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Rethinking the Barcelona clinic liver cancer guidelines:Intermediate stage and Child-Pugh B patients are suitable for surgery?

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World Journal of Gastroenterology 2021年第21期27卷 2784-2794页

作者： Fabrizio Romano Marco Chiarelli Mattia Garancini mauro Scotti mauro Zago Gerardo Cioffi Matilde De Simone Ugo Cioffi Department of Surgery School of Medicine and SurgeryUniversity of Milano-BicoccaMonza 20900Italy Emergency and Robotic Surgery A.Manzoni HospitalASST LeccoLecco 23900Italy Department of General Surgery San Gerardo HospitalMonza 20900Italy Department of Sciences and Technologies Universitàdegli Studi del Sannio di BeneventoBenevento 82100Italy Department of Surgery University of MilanMilano 20122Italy

According to Barcelona Clinic Liver Cancer recommendations,intermediate stage hepatocellular carcinomas(stage B)are excluded from liver resection and are referred to palliative ***,Child-Pugh B patients are not usually candidates for liver ***,many hepatobiliary centers in the world manage patients with intermediate stage hepatocellular carcinoma or Child-Pugh B cirrhosis with liver resection,maintaining that hepatic resection is not contraindicated in selected patients with non–early-stage hepatocellular carcinoma and without normal liver *** studies demonstrate that resection provides the best survival benefit for selected patients in very early/early and even in intermediate stages of Barcelona Clinic Liver Cancer classification,and this treatment gives good results in the setting of multinodular,large tumors in patients with portal hypertension and/or Child-Pugh B *** this review we explore this controversial topic,and we show through the literature analysis how liver resection may improve the short-and long-term survival rate of carefully selected Barcelona Clinic Liver Cancer B and Child-Pugh B hepatocellular carcinoma ***,other large clinical studies are needed to clarify which patients with intermediate stage hepatocellular carcinoma are most likely to benefit from liver resection.

关键词： Liver surgery Hepatocellular carcinoma Barcelona liver clinic cancer Child B Intermediate stage

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Fluid dynamic and thermal comfort analysis in an actual operating room with unidirectional airflow system

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Building Simulation 2021年第4期14卷 1127-1146页

作者： Nicola Massarotti Alessandro mauro Salahudeen Mohamed Andrzej J.Nowak Domenico Sainas Dipartimento di Ingegneria Universitàdegli Studi di Napoli“Parthenope”Centro DirezionaleIsola C480143NapoliItaly Institute of Thermal Technology Silesian University of TechnologyKonarskiego 2244-100GliwicePoland

Air velocity and temperature distributions inside operating rooms (ORs) play a crucial role to reduce the risk of infections and to ensure adequate comfort conditions for patient and medical staff. In this work, the authors have developed a three-dimensional thermo-fluid dynamic model to simulate airflow and thermal comfort in an actual OR equipped with High-Efficiency Particulate Air (HEPA) filters. The model takes into account the presence of surgical lights, people and equipment within the room. An experimental campaign is carried out inside the actual OR to measure velocity and temperature, to be employed as boundary conditions for the numerical model. The experimental data have also been used to validate the numerical results. The validated model has been used to analyze the effects of human shape, thermal boundary conditions and buoyancy forces on the main thermal and fluid dynamic quantities in the OR. The thermal comfort is evaluated based on Predicted Mean Vote (PMV) and Predicted Percentage of Dissatisfied (PPD) indices. The results prove that the present experimental-numerical approach is useful to analyze and improve the thermal comfort conditions for medical staff and patient.

关键词： heat and mass transfer thermal comfort operating room LAF system human body validation

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Insights into the Tricholomatineae (Agaricales, Agaricomycetes): a new arrangement of Biannulariaceae and Callistosporium, Callistosporiaceae fam. nov., Xerophorus stat. nov., and Pleurocollybia incorporated into Callistosporium

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Fungal Diversity 2020年第2期101卷 211-259页

作者： Alfredo Vizzini Giovanni Consiglio mauro Marchetti Pablo Alvarado Department of Life Sciences and Systems Biology University of TorinoViale P.A.Mattioli 2510125 TurinItaly Institute for Sustainable Plant Protection(IPSP-SS Turin) C.N.R.Viale P.A.Mattioli2510125 TurinItaly Via Ronzani 61 Casalecchio di Reno40033 BolognaItaly Via Molise 8 56123 PisaItaly ALVALAB Dr.Fernando Bongera St.Severo Ochoa Bldg.S1.0433006 OviedoSpain

A new classification of the taxa formerly ascribed to Biannulariaceae(≡Catathelasmataceae),***(type),Callistosporium,Pleurocollybia,Macrocybe,Pseudolaccaria,Guyanagarika and Anupama is here *** inference of the Tricholomatineae based on the analysis of a combined dataset of nuclear genes including ITS,18S and 28S rDNA,tef1 and rpb2 data supports significantly a monophyletic origin of the aforementioned genera with the exception of Catathelasma,which is significantly related with Bonomyces and *** is therefore emended to include the clade formed by Catathelasma,Bonomyces and ***,the new family Callistosporiaceae is proposed to name the clade containing Callistosporium(=Pleurocollybia)and related *** of Callistosporium with distant lamellae,long hygrophoroid basidia and large amygdaliform spores are accommodated in the new genus ***,the new species Callistosporium pseudofelleum and Macrocybe sardoa are described,Clitocybe hesleri and *** are combined into Callistosporium and Pseudolaccaria,respectively,and Callistosporium olivascens *** is upgraded to species rank and combined into Xerophorus.

关键词： Basidiomycota Tricholomatoid clade Catathelasma clade Multigene phylogenetic analysis Taxonomy

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Hemozoin triggers tumor necrosis factor alpha-mediated release of lysozyme by human adherent monocytes:new evidences on leukocyte degranulation in *** malaria

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Asian Pacific Journal of Tropical Medicine 2009年第3期2卷 35-40页

作者： mauro Prato Giribaldi G Arese P Department of Genetics Biology and BiochemistryUniversity of Torino Medical SchoolTorinoItaly

Objective:Avidly phagocytosed hemozoin(malarial pigment) alters several functions of human monocytes and stimulates generation of several ***,we showed that phagocytosis of hemozoin by human monocytes increases expression and activity of matrix metalloproteinase-9,a proteolytic enzyme available in specific gelatinase granules,which contain several enzymes including *** work investigated active lysozyme release after phagocytosis of hemozoin and its dependence on production of tumor necrosis factor alpha. Methods:After phagocytosis of hemozoin,hemozoin-containing trophozoites or control meals(opsonized nonparasitized red blood cells and latex particles),monocyte supematants were monitored for 2 hours,in presence of blocking anti-human tumor necrosis factor alpha antibodies or recombinant human tumor necrosis factor alpha cytokine in selected *** release was evaluated by a specific spectrometric assay measuring lysozyme activity after coincubation of cell supematants with suspensions of Mycrococcus Lysodeikticus,while levels of soluble tumor necrosis factor alpha were analyzed by specific enzyme-linked immunodsorbent assay. Results:Levels of lysozyme activity and soluble tumor necrosis factor alpha protein were increased in hemozoin in-or trophozoites-laden monocytes *** per se(control meals) also increased lysozyme release,but levels were significantly lower than those obtained after phagocytosis of hemozoin or trophozoites. Interestingly,all effects on lysozyme release observed after phagocytosis were abrogated by blocking anti-human tumor necrosis factor alpha antibodies,while they were mimicked by recombinant human tumor necrosis factor alpha ***:Present work shows that phagocytosis of hemozoin promotes monocyte degranulation and enhances active lysozyme *** effect requires tumor necrosis factor alpha mediation.

关键词： Hemozoin Plasmodium Falciparum Malaria Monocyte Phagocytosis Tumor necrosis factor alpha Lysozyme Degranulation Gelatinase granules Matrix metalloproteinases

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Optimal laser intensity profiles for a uniform target illumination in direct-drive inertial confinement fusion

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High Power Laser Science and Engineering 2014年第4期2卷 62-67页

作者： mauro Temporal Benoit Canaud Warren J.Garbett Rafael Ramis Centre de Mathématiques et de Leurs Applications ENS Cachan and CNRS 61 Av.du President WilsonF-94235 Cachan Cedex France CEA DIF F-91297 Arpajon Cedex France AWE plc Aldermaston ReadingBerkshire RG7 4PR United Kingdom ETSI Aeronuticos Universidad Polit'ecnica de Madrid28040 Madrid Spain

A numerical method providing the optimal laser intensity profiles for a direct-drive inertial confinement fusion scheme has been developed. The method provides an alternative approach to phase-space optimization studies, which can prove computationally expensive. The method applies to a generic irradiation configuration characterized by an arbitrary number NBof laser beams provided that they irradiate the whole target surface, and thus goes beyond previous analyses limited to symmetric configurations. The calculated laser intensity profiles optimize the illumination of a spherical *** paper focuses on description of the method, which uses two steps: first, the target irradiation is calculated for initial trial laser intensities, and then in a second step the optimal laser intensities are obtained by correcting the trial intensities using the calculated illumination. A limited number of example applications to direct drive on the Laser Mega Joule(LMJ) are described.

关键词： direct drive inertial confinement fusion laser system

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Effects of Plasmodium falciparum—infected erythrocytes on matrix metalloproteinase-9 regulation in human microvascular endothelial cells

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Asian Pacific Journal of Tropical Medicine 2013年第3期6卷 195-199页

作者： Sarah D' Alessandro Nicoletta Basilico mauro Prato Dipartimento di Sanita Pubblica-Microbiologia-Virologia Universita di MilanoMilanoItaly Dipartimento di Genetica Biologia e BiochimicaFacolta di Medicina e ChirurgiaUniversita di TorinoTorinoItaly

Objective:To investigate the regulation of matrix metalloproteinases(MMPs) and tissue inhibitors of melalloproleinases(TIMPs) in human microvascular endothelium(HMEC-1) exposed to erythrocytes infected by different strains of Plasmodium falciparum(***).Methods: HMEC—1 eells were co—incubated for 72 h with erythrocytes infected by late stage trophozoite of D10(chloroquine-sensilive) or W 2(chloroquine-resistant) *** *** supernatants were then collected and the levels of pro- or active gelatinases MMP-9 and MMP-2 were evaluated by gelatin zymograpln and *** release of pro-MMP-9,***-1 and TIMP-1 proteins was analyzed by western blotting and ***:Infected erythrocytes induced de novo proMMP-9 and MMP-9 *** basal levels of proMMP-2 were altered,nor active MMP-2 was ***-3 and MMP-1 secretion was significant!) enhanced,whereas basal TIMP-1 was *** effects were similar for both strains. Conclusions:*** parasites,either chloroquine-sonsitive or -resistant,induce the release of active MMP-9 protein from human microvascular endothelium,by impairing balances between proMMP-9 and its inhibitor,and by enhancing the levels of its *** work provides new evidence on MMP involvement in malaria,pointing at MMP-9 as a possible target in adjuvant therapy.

关键词： Plasmodium falciparum Malaria Endothelial cells Matrix metalloproteinases Tissue inhibitors of metalloproteinases Gelatinases

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Spectral properties of Tm,Ho:LiYF_4 laser crystal

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Journal of Rare Earths 2011年第6期29卷 592-595页

作者：李春张莹张学建曾繁明 mauro Tonelli 刘景和 School of Materials Science and Engineering Changchun University of Science and Technology Office of Foreign Affairs Jilin Architectural and Civil Engineering Institute NEST-CNR and Dipartimento di Fisica Universita` di Pisa Largo B. Pontecorvo 3 56127 Pisa Italy

The LiYF4 single crystal codoped with thulium and holmium ions was successfully grown by the Cz method. The optimal technical parameters obtained were as follows： the pulling rate was 0.16 mm/h; the rotation speed was 3 rpm; the cooling rate was 15 °C/h. The result of XRD curve showed that as-grown Tm,Ho：LiYF4 laser crystal belonged to the monoclinic system with scheelite-type structure and space group I41/a. The cell parameters calculated were： a=0.52160 nm, c=1.09841 nm and Z=4. Absorption and fluorescence spectra of Tm,Ho：LiYF4 laser crystal at room temperature were measured and analysed. The absorption cross section, FWHM and absorption coefficient at 779.3 nm calculated were 7.44×10–21 cm2, 8.7 nm and 2.23 cm–1, respectively. An intensive fluorescence emission peak appeared near 2045 nm. The emission cross section and fluorescence lifetime were 0.87×10–20 cm2 and 10.8 ms, respectively. The ratio of Tm–Ho transfer to its back-transfer process was 10.6.

关键词： Tm Ho:LiYF4 laser crystal Cz method absorption spectrum fluorescence spectrum rare earths

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NMR investigation of degradation processes of ancient and modern paper at different hydration levels

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Frontiers of physics 2018年第1期13卷 41-50页

作者： Domenico Mallamace Sebastiano Vasi mauro Missori Francesco Mallamace Carmelo Corsaro Consorzio interuniversitario per lo sviluppo dei Sistemi a Grande Interfase - CSGI Via della Lastruccia 3 50019 Sesto Fiorentino Firenze Italy Dipartimento MIFT Sezione di Fisica Universita di Messina Viale F. Stagno D'Alcontres 31 98166 Messina Italy Istituto dei Sistemi Complessi Consiglio Nazionale delle Ricerche Unit Sapienza Piazzale Aldo Moro 5 00185 Roma Italy CNR-IPCF Messina Istituto per i Processi Chimico-Fisici Viale F. Stagno D'Alcontres 37 98158 Messina Italy Center for Polymer Studies and Department of Physics Boston University Boston MA 02215 USA

The degradation process of cellulose-made materials was investigated by means of nuclear magnetic resonance （NMR） spectroscopy, with particular emphasis on the role of water and on the hydration mechanism of cellulose fibrils. To accomplish this, the structure and dynamics of water within ancient and modern samples with different aging histories were investigated. The results mainly indicated that hydrolytic and oxidative reactions provoked the formation of acidic by-products. Furthermore, degradation processes were enhanced by higher amounts of water giving a progressive consumption of the amorphous regions of the cellulose. We propose NMR experiments as a benchmark for character- ization of the degradation state of paper, as well as for investigating the effectiveness of restoration treatments.

关键词： ancient paper degradation NMR hydration solvent dynamics

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Heterogeneous Photooxidation of Phenol by Catalytic Membranes

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过程工程学报 2006年第4期6卷 645-650页

作者： Enrica Fontananova Enrico Drioli Laura Donato Marcella Bonchio mauro Carraro Gianfranco Scorrano Institute on Membrane Technology of the National Research Council (ITM-CNR) Via P.Bucci 17/C 87030Rende (CS) Italy Department of Chemical Engineering and Materials University of CalabriaVia P. BucciRende (CS)Italy ITM-CNR (sect.) c/o University of PadovaVia Marzolo 135131PadovaItaly

In this work the heterogenization in polymeric membranes of decatungstate,a photocatalyst for oxidation reactions,was *** state characterization techniques confirmed that the catalyst structure was preserved within the polymeric *** catalytic membranes were successfully applied in the aerobic photo-oxidation of phenol,one of the main organic pollutants in wastewater,providing stable and recyclable photocatalytic *** dependence of the phenol degradation rate by the catalyst loading and transmembrane pressure was *** comparison with homogeneous reaction,the catalyst heterogenized in membrane appears to be more efficient concerning the rate of phenol photodegradation and mineralization.

关键词： photo-oxidation decatungstate catalytic membrane phenol wastewater

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Protein kinase CK2: a potential therapeutic target for diverse human diseases

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Signal Transduction and Targeted Therapy 2021年第6期6卷 1698-1717页

作者： Christian Borgo Claudio D'Amore Stefania Sarno mauro Salvi Maria Ruzzene Department of Biomedical Sciences University of PaduaPaduaItaly CNR Institute of Neuroscience University of PaduaPaduaItaly

CK2 is a constitutively active Ser/Thr protein kinase,which phosphorylates hundreds of substrates,controls several signaling pathways,and is implicated in a plethora of human *** best documented role is in cancer,where it regulates practically all malignant *** well-known functions of CK2 are in human infections;in particular,several viruses exploit host cell CK2 for their life *** recently,also SARS-CoV-2,the virus responsible for the COVID-19 pandemic,has been found to enhance CK2 activity and to induce the phosphorylation of several CK2 substrates(either viral and host proteins).CK2 is also considered an emerging target for neurological diseases,inflammation and autoimmune disorders,diverse ophthalmic pathologies,diabetes,and *** addition,CK2 activity has been associated with cardiovascular diseases,as cardiac ischemia-reperfusion injury,atherosclerosis,and cardiac *** hypothesis of considering CK2 inhibition for cystic fibrosis therapies has been also entertained for many ***,psychiatric disorders and syndromes due to CK2 mutations have been recently *** these bases,CK2 is emerging as an increasingly attractive target in various fields of human medicine,with the advantage that several very specific and effective inhibitors are already ***,we review the literature on CK2 implication in different human pathologies and evaluate its potential as a pharmacological target in the light of the most recent findings.

关键词： diseases inflammation potential

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