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Amphiphilic AIEgen-polymer aggregates:design,self-assembly and biomedical applications

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Aggregate

Aggregate 2022年第1期3卷 75-92页

作者： Shoupeng cao Jingxin Shao Loai K.E.A.Abdelmohsen Jan c.m.van Hest Bio-Organic chemistry Institute for Complex Molecular SystemsEindhoven University of TechnologyEindhovenThe Netherlands

Aggregation-induced emission(AIE)is a phenomenon in which fluorescence is enhanced rather than quenched upon molecular *** fluorogens(AIEgens)are flexible,conjugated systems that are limited in their dynamics when assembled,which improves their fluorescent *** intriguing feature has been incorporated in many different molecular assemblies and has been extended to nanoparticles composed of amphiphilic polymer building *** integration of the fascinating AIE design principle with versatile polymer chemistry opens up new frontiers to approach and solve intrinsic obstacles of conventional fluorescent materials in nanoscience,including the aggregation-caused quenching ***,this integration has drawn significant attention from the nanomedicine community,due to the additional advantages of nanoparticles comprising AIEgenic molecules,such as emission brightness and fluorescence *** this regard,a range of AIEgenic amphiphilic polymers have been developed,displaying enhanced emission in the self-assembly/aggregated *** assemblies are regarded as attractive nanomaterials with inherent fluorescence,which display promising features in a biomedical context,for instance in biosensing,cell/tissue imaging and tracking,as well as(photo)*** this review,we describe recent strategies for the design and synthesis of novel types of AIEgenic amphiphilic polymers via facile approaches including direct conjugation to natural/synthetic polymers,polymerization,post-polymerization and supramolecular host−guest *** self-assembly behavior and biomedical potential will be discussed.

关键词： aggregation-induced emission amphiphilic polymers biomedical applications nanomotors supramolecular self-assembly

complex coacervate materials as Artificial cells

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Accounts of materials Research 2023年第3期4卷 287-298页

作者： Alexander B.cook Sebastian Novosedlik Jan c.m.van Hest Bio-Organic chemistry Institute for Complex Molecular SystemsEindhoven University of Technology5600 MB EindhovenThe Netherlands

cONSPEcTUS:cells have evolved to be self-sustaining compartmentalized systems that consist of many thousands of biomolecules and metabolites interacting in complex cycles and reaction *** subtle intricacies of these self-assembled structures are still largely *** importance of liquid−liquid phase separation(both membraneless and mem-brane bound)is,however,recognized as playing an important role in achieving biological function that is controlled in time and *** biochemical reactions in vitro has been a success of the last decades,for example,establishment of the minimal set of enzymes and nutrients able to replicate cellular activities like the in vitro transcription translation of genes to *** than this though,artificial cell research has the aim of combining synthetic materials and nonliving macromolecules into ordered assemblies with the ability to carry out more complex and ambitious cell-like *** activities can provide insights into fundamental cell processes in simplified and idealized systems but could also have an applied impact in synthetic biology and biotechnology in the *** date,strategies for the bottom-up fabrication of micrometer scale life-like artificial cells have included stabilized water-in-oil droplets,giant unilamellar vesicles(GUV’s),hydrogels,and complex ***-in-oil droplets are a valuable and easy to produce model system for studying cell-like processes;however,the lack of a crowded interior can limit these artificial cells in mimicking life more *** membrane stabilized vesicles,such as GUV’s,have the additional membrane feature of cells but still lack a macromolecularly crowded ***-based artificial cells have a macromolecularly dense interior(although cross-linked)that better mimics cells,in addition to mechanical properties more similar to the viscoelasticity seen in cells but could be seen as being not dynamic in nature and limi

关键词： interior stabilized simplified

design and thermodynamic analysis of a pathway enabling anaerobic production of poly-3-hydroxybutyrate in Escherichia coli

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Synthetic and Systems Biotechnology 2023年第4期8卷 629-639页

作者： Karel Olavarria marco V.Becker Diana Z.Sousa mark c.m.van Loosdrecht S.Aljoscha Wahl Laboratory of microbiology Wageningen University and ResearchStippenenweg 46708 WEWageningenThe Netherlands centre for Living Technologies Eindhoven-Wageningen-Utrecht AlliancePrincetonlaan 63584 CBUtrechtThe Netherlands department of Biotechnology Applied Sciences FacultyDelft University of Technologyvan der Maasweg 92629 HZDelftThe Netherlands Lehrstuhl für Bioverfahrenstechnik Friedrich-Alexander-Universit¨atPaul-Gordan-Strasse 391052ErlangenGermany

Utilizing anaerobic metabolisms for the production of biotechnologically relevant products presents potential advantages,such as increased yields and reduced energy ***,lower energy dissipation may indicate that certain reactions are operating closer to their thermodynamic *** stoichiometric analyses and genetic modifications are frequently employed in metabolic engineering,the use of thermodynamic tools to evaluate the feasibility of planned interventions is less *** this study,we propose a novel metabolic engineering strategy to achieve an efficient anaerobic production of poly-(R)-3-hydroxybutyrate(PHB)in the model organism Escherichia *** approach involves re-routing of two-thirds of the glycolytic flux through non-oxidative glycolysis and coupling PHB synthesis with NADH *** complemented our stoichiometric analysis with various thermodynamic approaches to assess the feasibility and the bottlenecks in the proposed engineered *** to our calculations,the main thermodynamic bottleneck are the reactions catalyzed by the acetoacetyl-coAβ-ketothiolase(Ec 2.***.1.9)and the acetoacetyl-coA reductase(Ec 1.***.1.36).Furthermore,we calculated thermodynamically consistent sets of kinetic parameters to determine the enzyme amounts required for sustaining the conversion *** the case of the engineered conversion route,the protein pool necessary to sustain the desired fluxes could account for 20%of the whole cell dry weight.

关键词： Pathway feasibility analysis Protein cost Anaerobic metabolism Engineered pathways metabolite concentrations

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ZnO薄膜的性能和应用

压电与声光 1991年第6期13卷 63-72页

作者： Frans c.m.van de Pol 陈运祥荷.Enschede Twente大学电气工程系

1 引言作为半导体、光导体、压电体和光波导材料的氧化锌(ZnO)在科学和技术上有着广泛的应用。ZnO引人注目的性能包括:晶体结构方面的各向异性;非化学计量缺陷结构;宽的带隙;可分解升华及其两性的化学特性;在可见光区光学透明和相当... 详细信息

1 引言作为半导体、光导体、压电体和光波导材料的氧化锌(ZnO)在科学和技术上有着广泛的应用。ZnO引人注目的性能包括:晶体结构方面的各向异性;非化学计量缺陷结构;宽的带隙;可分解升华及其两性的化学特性;在可见光区光学透明和相当大的折射率;大的压电常数以及大的声光、电光和非线性光学系数。

关键词： ZnO薄膜半导体薄膜应用

Dispersal of invasive species by drifting

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current Zoology 2011年第6期57卷 818-827页

作者： m.c. van RIEL G. van deR VELde A. BIJ de VAATE Radboud University Nijmegen Institute for Water and Wetland Research Department of Animal Ecology and Ecophysiology Section Aquatic Animal Ecology Heyendaalseweg 135 6525 AJ Nijmegen The Netherlands Team Freshwater Ecology DLO-Alterra P.O. Box 47 6700 AA Wageningen The Netherlands Netherlands centre for Biodiversity Naturalis EO. Box 9517 2300 RA Leiden The Netherlands Waterfauna Hydrobiologisch Adviesbureau Oostrandpark 30 8212 AP Lelystad The Netherlands

Drifting can be an effective way for aquatic organisms to disperse and colonise new areas. Increasing connectivity between European large rivers facilitates invasion by drifting aquatic macroinvertebrates. The present study shows that high abundances of invasive species drift in the headstream of the river Rhine. Dikerogammarus villosus and chelicorophium cur- vispinum represented up to 90% of the total of drifting macroinvertebrates. Drift activity shows seasonal and diel patterns. most species started drifting in spring and were most abundant in the water column during the summer period. Drift activity was very low during the winter period. Diel patterns were apparent; most species, including D. villosus, drifted during the night. Drifting macroinvertebrates colonised stony substrate directly from the water column. D. villosus generally colonised the substrate at night, while higher numbers of c. curvispinum colonised the substrate during the day. It is very likely that drifting functions as a disper- sal mechanism for crustacean invaders. Once waterways are connected, these species are no longer necessarily dependent on dispersal vectors other than drift for extending their distribution range

关键词： Amphipods Invaders colonization Drift Daily rhythms Seasonal variation

Waste materials to Replace Natural Resources

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武汉理工大学学报 2010年第17期32卷 35-42页

作者： van de VEN m F c mOLENAAR A A A POOT m R delft University of Technology

A number of waste materials were studied on their application into asphalt mixtures. materials tested were plastic waste as (soft) granular material,ceramic waste from electrical insulators,foundry sand and sintered granulate from burned household waste. Both plastic waste,crushed ceramics and large fractions of sintered household waste could be used as partial replacement for coarse aggregates. Foundry sand could partially replace natural sand in asphalt mixtures. The first step of the study was to find out if the waste materials could satisfy basic requirements and for some if their leaching behavior was acceptable. In the next phase mixtures were designed and mechanical tests were done on several mixtures with waste components to determine indirect tensile strength,stiffness,fatigue. In order to estimate the water sensitivity of some mixtures,retained indirect tension tests were done. The properties are reported and compared with each other and reference mixtures. From the research it becomes clear that it takes a lot of work to replace virgin materials in asphalt mixtures with waste materials.

关键词： waste materials plastic ceramic sintered household waste leaching,mechanical properties

consumer transparency in the production chain for plant varieties produced using new genomic techniques

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aBIOTEcH 2024年第2期5卷 239-246页

作者： J.m.Lukasiewicz c.c.m.van de Wiel L.A.P.Lotz m.J.m.Smulders Wageningen University&Research P.O.Box 386NL-6700 AJ WageningenThe Netherlands

Plants edited with new genomic techniques(NGTs)currently fall under the Genetically modified Organisms Directive(2001/18/Ec)in the European *** the proposal of the European commission,NGT plants are partially exempted from the regulations of this *** proposal makes a distinction between two categories of NGT plants:NGT-1 and ***-1 category plants are considered equal to plants obtained through conventional breeding *** plants will not be labelled for the consumer,although they will be labelled as ***-2 category plants may be labelled with additional information as a positive *** of seeds of varieties made with gene editing,but not the products,would mean that most steps in the production chain are transparent,but not the last step towards ***“right to know”and increasing knowledge of gene-edited food is a common theme in food labelling towards ***,we describe current labelling regimes and registers and how these may be applied to provide transparency on gene-edited products to ***,we also look into consumer studies,which indicate a greater acceptance of gene-edited food among consumers,especially when additional benefits such as sustainability are mentioned.

关键词： Labelling New genomic techniques consumer transparency Plant products

How to make capsules containing Rejuvenators for Their Use in Asphalt concrete

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武汉理工大学学报 2010年第17期32卷 18-21,34页

作者： GARcIA A ScHLANGEN E van de VEN m F c Faculty of civil Engineering and Geosciences Delft University of TechnologyMICROLAB2628CN DelftThe Netherlands Faculty of civil Engineering and Geosciences Road and Railway EngineeringDelft University of Technology2628CN DelftThe Netherlands

Rejuvenators are products designed to restore original properties to oxidized asphalt binders by restoring the original ratio of asphaltenes to maltenes. But,for a rejuvenator to be successful,it must penetrate the pavement surface. Besides,application of a rejuvenator will also reduce the skid resistance of the pavement. To solve this,these rejuvenators can be encapsulated and mixed in asphalt concrete. Once the stress in the capsules reaches a certain threshold,the particles break and the rejuvenator is released,giving back the original properties of the pavement. The objective of this paper is to show how these capsules behave and define the most appropriate testing methods to find their effect on asphalt concrete. For this,two different types of rejuvenators will be encapsulated and their effect on the properties of the capsules investigated. Besides,the release mechanisms of the capsules will be unravelled.

关键词： asphalt concrete rejuvenators encapsulation ageing

metallographic Analyses of Laser Gladded Wc-Ni and Wc-co Hard-facing metals

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材料热处理学报 2004年第05B期25卷 996-999页

作者： HK chikwanda m chiremba c van Rooyen department of chemical &metallurgical Engineering Tshwane University of Technology Pretoria South Africa.Department of Chemical &Metallurgical Engineering Tshwane University of Technology Pretoria South Africa.National Laser Centre CSIR Pretoria South Africa

Laser cladding is performed to improve the surface properties of metallic machine components. Extensive work is being conducted to investigate the relationships among the cladding parameters, clad powder characteristics and the quality of the clad layer. This work presents some of the metallographic analyses results of Wc -Ni and Wc-co clad layers. The clad layers are characterised with non-uniform carbide particles, mostly Wc imbedded in a more ductile matrix. The transition from the clad layer to the substrate metal had a distinct dilution zone. The ratio of this zone to the clad height was in the range of 10 -12% and this still needs to be refined.

关键词：激光包覆衬底合金包覆高度包覆深度 Wc-Ni Wc-co