检索结果-南通市图书馆

Nanocomposite electrospun fibers of poly(ε-caprolactone)/bioactive glass with shape memory properties

Bioactive Materials 2022年第5期7卷 230-239页

作者： Liliana Liverani Anna Liguori Paola Zezza Chiara Gualandi maurizio toselli Aldo R.Boccaccini Maria Letizia Focarete Department of Materials Science and Engineering University of Erlangen-NurembergCauerstr.691058ErlangenGermany Department of Chemistry“Giacomo Ciamician”and INSTM UdR of Bologna University of Bolognavia Selmi 240126BolognaItaly Interdepartmental Center for Industrial Research on Advanced Applications in Mechanical Engineering and Materials Technology CIRI-MAMUniversity of BolognaViale Risorgimento240136BolognaItaly Department of Industrial Chemistry“Toso Montanari” University of BolognaViale Risorgimento 440136BolognaItaly Health Sciences and Technologies–Interdepartmental Center for Industrial Research(HST-ICIR) Alma Mater Studiorum-Universit`a di Bologna40064Ozzano dell’EmiliaBolognaItaly

Electrospun fibers of shape memory triethoxysilane-terminated poly(epsilon-caprolactone)(PCL-TES)loaded with bioactive glasses(BG)are here *** PCL-TES,as well as PCL/BG nanocomposite fibers,are also considered for *** is proposed that hydrolysis and condensation reactions take place between triethoxysilane groups of the polymer and the silanol groups at the BG particle surface,thus generating additional crosslinking points with respect to those present in the PCL-TES *** as-spun PCL-TES/BG fibers display excellent shape memory properties,in terms of shape fixity and shape recovery ratios,without the need of a thermal crosslinking *** particles confer in vitro bioactivity to PCL-based nanocomposite fibers and favor the precipitation of hydroxycarbonate apatite on the fiber *** cytocompatibility tests demonstrate that the addition of BG particles to PCL-based polymer does not inhibit ST-2 cell *** novel approach of using bioactive glasses not only for their biological properties,but also for the enhancement of shape memory properties of PCL-based polymers,widens the versatility and suitability of the obtained composite fibers for a huge portfolio of biomedical applications.

关键词： PCL-TES Bioactive glasses Bioactivity Shape memory polymers Electrospinning Benign solvents

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Beyond functional MRI signals:molecular and cellular modifiers of the functional connectome and cognition

引用

Neural Regeneration Research 2024年第5期19卷 937-938页

作者： Lorenzo Pini Alessandro Salvalaggio maurizio Corbetta Padova Neuroscience Center University of PadovaItaly Veneto Institute of Molecular Medicine VIMMPadovaItaly Department of Neuroscience University of PadovaItaly

Our brain is constantly *** at rest,the brain carries out essential functions such as maintenance of resting potentials,subthreshold synaptic activity,and spiking activity related to information *** resting activity can be assessed with several in vivo tools,such as resting-state functional magnetic resonance *** technique measures subtle changes in blood flow,volume,and oxygenation that occur over *** vascular in nature,resting-state functional magnetic resonance imaging is considered a reliable proxy of neural activity and several studies have shown that the brain is functionally divided into interacting neural networks called the“functional connectome”.

关键词： functional neural measures

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Update on the reciprocal interference between immunosuppressive therapy and gut microbiota after kidney transplantation

引用

World Journal of Transplantation 2024年第1期14卷 72-83页

作者： maurizio Salvadori Giuseppina Rosso Department of Renal Transplantation Careggi University HospitalFlorence 50139TuscanyItaly Division of Nephrology San Giovanni di Dio HospitalFlorence 50143ToscanaItaly

Gut microbiota is often modified after kidney *** principally happens in the first period after *** and,most of all,immunosuppressive drugs are the main *** relationship between immunosuppressive drugs and the gut microbiota is *** one side immunosuppressive drugs modify the gut microbiota,often generating dysbiosis;from the other side microbiota may interfere with the immunosuppressant pharmacokinetics,producing products more or less active with respect to the original *** phenomena have influence over the graft outcomes and clinical consequences as rejections,infections,diarrhea may be caused by the dysbiotic ***,calcineurin inhibitors such as tacrolimus and cyclosporine,mycophenolate mofetil and mTOR inhibitors are the immunosuppressive drugs whose effect on the gut microbiota is better *** contrast is well known how the gut microbiota may interfere with glucocorticoids,which may be transformed into *** may be transformed by microbiota into a product called M1 that is 15-fold less active with respect to *** pro-drug mycophenolate mofetil is normally transformed in mycophenolic acid that according the presence or not of microbes producing the enzyme glucuronidase,may be transformed into the inactive product.

关键词： Immunosuppressive therapy Kidney transplantation Gut microbiota Dysbiosis Pathobionts Graft outcomes

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Glucagon-like peptide 1 agonists are potentially useful drugs for treating metabolic dysfunction-associated steatotic liver disease

引用

World Journal of Gastroenterology 2024年第30期30卷 3541-3547页

作者： maurizio Soresi Lydia Giannitrapani Department of Health Promotion Sciences Maternal and Infant CareInternal Medicine and Medical Specialties(PROMISE)University of PalermoPalermo 90127Italy

In this editorial,we comment on Yin et al’s recently published Letter to the *** particular,we focus on the potential use of glucagon-like peptide 1 receptor agonists(GLP-1RAs)alone,but even more so in combination therapy,as one of the most promising therapies in metabolic dysfunction-associated steatotic liver disease(MASLD),the new definition of an old condition,non-alcoholic fatty liver disease,which aims to better define the spectrum of steatotic *** is well known that GLP-1RAs,having shown outstanding performance in fat loss,weight loss,and improvement of insulin resistance,could play a role in protecting the liver from progressive *** clinical trials have shown that,among GLP-1RAs,semaglutide is a safe,well-studied therapeutic choice for MASLD patients;however,most studies demonstrate that,while semaglutide can reduce steatosis,including steatohepatitis histological signs(in terms of inflammatory cell infiltration and hepatocyte ballooning),it does not improve *** of therapies with different but complementary mechanisms of action are considered the best way to improve efficiency and slow disease progression due to the complex pathophysiology of the *** particular,GLP-1RAs associated with antifibrotic drug therapy,dual glucose-dependent insulinotropic polypeptide(GIP)/GLP-1RA or GLP-1 and glucagon RAs have promoted greater improvement in hepatic steatosis,liver biochemistry,and non-invasive fibrosis tests than ***,although to date there are no definitive indications from international drug agencies,there is the hope that soon the therapeutic lines in the most advanced phase of study will be able to provide a therapy for MASLD,one that will certainly include the use of GLP-1RAs as combination therapy.

关键词： Non-alcoholic fatty liver disease Glucagon-like peptide 1 Semaglutide Liver fibrosis Therapy

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Dexamethasone and N-acetylcysteine before transarterial chemoembolization in hepatocellular carcinoma:A Western perspective

引用

World Journal of Gastroenterology 2024年第31期30卷 3635-3639页

作者： Marco Biolato maurizio Pompili Department of Medical and Surgical Sciences CEMAD Digestive Disease CenterFondazione Policlinico Universitario Agostino Gemelli IRCCSRome 00168Italy Department of Translational Medicine and Surgery Catholic University of Sacred HeartRome 00168LazioItaly

Post-embolization syndrome(PES)is the most common complication in patients with hepatocellular carcinoma treated with transarterial *** strategies have been evaluated to reduce the incidence of PES,but no standard prevention guidelines currently *** a single-center,placebo-controlled trial,Simasingha et al evaluated the prophylactic administration of a combination of dexamethasone and N-acetylcysteine and documented a significant reduction in the incidence of PES(from 80%to 6%),of post-procedural liver decompensation(from 14%to 0%),and a shorter hospital stay(4 days vs 6 days),alongside an acceptable safety *** results of this study raise several controversial points regarding their applicability in the Western *** the West,there is a greater and increasing prevalence of metabolic and alcoholic etiologies of liver cirrhosis,so a not negligible number of patients with type II diabetes or hypertension would be excluded from high-dosage dexamethasone ***,in the West,there is a preferred use of drug-eluting beads loaded with doxorubicin,which are associated with a lower incidence of PES.A study on prophylaxis with dexamethasone and/or N-acetylcysteine in a Western population is hopefully awaited.

关键词： Chemotherapeutic drugs Lipiodol Post-embolization syndrome Prevention Prophylaxis

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Epoché as the Breakthrough of the Natural Attitude

引用

Philosophy Study 2024年第3期14卷 138-144页

作者： maurizio Trudu Universitàdegli Studi di Ferrara FerraraItaly Bergische Universität Wuppertal WuppertalGermany

The following contribution aims to interpret the methodical device of Husserl’s epochéin light of the concept of *** the epochéis a theoretical device directed towards the suspension of the natural attitude,I will first attempt to define the concept of natural ***,I will seek to understand the rich meaning of the concept of epoché.Finally,I will explore how this element is related to the concept of *** other words,I will endeavour to clarify how the epochédetermines a breakthrough of the natural attitude,which is not to be understood as“annihilation”or“destruction”but as a traversal.

关键词： Edmund Husserl epoché natural attitude phenomenology

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Frequency of and reasons behind non-listing in adult patients referred for liver transplantation: Results from a retrospective study

引用

World Journal of Transplantation 2024年第2期14卷 99-106页

作者： Marco Biolato Luca Miele Giuseppe Marrone Claudia Tarli Antonio Liguori Rosaria Calia Giovanni Addolorato Salvatore Agnes Antonio Gasbarrini maurizio Pompili Antonio Grieco Department of Medical and Surgical Sciences CEMADFondazione Policlinico Universitario Agostino Gemelli IRCCSRome 00168Italy Department of Translational Medicine and Surgery Catholic University of Sacred HeartRome 00168Italy

BACKGROUND Few studies have evaluated the frequency of and the reasons behind the refusal of listing liver transplantation *** To assess the ineligibility rate for liver transplantation and its *** A single-center retrospective study was conducted on adult patients which entailed a formal multidisciplinary assessment for liver transplantation *** predictors for listing were evaluated using multivariable logistic *** In our center,314 patients underwent multidisciplinary work-up before liver transplantation enlisting over a three-year *** most frequent reasons for transplant evaluation were decompensated cirrhosis(51.6%)and hepatocellular carcinoma(35.7%).The non-listing rate was 53.8%and the transplant rate was 34.4%for the whole *** hundred and five motivations for ineligibility were *** most common contraindications were psychological(9.3%),cardiovascular(6.8%),and surgical(5.9%).Inappropriate or premature referral accounted for 76(37.1%)*** multivariable analysis,a referral from another hospital(OR:2.113;95%CI:1.259–3.548)served as an independent predictor of *** A non-listing decision occurred in half of our cohort and was based on an inappropriate or premature referral in one case out of *** referral from another hospital was taken as a strong predictor of non-listing.

关键词： Controindication Eligibility Evaluation Referral Personalized medicine

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Update on the gut microbiome in health and diseases

引用

World Journal of Methodology 2024年第1期14卷 18-32页

The Human Microbiome Project,Earth Microbiome Project,and next-generation sequencing have advanced novel genome association,host genetic linkages,and pathogen *** microbiome is the sum of the microbes,their genetic information,and their ecological *** study will describe how millions of bacteria in the gut affect the human body in health and *** gut microbiome changes in relation with age,with an increase in Bacteroidetes and *** and environmental factors affecting the gut microbiome are diet,drugs,age,smoking,exercise,and host *** addition,changes in the gut microbiome may affect the local gut immune system and systemic immune *** this study,we discuss how the microbiome may affect the metabolism of healthy subjects or may affect the pathogenesis of metabolism-generating metabolic *** to the high number of publications on the argument,from a methodologically point of view,we decided to select the best papers published in referred journals in the last 3 *** we selected the previously published *** major goals of our study were to elucidate which microbiome and by which pathways are related to healthy and disease conditions.

关键词： Gut microbiome Dysbiosis Pathobionts Gut-brain axis Heart-brain axis Metabolic diseases Omics techniques

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Optic nerve crush as a model of retinal ganglion cell degeneration

引用

Annals of Eye Science 2022年第2期7卷 27-32页

作者： maurizio Cammalleri Department of Biology University of PisaPisaItaly

Background:Axonal degeneration caused by damage to the optic nerve can result in a gradual death of retinal ganglion cells(RGC),leading to irreversible vision *** example of such diseases in humans includes optic nerve degeneration in *** is characterized by the progressive degeneration of the optic nerve and the loss of RGCs that can lead to loss of *** different animal models developed to mimic glaucomatous neurodegeneration,all result in RGC loss consequent optic nerve ***:The present article summarizes experimental procedures and analytical methodologies related to one experimental model of glaucoma induced by optic nerve crush(ONC).Point-by-point protocol is reported with a particular focus on the critical point for the realization of the ***,information on the electroretinogram procedure and the immunohistochemical detection of RGCs are described to evaluate the morpho-functional consequences of ***:Although the model of ONC is improperly assimilated to glaucoma,then the ONC model simulates most of the signaling responses consequent to RGC apoptosis as observed in models of experimental *** this respect,the ONC model may be essential to elucidate the cellular and molecular mechanisms of glaucomatous diseases and may help to develop novel neuroprotective therapies.

关键词： Axonal injury retrograde degeneration cell death

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Exosomes:Key tools for cancer liquid biopsy

引用

BIOCELL 2022年第10期46卷 2167-2176页

作者： ISABELLA PANFOLI maurizio BRUSCHI GIOVANNI CANDIANO Dipartimento di Farmacia-DIFAR Universitàdi GenovaGenoa16132Italy Laboratory of Molecular Nephrology IRCCS Istituto Giannina GasliniGenoa16147Italy

Precision medicine is based on the identification of biomarkers of tumor development and *** biopsy is at the forefront of the ability to gather diagnostic and prognostic information on tumors,as it can be noninvasively performed prior or during *** biopsy mostly utilizes circulating tumor cells,or free DNA,but also *** latter are nanovesicles secreted by most cell types,found in any body fluid that deliver proteins,nucleic acids and lipids to nearby and distant cells with a unique homing *** function in signalling between the tumor microenvironment and the rest of the body,promoting metastasis,immune remodelling and drug *** are emerging as a key tool in precision medicine for cancer liquid biopsy,as they efficiently preserve their biomarker ***,exosomes strongly resemble the parental cell,which can help in assessing the oxidative and metabolic state of the donor *** this respect,exosomes represent one of the most promising new tools to fight *** review will discuss the clinical applications of profiling exosomal proteins and lipids by high-throughput proteomics and metabolomics,and nucleic acids by next generation sequencing,as well as how this may allow cancer diagnosis,therapy response monitoring and recurrence detection.

关键词： Cancer Exosome Liquid biopsy Precision medicine

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：