Outcome of Assisted Reproduction Treatment in Women with Extremely Low Antimullerian Hormone (AMH) Levels

作     者：Munawar Hussain David J. Cahill Valentine Akande Uma Gordon 

作者机构：St. Michael’s Hospital University Hospital Bristol NHS Foundation Trust Bristol UK Academic Unit of Obstetrics and Gynaecology School of clinical sciences University of Bristol & St. Michael’s Hospital Bristol UK Bristol Centre for Reproductive Medicine North Bristol NHS Trust Bristol UK 

出 版 物：《Open Journal of Obstetrics and Gynecology》 (妇产科期刊（英文）)

年 卷 期：2014年第4卷第15期

页      面：961-966页

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

主　　题：Extremely Low Antimullerian Hormone Assisted Reproduction Treatment Clinical Pregnancy Ongoing Pregnancy Miscarriage Rate 

摘      要：Purpose: To evaluate age related ovarian response to controlled ovarian hyperstimulation, clinical pregnancy and ongoing pregnancy rates beyond 20 weeks in women undergoing assisted reproduction treatment (ART) with antimullerian hormone (AMH) levels of 38 years of age. Non parametric variables were expressed as median (Interquartile range) and compared by Kruskal-Wallis test. Categorical variables were expressed as numbers with proportions (%) and compared by Fisher’s exact test. Results: There was no statistical difference in body max index, level of antimullerian hormone (AMH), follicle stimulating hormone (FSH), dose of gonadotrophins used and cycles cancellation rate in two groups. Although number of oocytes retrieved (median 5), clinical pregnancy (18.4%) and ongoing pregnancy rate beyond 20 weeks (18.4%) was higher in group 1, there was no statistical difference between the two groups. There was one miscarriage in group 2. Conclusion: Women with extremely low-serum AMH levels can still have clinical pregnancy and ongoing pregnancies beyond 20 weeks after ART, though chances will be lower than women with normal ovarian reserve.