongoing pregnancies beyond 20 weeks after ART, though chances will be lower than women with normal ovarian reserve.

关键词： Extremely Low Antimullerian Hormone Assisted Reproduction Treatment Clinical Pregnancy Ongoing Pregnancy Miscarriage Rate